The invention discloses a planting method of hylocereus with a high sugar content. The planting method comprises the following steps of performing soil preparation; culturing seedlings; performing field planting; performing trimming; and performing fertilizer and water management: at the growth period of the hylocereus, performing top dressing of organic fertilizers, and at a fruit swelling period of the hylocereus, additionally applying swelling fertilizers, wherein the organic fertilizers comprise peanut bran, tung oil bran, corn bran, rape seed cakes, thoroughly-decomposed tobacco leaves, thoroughly-decomposed sheep manure, bean dregs, calcium dihydrogen phosphate, calcium superphosphate, potassium humate, chitosan and brassinolide, and the swelling fertilizers comprise potassium dihydrogen phosphate, potassium sulfate, BSFA, boric acid, biologic selenium, composite amino acid and brassinolide. According to the planting method disclosed by the invention, the structure and the content of chloroplast of the hylocereus can be improved, photosynthesis can be promoted, the conversion of acidic materials into saccharides is accelerated, the mouth feel of the hylocereus is promoted, environment stress is alleviated, the content of organic matters in soil is increased, the soil hardening is avoided, and the raw materials are low in cost, easy to obtain and convenient to process.