534 results about "Alcoholisms" patented technology

Disclosed herein is a method for treating depression associated with alcoholism in a patient comprising administering to the patient a pharmacologically effective dose of an opioid antagonist, and a pharmacologically effective dose of at least one drug compound selected from the group consisting of a tricyclic antidepressant, an a-typical antidepressant, and lithium.

The invention provides applications of levorotary oxiracetam and oxiracetam in preparing drugs for preventing or treating coma. Experimental results indicate that levorotary oxiracetam has obvious awaking effect on coma caused by alcoholism, but dextrorotary oxiracetam basically has no effect, and the awaking effect of levorotary oxiracetam is two times of that of dextrorotary / levorotary mixed oxiracetam; levorotary oxiracetam has remarkable awaking effect on comas caused by both trauma and anesthesia.

The present invention provides methods for transdermal delivery of a therapeutically effective amount of Naltrexone Hydrochloride, Naltrexol Hydrochloride, and / or Naltrexone Diol Ester using microneedles. The invention also provides methods for treatment of narcotic dependence, alcohol abuse, and / or alcoholism. Preferably, the Naltrexone Hydrochloride, Naltrexol Hydrochloride, and / or Naltrexone Diol Ester is administered by creating a microneedle-treated site in the skin of a subject by inserting microneedles, followed by applying the Naltrexone Hydrochloride, Naltrexol Hydrochloride, and / or Naltrexone Diol Ester to the microneedle-treated site.

The present invention provides for the use of combinations of drugs to treat addictive disorders. More specifically, the present invention provides compositions and methods for treating disorders using combinations of drugs such as topiramate, ondansetron, and naltrexone.

The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target aldehyde dehydrogenase (ALDH) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and / or administering the lipid particles (e.g., for treating alcoholism in humans).

In various embodiments, the present invention is directed to a taste masked pharmaceutical composition comprising a therapeutically effective amount of taste masked sulfamate-substituted monosaccharide particles comprising a sulfamate-substituted monosaccharide or a pharmaceutically acceptable salt or derivative thereof that are coated with one or more taste-masking layers, and optionally one or more of taste-masked neltrexone, 5-HT3 receptor antagonist, phentermine, and vitamin B-12. The present invention relates to methods of making the taste masked and ODT compositions, and methods of using the compositions for treating a patient subject to an epileptic condition, migraines, dysphagia, achieving / maintaining weight loss, or alcoholism or drug addiction.

The present invention relates to a pure natural beverage with the function of relieving alcoholism. It is made of 23 Chinese medicinal materials of pueraria root, oyster shell, poria, Chinese yam, crataegus fruit, lablab bean, lily bulb and others through a special preparation process. It can quickly obtain obvious effect of relieving alcoholism and possesses the function of protecting liver.

The invention relates to an alcohol-detoxication inflammation-relieving liver-protection beverage and a preparation method thereof. The beverage is prepared by taking radix puerariae, pueraria flower, citrus trifoliate, honeysuckle, chrysanthemum, rhizoma zingiberis recens and glucose as raw materials and refining and processing the raw materials by extraction technology. The beverage balances and integrates the functions of alcohol-detoxication, fever reduction, inflammation or internal heat relieving, and liver detoxification promotion, can effectively relieve bad symptoms of headache, thirst, excessive internal heat, gastric distress, and the like caused by alcoholism after a person drinks too excessively, and has obvious protection functions for livers. The invention can be prepared into liquid drink and solid drink as well.

The sobering up and liver-protecting granule is prepared with Chinese herbal materials including Hovenia dulcis seed, orange peel, kudzu vine root, haw, corn whisker, angelica and tuckahoe, and through decoction, filtering, concentration, granulating and other steps. It has the functions of protecting liver, sobering up, regulating stomach, invigorating spleen, tranquilizing, clearing away heat and toxic matter, etc., so that it can eliminate dizziness, headache, drowsiness, asthenia and other alcoholism symptoms.

The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.

The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.

The invention relates to a health-care product composite with an alcoholism relieving function and a preparation method thereof, and discloses a health-care product composite with an alcoholism relieving function and a preparation method thereof. The composite is prepared from the following raw materials: pueraria flower, hovenia dulcis thumb, kudzuvine root, green tea and oligosaccharide, wherein plantain herb, chrysanthemum, lalang grass rhizome, liquoric root, tangerine peel and hawthorn fruit are also added into the raw materials of the composite. The health-care product composite is prepared by refining wild plants, does not have toxic or side effect, has excellent effects of relieving alcoholism and activating spleen and protecting liver and stomach, and can eliminate or relieve acute mild and moderate alcoholism, acute stomach injury, chronic gastritis and acute liver injury which are caused by drinking. The health-care product composite can be prepared into granules, tea bags and capsules.

The present invention features compositions for intranasal administration comprising an opioid receptor antagonist. The invention also features methods of using such compositions in the treatment of various diseases and disorders, such as the treatment of alcoholism. In certain embodiments, the opioid receptor antagonist is naltrexone or a pharmaceutically acceptable salt thereof.

The present invention provides compositions, methods, and kits for administration of nalmefene for treatment of alcoholism, nicotine dependence, or another condition for which treatment with nalmefene is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases nalmefene continuously with generally linear release kinetics for extended periods of time. Nalmefene is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with nalmefene.

The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.

Compositions and methods for treating, preventing, or reducing alcoholism, in particular methods for increasing patient compliance with therapies that require the intake of an ALDH inhibitor comprising the step of administering a monoamine oxidase B inhibitor.

The invention relates to a medicinal combination for relieving alcoholism and protecting liver and a functional chewing gum prepared therefrom. The medicinal combination is prepared by mixing the following components in portions by weight: 10-25 portions of flower of kudzuvine, 6-15 portions of kudzu root, 10-20 portions of Hovenia dulcis, 5-13 portions of chrysanthemum, 2-6 portions of kuh-seng, 2-8 portions of loquat leaf, 3-8 portions of mulberry leaf, 4-8 portions of fructus amomi, 2-5 portions of nutmeg, 1-4 portions of white lablab bean, 1-6 portions of galangal, 4-10 portions of Fructus Tsaoko, 6-16 portions of cogongrass rhizome and 3-12 portions of bamboo leaf. The alcoholism-relieving chewing gum prepared from the extract of the medicinal combination has high alcoholism-relieving effect, inhibiting effect of antagonizing ethylism, accelerating effects on ethanolysis and diuresis and health care effects on digestive system and liver.

The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs 1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.

The present invention provides for compositions and methods for treating or preventing addictive and compulsive diseases and disorders, particular alcohol-related diseases and disorders, disclosed herein. The GLP activators of the present invention are effective against various alcohol and drug dependency diseases. In accordance with the invention, the present compositions and methods can be used to intercede upstream or downstream in the signal transduction cascade involved in GLP action to treat various alcohol and drug dependency diseases. In one embodiment, the synthesis or release of endogenous GLP can be stimulated. In another embodiment, the endogenous synthesis or release of another molecule active in the cascade downstream from GLP, (e.g., a molecule produced in response to GLP binding to a receptor), can be stimulated. Accordingly, the methods and compositions of the invention are useful for preventing, treating, diagnosing, or monitoring the progression various alcohol and drug dependency diseases disclosed herein.

Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, sedation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.

The invention discloses a health care beverage that has effects of relieving alcoholism, protecting liver, invigorating spleen and nourishing stomach and a preparation method thereof. The health care beverage of the invention mainly consists of the following constituents based on proportions by weight: 2-8 portions of honey, 0.5-2 portions of royal jelly, 0.1-0.6 portion of bee glue and 4-12 portions of haw. The beverage of the invention can not only rapidly ease or reverse varied drunken symptoms of headache, dizziness, nausea, vomiting, inappetence, blurred vision, slow reaction, etc. but also supplement varied nutrients that are short in human body in time to improve human immunity and rapidly repair harm to the human body caused by alcohol. Besides, the beverage of the invention has unique flavor, pleasant sweetness and sourness but no toxicity or side effects, thereby being easily accepted by different groups of people.

The invention relates to a honey raisin tree oral liquid and a perpetration method thereof, belonging to the technical field of food processing. The oral liquid is characterized in that the raw materials comprise honey raisin tree, the root of kudzu vine, radix glycyrrhizae preparata, flower of kudzuvine, honey and acesulfame potassium, and the like; the oral liquid is puce; the content of soluble solid state material is 10-15%; the pH value is 3.5-4.2; and food additive meets the specification of GB2760. The perpetration method of the oral liquid comprises the following steps of: dosing withthe honey raisin tree, the root of kudzu vine, the radix glycyrrhizae preparata and the flower of kudzuvine according to proper proportion; adding proper amount of distilled water to distill; extracting active ingredients of mixture; and stewing for a certain time and filtrating to obtain extract. The extract is concentrated to reach a certain concentration, is added with a certain quantity of the honey or the acesulfame potassium to mix, and is preformed by the steps of sterilizing, disinfecting and sterile filling, and the like, to obtain the honey raisin tree oral liquid. The honey raisin tree oral liquid is a pure natural anti-alcoholism beverage, has the special aroma of the honey raisin tree, and has the functions of protecting the liver and the stomach and anti-alcoholism, thereby being the model of the homology of medicine and food.

Compositions and methods for treating, preventing, or reducing alcoholism, in particular methods for increasing patient compliance with therapies that require the intake of an ALDH inhibitor comprising the step of administering a monoamine oxidase B inhibitor.

The invention discloses a preparation method for a kudzu vine root and mulberry compounded anti-alcoholism beverage. The preparation method comprises the following steps of: (1) extracting kudzu vine root juice; (2) preparing mulberry juice; (3) mixing and blending; (4) centrifuging and filtering; and (5) sterilizing and cooling. According to the preparation method disclosed by the invention, a subcritical extraction method is used for extracting puerarin in kudzu vine roots so that the purity and the utilization rate of the puerarin are high. The beverage prepared by the preparation method disclosed by the invention is clarified in color and luster, is transparent, is uniform and is purple red; the color is not changed; the beverage is rich in aroma, is fresh and cool when being drunk and is soft and lasting; the aftertaste is sweet and the beverage has no extraneous odor; no sediment is formed; a material liquid is clear and has no sediment impurities visible to eyes. The beverage disclosed by the invention has certain effects on preventing drunkenness, alleviating a hangover and preventing alcoholic liver damages; raw materials of the beverage traditional Chinese medicines and fruits, which have both functions of medicines and foods, and are safe and have no toxic side effect.

The invention discloses a corn oligopeptide powder buccal tablet and a preparation method thereof. The corn oligopeptide powder buccal tablet comprises the following components in part by weight: 25-3-5 parts of corn oligopeptide powder, 10-20 parts of hovenia acerba extract, 5-1-5 parts of kudzu root extract, 0.5-5 parts of dried tangerine peel extract, 0.5-5 parts of amomum extract, 0.5-5 parts of ginger extract, 0.5-5 parts of poria extract, 0.1-0.-5 parts of food additive, 1.5-2.-5 parts of mint extract, 35-4-5 parts of white granulated sugar and 0.1-1 part of anti-caking agent. The preparation method comprises the following steps: crushing raw materials, softening the raw materials, granulating by a wet method, drying, sieving, finishing granules, adding the anti-caking agent, tabletting and packaging. The corn oligopeptide powder buccal tablet is scientific and reasonable in formulation, all-around in nutritional and health-care functions of protecting the liver, relieving alcoholism, strengthening the spleen and the stomach and reducing the blood pressure and the blood lipid, good in palatability, safe and non-toxic; and the preparation method is simple and feasible and low in cost.

The invention provides a wine decanting and hangover-preventing bevera traditional Chinese medicine extracting solution which is prepared by hawthorn extracting solution, traditional Chinese medicine extracting solution, vitamins and water, wherein the traditional Chinese medicine extracting solution is prepared through extracting semen hoveniae, pueraria lobata ohwi, poria cocos, semen cassiae, chrysanthemi, mint and hericium erinaceus; and the mass ratio of the hawthorn extracting solution to the traditional Chinese medicine extracting solution to the vitamins is (10-30) to (23-80) to (1-2). The hawthorn extracting solution has the effects of improving digestion, promoting qi circulation and removing obstruction in the collateral, gastral cavity bellying and the like; semen hoveniae has the effects of quenching thirst, relieving restlessness, eliminating dampness and heat and relieving alcoholism, and can be used for eliminating alcoholism, vomiting and difficulty in urination and defecation; pueraria lobata ohwi has the effects of powerfully alleviating hangover, clearing heat, relieving internal heat or fever, protecting liver, keeping young and tonifying kidney; poria cocos has the effects of clearing damp and promoting diuresis, tonifying spleen and calming nerves, and eliminating malaise; semen cassiae has the effects of clearing heat and improving eyesight, lubricating intestines and relaxing bowels, alleviating liver heat and headache; chrysanthemi has the effects of clearing away heat and toxic materials, improving eyesight, relieving headache and dizziness; the mint has the effects of dispelling wind-heat and clearing throats; and hericium erinaceus has good effects of helping digestion, benefiting five organs, relieving pain, and alleviate gastric ulcer.

The invention provides a ginseng candy and a production method thereof. The ginseng candy is prepared from the following raw materials: white granulated sugar, liquid glucose, ginseng granules and mentha camphor, and the procedures are as follows: dissolving sugar, boiling out, blending, cooling and molding, cutting, packaging and the like. The method helps obviously increase the content of the ginseng ingredient in the candy by reasonably selecting and proportioning various raw materials, thus providing the ginseng candy with a better nourishing and healthcare function and facilitating a ginseng candy eater to obtain a substantial nourishing and health effect. As the ginseng candy contains the mentha camphor, the cool and refreshing taste of the mentha camphor weakens the bitter taste of the ginseng ingredient, and the ginseng candy has pure, mellow, refreshing and sweet taste. Besides the nourishing and healthcare effect, the ginseng candy has the efficacies of moistening throat and reducing pathogenic fire, refreshing brain and tranquilizing mind, relieving restlessness and alcoholism, promoting salivation to quench thirst, refreshing breath and the like.

One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. The present invention also relates to the use of a compound of the invention for treating a mammal suffering from Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism or trichtillomania.