Applications of levorotary oxiracetam and oxiracetam in preparing drugs for preventing or treating coma

A technology of medicine and use, applied in the field of application of levo-oxiracetam and oxiracetam in the preparation of drugs for preventing or treating coma

Active Publication Date: 2014-04-23
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Levo-oxiracetam has not been repo

Method used

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  • Applications of levorotary oxiracetam and oxiracetam in preparing drugs for preventing or treating coma
  • Applications of levorotary oxiracetam and oxiracetam in preparing drugs for preventing or treating coma
  • Applications of levorotary oxiracetam and oxiracetam in preparing drugs for preventing or treating coma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Raw material composition:

[0100] (a) Levoxiracetam (99.5% pure) 200mg / capsule

[0101] (b) Lactose 80mg / capsule

[0102] (c) Microcrystalline cellulose 70mg / capsule

[0103] Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of levoxiracetam, lactose, and microcrystalline cellulose and mix evenly, directly Fill the capsule.

Embodiment 2

[0105] Raw material composition:

[0106]

[0107] Taking the production of 1000 levoxiracetam tablets as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of levoxiracetam, starch, and microcrystalline cellulose and mix evenly, add 2% HPMC aqueous solution is used to prepare soft materials, granulate, dry, and granulate, add talcum powder in the prescribed amount to the granules, mix evenly, and compress into tablets.

Embodiment 3

[0109] Raw material composition:

[0110]

[0111] Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is as follows: first the raw and auxiliary materials are passed through an 80 mesh sieve, and the levoxiracetam, lactose, and carboxymethyl starch sodium are mixed evenly by weighing the prescribed amount, Add 10% PVP ethanol solution to make soft material, granulate, dry, granulate, add prescription amount of talcum powder to the granules, mix evenly, and fill the capsules.

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PUM

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Abstract

The invention provides applications of levorotary oxiracetam and oxiracetam in preparing drugs for preventing or treating coma. Experimental results indicate that levorotary oxiracetam has obvious awaking effect on coma caused by alcoholism, but dextrorotary oxiracetam basically has no effect, and the awaking effect of levorotary oxiracetam is two times of that of dextrorotary/levorotary mixed oxiracetam; levorotary oxiracetam has remarkable awaking effect on comas caused by both trauma and anesthesia.

Description

[0001] The application of the present invention is a divisional application with the application number 2011103766076, the application date of November 23, 2011, and the invention name "levo-oxiracetam and the application of oxiracetam in the preparation of drugs for the prevention or treatment of coma". technical field [0002] The invention relates to levo-oxiracetam and the medical application of oxiracetam, in particular to the application of levo-oxiracetam and oxiracetam in the preparation of drugs for preventing or treating coma. Background technique [0003] Oxiracetam is a nootropic drug synthesized for the first time in 1974 by the Italian Skelebechem Company. The drug was launched in Italy in 1987. Oxiracetam is composed of two isomers (S) - A racemate of oxiracetam ((S)-oxiracetam) and (R)-oxiracetam ((R)-oxiracetam); reports on oxiracetam, which can promote ATP in the brain, promote Acetylcholine synthesizes and enhances the conduction of nerve excitation, which...

Claims

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Application Information

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IPC IPC(8): A61K31/4015A61P25/00
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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