The present invention provides a
blonanserin oral
soluble film composition, which comprises an active
drug, a film forming material and a
plasticizer, and the active
drug is one or more of 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5, 6, 7, 8, 9, 10-hexahydrocyclooctane
pyridine represented by a formula I, a pharmaceutically acceptable salt thereof, a
hydrate thereof and a solvate of the 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5, 6, 7, 8, 9, 10-hexahydrocyclooctane
pyridine. The
blonanserin oral
soluble film composition has the advantages of being thin in thickness, good in taste, stable in property, good in
dissolution rate, capable of being instantly dissolved in the
oral cavity without drinking water, especially suitable for patients with
dysphagia, free of grit feeling after being dissolved in the
oral cavity, high in oral absorption speed, uniform in appearance, good in flexibility, simple in process, low in cost and suitable for industrial production. And
sedimentation cannot occur in the membrane liquid preparation process, the content uniformity meets the requirement, the
drug loading capacity is high, and the marketization prospect is good. # imgabs0 #