The invention discloses a targeted slow-release
curcumin compound with an auxiliary liver protection function and a preparation method thereof.The preparation method comprises the steps that
whey protein isolate is heated under the acidic condition to prepare
whey protein isolate fibers, and then the
whey protein isolate fibers are compounded with kappa-
carrageenan; adjusting the mixed
system to be alkaline by adopting a pH migration method, adding a
curcumin alkaline solution, fully dissolving the
curcumin alkaline solution, and combining the curcumin alkaline solution with the
whey protein isolate fiber-kappa-
carrageenan composite
system; and adjusting the pH value of the
system back to be neutral to obtain the high-load amorphous curcumin solution and the
solid preparation. The whey
fiber and the kappa-
carrageenan are self-assembled in the pH circulation process to form a composite carrier, curcumin is converted into an amorphous state from a crystalline state, the
solubility of curcumin is remarkably improved, the loading capacity is greatly improved to 70% at most, the
heat stability,
oxidation resistance and biological
accessibility of curcumin are improved, targeted slow release of curcumin can be achieved, and the curcumin-targeted slow release preparation has a good application prospect. The positioning release performance of the curcumin in the intestinal tract part is improved, and the application form of the curcumin in liver protection function products is expanded.