The invention discloses an anti-fatigue compound preparation and a preparation method thereof, wherein the preparation comprises the following components in percentages by weight: 10-65% of 
salvia miltiorrhiza, 15-35% of 
astragalus, 15-35% of herba epimedii and 5-20% of Chinese wampee fruit. In the invention, the 
salvia miltiorrhiza, 
astragalus, herba epimedii and Chinese wampee fruit are adopted, which contain phenolic acids, flavonoids, 
pectin, polysaccharides and 
saponin compounds, have the functions of increasing coronary 
blood flow, reducing blood lipid, inhibiting 
thrombosis, improving 
microcirculation, eliminating free radicals, preventing oxidization and the like, and can be used for preventing body fatigue and movement injuries, enhancing the body 
immunity and protecting the organs and tissues from being damaged. A variety of nutrients in the present invention activate the immune systems at different levels and generate a comprehensive anti-fatigue effect, the 
traditional Chinese medicine with an 
immunity enhancement function is prepared into a novel compound preparation by means of modern extraction separation and preparation formation process, to improve the activity of the 
drug.