The invention relates to a daily ration feed for constructing a
hyperuricemia animal model as well as a preparation method and application thereof, and the daily ration feed comprises the following components in percentage by
mass: 30%-35% of corn, 10%-12% of wheat middling, 20%-25% of wheat, 10%-15% of
soybean meal, 1%-2% of a high-fat substance, 2%-3% of a premix, 1%-2% of stone
powder, 0.2%-0.3% of
choline chloride, 0.9%-1.4% of feed-grade minerals, 4%-9% of
soybean hulls, 1%-5% of chicken
meal and 2%-3% of
uric acid. The composition also comprises 0.05%-0.15% of a
fusobacterium nucleatum subsp. Multiforme freeze-dried
powder. According to the daily ration feed, different
raw material combinations and inactivated
fusobacterium nucleatum subsp.polymorpha are mixed to prepare the daily ration feed, a
hyperuricemia mouse model is constructed through feed feeding, and the comprehensiveness and stability of model
pathological characteristics are improved through exogenous
uric acid supplementation and a
fusobacterium nucleatum subsp.polymorpha
inflammation regulation and
uric acid axis mode; the method has the advantages that mouse stress is reduced, operation is simpler and more convenient, the built
hyperuricemia mouse model is higher in modeling rate, the model is more stable and
safer, the modeling process is quicker, and the
health problems such as renal failure
metabolism can be effectively avoided in the modeling process.