139 results about "Laboratory mouse" patented technology

The invention discloses an experimental mouse motion behavior identification method based on depth dynamic perception, and the method comprises the following steps: firstly, constructing an experimental mouse attitude estimation algorithm based on feature focusing and depth fusion, introducing a key point feature focusing mechanism based on SMamba in the algorithm, inhibiting background interference, and obtaining a motion behavior of an experimental mouse; and designing a depth feature fusion module based on cross cyclic convolution, and enhancing the positioning robustness of the key region in the shielding scene. Then, on the basis of the posture estimation algorithm, mouse key point heat maps are extracted to form spatio-temporal feature input of behavior recognition, an experimental mouse behavior recognition algorithm based on double-branch attention perception is constructed, and a skeleton spatio-temporal feature dynamic perception technology based on double-branch attention is introduced into a behavior recognition backbone network; differentiated expression and dynamic modeling of the target behavior are realized, so that four typical motion behaviors of face washing, head raising, turning around and standing of the experimental mouse are accurately identified.

The invention relates to a construction method and application of a loneliness mouse model, and the method comprises the steps: placing an experimental mouse in an isolation region in a transparent acrylic isolation cover through an environment in which physical isolation and social deprivation stimulation coexist, forming a visually accessible but physically isolated social environment with five normal living mice, and continuously inducing chronic loneliness for 4 weeks. The effectiveness of the model is verified through a multi-dimensional evaluation system, including behavioristics (open field, elevated maze and three-box experiment), neuroendocrine (serum noradrenaline and angiotensin II), immune inflammatory factors (IL-1beta, IL-6, TNF-alpha and CCL5) and nerve activation (blue spot, almond nucleus, lateral nucleus septum, medial prefrontal cortex and center joint dorsal nucleus C-Fos staining) indexes. According to the intervention method, dynamic environment abundance and social stimulation are adopted, running wheels are arranged, a modular abundance device is arranged, and a social environment of new mice is introduced, so that pathological phenotypes caused by loneliness are reversed. And a systematic experiment tool is provided for exploring association of aloneness and diseases.

The invention discloses a construction method and application of a bacterium-derived depression mouse model, and belongs to the technical field of biological medicines. The method comprises the following steps: randomly grouping SPF (specific pathogen free) grade C57BL / 6J experimental mice; using drinking water quadruple antibiotics or intragastric administration quadruple antibiotics to deplete mouse background intestinal flora; according to the method, a freshly prepared Eggera tarda bacterial liquid is applied to male mice of 7-9 weeks old in an intragastric administration manner, and the bacterial-derived depression mouse model is constructed. According to the construction method disclosed by the invention, by directly planting the Eggera tarda which has a definite causal relationship with the major depression, multivariable interference introduced by a traditional complex mental stress model is avoided, and a'bacterial origin 'animal model which is more single in variable, clearer in causal relationship and clearer in mechanism is constructed; and an efficient and reliable experimental tool is provided for accurately explaining the specific action mechanism of the'microorganism-intestine-brain axis' mediated by the Eggera tarda in the occurrence and development of the depression.

The utility model provides an efficient out-of-focus myopia model based on an anti-scratch lens fixing device, which comprises a gauze ring, a base, a mounting cylinder and a lens, the inner wall of the lower end of the base is glued with the gauze ring used for shading and dust prevention, and the upper side of the base is movably clamped with the mounting cylinder used for mounting the lens. Compared with the prior art, the laboratory mouse has the advantages that the base is arranged, the through holes in the side edge of the base are matched with the gauze, so that the eyes of the laboratory mouse can be ventilated, the situation that the experiment result is affected by eye discomfort caused by sealing is avoided, and dust and bacteria in the external environment can be intercepted; by matching with sponge columns of which the interiors of spaced through holes are fully sucked with silver ion antibacterial agents, the antibacterial effect can be effectively achieved, infection caused by the influence of bacteria on eye products of laboratory mice is avoided, the stable fixing performance is provided through deformation by arranging a protection plate and a mounting cylinder on the base, and then the lens is fixed more stably.

The invention belongs to the technical field of construction methods of disease animal models, and particularly relates to a construction method and application of a renal syndrome hemorrhagic fever mouse model. According to the HTNV infected mouse model established by the method disclosed by the invention, the symptom of the experimental mouse is close to the clinical symptom of a severe hemorrhagic fever with renal syndrome after challenge, the complete lethality and repeatability are high, and the HTNV infected mouse model has the advantages of simple operation, low cost and high efficiency. The method can be used for research on the HTNV pathogenic mechanism and immune mechanism and research and development of antiviral drugs and vaccines, and has great application value for perfecting an HTNV full-chain prevention and control system.

The utility model relates to a water feeding structure for experimental animal feeding, which comprises a water inlet pipe, a water outlet pipe and a water outlet pipe, the drainage assembly is installed at the bottom of the water inlet pipe, and the drainage assembly is used for guiding water of the water inlet pipe into the cage. According to the water feeding structure for experimental animal feeding, the drainage assembly is arranged, water of the water inlet pipe can be guided into the drainage groove of the drainage block, opening and closing of the drainage groove are achieved through the locking mechanism, the hidden drinking design can avoid the problem that a water source is exposed in the air for a long time and is polluted and deteriorated, and the service life of the water feeding structure is prolonged. The problem that bacteria breed in the cage due to damp when the water basin is overturned can be avoided, and the water drinking requirements of a plurality of laboratory mice can be met at the same time.

The invention relates to the technical field of laboratory devices, in particular to an intelligent intraperitoneal injection auxiliary fixing device for laboratory mice, which comprises a basic bearing module, and a mouse fixing module, a pressure monitoring module, a control module, an indication module and a power supply module which are mounted on the basic bearing module, wherein the mouse fixing module is used for fixing a mouse, the mouse fixing module comprises a lower arc-shaped latticed clamping plate, an upper arc-shaped clamping plate, a connecting piece and a hook lock, the lower arc-shaped latticed clamping plate and the upper arc-shaped clamping plate are connected through the connecting piece, and the upper arc-shaped clamping plate and the lower arc-shaped latticed clamping plate are jointly matched to clamp the mouse; the abdomen of the mouse faces the lower arc-shaped latticed clamping plate, the hook lock is used for fixing the upper arc-shaped clamping plate and the lower arc-shaped latticed clamping plate, the pressure monitoring module can monitor the stress condition of the mouse in real time, compressive stress or suffocation of the mouse is avoided, and animal welfare is improved.

The utility model discloses a laboratory mouse multi-layer three-dimensional cage structure which comprises a supporting bottom plate for feeding laboratory mice, two ends of the supporting bottom plate extend to form mounting plates, two sides of the supporting bottom plate are provided with side plates, the top of each mounting plate is provided with a separation net, each mounting plate is provided with a ventilation plate, and the other side of each mounting plate is provided with a mounting groove. An inserting groove is formed below the mounting groove, a turning cover plate is mounted in the inserting groove, and a supporting layer is inserted in the inserting groove; a water feeder is installed on the side plate, a feeding opening is further formed in the side plate, and a feeding trough is installed outside the side plate; the multi-layer three-dimensional layout is achieved through the slot type supporting layer, the space utilization rate is increased, the water feeder and the feeding system are independent, the requirement of experimental mice for the activity space is met, and separation net holes are matched with the transparent observation plate to form the three-dimensional activity space; due to the inclined plane design of the feeding trough and the sealing structure of the flip head, the feed residue rate is reduced; the inserting groove type supporting layer is matched with a supporting block locking structure, and the excrement leakage risk is completely eradicated.

The utility model relates to the technical field of experimental animal feeding device design, and discloses an easy-to-clean experimental mouse feeding cage which comprises a feeding box, a hollow inhabitation platform is arranged in the feeding box, and the inhabitation platform divides the feeding box into an inhabitation space and a dirt storage space in the vertical direction. The joints of the adjacent side walls in the inhabiting space and the joints of the inhabiting platform and the four walls in the inhabiting space are all in an arc-shaped connection mode, a box cover is arranged at the top of the feeding box, a guide groove is annularly formed in the top wall of the feeding box, a scraping plate is arranged on the inner side wall of the inhabiting space in an attached mode, the top end of the scraping plate is rotationally connected with a driving plate, and the driving plate is arranged in an L shape; the vertical part of the driving plate is inserted into the guide groove, a driving assembly is arranged in the guide groove, a collecting box is arranged at the inner bottom of the feeding box in a sliding mode, the collecting box is located below the hollowed-out through hole of the inhabiting platform, and a box door is hinged to the position, corresponding to the collecting box, of the feeding box. The cleaning device has the effect of improving the working efficiency of cleaning the laboratory mouse rearing cage.

The application provides a laboratory mouse tail skinner and an operating method thereof, which comprises a base, a cutting mechanism comprising a first assembly ring and a plurality of cutting assemblies, any cutting assembly comprising a first mounting seat and a cutting knife, the cutting knife being arranged on the first mounting seat and extending towards the center of the first assembly ring, and a skinning mechanism comprising a second assembly ring and a plurality of skinning assemblies, the second assembly ring being arranged concentrically with the first assembly ring, and the skinning assembly comprising a second mounting seat and a skinning knife, the skinning knife being connected to the second mounting seat and facing along the axial direction of the second assembly ring. The application replaces manual operation of a handheld blade with a mechanical structure, effectively avoiding the safety hazard of a sharp blade scratching the fingers of a laboratory worker. In addition, the application has a simple body structure and is convenient to assemble, can flexibly adjust the positions of the cutting assemblies and the skinning assemblies according to laboratory mouse tails of different specifications, has a wide range of applications, and has high practicality and promotional value.

This utility model discloses a transport box for laboratory mice with an anti-collision and buffer structure, including an outer anti-collision box and an inner placement box. The placement box holds the laboratory mice, and the outer wall of the placement box is provided with multiple buffer blocks, which are placed between the outer anti-collision box and the placement box. Both the outer anti-collision box and the top of the placement box are provided with door opening and closing components. The top and bottom of the placement box are provided with upper and lower buffer components, and the opposite side wall is provided with side buffer components. The upper and lower buffer components and the side buffer components are all set in conjunction with the buffer blocks. This utility model provides basic anti-collision protection through the outer anti-collision box, and with the buffer blocks on the outer wall of the placement box, it can initially mitigate the impact of external collisions. The upper and lower buffer components and the side buffer components work together to effectively absorb the vertical and lateral vibrations and bumps during transportation, reducing the stress response or physical injury to the laboratory mice caused by collisions and bumps.

The invention belongs to the technical field of animal model construction, and particularly provides a construction method and application of a mouse non-alcoholic fatty liver model, and the construction method comprises the following steps: S1, selecting an experimental mouse; s2, a high nitrogen compound aqueous solution with the mass concentration of 4-10 mg / mL is prepared; s3, according to the dosage, the dosage and the administration time, the prepared high-nitrogen compound aqueous solution is fed through the intragastric administration, and the non-alcoholic fatty liver animal model is obtained, the problems that an existing non-alcoholic fatty liver animal model is long in modeling time and expensive in modeling are solved, and the non-alcoholic fatty liver animal model does not need to be fed with high-fat feed, and is simple, convenient and feasible, low in cost, good in repeatability and stable; the establishment period of the non-alcoholic fatty liver animal model can be effectively shortened, the time cost of the medical research of the NAFLD is greatly saved, and a good animal model is provided for researching the pathogenesis and treatment strategy of the NAFLD.

The invention discloses a laboratory mouse feed and a preparation method thereof. The feed consists of the following raw materials in percentage by weight: 32-38% of corn flour, 22-28% of fermented soybean meal, 8-12% of fish meal, 4-6% of silkworm chrysalis meal, 10-15% of low-gluten wheat flour, 2-3% of purple perilla seed oil, 1.5-2.5% of calcium carbonate, 0.8-1.2% of calcium hydrophosphate, 0.3-0.5% of table salt, 0.8-1.2% of microencapsulated compound vitamins, 0.2-0.4% of an enzyme preparation compound, 3-5% of dietary fibers and the balance of mineral premix. The preparation method has the beneficial effects that the vitamin retention rate of the technical scheme is increased by 30-40% compared with a contrast, and the problem of nutrient loss caused by a traditional high-temperature process is solved; the water uniformity is improved by 68% through gradient cooling, the quality guarantee period is prolonged from 50 days to 85-95 days in combination with a microencapsulation technology, and the storage loss is reduced.

The application discloses a method for constructing a Parkinson's disease animal model with improved survival rate and application thereof, and relates to the biomedical field, and comprises the following steps: S1, injecting a gepefron solution into the abdominal cavity of an experimental mouse; S2, performing brain stereotactic injection on the experimental mouse by using a 6-OHDA solution; S3, injecting meloxicam into the abdominal cavity of the experimental mouse, and dynamically adjusting the dosage of meloxicam based on the daily weight change of the experimental mouse; S4, performing postoperative nursing on the experimental mouse, including nutritional support and graded gavage; and S5, performing behavior testing, pathological verification and inflammation evaluation on the experimental mouse, and obtaining a Parkinson's disease animal model through the above steps. The application has the advantages of high postoperative survival rate of the animal and high success rate of modeling.

The utility model discloses an automatic feeding device for laboratory mice, which belongs to the technical field of automatic feeding and comprises a bottom plate, a quantitative feeding mechanism is arranged above the bottom plate, and an alarm mechanism is arranged above the bottom plate. The quantitative feeding mechanism is arranged, the alternating-current power supply box supplies power to the electric actuator, the direct-current power supply box and the slide rheostat are matched to provide 4-20 mA electric signals for the electric actuator, the resistance value of the slide rheostat can be adjusted according to different weights of laboratory mice, and therefore the direct current is adjusted, and the feeding efficiency is improved. The opening degree of a valve is adjusted through an electric actuator, the feeding amount of laboratory mice with different weights is adjusted, meanwhile, an alarm mechanism is further arranged, when food is little, the weight of the food cannot press a sliding plate downwards by an enough distance, an alarm rod cannot make contact with an alarm, and when the alarm rod does not make contact with the alarm, the alarm triggers an alarm, and the alarm rod cannot make contact with the alarm. And a worker is reminded of insufficient food in the storage tank, so that the worker can add the food in time.

This utility model relates to a simple experimental mouse fixation and tail vein injection device, including a fixation platform, a transparent isolation cover, and a tail fixation component. The transparent isolation cover is used to cover the experimental mouse on the fixation platform. An isolation cover notch is formed at the edge of the open end of the transparent isolation cover, through which the tail of the experimental mouse protrudes. The tail fixation component is used to fix the protruding tail of the experimental mouse on the fixation platform. This utility model combines experimental mouse fixation, tail fixation, and visual monitoring, achieving a dual improvement in drug administration accuracy and simplified experimental operation. It can be operated by a single person and is suitable for precise drug delivery and real-time image monitoring in small animal experiments, possessing high practical value and promising prospects for widespread application.

The invention belongs to the technical field of intestinal flora sampling, and particularly relates to an experimental mouse intestinal flora sampling device which comprises a mounting cylinder, the side wall of the mounting cylinder is fixedly connected with a controller and a buzzer, the right side of the mounting cylinder is of an open structure, and the inner wall of the left side of the mounting cylinder is connected with an annular plate through a spring. And an injector is inserted into the right side of the mounting cylinder, a mounting frame is fixedly connected to the front side wall of the mounting cylinder, and the mounting frame is of a U-shaped structure. When the insertion head of the sampling device is inserted from the anus of the mouse, the diameter of the insertion head is reduced, so that the problems that the insertion head is too thick, the mouse is severely painful, the stress hormone level of the mouse is promoted to rise, and the intestinal flora composition is interfered are solved; and the insertion head can be expanded to a proper diameter, so that the problem that the insertion head is blocked by dietary fibers in intestinal tracts of mice is avoided.

The invention relates to the technical field of orthodontic tooth movement in animal experiments, in particular to a mouse orthodontic tooth movement model and a construction method thereof, and the mouse orthodontic tooth movement model comprises a traction assembly and an anchorage nail; the laboratory mouse is provided with a maxillary bone, second molar teeth growing on the maxillary bone and incisors growing on the maxillary bone, first molar teeth of the laboratory mouse are extracted, and an avoiding space is formed in front of the second molar teeth after the first molar teeth are extracted; the anchorage nail is connected to the maxillary bone and is positioned between the second molar and the incisors; the anchorage nail is fixed after being implanted into the maxillary bone, so that the position change of the traction assembly caused by connecting the traction assembly to the incisors can be avoided; the traction assembly is arranged between the second molar and the anchorage nail, the front end of the traction assembly is connected with the anchorage nail, the rear end of the traction assembly can penetrate through the avoiding space and is connected with the second molar, the second molar is used as an experimental moving tooth, and the movement rule of human clinical orthodontic teeth can be better simulated.

This invention discloses a blueberry anthocyanin nutritional solid composition for relieving eye discomfort. The composition comprises blueberry anthocyanin solid powder, algal oil powder, zinc gluconate, and selenium-enriched yeast, and may optionally contain lipid nutrients containing gamma-linolenic acid, as well as food additives and excipients. Oral administration of this composition provides the body with various nutritional supports related to ocular surface function and ocular moisture, helping to maintain tear secretion levels, improve tear film stability, and support the normal physiological state of the corneal epithelium, thereby relieving eye dryness and discomfort caused by environmental stimuli or increased eye strain. Animal experiments showed that after 14 days of continuous administration of the composition, experimental mice exhibited a significantly increased tear secretion volume compared to the control group without the composition, with an increase of approximately 165%. Corneal fluorescein staining scores were also significantly reduced, indicating improved ocular surface condition and significantly enhanced eye comfort.

The invention relates to an efficient energy supply type laboratory mouse feed which comprises the following components in percentage by weight: 20-40% of corn, 10-30% of wheat, 1-5% of wheat middling, 4-10% of soybean meal, 2-8% of fish meal, 2-6% of chicken meal, 1-10% of soybean hull, 1-5% of soybean oil, 1-5% of lard, 0.5-2% of stone powder, 0.5-1.5% of calcium hydrophosphate, 2-5% of premix, 1-5% of MCT microcapsule powder and 0.5-2% of glutamine. The stability of MCT is improved through a microencapsulation method, the activity of glutamine is reserved through an embedding method, the synergistic effect of MCT microcapsule powder and glutamine is utilized, meanwhile, lard oil and fat raw materials are added, high-temperature steam is used for curing materials in the production process, the fragrance of the feed is further improved, the palatability of the feed is jointly improved, the food intake of laboratory mice is not affected, and the production cost is reduced. The utilization efficiency of the feed is improved; the experimental mouse feed can reduce body fat and improve blood lipid level, can effectively prolong exhaustion time of mice, and is suitable for cultivation and maintenance of special experimental animals such as intestinal injury models and immunodeficiency models.

The invention provides a laboratory mouse fixing frame for acupuncture or moxibustion. The laboratory mouse fixing frame comprises a fixing assembly, an overturning assembly and a moxa stick clamping assembly. The fixing assembly is used for binding and constraining the laboratory mouse; the overturning assembly comprises a base, U-shaped frames are connected to the two sides of the upper end of the base, rotating plates are connected to the opposite sides of the two U-shaped frames, connecting rods are connected to the opposite sides of the two rotating plates, and each connecting rod is connected with the fixing assembly. According to the device, the overturning assembly is arranged, the fixing assembly for binding the laboratory mouse is arranged in a suspended mode, overturning of the fixing assembly and the laboratory mouse is achieved by rotating two rotating plates, the rotating plates can be locked through locking blocks, shaking of the laboratory mouse in the acupuncture or moxibustion process is avoided, and the double-face acupuncture effect on the laboratory mouse is achieved; meanwhile, the fixing assemblies and the connecting rods are detachably connected, fixing assemblies of different models can be conveniently selected according to the types of the laboratory mice, and the application range of the device is widened.

The invention discloses a state recognition method of an adaptive gene editing laboratory mouse, and aims to solve the problem of insufficient state recognition specificity of the gene editing laboratory mouse in the prior art. The method comprises the following steps: acquiring genotypes, disease model types and experimental environment parameters of laboratory mice; optimizing detection and optical flow analysis parameters, generating a time sequence behavior track map and segmenting a key area; extracting general and pathological specific composite features and standardizing the general and pathological specific composite features; calling a genotype pathological feature association database to calibrate a weight and a threshold value, and inputting a random forest classifier recognition state of transfer learning optimization; scores are calculated through a weighted scoring model, the state is judged, and credibility is calculated through a multi-dimensional confidence evaluation model. The method is suitable for various gene editing laboratory mice and experimental environments, the accuracy and suitability of state recognition are improved, and powerful support is provided for gene therapy research and development and disease mechanism research.

The invention discloses an experimental mouse grain crushing device with a multi-cavity structure, and relates to the technical field of mouse grain processing, the experimental mouse grain crushing device comprises a pre-crushing bin, a conveying bin and a crushing bin, the conveying bin is fixedly connected to the bottom of the pre-crushing bin, the crushing bin is fixedly connected to the bottom of the conveying bin, and two pre-crushing rollers are rotatably connected to the interior of the pre-crushing bin; the back face of the pre-crushing bin is fixedly connected with a first motor, an output shaft of the first motor is fixedly connected with the rear end of one of the pre-crushing rollers, the anti-blocking mechanism is arranged in the pre-crushing bin, and the anti-blocking mechanism comprises two transverse supporting beams fixedly connected to the two sides of the bottom end in the pre-crushing bin; and a vertical frame is fixedly connected to the bottom end of the interior of the pre-crushing bin, a reset spring is fixedly connected to the upper end of the vertical frame, and a connecting frame is fixedly connected to the front end of the reset spring, so that the problem that mouse food is prone to rolling when making contact with the roller surface, and mouse food pre-crushing treatment is affected is solved.

The utility model discloses a laboratory mouse mouth gag, which belongs to the technical field of animal medical experiment auxiliary instruments and comprises a V-shaped elastic piece, the V-shaped elastic piece comprises an elastic part and two connecting rods respectively positioned at two ends of the elastic part, and one ends of the two connecting rods far away from the elastic part are provided with an upper incisor fixer and a lower incisor fixer. The upper incisor fixer inwards rotates by 20-30 degrees by taking the axis of the connected connecting rod as the axial direction, and the lower incisor fixer inwards rotates by 20-30 degrees by taking the axis of the connected connecting rod as the axial direction. The upper and lower incisor connecting rods are connected with the length-adjustable sliding rod, and the length of the far end can be adjusted according to experiment requirements. According to the laboratory mouse mouth gag, an operator can operate the laboratory mouse mouth gag with one hand, the other hand of the operator can assist in fixing a laboratory mouse or conducting experimental operation, one person can complete the operation of opening the oral cavity of the mouse, and the laboratory mouse mouth gag is large in elasticity and can effectively prevent the oral cavity of an experimental part from being closed. An experiment oral cavity is always opened, so that an operator can conveniently carry out an experiment.

1. Name of the product in this design: Mouse restraint device. 2. Purpose of this design: To fix experimental mice during blood glucose testing. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The utility model discloses an experimental mouse fundus blood sampling device which comprises a capillary blood sampling tube, an anticoagulation tube and a handheld part, and a plane blood sampling opening is formed in one end of a tube body of the capillary blood sampling tube; a positioning plate is arranged at one end of a pipe body of the anticoagulation pipe, the other end of the pipe body of the capillary blood taking pipe penetrates through the positioning plate and extends into the pipe body of the anticoagulation pipe, and air holes are formed in the side face of a plate body of the positioning plate; the other end of the tube body of the anticoagulation tube is installed on the handheld part, and the handheld part is further provided with an illumination part facing the plane blood taking opening. According to the utility model, all the extruded fundus blood can enter the anticoagulation tube, and the condition that the blood sample is polluted by fallen hair is reduced.

The utility model discloses a mouse open field experiment device convenient to clean. The mouse open field experiment device comprises an open field platform, a supporting mechanism arranged on the open field platform, a lifting mechanism which is arranged on the outer side of the supporting mechanism and can move up and down, and a guide mechanism arranged on the open field platform. The guide mechanism comprises two guide plates arranged on the front side and the rear side of the open field platform respectively and two guide grooves formed in the opposite faces of the two guide plates respectively. Meanwhile, cleaning mechanisms capable of moving left and right along the surface of the open field platform are arranged on the two guide grooves; the open field platform has the advantages that the open field platform can be quickly switched to be opened / closed through matching of the supporting mechanism and the lifting mechanism, the open field platform can be exposed when the open field platform is in an upward moving and opening state of the test area, excrement and other impurities on the surface of the open field platform can be conveniently and quickly cleaned by the cleaning mechanism, and meanwhile experimental mice can be conveniently placed in the open field platform; and when the test area moves downwards and is closed, a mouse test open field is reconstructed.

The utility model discloses a pair of special cage changing tweezers for laboratory mice. According to the special cage changing tweezers, on the basis of existing stainless steel elbow tweezers, the similar-triangle-shaped fixing support is welded to the top end of the tweezers body, then the silica gel part is fixedly installed on the similar-triangle-shaped fixing support through the hot melting technology, and it is guaranteed that the silica gel part is firmly connected with the tweezers body and the similar-triangle-shaped fixing support; falling caused by soaking disinfection, repeated operation and the like is avoided; the silica gel part is made of a soft material and can be directly used for clamping the trunk of the experimental mouse, so that the situation that the trunk of the experimental mouse is rolled up to hurt an operator is avoided, and the epidermis and soft tissue of the experimental mouse cannot be damaged; in addition, the anti-skid lines are arranged on the opposite inner side faces of the silica gel components at the two top ends of the tweezers body, and the situation that the experimental mouse struggles and accidentally escapes when the smooth part of the body of the experimental mouse is clamped can be avoided.

The invention relates to the use of empty liposomes of defined lipid composition or mixtures of empty liposomes of defined lipid composition and to the use of other lipid bilayers or monolayers of defined lipid composition for the treatment and prevention of bacterial infections. It has been found that such liposomes, in particular a two- and a four-component mixture of liposomes comprising cholesterol and sphingomyelin, liposomes consisting of sphingomyelin, liposomes comprising sphingomyelin and phosphatidylcholine, and liposomes comprising cholesterol and phosphatidylcholine efficiently sequestrate a variety of toxins secreted by bacteria, thus preventing binding of bacterial toxins to target cells and toxin-induced lysis of the target cells. Injected intravenously, liposome mixtures prevented death of laboratory mice infected with lethal doses of Staphylococcus aureus or Streptococcus pneumoniae.

The invention provides a visual quantitative gavage device for laboratory mice, and particularly relates to the technical field of biological experiment instruments.The visual quantitative gavage device comprises a fixed bottom plate, a supporting frame is fixedly connected to the center of the top face of the fixed bottom plate, the laboratory mice are restrained in the mode that the belly faces downwards in the laboratory mouse restraining process, and the situation that when an experimenter manually restrains the laboratory mice, the laboratory mice are restrained by the supporting frame is avoided; according to the lavage device, four limbs of an experimental mouse easily scratch the hand of an experimenter, after the experimental mouse is restrained and fixed, the body of the experimental mouse can be automatically turned over by 180 degrees, so that the experimental mouse is finally inclined upwards, and the experimenter can conduct lavage operation conveniently, and compared with the mode that the experimental mouse is manually held by hand and then the abdomen of the experimental mouse is inclined upwards, the lavage operation is more convenient. The automatic rotating mode is more convenient, the laboratory mouse can be stably kept in the overturned posture, the situation that in the prior art, lavage operation is unstable only by holding the laboratory mouse manually is avoided, and the stability and safety of lavage operation of the laboratory mouse are improved.