533 results about "Visceral organ" patented technology

Methods of modeling anatomical structures, along with pathology including the vasculature, spine and internal organs, for visualization and manipulation in simulation systems. A representation of on the human vascular network is built up from medical images and a geometrical model produced therefrom by extracting topological and geometrical information. The model is constructed using topological and geometrical information. The model is constructed using segments containing topology structure information, flow domain information contour domain information and skeletal domain information. A realistic surface is then applied to the geometric model, by generating a trajectory along a central axis of the geometric model, conducting moving trihedron modeling along the generated trajectory and then creating a sweeping surface along the trajectory. A novel joint reconstruction approach is also proposed whereby a part surface sweeping operation is performed across branches of the joint and then a surface created over the resultatn holes therebetween. A 3-D mesh may also be generated, based upon this model, for finite element analysis and pathology creation.

The present invention relates generally to medical measurement systems for evaluation of organ function and understanding symptom and pain mechanisms. This model takes into account a number of factors such as volume and properties of the fluid and the surrounding tissue. Particular emphasis is on a multifunctional probe that can provide a number of measurements including volume of refluxate in the esophagus and to what level it extents. The preferred embodiments of the invention relate to methods and apparatus for measuring luminal cross-sectional areas of internal organs such as blood vessels, the gastrointestinal tract, the urogenital tract and other hollow visceral organs and the volume of the flow through the organ. It can also be used to determine conductivity of the fluid in the lumen and thereby it can determine the parallel conductance of the wall and geometric and mechanical properties of the organ wall.

Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-neutrophilic mechanism, wherein two components of an initiating system are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.

Lysosomal storage diseases can be successfully treated using intraventricular delivery of the enzyme which is etiologically deficient in the disease. The administration can be performed slowly to achieve maximum effect. Surprisingly, effects are seen on both sides of the blood-brain barrier, making this an ideal delivery means for lysosomal storage diseases which affect both brain and visceral organs.

The invention features methods of treating visceral pain in humans by administering an effective amount of a 5HT1B or 5HT1D receptor agonist, (e.g., a triptan). These methods can be used, for example, to treat a human suffering from visceral pain secondary to an underlying disease of a visceral organ, such as pancreatitis. Visceral pain treatable by the methods of the invention may also be secondary to a disease of the liver, kidney, ovary, uterus, bladder, bowel, stomach, esophagus, duodenum, intestine, colon, spleen, pancreas, appendix, heart, or peritoneum.

There is disclosed an isolated, modified recombinant β-glucuronidase wherein the modification is having its carbohydrate moeties chemically modified so as to reduce its activity with respect to mannose and mannose 6-phosphate cellular delivery system while retaining enzymatic activity Also disclosed are methods for the treatment of lysosomal storage disease in mammals wherein the mammal is administered a therapeutically effective amount of isolated, modified recombinant β-glucuronidase whereby said storage diseased is relieved in the brain and visceral organs of the mammal. Also disclosed are other lysosomal enzymes within the scope of the invention.

The invention discloses a fibrous membrane for tissue repair, a manufacturing method thereof, application thereof for the preparation of products for tissue repair, and a product for tissue repair which is made by the fibrous membrane for tissue repair. The fibrous membrane for tissue repair is formed by interweaving cellosilks with the diameter of 10 nanometers-100 micrometers, and is of a porous structure; the filling power is 200-2000 cm<3> / g. According to the fibrous membrane for tissue repair, the conglutination and the proliferation of cells are facilitated, the guide of the cell differentiation is facilitated, the rapid growth of fibrocytes is facilitated, the tight suture between the fibrous membrane and tissue is facilitated, the comfort of a patient is improved, and the occurrence of conditions of patch shrink, infection and conglutination with visceral organs and the like is reduced.

The invention relates to flour suitable for patients with diabetes mellitus. The flour is prepared by uniformly stirring powder made of traditional Chinese medicines, such as rhizoma polygonati, kudzu-vine root, Chinese yam, tuckahoe, semen coicis, mulberry fruit, frosted mulberry leaf, raw hawthorn and semen euryales and the mixed flour of different grain, such as soya bean, string bean, cow peaand wheat which are beneficial to the patients with diabetes mellitus in a certain proportion and can be used for producing various foods suitable for the patients with diabetes mellitus to have as aprincipal food. The special meal flour has the obvious effects of systemically adjusting glucose metabolism, lightening the pancreatic island load, improving carbohydrate tolerance, microcirculation and the function of the visceral organ, reducing blood fat and blood viscosity and eliminating radicals. The special meal flour is suitable for the patient withs diabetes mellitus, adiposity, hyperlipemia, high blood viscosity, adiposis hepatica, hypertension and heart cerebrovascular disease and middle-aged and old people to have as the principal food.

The invention provides a novel fourth-generation infant formula. The novel fourth-generation infant formula comprises the following ingredients: lactose, desalted whey powder, 1,3-dioleoyl 2-palmitoyl triglyceride, hydrolyzed whey protein, fructo-oligosaccharide, galactooligosaccharide, mineral substance premix compound, casein hydrolysate, whey protein concentrate, soyabean lecithin, vitamin premix, lactoferrin, L-tyrosine, nucleotide, L-tryptophan, L-methionine and the like. The infant formula is added with appropriate amount of 1,3-dioleoyl 2-palmitoyl triglyceride, appropriate amount of protein hydrolysate, monomer amino acid and the like, mineral contents such as phosphorus, sodium and the like in milk powder are reduced, therefore, the fat structure, the amino acid composition, the amino acid content and the osmotic pressure in the milk powder are close to those of the breast milk, the infant formula is balanced and comprehensive in nutrition and is appropriate in composition, all substances have synergistic effect, the bioavailability of protein and the fat is effectively improved, and the infant formula can promote digestive absorption and skeletal development of babies and can reduce the visceral organ burden.

The invention belongs to the application field of traditional Chinese medicine meridian doctrine and acupuncture and moxibustion medical skill, in particular to a three-dimensional meridian and acupoint positioning method under a 3D MAX (Three-dimensional Studio Max) environment, which comprises the following steps of: (1) generating a real three-dimensional image of a human body by adopting a virtual reality technology; (2) constructing 3D meridian and acupoint models on a computer by utilizing a 3D model of the human body; (3) carrying out image combination processing to the real three-dimensional image of the human body and the 3D model of the human body so as to enable the images to be overlapped; and (4) comparing and correcting the meridian and acupoint data of the 3D model of the human body, finally forming the real meridian and acupoint data of the human body, and storing the data into a preset database. According to the invention, on the computer, meridians and acupoints are shown on skeletons, muscle, vessels, nerves, lymph, visceral organs and other related positions of the model in the 3D form by a three-dimensional way, so that the error that human body epidermis needle-inserting points are used as meridians and acupoints by mistakes can be corrected, and the defects of the traditional two-dimensional drawing or three-dimensional reality model in expression of meridians and acupoints of the human body can be overcome.

The invention discloses a gRNA sequence. The sequence is capable of editing a DNA sequence in the manner of taking a hepatitis B viral genome specific locus as a target sequence. The invention also discloses a CRISPR-SaCas9 system containing the gRNA sequence and a recombinant adeno-associated virus packaged with the system. The system and the packaging virus show higher HBV scavenging activity in cells and in transgenic mice body. On the 38th day after twice continuous high dose injection, the contents of HBsAg and HBeAg in experimental group mice serum, compared with the control group, are respectively reduced by 62.96+ / -7.59% and 65.18+ / -3.08%; the HBV DNA content in the serum, compared with the control group, is reduced by 92.82+ / -3.67%; the liver and other visceral organs of the experimental mice are all free from any pathologic change, the off-target effect is also not detected and the application prospects of the gRNA sequence and the corresponding CRISPR-SaCas9 system provided by the invention in preparing the hepatitis B therapeutics are shown.

A low profile gastrointestinal tube feeding system having a securing member for securing a feeding set to a low profile gastrostomy tube disposed inside a visceral organ of a patient's body so that inadvertent removal of the feeding set from the gastrostomy tube is prevented. Also provided is a securing member that secures a connection member to an external retention member. Once the securing member has connected the connection member to the external retention member, neither the connection member nor the external retention member can be separated from one another until the securing member is first disengaged from either member.

A stimulator device for providing stimulation to the gastrointestinal tract of a user including a housing, at least two electrodes, and a pulse generator. The housing has an exterior surface and an interior surface defining a sealed interior space. The housing is constructed of bio-compatible materials and sized and shaped for transport through the gastrointestinal tract. A portion of the at least two electrodes is disposed on the exterior surface of the housing. The pulse generator is disposed in the interior space of the housing and delivers pulses to the electrodes. Also presented are methods of using a stimulator device in the treatment of: gastrointestinal disorders such as dysphagia, gastroesophageal reflux diseases, functional dyspepsia, gastroparesis, postoperative ileus, irritable bowel syndrome, constipation, diarrhea, fecal incontinence, nausea and vomiting; gastrointestinal obstruction or pseudo-obstruction; pain and / or discomfort related to visceral organs; eating disorders, such as obesity, binge eating, bulimia, anorexia, and chemotherapy-induced emesis or emesis of other origin.

The invention relates to a forensic medical diatom detection automation method, comprising the following steps: the building of a diatom scanning electron microscope image database, the building of a diatom automation recognition system and the diatom automation detection process in a water sample and a corpse visceral organ are sequentially carried out; wherein the diatom automation detection process in the water sample and the corpse visceral organ comprises the following steps: (1) microwave digestion and vacuum filtration are carried out to the water sample and the visceral organ; (2) divided field images of the sample are shot one by one by an automatic scanning electron microscope; (3) image reinforcement, image cutting and binaryzation treatment are carried out to the shot sample field scanning electron microscope images by adopting a Gabor filter, and gray threshold segmentation processing and mathematical morphology processing methods; morphological structure characteristics are extracted, and match retrieval and statistical calculation are carried out in a diatom morphological structure characteristic database. The method has the characteristics of simpleness, high efficiency, environment protection, accurate qualitative and quantitative analysis, thereby having good application prospect in the forensic medical drowning diagnosis practice.

The invention provides a CT scan perfusion method and device. The method includes the following steps: after a prescribed time t1 has passed since injection of a contrast agent, carrying out a single-slice CT tracking scan of the contrast agent concentration in the artery with a first radiation dosage; during scan tracking, trigging a scan program when a trigger point is reached, and carrying out an arterial phase scan of a visceral organ at a time t2 with a second radiation dosage, which is larger than the first radiation dosage, so as to obtain an arterial phase CT value; obtaining a CT value increment according to the arterial phase CT value; setting a time density curve of the contrast agent in the artery as an arterial input function during the contrast agent scan tracking process, and obtaining the blood flow volume of the visceral organ according to the arterial input function and the CT value increment. The CT scan perfusion method avoids repeated scans of the visceral organ in the traditional method, so as to reduce radiation on a human body, achieve simpler and easier operations and accurate results, and lessen the discomfort of an examinee.

The present invention is used for evaluating the advantages of haliotis discus hannai. A multi-phase HPLC purification system is used to purify anti-inflammatory peptide from abalone (AAIP, abalone anti-inflammatory peptide). In tandem MS analysis, a fragmentation result shows that the amino acid sequence of the AAIP with nitrogen monoxide (NO) inhibitory activity (IC50=55.8[um]M) is Pro-Phe-Asn-Glu-Gly-Thr-Phe-Ala-Ser (1175.2Da). While the anti-inflammatory effect of RAW264.7 macrophages generated by the stimulus of the AAIP to lipopolysaccharides (LPS) is further studied, and the molecular mechanism is elaborated. The result shows that the AAIP peptide inhibits the nitrogen monoxide (NO) generation induced by the LPS through the expression of inducible nitric oxide synthase (iNOS) by a dose-dependent manner, and the gene transcription of pro-inflammatory cytokines is also obviously reduced, wherein the pro-inflammatory cytokines comprise such as interleukin (IL-1 beta), tumor necrosis factors (TNF-beta) and IL-6. In addition, the AAIP obviously inhibits phosphorylation of mitogen-activated protein kinases (MAPK), such as p-p38 and p-JNK. These results indicate that the AAIP inhibits inflammatory response induced by LPS by intercepting the MAPK pathway of the macrophages. Therefore, the AAIP can be applied to therapeutic drugs for inflammations treatment or healthcare food products.

Oil-in-Water emulsion vaccines induce higher biliary IgA responses which decrease mucosal / internal organ invasion and fecal shedding, increase specific activity of serum IgG subpopulations, and increase the relative avidity index of serum IgG subpopulations, resulting in increased protection from disease in animals.

The invention relates to a bionic in-situ regeneration repair nano sticking patch, which is formed by overlapping an layer A with a cationic group material and a layer B with an anionic group material sequentially, wherein the sticking patch comprises 20 to 80 percent by mass of the A layer with the cationic group material and the balance of the layer B with the anionic group material; layer A with the cationic group material comprises at least one of polysaccharide with a cationic group, protein with the cationic group or opypeptide (polypeptide) with the cationic group; layer B with the anionic group material comprises at least one of polysaccharide with an anionic group, protein with the anionic group or opypeptide (polypeptide) with the anionic group; and the sticking patch comprises not more than 10 percent by mass of added functional factors and / or functional polypeptide. The raw materials used by the invention are materials which can be degraded in vitro and have biocompatibility. The sticking patch is flexible, has good tissue adhesivity, is suitable for concave-convex surfaces of visceral organs, has strong stretching resistance and air pressure resistance, is suitable for application of sticking, sealing, leak stoppage, hemostasia, isolation, repair, adhesion prevention and artificial meninges of defect tissues and can also be used as a slowly-releasing carrier of a medicament and a nano-grade tissue engineering support material.

The invention discloses a puncture robot and a needle insertion system for a mechanical arm of the puncture robot. The system comprises a needle body arranged on the mechanical arm; the mechanical arm comprises a clamping base and a middle-segment clamping part, and the clamping base is provided with a first pressure detection device; a control device controls the mechanical arm to drive the needle body to conduct corresponding action according to a pressure signal of the first pressure detection device. The middle-segment clamping part sleeves the middle segment of the needle body so as to clamp the needle body, the situation is avoided that the needle body is bent and deformed when subjected to resistance of the muscle and tissue of the human body, the rigidity of the needle body is improved, and the errors of a puncture path from a needle tip to the middle segment of the needle body are reduced, so that puncture is more accurate; the first pressure detection device is arranged on a clamping base and used for detecting the forward pressure of the needle body, when the needle body comes across the visceral organ or organs in the needle insertion process, the control device controls the mechanical arm to drive the needle body to conduct a corresponding action, and the needle insertion path of the needle body is adjusted in time, so that the needle body effectively avoids the visceral organ or organs.

The invention discloses an iris partitioning and sunlight radiating canal extracting method based on a basic-element structure definition and a region growing technology, which comprises a new iris partitioning map (CADIC) integrating Chinese and western medicine iridology iris partitioning, invents the region growing technology required for applying the map, based on the basic-element definitionand used for the extraction of a typical iris characteristic, i.e. a sunlight radiating canal and invents a self-adaptive coverage method required for applying the map and based on an iris image dynamic partitioning technology and an iris map. The invention ensures the accurate positioning of each visceral organ of an organism on an iris, and simultaneously highlights the practicability of the iris map and realizes the dynamic cutting technology of complete iris characteristics and the positioning technology thereof on the iris map under medical significance. Experiments prove that the technology can greatly improve the reliability of iris identification and disease diagnosis.

The invention relates to a medical puncture device, in particular to a retraction type laparoscope puncture device capable of preventing an abdominal cavity or thoracic cavity visceral organ and a muscular tissue from being damaged. The puncture device comprises a sheath body (8) of which the cross section is circular and a core rod (9), wherein a cylindrical cavity (12) is formed close to the rear end of the sheath body (8). The puncture device is characterized in that: a core rod positioning mechanism (3) is arranged on one side of the cavity (12); a circular clamping hole groove (20) is formed at the rear end of the core rod (9); the clamping hole groove (20) is matched with a clamping rod (6) at the tail end of the core rod positioning mechanism; the tail end of the core rod (9) is horizontally connected with a second spring piece (11); the other end of the second spring piece (11) is horizontally and fixedly connected to a connecting seat (15); a T-shaped push rod (1) is matched with the connecting seat (15); and the connecting seat (5) is positioned between the push seat of the T-shaped push rod (1) and the cylindrical cavity (12). Due to the adoption of the technical scheme, the puncture device can completely prevent the abdominal cavity or thoracic cavity visceral organ and the muscular tissue from being damaged for a second time.

The invention relates to a laparoscope suture knot pushing and suturing device. The device is characterized by comprising a guider (11) and a suturing probe (12); the opposite sidewalls of the guider are each obliquely provided with a guide hole (10), the two guide holes are staggered in the opposite directions of the guider, and the suturing probe is correspondingly matched with the guide holes in a guiding mode; the guider comprises a fixed sleeve, a pull rod (3) is connected into the fixed sleeve in a sliding fit mode, one side of the pull rod is connected with a locking handle (2), two movable wing plates (4) are hinged to the two symmetrical sides of the other end of the pull rod respectively, and a silicon thin film sheet (7) is arranged in each movable wing plate; the silicon thin film sheets are arranged on extension lines of the corresponding guide holes after the movable wing plates rotate. The laparoscope suture knot pushing and suturing device has the advantages of being reasonable in design, accurate in locating, ingenious in structure, easy to operate and capable of simplifying the suturing process; compared with a conventional suturing mode, the puncture hole suturing time is shortened obviously, so the laparoscope suture knot pushing and suturing device has an obvious safety function and will not hurt blood vessels in the body of a patient or potential visceral organs.

The invention provides an apparatus and method for automatic evaluation of skin resistance or impedance variations in order to diagnose the state of health of at least a portion of a human or animal body. The difference between an AC impedance measured at a specific frequency and at a specific skin area with calibration electrode and a reference electrode and the impedance measured at a similar frequency and in the same area with a measurement electrode and a reference electrode, is used to determine the state of health of the internal organ corresponding to the examined skin area. Alternatively, the skin between the electrodes is exposed to a DC potential of a magnitude selected to give a breakthrough effect. The resistance of the skin is measured between a measurement electrode polarised negatively with respect fo a reference electrode, and the DC resistance of the same skin area is again measured but with the measurement electrode polarised positively with respect to the reference electrode. The ratio of these two values is used to determine the state of health of the internal organ corresponding with the examined skin area.

The invention discloses an anti-aging traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicines. The anti-aging traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3 g of Chinese magnoliavine fruit, 6 g of Chinese angelica, 12 g of spina date seed, 20 g of astragalus mongholicus, 3 g of ginseng, 25 g of Chinese yam, 6 g of medlar, 12 g of rehmannia, 4 g of rhodiola rosea, 10 g of poria cocos, 20 g of acanthopanax and 6 g of polygonum multiflorum. The anti-aging traditional Chinese medicine composition has the effects of activating metabolism of a human body, promoting blood circulation, improving an immunologic function of the human body, delaying degenerating and aging process of physiological functions of the human and the visceral organs, improving physique and physical strength, improving spirit and sleep and reducing age pigment, is used for delaying aging of the human body, and has no obvious toxic or side effect.

The invention relates to a simulated thoracoscope simulation training device for surgery. The device comprises a dummy man unit, a blood collection pool for collecting blood and connected with the dummy man unit, and a pump unit providing the perfusate circulation driving force. The dummy man unit comprises a dummy head and a dummy thoracoabdominal cavity unit connected with the dummy head. The dummy thoracoabdominal cavity unit consists of a front wall skin and a back skin that are separable and that are connected by a sealing buckle to form a hollow cavity provided therein with a dummy thoracic cavity and a dummy abdominal unit. The dummy thoracoabdominal cavity unit is also provided therein with an animal visceral organ group for simulation training. The animal visceral organ group includes a dummy lung and a dummy stomach. The dummy lung is disposed inside the dummy thoracic cavity. The dummy stomach is disposed inside the dummy abdominal cavity. The simulated thoracoscope surgerysimulation training device improves simulation training level of surgery and has low cost.

The invention relates to a lactose acidized glycyrrhetinic chitosan material and a preparation method and the application thereof. The lactose acidized glycyrrhetinic chitosan material is a glycyrrhetinic acid and lactobionic acid jointly modified chitosan material which is synthesized through N-acylation reaction with chitosan serving as carrier and glycyrrhetinic acid and lactobionic acid serving as ligands. The invention further provides a lactose acidized glycyrrhetinic chitosan / 5-fluorouracil medicine carrying nano particle. The lactose acidized glycyrrhetinic chitosan material and the preparation method and the application thereof have the advantages that the dual-ligand co-modified chitosan material is synthesized for the first time, and the nano particle is prepared for target research; and the lactose acidized glycyrrhetinic chitosan which is prepared into the nano particle has higher liver targeting performance and hepatoma cell receptor mediate initiative targeting performance as compared with GA (glycyrrhetinic acid )-CTS (chitosan) and CTS, distribution in other visceral organs can be evidently reduced, reliability in hepatoma targeting is improved, and the lactose acidized glycyrrhetinic chitosan material can be used as a carrier material which has wide application prospect in clinical hepatoma targeted treatment.

The invention provides a chemiluminescent immunoassay kit for detecting clenbuterol, and the kit belongs to the field of immunoassay. The kit is composed of a non-transparent white enzyme-labeled plate which is coated by a clenbuterol-carrier protein cross-linked complex, a clenbuterol standard product, a clenbuterol-peroxidase-labeled antibody, luminescent substrate solution and concentrated buffer solution. The clenbuterol-carrier protein cross-linked complex is obtained by coupling the clenbuterol and a carrier protein through the mixed-anhydride method or the direct protein activation method, and the concentrated buffer solution contains Tween-20 buffer solution. The kit has the advantages of rapidness, simpleness, high sensitivity, low detection cost, good repeatability, high throughput, and the like, and the kit can be used in the detection of residual clenbuterol in animal urine, blood, tissues, visceral organs and other samples.

The invention discloses a method for culturing large pearls by using clam visceral sac implanted nucleuses. The method is characterized by comprising the following steps of: determining three nucleus implanting positions, namely a ridge nucleus position, an abdominal foot nucleus position and an annular intestine nucleus position capable of culturing the pearls in clam visceral sacs according to the size and physique conditions of clams, then implanting 1 to 3 pearl nucleuses and small cell fragments into the selected position in the three nucleus positions, putting the clams implanted with nucleuses back to a culture water area to culture the pearls, and harvesting free large pearls from the visceral sacs of the clams after the cultured pearls are mature. The method for implanting the nucleuses and culturing the pearls by selecting the three key nucleus implanting positions of the visceral sacs of the clams, namely the ridge nucleus position, the abdominal foot nucleus position and the annular intestine nucleus position effectively improves the pearl forming rate by fully using the characteristics of large gonad positions of the three nucleus positions adaptive to culturing the pearls, few intestines and visceral organs affecting nucleus implantation and the like; the nucleus implanted mother clams have extremely low death rate and high implanted pearl nucleus retention rate and high-quality pearl rate; and the method has remarkable economic benefit and social benefit, and can be applied to scale production.

The invention relates to a Chinese herbal medicine pill capable of clearing blood fat and lowering blood pressure, which is prepared from 11 Chinese herbal medicines, i.e. Polygonum multiflorum, lucid ganoderma, rhizoma polygonati, arillus longan, barbary wolfberry fruit, raspberry, ginseng fruit, lotus seed, lily, gingko nut and folium mori. The Chinese herbal medicine pill has precise and appropriate compatibility, strengthens roots by strengthening kidney and tonifying spleen, roundly conditions all visceral organs, treats both principal and secondary aspect of hypertension and hyperlipidemia, can quickly alleviate external symptom, can effectively eliminate various complications and can avoid relapse of hypertension and hyperlipidemia. The pill has the advantages of simple manufacture, low cost, convenient taking, no toxic and side effect and the like.