The application discloses a TOF-PET
reconstruction method based on implicit neural representation, which has a significant technical
advantage in the
deep integration of physical modeling and data-driven methods. Unlike traditional
deep learning methods that rely only on large-scale training data for end-to-end mapping, the method explicitly embeds the physical forward model of TOF-
PET imaging in the INR framework. By introducing a strict
data consistency term, the
network output always satisfies the
system projection constraint and TOF
response characteristics. This effectively avoids problems such as excessive
smoothing, artifact enhancement, and structural
distortion under adverse imaging conditions such as low count and
low dose. The method achieves high-precision, quantifiable, and physically interpretable reconstruction results, significantly improving the reliability of the reconstructed image in clinical quantitative analysis. Without changing the overall modeling idea, the method can be flexibly extended to dynamic
PET imaging, activity-attenuation
joint reconstruction, motion compensation reconstruction, and multi-
modal fusion tasks such as PET-CT and PET-MRI, and can
handle a variety of complex imaging problems.