54 results about "Coloboma" patented technology

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

The invention discloses a bionic design method of a skull tissue engineering scaffold, which comprises the following steps of: implementing three-dimensional reconstruction according to naturally aired skull micro CT (computed tomography) data to obtain a skull sample three-dimensional model; implementing statistics and analysis for the skull sample three-dimensional model to build a skull microporous structure parametric model; implementing skull scaffold bionic design through the skull microporous structure parametric model; and generating a bionic scaffold. Based on measurement of a natural skull micro CT image, the method raises three elements of a space network architecture, a cavity and a connection tube to implement the bionic design for the scaffold; an obtained internal microporous architecture is similar to a bone trabecula of a natural skull, and the average hole scale is about 500-700 microns, so that bone cell growth and climbing demands are satisfied; and moreover, the skull scaffold, obtained by intersection operation with a patch model of a coloboma part, can be matched with an adjacent part, so that the communication among holes is realized, and a bone structure of a true skull is suited better.

The invention discloses a plugging device. The plugging device comprises at least one disc-shaped structure and a waist part connected with the disc-shaped structures, wherein the waist part comprises at least one wavelike ring, and the central axis of each wavelike ring is parallel to that of each disc-shaped structure. Because the waist part is provided with the wavelike rings, when the waist part is stressed with radial acting force, the wavelike structures of the wavelike rings act on the waist part in the radial direction so that the radial acting force can be transmitted in the peripheral direction of wavelike bodies, namely, the wavelike rings, thus, the perimeter of the waist part can be kept unchanged fundamentally under the radial acting force, axial tension is reduced as much as possible, even a coloboma part with an irregular section shape can be well attached to the wall of the plugging device, a gap between the waist part and the coloboma part can be reduced as much as possible, accordingly, residual shunts can be reduced, and the plugging effect can be improved.

The invention discloses a 3D printing personalized customization artificial vertebral body and a preparation method thereof. Pre-operation CT scanning is performed on a coloboma vertebra to build a 3Dmodel, due to the optimized design, a 3D porous bionic personalized spine vertebra is printed, and the biological compatibility is improved due to biological activity processing. Compared with the prior art, the personalized vertebra precisely replaces coloboma, the immediate stability of the artificial vertebra is improved, the vertebra biological compatibility is improved due to activated processing, the vertebra and peripheral bone combining capacity is improved, and long-term stability of the artificial vertebra inside the human body is improved.

The invention discloses a medical planted osteochondral prosthesis system which comprises a metal base and an articular surface, wherein the metal base adopts a metal with mechanical intensity; the articular surface adopts an ultra-high molecular weight polyethylene or ceramic alloy with a low friction coefficient. After being planted, the medical planted osteochondral prosthesis system disclosed by the invention can take an effect of replacing osteochondral coloboma, plays functions of the articular cartilage, can delay abrasion of the articular surface and degeneration of the proximate articular surface, delays or prevents osteoarthritis, can replace the functions of the normal articular cartilage, rebuilds a strong subchondral bone support and achieves effects of delaying or stopping articular degeneration and alleviating symptoms. The medical planted osteochondral prosthesis system has a simple structure and is safe and convenient to use.

The invention discloses a method for preparing a cornea lamina material. The method comprises the following steps of: carrying out accellular processing on a cornea-sclera complex of a mammal eyeball, culturing an amnion epithelial stem cell, inducing and secreting TSP (Thrombospondin)-1 and co-culturing accellular cornea stroma and the amnion epithelial stem cell, sizing, packaging and sterilizing, and the like. According to an obtained cornea lamina transplanting material, the promotion and the balance among the biocompatibility, the stability, the transparency, the mechanical strength and the bioactivity are realized; the integrity of cornea collagen molecules and a lamina structure can be kept to the largest extent, and compared with that prepared with the traditional method, the accellular cornea stroma prepared according to the method disclosed by the invention is larger in tensile strength and has the moisture content and the transparency close to those of normal cornea; and various cell growth factors and the TSP-1 are gathered, and the cornea lamina material has special effects of inflammatory resistance and vascularization resistance, has the capability of greatly enhancing the bioactivity of the cornea lamina material and can be widely used for repairing complicated ocular surface coloboma such as inflammation and corneal ulcer grown in a vascularization way.

The invention provides a complex hernia patch and a preparing method and application thereof. The complex hernia patch comprises three layer structures which are an outer biological layer, an inner supporting layer and an outer biological layer from bottom to top respectively, wherein the outer biological layers are accellular stent layers, and the inner supporting layer is a polypropylene mesh layer. The complex hernia patch prepared through the preparing method comprises the three layer structures, accellular stents in contact with tissue are located on the outer layers, cells can be induced to grow, and thus infection of a hernia coloboma part and formation of scars can be reduced; the polypropylene mesh layer serves as the inner supporting layer so that the mechanical strength of the complex hernia patch can be maintained, the stability of the patch can be improved, and high abdomen expansion pressure can be borne; furthermore, the binding force of the inner layer and the outer layers is good, and thus the problems that due to the fact that the strength of an existing product is not stable, high abdomen expansion pressure cannot be borne, a stent is gradually degraded after cells grow into the stent, consequently tardive pain of hernia repair is brought and relapse is likely to occur can be effectively solved; in addition, the preparing method is simple and capable of being applied to industrial production.

The invention relates to a human body vertebral column implanting appliance, in particular to an artificial vertebral plate, which comprises a vertebral plate body. The artificial vertebral plate is characterized in that the vertebral plate body is an arc-shaped netty vertebral plate, side wings are arranged on two sides of the arc-shaped netty vertebral plate, screw holes are arranged on the side wings, netty bumps are arranged on the back side of the arc-shaped netty vertebral plate, and meshes are arranged on the arc-shaped netty vertebral plate and the netty bumps. The invention is used for reconstruction by the aid of the artificial vertebral plate after laminectomy in posterior spinal surgery for a human body, coloboma of a vertebral plate is repaired, the human body vertebral plate is imitated, spinal cord compression caused by swelling of posterior tissues of the spinal cord of the human body after the surgery is prevented, completeness of a vertebral canal is kept, the vertebral column of the human body is stabilized, and the spinal cord is protected. During usage, the artificial vertebral plate is fixed on a transverse process or a vertebral pedicle of the vertebral column of the human body by screws via the screw holes on the side wings on the two sides, and paraspinal muscle, supraspinal ligament and the like are sewn on the meshes of the netty bumps. The vertebral plate body is the arc-shaped netty structure, so that the volume of the vertebral canal is guaranteed; and the netty structures of the arc-shaped netty vertebral plate and the netty bumps bring convenience for growth of tissues on two sides so as to realize tissue connection.

The invention relates to a medical implantation material and especially relates to a temporomandibular joint fovea prosthesis. The temporomandibular joint fovea prosthesis is especially suitable for various diseases, such as serious bony ankylosis, joint retrogression, rheumatic arthritis, joint coloboma caused by tumor and traumatism, failure of replacing operation for local joint prosthesis and failure of joint reconstruction of autologous tissues. The temporomandibular joint fovea prosthesis comprises a joint fovea prosthesis, a joint fovea bolt, a mandible prosthesis and a mandible bolt, wherein the joint fovea prosthesis is composed of two parts: a joint surface of joint fovea and a joint fovea main body; the joint surface of joint fovea has a shape of an oval hole sunken toward the joint fovea main body; the joint fovea main body is hollow; the joint fovea prosthesis is fixed on a bone through the joint fovea bolt mounted in a joint fovea bolt hole; the mandible prosthesis is composed of two parts: a hemispheroid and a mandible main body; the hemispheroid is connected with the upper part of the mandible main body; the hemispheroid is in contact with the joint surface of joint fovea of the joint fovea prosthesis; the mandible prosthesis is placed on the bone; and the mandible prosthesis is fixed on the bone through the mandible bolt mounted in a mandible bolt hole.

The invention discloses a mesenchymal stem cell preparation for repairing articular cartilage injury or coloboma, a preparation method and application thereof. According to the preparation method, mesenchymal stem cells and synovial cells are indirectly cocultured, so as to obtain the mesenchymal stem cells after coculture, and then the mesenchymal stem cells are cryopreserved, umbilical cord mesenchymal stem cells, which are acquired after the synovial cells and the umbilical cord mesenchymal stem cells are inoculated at density ratio of 4:1 and cocultured, are easier to differentiate towardcartilage direction under a same induction condition. The preparation method utilizes a constructed animal knee joint cartilage injury or coloboma model to prove that the umbilical cord mesenchymal stem cells cocultured with the synovial cells have an obvious effect of facilitating the repairing of articular cartilage injury or coloboma. The invention further provides a preparation which is prepared from the cocultured mesenchymal stem cells. The preparation can be applied to clinic repairing of articular cartilage injury or coloboma; the preparation can effectively promote the repairing of articular cartilage injury or coloboma through anticular injection; the therapeutic effect of the preparation is obviously better than that of a pure mesenchymal stem cell preparation.

The invention discloses a skeletal muscle whole organ acellular matrix, its derived medical products, such as particles, fluidized compositions, gels and active peptides, and preparation and use methods of the matrix and the medical products. The skeletal muscle whole organ acellular matrix completely reserves the skeletal muscle three-dimensional parallelly-arrayed skeletal muscle basement membrane ultra-structure, the vascular matrix network and muscle-tendon joints, reserves large amounts of bioactive components comprising growth factors, hyaluronic acid, glycosaminoglycan, laminins and the like, is highly affinity to muscle-derived stem cells, has the advantages of certain mechanical strength and toughness, thorough decellularization, no obvious immunological rejection, and no ethical or moral issues, and is a skeletal muscle regeneration scaffold and platform having the most advantages reported so far. The prepared skeletal muscle whole organ acellular matrix and its derived medical products can be used for the in-vitro and in-vivo construction and regeneration of the skeletal muscles, are suitable for restoring the skeletal muscle coloboma of various positions in various ranges, and are expected to solve the large-range skeletal muscle coloboma restoration and muscle regeneration problems.

The invention relates to a magnesium alloy fixing screw capable of being degraded under control in vivo, belonging to the technical field of medical instruments. The magnesium alloy fixing screw capable of being degraded under control in vivo comprises a magnesium alloy screw body on which an oxidation film layer with a thickness of 50-200 microns is formed, and the oxidation film layer is coatedwith a degradable polymer coating with a thickness of 1-50 microns. The magnesium alloy fixing screw can be degraded under control in vivo, the strength maintaining period of the fixing screw is about3 months, the degradable period can be controlled within about 6-8 months, and the fixing screw is suitable for fixing between tissue and tissue or between the tissue and a patching material, and particularly suitable for repairing coloboma of soft tissue such as hernia.

Provided is an attachment reconstructive artificial rotator cuff patch and a manufacture method thereof. The method comprises the following steps that a patch intermediate layer with a nanofiber structure is constructed through electrostatic spinning, or a patch intermediate layer with a meshy fabric body structure is constructed by weaving, and the patch intermediate layer with a nanofiber structure or the patch intermediate layer with the meshy fabric body structure serves as a supporting body of the whole patch; the two ends of the patch intermediate layer are respectively a muscle tendon part and an attachment part, a patch muscle tendon part intermediate layer wraps and crosslinks on the muscle tendon part of the patch intermediate layer, and a patch attachment part intermediate layerwraps and crosslinks on the attachment part of the patch intermediate layer; the upper surfaces of the patch muscle tendon part intermediate layer and patch attachment part intermediate layer are correspondingly coated and crosslinked with patch upper layers, and the lower surfaces of the patch muscle tendon part intermediate layer and patch attachment part intermediate layer are correspondinglycoated and crosslinked with patch muscle tendon part lower layers and patch attachment part lower layers to form the whole attachment reconstructive artificial rotator cuff patch. The provided rotatorcuff patch can repair rotator cuff coloboma and reconstruct tendon-bone attachment, and has good mechanical strength and good biocompatibility.

The embodiment of the invention discloses a construction method of a bone tissue restoration model and a preparation method of a bone tissue restoration. The construction method of the bone tissue restoration model comprises the steps that first jawbone bone tissue coloboma image data are obtained, and the types of first jawbone bone tissue coloboma parts are determined; according to the types ofthe first jawbone bone tissue coloboma parts and the weights of the jawbone bone tissue coloboma parts, the morphological structure of the jawbone bone tissue restoration is determined, and the jawbone bone tissue restoration model is constructed; the jawbone bone tissue restoration model is subjected to simulation checking; and if the jawbone bone tissue restoration model meets the checking condition, it is determined that the jawbone bone tissue restoration model is successfully constructed, and the jawbone restoration is stored and prepared. According to the construction method and the preparation method, the bone tissue restoration model can meet the demands of a patient, secondary damage caused by autogenous bone graft for meeting the demands of the different coloboma parts is avoided, and humanization and intelligentization of bone tissue restoring are improved.

The invention relates to a single-sided bacterial cellulose/polypropylene composite sticking patch suitable for intra-abdominal repair and a preparation method of the single-sided bacterial cellulose/polypropylene composite sticking patch. The single-sided bacterial cellulose/polypropylene composite sticking patch is a double-layer sticking patch with a bacterial cellulose layer and a polypropylene layer, and the preparation method comprises the following steps: floating sterilized polypropylene meshes on the surface of a bacterial cellulose culture solution, standing for compound culture 3-5 days, then taking out a fermentation product, and treating the fermentation product by using chemical reagents of acids, alkalis and the like to obtain the single-sided bacterial cellulose/polypropylene composite sticking patch for repairing abdominal wall coloboma. According to the composite sticking patch provided by the invention, the bacterial cellulose layer serving as an abdominal cavity surface is good in biocompatibility and can reduce adhesion of abdominal internal organs; and the polypropylene layer serving as an abdominal wall surface can be firmly fixed with an abdominal wall by virtue of adhesion with the abdominal wall, thereby ensuring the repairing effect and reducing the disease relapse rate.

The invention discloses a personalized acetabulum based on 3D (three-dimensional) printing and a intraosseous support prosthesis. The personalized acetabulum comprises an acetabulum cup based on 3D printing, and a honeycomb-shaped support body which is in integral printing connection with the acetabulum cup; the surface of the inner wall of the acetabulum cup is provided with bulges; a fixing holeof the acetabulum cup is formed in the wall body of the acetabulum cup. The invention also provides an operation guide plate which is matched with the support prosthesis, and provides a preparation method thereof. The personalized acetabulum based on the 3D printing, the intraosseous support prosthesis and the inner operation guide plate have the advantages that the matching degree in re-construction of a lesion region is high, the positioning on the operation guide plate is accurate, a doctor is assisted to quickly cut the lesion part, and the positioning on the screw fixing position is precise; the honeycomb-shaped support structure is suitable for the bone tissues to quickly grow, the rehabilitation time of a patient is shortened, and the effect is better than the traditional post-operation effect; compared with the traditional type, the operation is simpler and more precise and reliable; for the defects in the reconstruction plan of hip joints, the personalized and accurate reconstruction on the target coloboma region can be realized through detailed planning before operation.

The invention discloses a polypeptide growth factor copolymer and preparing method and application, which is characterized by the following: the polypeptide growth factor connects with biological medical polymers carrier substance through conjugated linkage or hydrocarbon chain to form copolymer; the invention has fouw methods to prepare it. The invention can be used for preparing the drug of rebuilding animal body lesion and coloboma organization or organ.

The invention discloses a preparation method of a personalized customization type craniomaxillofacial bone surgery repair and reconstruction implant based on patient CT image design and repair body assembly. The preparation method is characterized in that after a computer storing medical image control system software and reverse engineering design software performs data segmentation on a tomography image, a patient head 3D prototype is reconstructed, a repair body for a coloboma part is designed according to the 3D prototype, 3D printing equipment acquires 3D entity model data, and hierarchy software is used to perform hierarchical processing on the 3D entity model data to obtain hierarchy data; and 3D printing control software performs reverse engineering manufacturing according to the hierarchy data, including hierarchy printing and hierarchy accumulation to obtain a metal prosthesis finally.

The invention discloses a bionic antimicrobial abdominal wall repair material. The bionic antimicrobial abdominal wall repair material includes a pig small intestine submucosa and a chitosan-elastin fiber mesh layer laminating on one side of the pig small intestine submucosa; and the chitosan-elastin fiber mesh layer is an electrostatic spinning nanoscale chitosan- elastin fiber mesh. According tothe bionic antimicrobial abdominal wall repair material, the laminating combination of the chitosan-elastin fiber mesh layer and the pig small intestine submucosa, so that the antimicrobial ability of the prepared abdominal wall repair material is improved effectively; meanwhile, the mechanical strength and degradation performance of the abdominal wall repair material meet the requirement of abdominal wall repair, angiogenesis can further be facilitated, tissue regeneration is facilitated, the existing technical bottleneck of the abdominal wall repair material is solved conveniently, and thetreatment effect of abdominal wall coloboma repair is effectively improved.

The invention discloses a simulation three-dimensional incubator and a culture method for mouth mucosa epithelial cells and applications of the incubator and the culture method. The incubator comprises a single or a plurality of basic structural units, wherein each basic structural unit consists of an inner container and an outer container which are tightly nested with each other, and are prepared from an organic material for cell culture; and the bottom of the inner container consists of a permeable supporting film, and a certain gap is formed between the bottom of the inner container and the bottom of the outer container. The incubator takes the factors of nutrient supply of the mouth mucosa epithelial cells, blood vessels and blood vessel endothelial cells into account, and the growing environment of the mouth mucosa epithelial cells in the incubator is close to that in a human body, so that the incubator can be used for physiological, pharmacological, toxicological and micro-ecological studies of mouth mucosas, and can also be used for constructing human tissue engineering mouth mucosas and repairing and reconstructing mucosal coloboma. The new technology of the simulation three-dimensional incubator promotes an in vitro culture model of a mouth mucosa to a new height, so that related studies are closer to clinical practices.

The invention discloses a tissue-engineered bone and cartilage double-chamber cultivation system, and belongs to the technical field of cultivation devices. The tissue-engineered bone and cartilage double-chamber cultivation system consists of a bone cultivation circulating system and a cartilage cultivation circulating system which are communicated with an bone and cartilage double-cavity cultivation chamber and are independent, wherein the bone and cartilage double-cavity cultivation chamber consists of an outer layer cavity, an inner layer cavity and a bone and cartilage biomimetic integrated bracket; the outer layer cavity and the inner layer cavity are isolated from each other through the bone and cartilage biomimetic integrated bracket to form a bone cultivation chamber and a cartilage cultivation chamber which are independent; the bone cultivation circulating system is communicated with the bone cultivation chamber; the cartilage cultivation circulating system is communicated with the cartilage cultivation chamber. Through the arrangement of the bone and cartilage double-cavity cultivation chamber formed at the same time when cultures are formed, cultivation of bone and cartilage regeneration is carried out at the same time, so that the cultivation efficiency and the quality can be greatly improved; the treating period for a patient suffering from bone and cartilage coloboma is shortened, the pain and the economical burden of the patient can be reduced, and the tissue-engineered bone and cartilage double-chamber cultivation system is extremely high in economical value.

The invention relates to a preparing method of a finger phalanx skeleton thickening shaping bone block model. The preparing method includes the following steps that (1), the double-handle CT data of a target object is collected, and a virtual double-handle skeleton three-dimensional model is obtained through three-dimensional reconstruction; (2), reconstruction model data is guided into a three-dimensional printer, and a double-handle skeleton physical model is printed; (3), an uninjured side phalanx form outline is drawn, and the normal phalanx outline range is obtained through clipping; (4), the injured side phalanx form is compared, and the phalanx size and form of the coloboma part are obtained through drawing and clipping; (5), the long diameter and the short diameter of the coloboma phalanx part are measured, and digital numbers are recorded; (6), the bone block model is cut and ground according to the measurement digital numbers and form of the coloboma phalanx part to obtain a repaired bone block model, and the obtained repaired bone block model morphologically approaches the form of the coloboma phalanx part. Finger phalanx skeleton thickening shaping is carried out through the method, the form of the obtained repair bone block model approaches the height of the coloboma phalanx part, and form recovery of phalanx thickening shaping can be achieved well.