Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

65 results about "Functional reconstruction" patented technology

Biological material for repairing meniscus tear and preparation method for biological material

The invention relates to a biological material for repairing meniscus tear and a preparation method for the biological material. The material consists of an acellular matrix membrane on the inner layer, a porous structure collagen matrix membrane on the middle layer, a cell layer formed by cartilage cells on the outer layer and a cell sheet. The repair material has certain elasticity and toughness and is high in biological activity; the cartilage cells can secrete cell factors per se, and nutritional ingredients can be directly obtained through articular cavity synovia, and thus, the establishment of communication link between tissue cells at both ends of the tear during the meniscus tear process is accelerated; the immigration and the infusion of the cells in the material and autologous tissue cells are promoted; the tissue regeneration and functional reconstruction time is shortened; and the ideal novel material and the preparation method for the material are provided for clinically repairing the damage of the meniscus tear (including blood supply zones), especially the tissue regeneration and the functional reconstruction of no-blood zones and low-blood zones.
Owner:西安博鸿生物技术有限公司

Bionic bone repair scaffold body with layered structure and preparation method

Disclosed are a bionic bone repairing scaffold of a layered structure and a manufacturing method thereof. The scaffold is formed by at least one scaffold unit (4). The scaffold unit (4) is of a cylinder structure with a helical section, the cylinder structure is formed by continuously rolling a laminar material (2) tightly from inside to outside, and the diameter of the cylinder structure is from 0.1 mm to 50 mm. The structure is similar to the Harvard system of the natural bone, has a highly bionic effect, can well implement mechanical transfer between a defect site and normal bone tissue, can maintain good structure stability even in a degradation process, and completes the repair and function reconstruction of the bone tissue. The three-dimensional size of the bone repairing scaffold can be adjusted flexibly by controlling the thickness and height of the laminar material (2), and the number of rolling layers, so as to satisfy different use requirements.
Owner:SICHUAN UNIV

In-situ osteoplastic active calcium phosphate cement and its prepn and application

InactiveCN1416913AKeep aliveCut off direct contactSurgeryBone tissueBiology
The present invention discloses an in-situ osteoplastic active calcium phosphate cement and its preparation process and application. Sodium alginate, collagen, hydrocellulose, polypeptide molecular beam, etc. are used to embed BMP, FGF, TGF-beta and other composite to maintain the activity of bioactive factor. Embedded bioactive factor is made to compound with CPC powder and mix with curing liquid to form paste capable of being moulded at will and self hardened in human body environment and humidity. Inside body, the bioactive factor can induce formation of blood vessel and new bone, formation of active tissue and functional reconstruction. The used CPC cured body may be used as calcium source and phosphorus source for forming new bone and speeding bone tissue formation. The present invention is applied for filling and repairing of bone.
Owner:SHANGHAI REBONE BIOMATERIALS

Service robot controller and control method thereof

The invention discloses a service robot controller and a control method thereof. The service robot controller adopts an open type secondary layered architecture and comprises a task planning layer and a motion control layer which are connected by virtue of a communication interface, wherein the task planning layer accepts tasks by virtue of a human-machine interface, carries out task planning and action sequence planning and adjusts an action sequence according to visual, hearing and proximity sense information obtained by a vision sensor and a hearing sensor; and the motion control layer carries out corresponding motion control according to a motion trail planned by the task planning layer and adjusts a motion control process in real time according to touch information obtained by a touch sensor. The service robot controller adopts an open architecture and provides a platform which flexibly defines and develops different function of the service robot. A layered open software-hardware platform can provide openness at different levels according to different requirements, and application requirements of the service robot on task reconfiguration and functional reconstruction can be met.
Owner:SHANDONG YOUBAOTE INTELLIGENT ROBOTICS CO LTD

Cylinder support for repairing spinal cord injury and application method thereof

InactiveCN103127552AUltra high porosityReduce the impactProsthesisMyelinCylindroma
The invention provides a cylinder support for repairing spinal cord injury. The cylinder support comprises a collagen sponge cylinder support body. An epidermal growth factor receptor antibody cetuximab is crosslinked with the collagen sponge cylinder support body. Neural stem cells are loaded through the collagen sponge cylinder support body crosslinked with the epidermal growth factor receptor antibody cetuximab so as to promote transplanted neural stem cells to be differentiated into neurons, and the cylinder support which facilitates injured spinal nerve regeneration and functional reconstruction is constructed. The collagen sponge cylinder support body has ultrahigh porosity and provides sufficient space for cell growth. More importantly, controlled-release of the antibody cetuximab can relieve effect myelin protein in a microenvironment after spinal cord injury, promotes transplanted neural stem cells to be differentiated into neurons, restrains transplanted neural stem cells from being differentiated into astroglia cells, and also promotes growth of nerve axons so as to facilitate injured spinal nerve regeneration and functional reconstruction. In addition, the invention further provides an application method of the cylinder support for repairing spinal cord injury.
Owner:BEIJING LANGJIAYI BIOTECH CO LTD

Preparation method and application thereof for cell-biological bracket compound based on biological print technology

InactiveCN103272288ABioprinting technology is simple and easyLow costSurgerySpinal cord lesionNerves regeneration
The invention provides a preparation method and the application thereof for a cell-biological bracket compound based on biological print technology. The cell-biological compound is formed by fibrous protein which is drawn out from the autoblood of a patient and processed by an ink-jet print technology. The surface and the interior of the cell-biological compound encompass one or more trophic factors and bone mesenchymal stem cells derived from self. According to the invention, the biological print technology is adopted, the appearance shape, cells and encompassing state model of the trophic factors can be designed according to requirements and practical situation, the cell-biological bracket compound is obtained through printing accurately, the fibrous protein and the bone mesenchymal stem cells are derived from self, so that the problem of immunological rejection is avoided, the trophic factors are cultivated in the bracket and are released slowly with the degradation of the bracket material, the cell-biological compound is applied to the spinal cord injured part to promote nerve regeneration and functional reconstruction on the injured part.
Owner:谢杨 +1

Bioactive ceramic fiber composite scaffold for bone repair and preparation method of composite scaffold

The invention discloses a bioactive ceramic fiber composite scaffold for bone repair and a preparation method of the composite scaffold, and relates to the field of bone repair materials. In order toovercome the shortcomings of large brittleness, difficulty in processing, unsatisfactory degradability and biological activity and the like of a traditional ceramic scaffold material, bioactive ceramics such as calcium silicate serve as a scaffold body, and the surfaces of ceramic fibers are uniformly coated with a layer of degradable biomedical high polymer materials by an impregnation-centrifugation-drying process to obtain a high-porosity, good-mechanical-property and biodegradable bioactive ceramic fiber composite scaffold material for bone repair. The bioactive ceramic materials are easily subjected to synostosis with host bones, inorganic ions released by degrading the bioactive ceramic materials can participate in and promote osteogenesis and even angiogenesis metabolism activity ofa body and have irritating or inducing functions for tissue regeneration repair, and defective bone tissue repair and functional reconstruction are promoted. Degradation products of the biomedical high polymer materials on the surface of the scaffold are harmless and can be excreted to the outside of the body by metabolism.
Owner:BEIJING UNIV OF CHEM TECH

Multimodal brain function reconstruction assessment method based on magnetoencephalogram and diffusion tensor imaging

The invention discloses a multimodal brain function reconstruction assessment method based on magnetoencephalogram and diffusion tensor imaging. The multimodal brain function reconstruction assessment method based on magnetoencephalogram and diffusion tensor imaging comprises the following steps: 1) selecting brain regions of interest from a subject, extracting magnetoencephalogram signals of corresponding brain regions, performing sliding time window splitting processing to extracted time series signals of each brain region, and calculating a function connection matrix existing in the subject; 2) according to the selected brain regions of interest, extracting diffusion tensor imaging data and calculating a structure connection matrix existing in the subject; 3) calculating the function-structure coupling value set of the subject; 4) performing calculation of functional state transition time periods to obtain a time period with the highest final function connection ascending velocity; 5) extracting a function-structure coupling value of time corresponding to the time period obtained in step 4) according to function-structure coupling values obtained in step 3). The method disclosed by the invention avoids errors caused by subjective factors; in combination with brain structure and function information, the limitation of making a judgment purely from the angle of function is avoided.
Owner:SOUTHEAST UNIV

Implant and method for manufacturing mandibular implant with PEKK (polyetherketoneketone) supporting and fixing units and tissue engineering growth unit

ActiveCN106580520APrevent atrophyAvoid adverse effects such as implant looseningBone implant3D printingUltimate tensile strengthPolyetherketoneketone
The invention provides an implant and a method for manufacturing a mandibular implant with PEKK (polyetherketoneketone) supporting and fixing units and a tissue engineering growth unit. The method includes steps: 1) image acquisition and three-dimensional model establishment; 2) molding unit and fixing unit design; 3) supporting unit design; 4) growth unit design; 5) individual composite-structure implant assembly; 6) individual composite-structure implant manufacturing; 7) in-vitro culture. A molding unit, fixing units, supporting units and the growth unit jointly form an individual composite-structure implant, the supporting units, the fixing units and the molding unit are made of PEKK materials and capable of providing sufficient mechanical strength to keep structural integrity from occlusion functional reconstruction, and the growth unit which is an internally degradable stent is capable of guiding new bone generation.
Owner:ZHEJIANG UNIV OF TECH

Method for establishing human bladder transitional cell carcinoma cell line and a mouse model of bladder carcinoma tissue recombination functional reconstruction

The invention discloses a method for establishing a human bladder transitional cell carcinoma cell line and a mouse model of bladder carcinoma tissue recombination functional reconstruction. The method includes the primary cell culture, immortalized cell line identification, tissue reorganization and planting, HE staining, and immunohistochemistry. The invention establishes a novel stable human bladder transitional cell carcinoma cell line, and uses the cell line to construct the mouse model of bladder carcinoma tissue recombination functional reconstruction. The occurrence and development of bladder carcinoma are simulated in mice. The method researches on the biological behavior of bladder carcinoma from in vitro molecular and cell biology and in vivo animal models, and provides an effective tool for the discovery of new biomarkers and therapeutic measures.
Owner:NANTONG UNIVERSITY

Co-culture method of photosensory precursor cells and retinal tissue in vitro

The invention relates to a co-culture method of photosensory precursor cells and retinal tissue in vitro and aims to build a co-culture system for the photosensory precursor cells and denaturation retinal tissue of retina photoreceptor cells. The method comprises the following steps: a photosensory precursor cell layer of an embryonic eye source is prepared; a nerve cell layer of a denatured retina is prepared; the nerve cell layer of the denatured retina is placed on the photosensory precursor cell layer; an epithelial layer of retinochrome is prepared in the lower chamber of a plug-in type tissue culture dish; the co-culture system of the retinal tissue and cells is built in vitro, and the retinal tissue and cells are cultured in an incubator with 5% CO2 at the temperature of 37 DEG C. By adopting the method provided by the invention, the biological characteristics and cellular structure of host cells and transplanted cells, the synaptic contact of the transplanted cells and the host cells, and the chromatin conformation reconstruction of the transplanted cells and the host cells can be observed and detected directly in vitro, and the traces of survival, proliferation, differentiation and functional reconstruction of photosensory precursor cells of a transplanted embryonic eye source can be tracked.
Owner:GENERAL HOSPITAL OF PLA

Autologous whole blood homogenate compound for reconstruction of autologous skin epidermis protective screen

InactiveCN102188362APromote proliferationEasy to synthesizeCosmetic preparationsPeptide/protein ingredientsAutologous Whole BloodAutografting skin
The invention discloses an autologous whole blood homogenate compound for reconstruction of an autologous skin epidermis protective screen. After the autologous whole blood is homogenized, under the synergetic effects of multiple bioactive substances and cell growth factors released by the autologous whole blood, the autoblood is effectively applied to epidermis repair and reconstruction of the skin protective screen, thereby giving better play to the maximum value and biological effects of the autoblood in autologous application; and because the autologous whole blood homogenate liquid plays a mutually cooperative protective effect with other auxiliary components and strengthens the compounding effect of the cell factors in epidermis reconstruction, the autologous whole blood homogenate liquid compound has good effects on epidermis repair and functional reconstruction of the epidermis protective screen, can improve the functional problems of the human skin protective screen in multiple aspects at different levels, restores the health of skin, and basically solves the functional problems of the epidermis protective screen. In addition, the preparation method disclosed by the invention is simple, convenient to operate, easy to learn and popularize, and suitable for medical cosmetology institutions with legal qualification for medical cosmetology.
Owner:董萍 +1

Growth-factor-containing nanofibre porous composite material capable of repairing bone and preparation method thereof

The invention discloses a growth-factor-containing nanofibre porous composite material capable of repairing a bone and a preparation method thereof. The preparation method comprises the following steps of: dissolving chitosan in acetic acid; adding bone growth factors into the solution, and uniformly mixing the solution; immersing a porous inorganic material capable of repairing the bone in the solution under a negative pressure for 1-2 hours, and taking out the material; and freezing the porous material capable of repairing the bone at a low temperature, lyophilizing the material, immersing the material in a stabilizer solution to stabilize the material, washing the material with water, lyophilizing the material again, and sterilizing the material to prepare the growth-factor-containing nanofibre porous composite material capable of repairing the bone. In the invention, the growth-factor-containing nanofibre porous composite material capable of repairing the bone simulates the nanofibre structure of an extracellular matrix of the bone; the bioactivity of the bone growth factors can be kept, and the bone growth factors can be released continuously and slowly; the growth-factor-containing nanofibre porous composite material is beneficial for the regeneration and functional reconstruction of bone tissues; and the defect that traditional slow-release systems of the bone growth factors cannot better simulate a physiological microenvironment required for the regeneration of the bone tissues is overcome.
Owner:JINAN UNIVERSITY

Hernia bioremediation mesh and preparation method thereof

The invention discloses a hernia bioremediation mesh and a preparation method thereof. The hernia bioremediation mesh is made of animal tissues, immune ingredients such as cells and DNA are removed, and the animal tissues are cut into thin strips, twisted into threads, and woven into the bioremediation mesh. Xenogeneic decellularized materials obtain greater intensity through twisting into the threads, so that the xenogeneic decellularized materials are not prone to breaking; since the threads are interwoven with each other after weaving, external force of tensile tearing does not act on one point but on a plurality of interwoven points, so that the mechanical properties are good; and the defects that the xenogeneic decellularized material hernia bioremediation mesh has poor mechanical intensity and needs to be introduced with cross-linking agents or synthetic materials are overcome. The structure of the mesh is prepared by a weaving process, and the size of a mesh aperture can be easily adjusted through weaving parameters, so that requirements of practical application are met. Meanwhile, the hernia bioremediation mesh retains an original three-dimensional structure, non-collagen proteins, growth factors and other components of an extracellular matrix, so that the functional reconstruction and postoperative healing of the tissues are promoted.
Owner:上海白衣缘生物工程有限公司

Follicular stem cell originated from human hair and its amplifying prepn process

The present invention relates to follicular stem cell originated from human hair and its amplifying preparation process, and belongs to the field of medical preparation and human cell culture technology. The present invention adopts improved two-step protease digesting method to amplify follicular stem cell originated from human hair and obtains follicular stem cell with active expression of beta-integrin and keratin 19 in an optimized follicular stem cell preparing environment. The optimized micro environment endows follicular stem cell with fast amplification, antisenile characteristic, the epidermic cell-like, fibroblst-like and hair bulb tissue-like structure or functional expression. The present invention makes it possible to provide sufficient seed cell sources for the fast repair and functional reconstruction of skin defect.
Owner:TIANJIN HOSPITAL

Dynamic overloading method for DSP (Digital Signal Processor)

The invention relates to a dynamic overloading method for a DSP (Digital Signal Processor). The method comprises the following steps: 1, generating mapping files; 2, initializing the DSP; 3, guiding and copying overloading kernels in the mapping files into an internal storage of the DSP so as to cover primary application programs through overloading interface functions; 4, guiding and copying application programs in the mapping files which are stored in an external storage space into the internal storage of the DSP so as to cover the overloading kernels through the overloading kernels in the internal storage, and generating application programs to be operated; and 5, executing the application programs to be operated so as to finish dynamic overloading. As the traditional boot loading mode of an embedded type signal processing ADSP-TS20xS serial processor hardware platform cannot satisfy requirements of system functional reconstruction, the dynamic overloading method is additionally provided with the overloading kernels, and can use the overloading kernels to realize the real-time dynamic overloading operation for program mapping, so that the reconstruction ability of an embedded system is improved.
Owner:AVIC NO 631 RES INST

Ultra wide band reconfigurable receiving and transmitting front end and a signal receiving and transmitting method

The invention discloses an ultra wide band reconfigurable receiving and transmitting front end and a signal receiving and transmitting method, and belongs to the technical field of communication. Thetransmitting-receiving front end comprises a reconfigurable frequency converter. According to the reconfigurable intermediate frequency link and the reconfigurable zero intermediate frequency transceiver, a superheterodyne frequency conversion scheme is combined with a zero intermediate frequency conversion scheme, a two-way amplifier, a reconfigurable band-pass filter, a reconfigurable low-pass amplifier, a numerical control attenuator and a variable gain amplifier are adopted, and a zero intermediate frequency receiving and transmitting self-closed loop technology is combined, so that 3GHz-can be realized; And transmitting and receiving conversion from the 18GHz radio frequency signal to the baseband signal. Functional reconstruction of receiving and transmitting, frequency conversion architecture and the like and reconstruction of technical indexes of gain, instantaneous bandwidth and the like are achieved, and the method is particularly suitable for being used in software radio andcognitive wireless receiving and transmitting systems in the communication field.
Owner:NO 54 INST OF CHINA ELECTRONICS SCI & TECH GRP

Temporo-mandibular joint biological condyle constructed based on tissue engineering related technology

ActiveCN107899087ASolve the biggest bottleneck that cannot achieve joint function reconstructionImprove joint symptomsTissue regenerationCoatingsUpper floorCostal cartilage
The invention discloses a temporo-mandibular joint biological condyle constructed based on a tissue engineering related technology. The temporo-mandibular joint biological condyle is characterized bycomprising an upper cartilage layer, a middle cellular hydrogel layer and a lower phrenological compound layer which are mutually laminated, wherein the upper cartilage layer comprises a tissue surface making contact with an upper articular disc, a connecting surface making contact with the middle cellular hydrogel layer and a dense tissue layer positioned between the tissue surface and the connecting surface. According to the temporo-mandibular joint biological condyle disclosed by the invention, on the basis of ensuring accurate control over a three-dimensional morphological structure, functional reconstruction of a temporo-mandibular joint is realized; besides, the temporo-mandibular joint biological condyle has the advantages of reducing operative wound, facilitating the use in the operation, reducing osteotomy and bone grinding change, avoiding skull base damage and massive hemorrhage risk and the like so as to overcome the defects of current artificial joint replacement and costal cartilage grafting; transformation from joint reconstruction and replacement to joint reconstruction and regeneration is realized.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Method for reprogramming spinal marrow astrocytes into motor neurons through induction

The invention provides a method for reprogramming spinal marrow astrocytes into motor neurons through induction. The method comprises steps as follows: (1) primary rat astrocytes are subjected to pure culture; (2) 7 small molecule drugs including SB431542, LDN-193189, RA, bFGF, Purmorphamine, Forskolin and VPA are selected according to substances required in the stages of neuron induction and motor neuron formation and development, and the astrocytes are induced and reprogrammed in vitro through the small molecule drugs; (3) the reprogramming and differentiation conditions of the astrocytes to the motor neurons are analyzed through observation of morphologic change of cells and methods of chemical technology analysis of immunofluorescent cells, real-time fluorescent quantitative PCR analysis and statistical analysis. The rat astrocytes can be successfully induced and reprogrammed into the motor neutrons in vitro through small molecular drug composition, and the transdifferentiation exceeds 75%; in-situ direct reprogramming of the astrocytes to the neurons is a possibly comparatively feasible thought in SCI (spinal cord injury) repairing and functional reconstruction treatment.
Owner:NANTONG UNIVERSITY

System and method for detecting activity of nerve cells in spinal cord injury part

The invention discloses a system and method for detecting activity of nerve cells in the spinal cord injury part. The system and the method mainly solve the problem that a traditional medical device can not accurately obtain information of activity of the nerve cells in the spinal cord injury position. The system comprises a light source subsystem, a light splitting subsystem, a reflective mirror, a detection subsystem, a data processing and image processing subsystem and a display. Near-infrared light generated by the light source subsystem passes through the light splitting subsystem and is projected to the spinal cord injury part after the light path is changed through the reflective mirror. The data processing and image processing subsystem obtains the positioned, qualitative and quantitative relation of neurotransmitter and nerve cell specificity nucleocapsid protein by analyzing a diffuse reflection spectrum and a transmission spectrum which are detected by the detection subsystem, draws a nerve cell activity information graph and makes the nerve cell activity information graph displayed on the display. By means of the system and the method, detailed information of the state of the nerve cells in the spinal cord injury part can be obtained, and the foundation can be provided for spinal cord injury treatment and research on nerve functional reconstruction conducted after the spinal cord injury is caused.
Owner:XIAN UNIV OF POSTS & TELECOMM

Multi-channel functional electrical stimulation output control method for lower limb rehabilitation of myoelectric modulation

InactiveCN108392737AAchieve motor function reconstructionConsistent shrinkage characteristicsDiagnostic recording/measuringSensorsKnee JointMuscle spasm
The invention relates to a multi-channel functional electrical stimulation output control method for lower limb rehabilitation of myoelectric modulation. Electromyographic signals of two pairs of antagonist muscles for controlling knee and ankle joint movement when a healthy person walks normally are collected offline, and the processed ectromyographic signals modulate multi-channel electrical stimulation output intensity enveloping lines to stimulate the two pairs of the antagonist muscles in the lower limbs of a patient. The method is applied to the lower limb rehabilitation training processof the apoplexy patient, can not only prevent muscle spasm, but also achieve multi-joint coordinated movement similar to normal people, and can achieve the rehabilitation training of a lower limb walking function, thereby achieving the purpose of lower limb functional reconstruction.
Owner:FUZHOU UNIV

Icariin and hyaluronic acid composition, method for preparing same and application of icariin and hyaluronic acid composition

The invention relates to an icariin and hyaluronic acid composition, a method for preparing the same and application of the icariin and hyaluronic acid composition. The icariin and hyaluronic acid composition, the method and the application have the advantages that the icariin and hyaluronic acid composition can be used for preparing medicines for treating cartilage diseases and can be particularly used for preparing injection for joint cavities, accordingly, the shortcoming of limitation of single hyaluronic acid treatment can be overcome, the application range can be expanded, and adverse reaction can be reduced; effects of covering and protecting the surfaces of cartilage can be enhanced by the aid of pharmacological effects of icariin on cartilage cells; the icariin and hyaluronic acid composition can act on synovial cells, synthesis of autologous macromolecular hyaluronic acid can be promoted, and accordingly the purposes of nourishing the cartilage, lubricating the joint cavities, relieving pain, improving the daily activity ranges and the joint activity ranges of patients and the like can be achieved; the icariin and hyaluronic acid composition can act on the cartilage cells, accordingly, the viability of the cartilage cells can be enhanced, secretion of active substances such as type II collagen of the cartilage cells and mucopolysaccharide can be promoted, and nourishing, lubricating, regenerating and functional reconstruction effects and the like can be jointly realized; knowledge on traditional Chinese medicine injection can be changed, the adverse reaction can be reduced to a great extent, curative effects of hyaluronic acid and the traditional Chinese medicine injection can be improved, and the application ranges of the hyaluronic acid and the Chinese medicine injection can be expanded.
Owner:张君涛

Reconstructible wireless information network system structure and reconstruction realization method thereof

The invention discloses a reconstructible wireless information network system structure and a reconstruction realization method thereof; the network system structure comprises a flexible node module,a data center module, a user center module, a web master and reconstruction center and a target management center; the reconstruction realization method comprises the following steps: multi-mode capture tracking based on a task plan, a target mark, and service demands; target classification based on target features; network reconstruction management based on the task plan, the target features andthe service information; flexible node functional reconstruction management based on target types. The structure and method can provide various types of information services for users through networkreconstruction and function reconstruction.
Owner:成都迪优联科技有限公司

Medical biological yarn, medical biological repair mesh and preparation method thereof

The invention discloses a medical biological yarn, a medical biological repair mesh and a preparation method thereof. The medical biological yarn can be woven into the repair mesh by taking tissues ofan animal as a raw material, removing immune components such as cells and DNA and slicing the raw material into strips and twisting the strips to the yarn. A special cell-removal material is twistedto yarns to obtain greater strength, so that the yarns are hard to break. The yarns are interwoven after being woven, a stretching and tearing external force is not applied to one point but to multiple interwoven points, so that the yarn has good mechanical property. The defect that the mechanical strength of the biological repair mesh is poor and a crosslinking agent or a synthetic material is needed is overcome. Moreover, the structure of the mesh is prepared from a weaving process. The size of the pore diameter of the mesh can be adjusted easily by means of weaving parameters to meet the demand of actual applications. In addition, the medical biological yarn keeps original components such as three-dimensional structures, collagenous fibers, non-collagenous fibers and growth factors in an extracellular matrix and promotes functional reconstruction and postoperation reunion of tissues.
Owner:上海白衣缘生物工程有限公司

NGF monoshell-multinuclear microsphere/PCL nanofiber catheter and preparation method thereof

The invention discloses a NGF monoshell-multinuclear microsphere / PCL nanofiber catheter which can promote regeneration of peripheral nerves, govern functional reconstruction of target muscles and better promote recovery of motor function of peripheral nerves more quickly. The invention also discloses a preparation method of the NGF monoshell-multinuclear microsphere / PCL nanofiber catheter. The preparation method comprises the following steps: first, preparing NGF buried PLGA microspheres; then preparing NFG-buried monoshell-multinuclear microsphere and a polycaproloactone PCL nano fiber nervehollow catheter; and finally, dissolving the prepared NFG-buried monoshell-multinuclear microspheres in a PBS solution and injecting the solution into the polycaproloactone PCL nano fiber nerve hollowcatheter to obtain the NGF monoshell-multinuclear microsphere / PCL nanofiber catheter.
Owner:XIAN HONGHUI HOSPITAL

Processor and processing method thereof, chip, chip packaging structure and electronic device

The invention discloses a processor. The processor includes an instruction control unit and a calculating unit; the instruction control unit is used for extracting a processing instruction to controlthe calculating unit; and the calculating unit is used for executing neural network operation based on input frame information and neural network parameters. The processor realizes efficient functional reconstruction on neural network processors, and can give full play to performance in application environments with low memory and strong real-time performance.
Owner:SHANGHAI CAMBRICON INFORMATION TECH CO LTD

Ship redundancy device oriented use assistant decision support method and system

The invention relates to a ship redundancy device oriented use assistant decision support method and a ship redundancy device oriented use assistant decision support system, wherein the method comprises the following steps: each terminal carries out monitoring and data collection on use and maintenance guarantee conditions of a ship diesel engine system and an electromechanical platform system, and reports to a server; and the server analyzes the received data to obtain a ship redundancy device oriented use assistant decision. The ship redundancy device oriented use assistant decision support method is provided by referring to the characteristics of a ship redundancy device and the modern information processing mode; and meanwhile, the support for use assistant decisions such as device redundancy degradation and functional reconstruction assistant decision, device reasonable usage period assistant decision, device update assistant decision and the like can be provided, the matching degree with the actual demand is increased, and the accuracy rate is improved.
Owner:CSSC SYST ENG RES INST

Application of polypyrimidine sequence binding protein in preparation of drugs for repairing spinal cord injury

The invention discloses an application of a polypyrimidine sequence binding protein silencing agent combined with retinoic acid and purinine amine in preparation of a medicine for repairing spinal cord injury, and belongs to the technical field of biological medicine. The polypyrimidine sequence binding protein (PTB) is silenced in vitro through a virus, and meanwhile, micromolecule retinoic acid (RA) and purinol amine (PMA) which are related to motor neuron differentiation are jointly added, so that mouse spinal cord reactive astrocytes are successfully reprogrammed into motor neuron; and help is provided for further in-vivo research on the effect of a PTB combined micromolecule reprogramming strategy in spinal cord injury post-repair, so that better spinal cord injury repair and function reconstruction effects are realized.
Owner:NANTONG UNIVERSITY

Biological material for repairing meniscus tear and preparation method for biological material

The invention relates to a biological material for repairing meniscus tear and a preparation method for the biological material. The material consists of an acellular matrix membrane on the inner layer, a porous structure collagen matrix membrane on the middle layer, a cell layer formed by cartilage cells on the outer layer and a cell sheet. The repair material has certain elasticity and toughness and is high in biological activity; the cartilage cells can secrete cell factors per se, and nutritional ingredients can be directly obtained through articular cavity synovia, and thus, the establishment of communication link between tissue cells at both ends of the tear during the meniscus tear process is accelerated; the immigration and the infusion of the cells in the material and autologous tissue cells are promoted; the tissue regeneration and functional reconstruction time is shortened; and the ideal novel material and the preparation method for the material are provided for clinically repairing the damage of the meniscus tear (including blood supply zones), especially the tissue regeneration and the functional reconstruction of no-blood zones and low-blood zones.
Owner:西安博鸿生物技术有限公司

Nutritive bowl for field planting of leymus chinensis in deteriorated grassland

The invention discloses a nutritive bowl for field planting of leymus chinensis in deteriorated grassland. The nutritive bowl comprises nutritive bowl soil, wherein a brassinosteroid aqueous solution,formulation complex fertilizer and pregelatinized starch as a soiling bonding and nutritive bowl setting substance are added in the nutritive bowl soil; the success rate of field planting and expanding propagation of the leymus chinensis can be effectively improved, centralized management at seedling stage is facilitated and the utilization rate of the seeds and the survival rate of seedlings areimproved; rapid planting of the leymus chinensis in the deteriorated grassland and functional reconstruction of an ecological system are promoted; sufficient nutrients of the nutritive bowl can meetthe demands of field planting and expanding propagation of the leymus chinensis; once a cultivated nutritive bowl is transplanted to the deteriorated grassland, a large grassy field can be quickly restored by means of the advantages of colonizing division and integration of the leymus chinensis; by adopting the pregelatinized starch as a bonding and setting substance, the nutritive bowl is not easy to loosen or disintegrate, and the seedling stage management, movement, transportation and transplanting are facilitated.
Owner:INST OF BOTANY CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products