A novel
humectant eye drop composition is disclosed. The composition comprises a
synergistic combination of
nicotinamide and
adenosine in concentrations at which neither component is effective individually. In preferred embodiments of the invention, the composition comprises 0.025% (w / v) and 0.05% (w / v)
nicotinamide. Within 2 - 3 weeks of commencement of application, the composition improves the Tear Film
Breakup Time, improves
tear production as measured by the Schirmer Test, reduces the severity of the Dry Eye Syndrome as measured by Lissamine Green
staining, and shows anti-inflammatory effects.