54 results about "Glucose sensing" patented technology

The present invention relates to organic thin film sensors and the preparation and use thereof in sensing applications, and in particular in glucose sensing. The sensor is characterised by a layered structure comprising a porous wicking layer whose surface is configured to receive a liquid sample. An enzyme is disposed on or within the porous layer for facilitating the generation of a charge carrier from an analyte. A polymer layer in contact with the porous layer is connected to an ohmic conductor for applying a gate voltage to the polymer layer, the polymer layer being conductive to the charge carrier; and an organic semiconducting layer is connected to a source electrode and a drain electrode.

The invention relates to the technical field of sensors, and discloses a continuous glucose sensing device based on a microneedle array and a preparation method, the device comprises a base and a metal microneedle array, the base is a printed circuit board, conductive contacts are attached to the back surface of the base, and a metal through hole array is arranged on the base; the metal microneedle array is fixed in the metal through hole array from the front surface of the base; the adjacent metal microneedles are electrically connected, and the metal microneedles and the conductive contacts are electrically connected. The metal microneedle array is divided into a glucose sensing area and a differential sensing area, metal microneedles in the glucose sensing area and the differential sensing area are modified to comprise counter electrodes, working electrodes and reference electrodes, the working electrodes of the glucose sensing area are modified with glucose oxidase layers, and the reference electrodes of the glucose sensing area are modified with reference electrodes. And no glucose oxidase layer is arranged on the working electrode in the differential sensing area. By introducing the differential sensing electrode, common-mode interference signals caused by other electrochemical active substances can be effectively removed, and an accurate detection result is obtained.

The invention provides a coin-sized, fully integrated and wearable continuous blood glucose monitoring (CGM) system in combination with frontier technologies in crossing fields of biosensors, minimally invasive tools, hydrogels and the like. The invention comprises the following three main parts: 1) an emerging biochemical amplifier, namely an organic electrochemical transistor (OECT), for improving the sensitivity and exceeding the traditional electrochemical sensor; 2) a microneedle array for sampling interstitial fluid (ISF), which reduces pain in the skin penetration process; and 3) a tough and viscous enzyme hydrogel film which can improve the reliability of glucose sensing on the skin. Different from a traditional CGM, the CGM (OECT-CGM) provided by the invention has high anti-noise capability, adjustable sensitivity and current regeneration capability due to the adoption of the OECT amplifier, so that long-term stable glucose sensing can be realized within a specific clinical range (1-20mM). The CGM provided by the invention can provide high and adjustable sensitivity, minimally invasive property and better wearable property at the same time, and also paves a way for developing the next generation of CGM.

This invention provides a coin-sized, fully integrated and wearable continuous glucose monitoring system (CGMs) via combining cutting-edge technologies from the intersecting fields of biosensors, minimally invasive tools, and hydrogels. The invention includes three major parts: 1) an emerging biochemical amplifier, the organic electrochemical transistor (OECT), to improve sensitivity beyond traditional electrochemical modules; 2) a microneedle array for interstitial-fluid (ISF) sampling with reduced pain during skin penetration; and 3) a tough, adhesive enzymatic-hydrogel-membrane to enhance reliability of glucose sensing on skin. Unlike conventional CGMs, the employed OECT amplifier empowers the CGM (OECT-CGMs) with a high anti-noise ability, an on-demand-tunable sensitivity and current regeneration ability, enabling long-term stable glucose sensing within specific clinical ranges (1˜20 mM). This work paves the way for the development of next-generation CGMs that can simultaneously deliver high and adjustable sensitivity, minimal invasiveness, and improved wearability.

The invention discloses a glucose detection device for synchronously collecting and analyzing sweat interstitial fluid and a manufacturing method, and belongs to the technical field of sensors. In the device, a sweat discharge module and an interstitial fluid discharge module are embedded and fixed in a supporting layer; the sealing layer, the body fluid storage layer and the flow guide layer jointly define a sweat storage cavity and an interstitial fluid storage cavity which are distributed at intervals, and a sweat pH sensing module and an interstitial fluid pH sensing module are fixed to the sealing layer; the flow guide layer, the microfluidic layer and the detection layer jointly define a sweat microfluidic detection cavity and an interstitial fluid microfluidic detection cavity, a sweat temperature sensing module and an interstitial fluid temperature sensing module are fixed on the flow guide layer, and a sweat glucose sensing module and an interstitial fluid glucose sensing module are fixed on the detection layer; a sweat collection module and an interstitial fluid collection module are embedded in the detection layer and the skin adhesion layer. The non-invasive, high-precision and continuous blood glucose detection is realized, the processing is convenient, the processing efficiency is high, and the cost is low.

The present disclosure presents glucose sensing methods and systems. One such system comprises an electrospun-nanofibrous-membrane (ENFM)-based amperometric glucose sensor integrated on a silicon chip, in which the glucose sensor has a working electrode, a reference electrode, and a counter electrode, wherein the working electrode comprises an ENFM-based sensing electrode. The system further comprises a potentiostat circuit integrated on the silicon chip such that the potentiostat circuit comprises a voltage control unit to control a voltage difference between the working electrode and the reference electrode and a transimpedance amplifier to measure a current flow between the working electrode and the counter electrode, in which a strength of the current flow corresponds to an amount of glucose present in a sample of blood on the glucose sensor.

An active Fano resonance blood glucose sensor, relating to the field of non-invasive blood glucose monitoring. The blood glucose sensor comprises a resonator, an excitation layer, a low-noise amplifier (8) and a phase shifter (9), wherein the resonator, the low-noise amplifier (8) and the phase shifter (9) form a connection loop; the resonator is provided on the excitation layer; and the excitation layer is connected to an external excitation source. By using the phase shifter (9), the phase of an active circuit can be changed to selectively enhance resonance, improve the resonance Q factor, and realize detection of minor changes in blood glucose concentration, and thus the active Fano resonance blood glucose sensor can be applied to human blood glucose sensing and the problems in the prior art of poor stability and robustness. Moreover, by using the resonator and the excitation layer, self-reference error elimination can be achieved, significantly improving the performance of the microwave blood glucose sensor and improving the reliability of blood glucose measurement.

An oxygen-independent analyte sensor includes at least one electrode and an oxygen-independent analyte sensing molecule disposed on the at least one electrode. The oxygen-independent analyte sensing molecule is electrografted on to the at least one electrode. The sensor may process an electrochemical impedance spectroscopy (EIS) parameter value in response to exposure to an analyte.

The invention relates to a flexible noninvasive blood glucose sensing antenna integrated with an electromagnetic band gap and a double-split resonant ring, which adopts a flexible substrate and a coplanar waveguide feed network, and integrates an electromagnetic band gap array structure formed by periodic metal through holes on a ground plane; two symmetrically-distributed double-split resonant rings and parasitic branches for impedance matching are constructed at the top of the sensing antenna.

The invention provides a stable and durable wearable sweat and sugar electrochemical sensor. A sensing interface of the sensor is prepared by sequentially dispensing a glucose sensing solution and a film forming solution on the surface of a carbon electrode, the glucose sensing solution comprises a zeolite imidazate framework-90 (ZIF-90 at GOx) composite material loaded with glucose oxidase, Prussian blue nanoparticles (PBNPs) and a conductive gel solution, and the film forming solution comprises ammonium persulfate and tetramethylethylenediamine. Glucose in sweat is oxidized by using ZIF-90 at GOx on a sensing interface, generated hydrogen peroxide reacts with PBNPs to generate a current signal on an electrode, and then quantitative analysis is performed on the glucose in the sweat based on a standard curve method. The wearable sweat and sugar electrochemical sensor provided by the invention has excellent environmental adaptability and durability, can be used outdoors for a long time, is simple to prepare and good in product performance, and has a very good application prospect in the field of development of wearable sweat and sugar sensors.

A molecular conjugate comprising a glucose binding macrocycle as represented below that is covalently bonded directly or via linkers to a polypeptide such as insulin to form a glucose sensing insulin (GSI) are described herein. The disclosure includes pharmaceutical compositions, use and method of treatments with such GSIs. Substituents and the various moieties of the structures below are further specified herein. (II) or (III)

Disclosed are systems and techniques for glucose sensing. For example, an example of a process can include transmitting, by at least one transmitter into living tissue, a first signal with a first wavelength, a second signal with a second wavelength, and a third signal with a third wavelength to produce an acoustic response from the living tissue. The first wavelength has a first correlation with the blood glucose concentration, the second wavelength has a second correlation with the blood glucose concentration, and the third wavelength has a third correlation with the blood glucose concentration. The process can include receiving, by at least one receiver, a response signal of the acoustic response. The process can include determining, by at least one processor, the blood glucose concentration based on a photoacoustic spectrum of the response signal.

The present invention is directed to intracellular and extracellular glucose indicators and use thereof in a method for determining glucose concentration within a cell and its surrounding. Furthermore, there is provided a method for intracellular delivery of glucose using the intracellular indicator of the invention.

The present invention relates to the field of biosensor technology, and in particular to a preparation method and use method of a non-enzymatic glucose catalyst, comprising the following steps: rapidly pouring a hexahydrate cobalt nitrate aqueous solution into a 2-methylimidazole aqueous solution; adding a conductive substrate to the mixed solution to obtain a product; repeatedly washing the product, placing it in a drying oven for drying, and then suspending it in ultrapure water to obtain a sample; washing and drying the sample to obtain a non-enzymatic glucose catalyst. The present invention adopts the above-mentioned preparation method, uses a cobalt-based metal organic framework material as a precursor, and adopts an in-situ etching-growth method to synthesize a cobalt hydroxide micro-nano material with a hierarchical porous structure. The obtained non-enzymatic glucose catalyst can be directly used as an electrode to measure glucose concentration, has good glucose sensing performance, has high sensitivity while maintaining a wide linear response range, and also has the characteristics of high selectivity, strong reproducibility and reliable detection of real samples.

This disclosure relates to an apparatus for glucose-sensing that address interference of ascorbic acid and acetaminophen. The apparatus includes a first electrode capable of oxidizing glucose and at least one of ascorbic acid and acetaminophen. The apparatus further includes a second electrode capable of oxidizing at least one of ascorbic acid and acetaminophen but not capable of oxidizing glucose. The first electrode includes a deposit of irregularly shaped bodies that are formed of numerous nanoparticles having a generally oval or spherical shape with a length ranging between about 2 nm and about 5 nm.

This disclosure relates to an apparatus for glucose-sensing that address interference of ascorbic acid and acetaminophen. The apparatus includes a first electrode capable of oxidizing glucose and at least one of ascorbic acid and acetaminophen. The apparatus further includes a second electrode capable of oxidizing at least one of ascorbic acid and acetaminophen but not capable of oxidizing glucose. The first electrode includes a deposit of irregularly shaped bodies that are formed of numerous nanoparticles having a generally oval or spherical shape with a length ranging between about 2 nm and about 5 nm.

The present invention relates to a biosensor for measuring the concentration of glucose and its use in glucose sensing. The biosensor of the present invention comprises a polymer comprising a boronic acid-based glucose-binding moiety, wherein said boronic acid-based glucose-binding moiety is immobilized in said polymer, and an inhibitor moiety, wherein said inhibitor moiety is immobilized in said polymer, and wherein said inhibitor moiety is capable of forming reversible crosslinks by binding to said boronic acid-based glucose-binding moiety. In the absence of glucose, the polymer is crosslinked by a bond formed between the boronic acid-based glucose-binding moiety and the inhibitor moiety. In the presence of glucose, the boronic acid-based glucose-binding moiety binds to glucose, whereby the bond between the boronic acid-based glucose-binding moiety and the inhibitor moiety is broken, which results in a change of volume of the polymer. The biosensor of the present invention is particularly useful for glucose monitoring performed on a subject under intensive care as well as in the situations wherein the glucose monitoring is performed on an unconscious subject.

The application discloses an implantable blood glucose sensor outer membrane swelling calibration method based on ion concentration monitoring, which comprises the following steps: establishing a target ion concentration-functional outer membrane swelling kinetics relationship model, determining each parameter in the model through in-vitro simulation test; acquiring an initial electrochemical signal in subcutaneous tissue fluid by using a blood glucose sensing unit; acquiring the concentration of a target ion by using an ion concentration sensing unit; correcting the outer membrane swelling rate based on the target ion concentration-functional outer membrane swelling kinetics relationship model; and compensating and calibrating the initial electrochemical signal to obtain an electrochemical signal and a blood glucose concentration value after swelling correction. The application also discloses a system for executing the above method. The method effectively overcomes the problem of insufficient measurement accuracy caused by outer membrane swelling in the initial implantation stage, significantly improves the accuracy and reliability of the sensor in the key start-up stage, provides more timely and reliable blood glucose dynamic information for users, and has important application value.

The present invention discloses an integrated wireless control patch for blood glucose sensing and regulation similar to an artificial pancreas and its preparation method, belonging to the field of biomedical engineering. The present invention realizes the integration of blood glucose sensing and regulation, integrates a color sensor and an ultraviolet cut-off filter, and monitors blood glucose in real time in situ, facilitating the timely acquisition of blood glucose information; then, a heater controls the release of metformin by temperature-responsive therapeutic microneedles to regulate blood glucose levels; the present invention uses near-field communication technology for wireless power supply regulation and communication. It gets rid of the limitations of power supplies and batteries, reduces the volume and weight of the patch, and improves the wearing comfort of patients. The present invention integrates monitoring and treatment functions to form a closed-loop system similar to an artificial pancreas. When a high blood glucose level is detected, the heater is automatically turned on for metformin drug delivery to reduce the blood glucose level, ensuring precise and timely blood glucose regulation. When the blood glucose level is low, the heater is not turned on, reducing the risk of hypoglycemia.

A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

The invention discloses an artificial pancreas-like blood glucose sensing and regulating integrated wireless control patch and a preparation method thereof, and belongs to the field of biomedical engineering. The blood glucose sensing and adjusting are integrated, the color sensor and the ultraviolet cut-off filter are integrated, real-time in-situ blood glucose monitoring is achieved, and blood glucose information can be conveniently obtained in time; then the heater controls the temperature-responsive treatment microneedle to release metformin so as to adjust the blood glucose level; according to the invention, wireless energy supply regulation and control and communication are carried out by adopting a near field communication technology. The limitation of a power supply and a battery is eliminated, the size and the weight of the patch are reduced, and the wearing comfort of a patient is improved. According to the invention, monitoring and treatment functions are integrated, and a closed-loop system similar to artificial pancreas is formed. When the hyperglycemia level is monitored, the heater is automatically started for delivering the metformin medicine, the blood glucose level is reduced, and accurate and timely blood glucose regulation is ensured. When at a hypoglycemic level, the heater is not turned on, reducing the risk of hypoglycemia.

The invention relates to an organic thin film sensor, preparation thereof and application of the organic thin film sensor in sensing, in particular to application of the organic thin film sensor in glucose sensing. The sensor features a layered structure comprising a porous wicking layer, the surface of which is configured to receive a liquid sample. An enzyme on or within the porous layer, the enzyme to promote the analyte to generate charge carriers; a polymer layer in contact with the porous layer is connected to an ohmic conductor for applying a gate voltage to the polymer layer, the polymer layer conducting charge carriers; the organic semiconductor layer is connected to the source electrode and the drain electrode.

The invention discloses a microwave noninvasive blood glucose prediction method, device, equipment, medium and product, and relates to the field of microwave sensing, the method comprises the following steps: constructing a data set according to a blood glucose time sequence collected by a microwave noninvasive blood glucose sensing system; based on a convolution block attention module and an improved quantum particle swarm optimization algorithm, constructing an optimal bidirectional gating loop network model according to the data set; the optimal two-way gating circulation network model is a two-way gating circulation network model fusing a convolution block attention module and an improved quantum particle swarm optimization algorithm; and predicting the blood sugar of the to-be-tested person according to the optimal bidirectional gating circulation network model. According to the application, accurate prediction and effective management of the blood sugar level of the human body are realized.

Provided are glucose sensing luminescent dyes, polymers, and sensors. In addition, provided are systems comprising the sensors and methods of using the sensors and systems.

Embodiments of the invention provide skin adhesive patches designed to ease a diabetic patient's maneuverability and alignment of a glucose sensing device as the patient adheres the device to their skin. Embodiments of the invention can be adapted for use with a wide variety of medical components that are coupled to the skin of patients, including insulin infusion sets, patch pumps, and all-in-one patch sets.

This application discloses an implantable dual-channel monitoring sensor and its fabrication method. The sensor includes a substrate and an electrode assembly, a sensing component, and a functional component disposed on the substrate. The sensing component includes a glucose sensing layer and a ketone body sensing layer, and the functional component includes a first functional film layer and a second functional film layer. The electrode assembly includes a first working electrode, a second working electrode, a reference electrode, and a counter electrode. The first working electrode has a glucose sensing layer disposed on it, and the second working electrode has a ketone body sensing layer disposed on it. The first functional film layer encapsulates the glucose sensing layer, and the second functional film layer encapsulates the ketone body sensing layer. This application enables dual-channel collaborative continuous monitoring and seamless integration of the two monitoring data. Furthermore, this implantable dual-channel monitoring sensor has low design cost, simple manufacturing process, and mass production advantages.

The invention belongs to the technical field of glucose sensing, and discloses an enzyme-free glucose sensing electrode based on a porous biological membrane, a preparation method and application, and the sensing electrode comprises a graphite substrate, a conductive silver layer, an egg shell membrane layer, a platinum conductive layer and a ferroferric oxide magnetic nanoparticle layer from bottom to top. The graphite substrate and the egg shell membrane layer are conductively glued through the conductive silver layer, and the structural advantages of the three-dimensional porous microstructure of the egg shell membrane are fully reserved. The platinum conducting layer improves the conductivity of the electrode substrate, and achieves efficient electron transmission performance through the synergistic effect of the platinum conducting layer and ferroferric oxide serving as nano-enzyme. The three-dimensional porous microstructure of the egg shell membrane increases the specific surface area of the surface of the sensor electrode, can provide a stable and solidified substrate for a nano-enzyme catalytic material, greatly enriches the active sites of the sensor working electrode, and ensures rapid and accurate enzyme-free glucose sensing detection. Meanwhile, the sensing electrode has the advantages of being easy to degrade, high in biocompatibility, environmentally friendly and the like.

A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

A blood glucose sensing system includes a plurality of physiological sensors. The system can estimate blood glucose based on discrete invasive blood glucose estimates from a blood sample, discrete noninvasive blood glucose estimates derived from optical sensors, and continuously-calculated blood glucose estimates derived from a nonlinear state-space model of glucose and insulin reactions within a human body. The state-space model has user-entered values corresponding to their insulin and meal intake. The user's blood glucose is estimated from a combination of the discrete invasive blood glucose estimates, the discrete noninvasive blood glucose estimates and the continuously-calculated blood glucose estimate.

The present technology pertains to a measurement device that enables the improvement of measurement accuracy. This measurement device has: a circuit unit that is disposed on one surface of a sensor substrate and is for measuring an S parameter; and a sensor electrode that is disposed on the other surface of the sensor substrate and irradiates a measurement target with a signal for measuring the S parameter output from the circuit unit. In a plan view, the distance between the circuit unit and the sensor electrode is equal to or less than a predetermined distance, and the terminal that outputs the signal of the circuit unit is directly connected to the sensor substrate. The present technology can be applied to a glucose sensing system.