17 results about "Glucose sensing" patented technology

The present disclosure presents glucose sensing methods and systems. One such system comprises an electrospun-nanofibrous-membrane (ENFM)-based amperometric glucose sensor integrated on a silicon chip, in which the glucose sensor has a working electrode, a reference electrode, and a counter electrode, wherein the working electrode comprises an ENFM-based sensing electrode. The system further comprises a potentiostat circuit integrated on the silicon chip such that the potentiostat circuit comprises a voltage control unit to control a voltage difference between the working electrode and the reference electrode and a transimpedance amplifier to measure a current flow between the working electrode and the counter electrode, in which a strength of the current flow corresponds to an amount of glucose present in a sample of blood on the glucose sensor.

The invention relates to a flexible noninvasive blood glucose sensing antenna integrated with an electromagnetic band gap and a double-split resonant ring, which adopts a flexible substrate and a coplanar waveguide feed network, and integrates an electromagnetic band gap array structure formed by periodic metal through holes on a ground plane; two symmetrically-distributed double-split resonant rings and parasitic branches for impedance matching are constructed at the top of the sensing antenna.

The invention provides a stable and durable wearable sweat and sugar electrochemical sensor. A sensing interface of the sensor is prepared by sequentially dispensing a glucose sensing solution and a film forming solution on the surface of a carbon electrode, the glucose sensing solution comprises a zeolite imidazate framework-90 (ZIF-90 at GOx) composite material loaded with glucose oxidase, Prussian blue nanoparticles (PBNPs) and a conductive gel solution, and the film forming solution comprises ammonium persulfate and tetramethylethylenediamine. Glucose in sweat is oxidized by using ZIF-90 at GOx on a sensing interface, generated hydrogen peroxide reacts with PBNPs to generate a current signal on an electrode, and then quantitative analysis is performed on the glucose in the sweat based on a standard curve method. The wearable sweat and sugar electrochemical sensor provided by the invention has excellent environmental adaptability and durability, can be used outdoors for a long time, is simple to prepare and good in product performance, and has a very good application prospect in the field of development of wearable sweat and sugar sensors.

This disclosure relates to an apparatus for glucose-sensing that address interference of ascorbic acid and acetaminophen. The apparatus includes a first electrode capable of oxidizing glucose and at least one of ascorbic acid and acetaminophen. The apparatus further includes a second electrode capable of oxidizing at least one of ascorbic acid and acetaminophen but not capable of oxidizing glucose. The first electrode includes a deposit of irregularly shaped bodies that are formed of numerous nanoparticles having a generally oval or spherical shape with a length ranging between about 2 nm and about 5 nm.

The application discloses an implantable blood glucose sensor outer membrane swelling calibration method based on ion concentration monitoring, which comprises the following steps: establishing a target ion concentration-functional outer membrane swelling kinetics relationship model, determining each parameter in the model through in-vitro simulation test; acquiring an initial electrochemical signal in subcutaneous tissue fluid by using a blood glucose sensing unit; acquiring the concentration of a target ion by using an ion concentration sensing unit; correcting the outer membrane swelling rate based on the target ion concentration-functional outer membrane swelling kinetics relationship model; and compensating and calibrating the initial electrochemical signal to obtain an electrochemical signal and a blood glucose concentration value after swelling correction. The application also discloses a system for executing the above method. The method effectively overcomes the problem of insufficient measurement accuracy caused by outer membrane swelling in the initial implantation stage, significantly improves the accuracy and reliability of the sensor in the key start-up stage, provides more timely and reliable blood glucose dynamic information for users, and has important application value.

The invention relates to an organic thin film sensor, preparation thereof and application of the organic thin film sensor in sensing, in particular to application of the organic thin film sensor in glucose sensing. The sensor features a layered structure comprising a porous wicking layer, the surface of which is configured to receive a liquid sample. An enzyme on or within the porous layer, the enzyme to promote the analyte to generate charge carriers; a polymer layer in contact with the porous layer is connected to an ohmic conductor for applying a gate voltage to the polymer layer, the polymer layer conducting charge carriers; the organic semiconductor layer is connected to the source electrode and the drain electrode.

This application discloses an implantable dual-channel monitoring sensor and its fabrication method. The sensor includes a substrate and an electrode assembly, a sensing component, and a functional component disposed on the substrate. The sensing component includes a glucose sensing layer and a ketone body sensing layer, and the functional component includes a first functional film layer and a second functional film layer. The electrode assembly includes a first working electrode, a second working electrode, a reference electrode, and a counter electrode. The first working electrode has a glucose sensing layer disposed on it, and the second working electrode has a ketone body sensing layer disposed on it. The first functional film layer encapsulates the glucose sensing layer, and the second functional film layer encapsulates the ketone body sensing layer. This application enables dual-channel collaborative continuous monitoring and seamless integration of the two monitoring data. Furthermore, this implantable dual-channel monitoring sensor has low design cost, simple manufacturing process, and mass production advantages.

This invention proposes a microneedle electrochemical biosensor and its fabrication method. The sensor comprises: a substrate and a glucose sensing electrode, a sodium penicillin sensing electrode, a sodium chloride sensing electrode, a reference electrode, and a counter electrode disposed on the substrate. Specifically: the glucose sensing electrode comprises a first graphite layer, a Prussian blue layer, and an enzyme immobilization layer stacked from bottom to top; the sodium penicillin sensing electrode comprises a second graphite layer and a β-lactamase immobilization layer stacked from bottom to top; and the sodium chloride sensing electrode comprises a third graphite layer, a signal conversion layer, and an ion recognition membrane layer stacked from bottom to top. This sensor selectively measures the concentrations of glucose, sodium penicillin, and sodium chloride, achieving high sensitivity and accuracy in detection.

Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

The application provides a skin-core structure glucose sensing fiber and a preparation method thereof, and belongs to the technical field of wearable colorimetric sensing. The skin-core structure glucose sensing fiber is prepared by a coaxial wet spinning process, wherein the fiber core layer is composed of a color developing functional material and a high molecular polymer, and the skin layer is composed of a composite enzyme and a high molecular polymer. The color developing agent in the color developing functional material is coated by a sensitizer, which not only solves the problem that the color developing agent is difficult to disperse uniformly in an aqueous solvent, but also protects the color developing agent from directly contacting with the external environment, thereby preventing the generation of false negative or false positive conditions. Meanwhile, the color developing functional material as the core layer further avoids the generation of false negative or false positive conditions. The skin layer and the core layer adopt a specific polymer as a spinning base material, so that the color developing reaction can be rapidly generated, and the sensitivity is improved. The prepared skin-core structure glucose sensing fiber can be used for glucose detection in biological body fluids (blood, sweat, urine and tissue fluid).

The invention relates to the field of measurement, and discloses an artificial intelligent cell culture medium glucose concentration measurement method, which is used for providing an accurate glucose concentration measurement method for a cell culture process. Comprising the steps that first and second glucose sensing electrodes are arranged to obtain current signals, differential current signals are obtained through processing, and the glucose concentration value after environment compensation is determined by combining temperature and pH value correction coefficients. In continuous measurement, the baseline noise level is determined according to the second current signal, the electrode response state is determined according to the differential current signal dynamic response, calibration is triggered, the conversion parameters are updated, and the actual glucose concentration value is obtained according to the conversion parameters. The device is accurate and stable in measurement, can realize real-time monitoring and maintenance, and provides reliable data support for cell culture.

The present application provides a kind of contact lens type tear glucose sensing monitoring system, comprising: substrate, the substrate is made of flexible transparent material;Bionic microfluid channel sample collection module, the bionic microfluid channel sample collection module is used to collect tear fluid;Tear glucose monitoring sensor, the tear glucose monitoring sensor is used to detect the glucose content in tear fluid, the tear glucose monitoring sensor is connected with the bionic microfluid channel sample collection module;Wireless signal transmission module, the wireless signal transmission module is connected with the tear glucose monitoring sensor;Contact lens external circuit module, the contact lens external circuit module is used to receive the detection result signal transmitted by the wireless signal transmission module;The bionic microfluid channel sample collection module, the tear glucose monitoring sensor and the wireless signal transmission module are all arranged on the substrate. Can improve the security, comfort and portability of eye physiological information monitoring.

The present invention relates to a biosensor for measuring glucose concentration and its use in glucose sensing, wherein the biosensor comprises a polymer comprising a moiety of formula (I). The biosensor of the invention is particularly useful in glucose monitoring of individuals under intensive care, as well as in cases where glucose monitoring is performed on unconscious individuals.

This patent designs and synthesizes a metal-organic framework material—Co-TBTT—based on the dithienyloctacarboxylic acid ligand, and uses it as a non-enzymatic glucose electrochemical sensing material for glucose detection. Its potential in glucose sensing was evaluated through electrochemical performance testing. Experimental results show that the Co-TBTT-modified electrode exhibits excellent electrochemical response to glucose under enzyme-free conditions, with a linear detection range of 13.5 μM to 3 mM and a detection limit as low as 0.20 μM, outperforming most currently reported enzyme-free glucose sensors. The Co-TBTT electrode in the presence of Na... + K + Even in mixed solutions containing coexisting ions and interfering substances such as uric acid (UA), ascorbic acid (AA), and dopamine (DA), it maintains good anti-interference ability and exhibits strong selectivity. These excellent properties can be attributed to the porous structure and abundant metal active sites of the Co-TBTT material, providing a novel functional material for the electrochemical sensor detection of glucose.

The invention discloses an establishment method and device of a radio frequency noninvasive blood glucose monitoring electromagnetic sensing model, a storage medium and equipment. The method comprises the following steps: preliminarily dividing human tissues into static tissues and dynamic tissues; the radio frequency sensing signals are transmitted to the static tissue and the dynamic tissue respectively, response characteristics of the radio frequency sensing signals are obtained, clustering is carried out according to the response characteristics, and a plurality of types of human tissue are obtained; carrying out voxel reconstruction on the plurality of types of human tissues by utilizing a sparse regularization graph variation method to obtain a blood glucose monitoring electromagnetic sensing model; based on a Cole-Cole formula modeling method, dielectric property analysis is carried out on the multiple types of human tissues, dielectric property assignment is carried out on all voxel points of the blood glucose monitoring electromagnetic sensing model according to analysis results, and a response function of the human tissues to blood glucose sensing signals is established. The radio frequency blood glucose monitoring electromagnetic sensing model established by the method is more practical, and a theoretical and simulation model is provided for subsequent more accurate blood glucose monitoring.

The application discloses a kind of Ni (II) based metal organic framework Ni (II)-MOF material and application in electrochemical glucose sensing.The application is applied in electrochemical glucose sensing field by synthesizing a case of Ni (II)-MOF by hydrothermal method.The application uses benzene-1,2,3,4,5,6-hexacarboxylic acid (H6L) as organic ligand, introduces 1,4-bis (1-imidazole) benzene (bib), and constructs with periodic three-dimensional framework structure.The Ni (II)-MOF material synthesis process is simple, crystallinity is strong, product purity and yield are high, and structure is novel.The obtained Ni (II)-MOF has ultrafast response time, lower detection limit and higher sensitivity, and has good application prospect in electrochemical glucose sensing.