29 results about "Glucose sensing" patented technology

The present disclosure presents glucose sensing methods and systems. One such system comprises an electrospun-nanofibrous-membrane (ENFM)-based amperometric glucose sensor integrated on a silicon chip, in which the glucose sensor has a working electrode, a reference electrode, and a counter electrode, wherein the working electrode comprises an ENFM-based sensing electrode. The system further comprises a potentiostat circuit integrated on the silicon chip such that the potentiostat circuit comprises a voltage control unit to control a voltage difference between the working electrode and the reference electrode and a transimpedance amplifier to measure a current flow between the working electrode and the counter electrode, in which a strength of the current flow corresponds to an amount of glucose present in a sample of blood on the glucose sensor.

The invention relates to a flexible noninvasive blood glucose sensing antenna integrated with an electromagnetic band gap and a double-split resonant ring, which adopts a flexible substrate and a coplanar waveguide feed network, and integrates an electromagnetic band gap array structure formed by periodic metal through holes on a ground plane; two symmetrically-distributed double-split resonant rings and parasitic branches for impedance matching are constructed at the top of the sensing antenna.

The invention provides a stable and durable wearable sweat and sugar electrochemical sensor. A sensing interface of the sensor is prepared by sequentially dispensing a glucose sensing solution and a film forming solution on the surface of a carbon electrode, the glucose sensing solution comprises a zeolite imidazate framework-90 (ZIF-90 at GOx) composite material loaded with glucose oxidase, Prussian blue nanoparticles (PBNPs) and a conductive gel solution, and the film forming solution comprises ammonium persulfate and tetramethylethylenediamine. Glucose in sweat is oxidized by using ZIF-90 at GOx on a sensing interface, generated hydrogen peroxide reacts with PBNPs to generate a current signal on an electrode, and then quantitative analysis is performed on the glucose in the sweat based on a standard curve method. The wearable sweat and sugar electrochemical sensor provided by the invention has excellent environmental adaptability and durability, can be used outdoors for a long time, is simple to prepare and good in product performance, and has a very good application prospect in the field of development of wearable sweat and sugar sensors.

Disclosed are systems and techniques for glucose sensing. For example, an example of a process can include transmitting, by at least one transmitter into living tissue, a first signal with a first wavelength, a second signal with a second wavelength, and a third signal with a third wavelength to produce an acoustic response from the living tissue. The first wavelength has a first correlation with the blood glucose concentration, the second wavelength has a second correlation with the blood glucose concentration, and the third wavelength has a third correlation with the blood glucose concentration. The process can include receiving, by at least one receiver, a response signal of the acoustic response. The process can include determining, by at least one processor, the blood glucose concentration based on a photoacoustic spectrum of the response signal.

This disclosure relates to an apparatus for glucose-sensing that address interference of ascorbic acid and acetaminophen. The apparatus includes a first electrode capable of oxidizing glucose and at least one of ascorbic acid and acetaminophen. The apparatus further includes a second electrode capable of oxidizing at least one of ascorbic acid and acetaminophen but not capable of oxidizing glucose. The first electrode includes a deposit of irregularly shaped bodies that are formed of numerous nanoparticles having a generally oval or spherical shape with a length ranging between about 2 nm and about 5 nm.

This disclosure relates to an apparatus for glucose-sensing that address interference of ascorbic acid and acetaminophen. The apparatus includes a first electrode capable of oxidizing glucose and at least one of ascorbic acid and acetaminophen. The apparatus further includes a second electrode capable of oxidizing at least one of ascorbic acid and acetaminophen but not capable of oxidizing glucose. The first electrode includes a deposit of irregularly shaped bodies that are formed of numerous nanoparticles having a generally oval or spherical shape with a length ranging between about 2 nm and about 5 nm.

The application discloses an implantable blood glucose sensor outer membrane swelling calibration method based on ion concentration monitoring, which comprises the following steps: establishing a target ion concentration-functional outer membrane swelling kinetics relationship model, determining each parameter in the model through in-vitro simulation test; acquiring an initial electrochemical signal in subcutaneous tissue fluid by using a blood glucose sensing unit; acquiring the concentration of a target ion by using an ion concentration sensing unit; correcting the outer membrane swelling rate based on the target ion concentration-functional outer membrane swelling kinetics relationship model; and compensating and calibrating the initial electrochemical signal to obtain an electrochemical signal and a blood glucose concentration value after swelling correction. The application also discloses a system for executing the above method. The method effectively overcomes the problem of insufficient measurement accuracy caused by outer membrane swelling in the initial implantation stage, significantly improves the accuracy and reliability of the sensor in the key start-up stage, provides more timely and reliable blood glucose dynamic information for users, and has important application value.

A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

The invention relates to an organic thin film sensor, preparation thereof and application of the organic thin film sensor in sensing, in particular to application of the organic thin film sensor in glucose sensing. The sensor features a layered structure comprising a porous wicking layer, the surface of which is configured to receive a liquid sample. An enzyme on or within the porous layer, the enzyme to promote the analyte to generate charge carriers; a polymer layer in contact with the porous layer is connected to an ohmic conductor for applying a gate voltage to the polymer layer, the polymer layer conducting charge carriers; the organic semiconductor layer is connected to the source electrode and the drain electrode.

The invention discloses a microwave noninvasive blood glucose prediction method, device, equipment, medium and product, and relates to the field of microwave sensing, the method comprises the following steps: constructing a data set according to a blood glucose time sequence collected by a microwave noninvasive blood glucose sensing system; based on a convolution block attention module and an improved quantum particle swarm optimization algorithm, constructing an optimal bidirectional gating loop network model according to the data set; the optimal two-way gating circulation network model is a two-way gating circulation network model fusing a convolution block attention module and an improved quantum particle swarm optimization algorithm; and predicting the blood sugar of the to-be-tested person according to the optimal bidirectional gating circulation network model. According to the application, accurate prediction and effective management of the blood sugar level of the human body are realized.

This application discloses an implantable dual-channel monitoring sensor and its fabrication method. The sensor includes a substrate and an electrode assembly, a sensing component, and a functional component disposed on the substrate. The sensing component includes a glucose sensing layer and a ketone body sensing layer, and the functional component includes a first functional film layer and a second functional film layer. The electrode assembly includes a first working electrode, a second working electrode, a reference electrode, and a counter electrode. The first working electrode has a glucose sensing layer disposed on it, and the second working electrode has a ketone body sensing layer disposed on it. The first functional film layer encapsulates the glucose sensing layer, and the second functional film layer encapsulates the ketone body sensing layer. This application enables dual-channel collaborative continuous monitoring and seamless integration of the two monitoring data. Furthermore, this implantable dual-channel monitoring sensor has low design cost, simple manufacturing process, and mass production advantages.

The invention belongs to the technical field of glucose sensing, and discloses an enzyme-free glucose sensing electrode based on a porous biological membrane, a preparation method and application, and the sensing electrode comprises a graphite substrate, a conductive silver layer, an egg shell membrane layer, a platinum conductive layer and a ferroferric oxide magnetic nanoparticle layer from bottom to top. The graphite substrate and the egg shell membrane layer are conductively glued through the conductive silver layer, and the structural advantages of the three-dimensional porous microstructure of the egg shell membrane are fully reserved. The platinum conducting layer improves the conductivity of the electrode substrate, and achieves efficient electron transmission performance through the synergistic effect of the platinum conducting layer and ferroferric oxide serving as nano-enzyme. The three-dimensional porous microstructure of the egg shell membrane increases the specific surface area of the surface of the sensor electrode, can provide a stable and solidified substrate for a nano-enzyme catalytic material, greatly enriches the active sites of the sensor working electrode, and ensures rapid and accurate enzyme-free glucose sensing detection. Meanwhile, the sensing electrode has the advantages of being easy to degrade, high in biocompatibility, environmentally friendly and the like.

The invention discloses an implantable blood glucose sensor outer membrane swelling calibration method based on ion concentration monitoring, which comprises the following steps: establishing a target ion concentration-functional outer membrane swelling dynamic relationship model, and determining various parameters in the model through an in-vitro simulation test; acquiring an initial electrochemical signal in the subcutaneous tissue fluid by using the blood glucose sensing unit; acquiring the concentration of target ions by using an ion concentration sensing unit; correcting the swelling rate of the outer membrane based on the target ion concentration-functional outer membrane swelling dynamic relation model; and performing compensation calibration on the initial electrochemical signal to obtain an electrochemical signal subjected to swelling correction and a blood glucose concentration value. The invention further discloses a system for executing the method. According to the method, the problem of insufficient measurement precision caused by swelling of the outer membrane at the initial stage of implantation is effectively solved, the accuracy and reliability of the sensor at the key starting stage are remarkably improved, more timely and credible blood glucose dynamic information is provided for a user, and the method has important application value.

This invention proposes a microneedle electrochemical biosensor and its fabrication method. The sensor comprises: a substrate and a glucose sensing electrode, a sodium penicillin sensing electrode, a sodium chloride sensing electrode, a reference electrode, and a counter electrode disposed on the substrate. Specifically: the glucose sensing electrode comprises a first graphite layer, a Prussian blue layer, and an enzyme immobilization layer stacked from bottom to top; the sodium penicillin sensing electrode comprises a second graphite layer and a β-lactamase immobilization layer stacked from bottom to top; and the sodium chloride sensing electrode comprises a third graphite layer, a signal conversion layer, and an ion recognition membrane layer stacked from bottom to top. This sensor selectively measures the concentrations of glucose, sodium penicillin, and sodium chloride, achieving high sensitivity and accuracy in detection.

Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

The application provides a skin-core structure glucose sensing fiber and a preparation method thereof, and belongs to the technical field of wearable colorimetric sensing. The skin-core structure glucose sensing fiber is prepared by a coaxial wet spinning process, wherein the fiber core layer is composed of a color developing functional material and a high molecular polymer, and the skin layer is composed of a composite enzyme and a high molecular polymer. The color developing agent in the color developing functional material is coated by a sensitizer, which not only solves the problem that the color developing agent is difficult to disperse uniformly in an aqueous solvent, but also protects the color developing agent from directly contacting with the external environment, thereby preventing the generation of false negative or false positive conditions. Meanwhile, the color developing functional material as the core layer further avoids the generation of false negative or false positive conditions. The skin layer and the core layer adopt a specific polymer as a spinning base material, so that the color developing reaction can be rapidly generated, and the sensitivity is improved. The prepared skin-core structure glucose sensing fiber can be used for glucose detection in biological body fluids (blood, sweat, urine and tissue fluid).

The invention relates to the field of measurement, and discloses an artificial intelligent cell culture medium glucose concentration measurement method, which is used for providing an accurate glucose concentration measurement method for a cell culture process. Comprising the steps that first and second glucose sensing electrodes are arranged to obtain current signals, differential current signals are obtained through processing, and the glucose concentration value after environment compensation is determined by combining temperature and pH value correction coefficients. In continuous measurement, the baseline noise level is determined according to the second current signal, the electrode response state is determined according to the differential current signal dynamic response, calibration is triggered, the conversion parameters are updated, and the actual glucose concentration value is obtained according to the conversion parameters. The device is accurate and stable in measurement, can realize real-time monitoring and maintenance, and provides reliable data support for cell culture.

Disclosed are systems and techniques for glucose sensing. For example, an example of a process can include transmitting, by at least one transmitter into living tissue, a first signal with a first wavelength, a second signal with a second wavelength, and a third signal with a third wavelength to produce an acoustic response from the living tissue. The first wavelength has a first correlation with the blood glucose concentration, the second wavelength has a second correlation with the blood glucose concentration, and the third wavelength has a third correlation with the blood glucose concentration. The process can include receiving, by at least one receiver, a response signal of the acoustic response. The process can include determining, by at least one processor, the blood glucose concentration based on a photoacoustic spectrum of the response signal.

The invention relates to the technical field of blood glucose data monitoring, in particular to a blood glucose management system and method.The system is based on a collaborative architecture of a user side program and a manufacturer side program of an intelligent terminal, and a cloud platform is used for endowing a blood glucose management social attribute and a user-manufacturer collaborative characteristic; suitability quantitative evaluation of the blood glucose sensing equipment is brought into blood glucose management, physical and psychological burdens possibly brought by the blood glucose sensing equipment to a user are fully considered, and connection, data transmission and processing of all the equipment are achieved through the characteristics of intelligence, interconnection and convenience of an intelligent terminal. According to the invention, a user is helped to carry out deeper, safer and more comprehensive blood glucose management.

The present application provides a kind of contact lens type tear glucose sensing monitoring system, comprising: substrate, the substrate is made of flexible transparent material;Bionic microfluid channel sample collection module, the bionic microfluid channel sample collection module is used to collect tear fluid;Tear glucose monitoring sensor, the tear glucose monitoring sensor is used to detect the glucose content in tear fluid, the tear glucose monitoring sensor is connected with the bionic microfluid channel sample collection module;Wireless signal transmission module, the wireless signal transmission module is connected with the tear glucose monitoring sensor;Contact lens external circuit module, the contact lens external circuit module is used to receive the detection result signal transmitted by the wireless signal transmission module;The bionic microfluid channel sample collection module, the tear glucose monitoring sensor and the wireless signal transmission module are all arranged on the substrate. Can improve the security, comfort and portability of eye physiological information monitoring.

The present invention relates to a biosensor for measuring glucose concentration and its use in glucose sensing, wherein the biosensor comprises a polymer comprising a moiety of formula (I). The biosensor of the invention is particularly useful in glucose monitoring of individuals under intensive care, as well as in cases where glucose monitoring is performed on unconscious individuals.

Intestinal epithelial cells (enterocytes) sense the presence of sugars in the gut to stimulate sugar absorption, but the receptor has remained unknown. We show strong expression of the β2-adrenergic receptor (β2-AR) at the enterocyte apical membrane and reveal its function in stimulating glucose uptake from the gut by the sodium / glucose-linked transporter, SGLT1. Upon heterologous expression, the β2-AR responds to multiple sugars in the mM range, consistent with estimated gut sugar levels after a meal. Some adrenergic receptor antagonists differentially inhibit epinephrine and sugar responses. Glucose uptake into everted sacs from rat intestine was stimulated by epinephrine and sugars in a β2-AR-dependent manner. STD-NMR confirmed binding of glucose to β2-AR. Administration of glucose with a non-bioavailable β2-AR antagonist lowered the subsequent increase in blood glucose levels, confirming a role for apical β2-ARs in stimulating gut glucose uptake and suggesting enterocyte β2-AR as novel drug target in diabetic and obese patients. Future work will have to reveal how glucose sensing by enterocytes and neuroendocrine cells is connected and whether β2-ARs mediate glucose sensing also in other tissues.

This patent designs and synthesizes a metal-organic framework material—Co-TBTT—based on the dithienyloctacarboxylic acid ligand, and uses it as a non-enzymatic glucose electrochemical sensing material for glucose detection. Its potential in glucose sensing was evaluated through electrochemical performance testing. Experimental results show that the Co-TBTT-modified electrode exhibits excellent electrochemical response to glucose under enzyme-free conditions, with a linear detection range of 13.5 μM to 3 mM and a detection limit as low as 0.20 μM, outperforming most currently reported enzyme-free glucose sensors. The Co-TBTT electrode in the presence of Na... + K + Even in mixed solutions containing coexisting ions and interfering substances such as uric acid (UA), ascorbic acid (AA), and dopamine (DA), it maintains good anti-interference ability and exhibits strong selectivity. These excellent properties can be attributed to the porous structure and abundant metal active sites of the Co-TBTT material, providing a novel functional material for the electrochemical sensor detection of glucose.

The invention discloses an establishment method and device of a radio frequency noninvasive blood glucose monitoring electromagnetic sensing model, a storage medium and equipment. The method comprises the following steps: preliminarily dividing human tissues into static tissues and dynamic tissues; the radio frequency sensing signals are transmitted to the static tissue and the dynamic tissue respectively, response characteristics of the radio frequency sensing signals are obtained, clustering is carried out according to the response characteristics, and a plurality of types of human tissue are obtained; carrying out voxel reconstruction on the plurality of types of human tissues by utilizing a sparse regularization graph variation method to obtain a blood glucose monitoring electromagnetic sensing model; based on a Cole-Cole formula modeling method, dielectric property analysis is carried out on the multiple types of human tissues, dielectric property assignment is carried out on all voxel points of the blood glucose monitoring electromagnetic sensing model according to analysis results, and a response function of the human tissues to blood glucose sensing signals is established. The radio frequency blood glucose monitoring electromagnetic sensing model established by the method is more practical, and a theoretical and simulation model is provided for subsequent more accurate blood glucose monitoring.

The present invention is entitled "Colloid with Nanoporous Structure and Device and System for Non-enzymatic Glucose Sensing." This disclosure relates to a colloidal composition comprising a plurality of nanoparticle clusters dispersed in a liquid, a nanoporous layer formed from said colloid, a glucose oxidation electrode including said nanoporous layer, and a glucose sensing device, apparatus, and system including said glucose oxidation electrode. This disclosure also relates to a method for preparing said colloidal composition, said nanoporous layer, said glucose oxidation electrode, and said glucose sensing device and system. Furthermore, this disclosure relates to devices, systems, and methods for continuous glucose monitoring (CGM) and blood glucose monitoring (BGM).

The invention discloses a flexible high-sensitivity glucose concentration sensing electrode and a batch preparation method and application thereof, and the glucose concentration sensing electrode comprises an insulating substrate with a smooth and flat surface and a conductive three-electrode printed on the surface of the insulating substrate, the three conductive electrodes comprise a working electrode, a counter electrode and a reference electrode which are arranged at intervals, a copper nano material structure is deposited on the surface of the working electrode, and palladium clusters are loaded on the surface of the copper nano material structure. According to the sensing electrode disclosed by the invention, a trace amount of glucose in a solution is oxidized by using an electrochemically deposited copper nanostructure to generate current, so that the basic function of glucose sensing is realized. The flexible glucose concentration sensing electrode has good stability and glucose detection performance, can be applied to concentration detection of trace glucose in sweat, and is simple in device structure, mature in manufacturing process and suitable for large-scale industrial production.

The application discloses a kind of molecular imprinting glucose sensing probe systems based on optical fiber LMR sensing, including halogen lamp light source, Y type optical fiber bundle, molecular imprinting glucose sensing probe, micro optical fiber spectrometer and host computer;The molecular imprinting glucose sensing probe is removed from inside to outside in order multimode optical fiber, ITO film layer, glucose molecular imprinting film layer, the glucose molecular imprinting film layer has imprinting hole;The ITO film layer generates LMR effect at specific thickness;Located at the imprinting hole of the glucose molecular imprinting film layer is combined with glucose molecule specifically, and the effective refractive index of glucose molecular imprinting film layer changes and causes LMR resonance wavelength change, and glucose concentration is obtained by demodulation of the change of LMR resonance wavelength.The application realizes the sensing method capable of high specificity, high sensitivity and detecting glucose.

The application discloses a kind of Ni (II) based metal organic framework Ni (II)-MOF material and application in electrochemical glucose sensing.The application is applied in electrochemical glucose sensing field by synthesizing a case of Ni (II)-MOF by hydrothermal method.The application uses benzene-1,2,3,4,5,6-hexacarboxylic acid (H6L) as organic ligand, introduces 1,4-bis (1-imidazole) benzene (bib), and constructs with periodic three-dimensional framework structure.The Ni (II)-MOF material synthesis process is simple, crystallinity is strong, product purity and yield are high, and structure is novel.The obtained Ni (II)-MOF has ultrafast response time, lower detection limit and higher sensitivity, and has good application prospect in electrochemical glucose sensing.