Two-dimensional nickel and cobalt MOFs (metal organic frameworks) nano-sheet and application of nano-sheet to glucose detection

A bimetal and nanosheet technology, applied in the field of biosensing, can solve the problems of easily destroying the structure of MOFs, complicated operation, low yield, etc., and achieve the effect of improving sensing performance, simple operation and large specific surface area.

Active Publication Date: 2017-10-10
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the synthesis of two-dimensional MOFs mainly uses the top-down method or the method of adding a structure-directing agent to the down-top method. These synthesis methods have low yields, cumbersome operations, and are easy to destroy the structure of MOFs.

Method used

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  • Two-dimensional nickel and cobalt MOFs (metal organic frameworks) nano-sheet and application of nano-sheet to glucose detection
  • Two-dimensional nickel and cobalt MOFs (metal organic frameworks) nano-sheet and application of nano-sheet to glucose detection
  • Two-dimensional nickel and cobalt MOFs (metal organic frameworks) nano-sheet and application of nano-sheet to glucose detection

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Experimental program
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Effect test

Embodiment 1

[0017] Embodiment 1: This embodiment prepares two-dimensional nickel-cobalt bimetallic MOFs nanosheet material, which specifically includes the following steps:

[0018] (1) 0.8724g nickel nitrate hexahydrate and 0.8731g cobalt nitrate hexahydrate are uniformly dispersed in 100mL of deionized water to obtain a nickel-cobalt metal salt mixed solution;

[0019] (2) Dissolve 0.4348g aminoterephthalic acid in 20mL N,N dimethylformamide (DMF) to obtain an organic ligand solution;

[0020] (3) Transfer 6 mL of the mixed solution obtained in step 1 and 1 mL of step 2 to a 25 mL reaction kettle with 5 mL of DMF and a nanoporous gold needle, and react at 120 ° C for 6 h, and a purple color is obtained on the nanoporous gold needle product;

[0021] (4) Wash the purple product obtained from the reaction in step 3 with ethanol and dry it in vacuum at 60° C. to obtain two-dimensional nickel-cobalt bimetallic MOFs nanosheets.

[0022] figure 1 The scanning electron microscope picture (S...

Embodiment 2

[0024] Example 2: In this example, the prepared two-dimensional nickel-cobalt bimetallic MOFs nanosheet material is used as a glucose biosensor, and the main steps are as follows:

[0025] a. The gold electrode decorated with two-dimensional nickel-cobalt bimetallic MOFs nanosheets was used as the working electrode, the Pt sheet was used as the counter electrode, and the SCE was used as the reference electrode to assemble a three-electrode electrochemical system for testing;

[0026] b. During the cyclic voltammetry test, the electrochemical window is selected as 0V ~ 0.6V, and the scan rate is 50mV / s; the voltage of the I-T curve is selected as 0.5V, and after the background current reaches a steady state after 10 minutes, use a pipette to continuously add different concentrations The glucose solution and serum were stirred and tested, and the current response values ​​at different glucose concentrations, namely the step curve and the calibration curve were obtained;

[0027]...

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Abstract

The invention discloses a two-dimensional nickel and cobalt MOFs (metal organic frameworks) nano-sheet and an application of the nano-sheet to glucose detection. The two-dimensional nickel and cobalt MOFs nano-sheet is synthesized on substrates such as nano-porous gold needles, carbon paper and gold sheets by a one-step hydrothermal method from bottom to top, serves as an electrode and is applied to a non-enzyme electrochemical glucose sensor. A two-dimensional nickel and cobalt MOFs nano-sheet material has the advantages that more active sites are exposed, nickel and cobalt are cooperated, charge transfer capacity is high and the like relative to a traditional spherical polyhedral MOFs material, so that glucose sensing properties of the nano-sheet material is effectively improved.

Description

technical field [0001] The invention belongs to the technical field of biosensing, in particular to a two-dimensional nickel-cobalt bimetallic MOFs nanosheet and its application in glucose detection. Background technique [0002] Improving the performance of enzyme-free glucose biosensors is crucial for the diagnosis and control of diabetes. Two-dimensional materials will have higher catalytic activity due to the advantages of larger specific surface area, more active sites, and faster mass transport. At present, the research on the application of two-dimensional materials in enzyme-free glucose sensors is mainly concentrated on materials such as graphene, transition metal sulfides, metal oxides, and layered double metal hydroxides, while direct use of metal ions or metal Metal-organic frameworks (MOFs) materials with periodic network structure formed by clusters as nodes and bridges with organic ligands are rarely used as electrode materials for glucose sensors. Currently,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/48G01N27/30
CPCG01N27/30G01N27/48
Inventor 崔小强李威威吕爽张雷
Owner JILIN UNIV
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