7 results about "Cartilage lesion" patented technology

This invention provides a stress-triggered selective targeting hydrogel microsphere, its preparation method, and its application, belonging to the field of biomedical technology. The core of this invention is the "stress-triggered charge reversal" mechanism. It utilizes the interaction between weakly cross-linked disulfide bonds broken under stress and "charge reversal" messenger molecules to achieve "charge reversal" of nanoparticles under stress. A dual-network hydrogel microsphere system is prepared using microfluidic technology to achieve bearing lubrication and stress relaxation within the joint cavity. Stress-triggered charge reversal is achieved at stress-overloaded cartilage lesions, imparting a positive charge to the drug-loaded nanoparticles within the hydrogel microspheres. This significantly enhances the ability of the drug-loaded nanoparticles to penetrate deep into the cartilage matrix and target chondrocytes for drug release under the guidance of the charge. This enables the selective and targeted release of appropriate drug concentrations to deep-seated chondrocytes in pathological microenvironments induced by different stress intensities, achieving highly effective and low-toxicity treatment of osteoarthritis.

This invention relates to the fields of regenerative medicine and neuromodulation technology, specifically disclosing the application of mediators that inhibit the activity of the auditory cortex in the preparation of drugs or intervention devices for promoting cartilage regeneration, repairing cartilage damage, and delaying or treating osteoarthritis. This invention promotes cartilage damage repair and osteoarthritis treatment by modulating the auditory cortex of the auditory center, providing two technical means: a chemogenetic method involving targeted injection of a viral vector carrying an artificial inhibitory receptor into the auditory cortex followed by administration of a DREADD agonist; and a sound stimulation method involving outputting sound stimulation to the individual at a level 5 dB higher than the ambient background noise. Animal experiments have confirmed that both methods can upregulate the expression of cartilage synthesis markers Col2, Acan, and PRG4, downregulate the expression of degradation markers Col1 and Mmp13, improve histological scores, and alleviate pain. This invention also provides an intervention device, including a sound insulation unit, a sound acquisition unit, a control unit, and a sound output unit. This device has the advantages of being non-invasive, easy to operate, and highly safe, providing an innovative strategy for cartilage regeneration and osteoarthritis treatment.

The embodiments of the present disclosure provide a composition including mitochondria. By providing the mitochondria to cartilage, the composition can improve the mitochondrial function of the chondrocytes in the cartilage so as to increase the repair ability of the chondrocytes and repair the cartilage damage caused by aging of the chondrocytes, thereby achieving the purpose of treating osteoarthritis.

The application discloses a cartilage injury treatment preparation and application of M2 myeloid macrophage-derived exosomes in preparation of the cartilage injury treatment preparation. The cartilage injury treatment preparation comprises 50-100 mu g / mL of separated and purified M2 myeloid macrophage-derived exosomes and excipients. The M2 myeloid macrophage-derived exosomes can promote polarization of macrophages at a cartilage injury site to M2 myeloid macrophages, so that the cartilage injury site has more M2 myeloid macrophages to promote cartilage repair and regeneration, and the use of cells derived from an allogeneic body at the cartilage injury site is avoided, so that biocompatibility and immunogenicity problems are avoided.

The application provides application of Nell-1 and a derivative product thereof in preparation of a medicine for preventing and / or treating mechanical cartilage degeneration, and belongs to the technical field of biological medicines. The application explores response, function and molecular mechanism of Nell-1 in mechanical cartilage degeneration, and innovatively reveals that pathological mechanical stress inhibits expression of Nell-1 of chondrocytes. 2+ Ca internal flow and abnormal activation of YAP, breaks the vicious cycle of "mechanical overload-mechanical hypersensitivity" from the source. Nell-1 has multiple effects of regulating the mechanical adaptability of cartilage, inhibiting the terminal differentiation of chondrocytes, reducing the release of inflammatory factors and cell apoptosis, and has significant and comprehensive protective effect on cartilage damage caused by mechanical overload. This shows that Nell-1 or the derivative product of Nell-1 provides a new means for clinical treatment of mechanical cartilage degeneration.

The application provides a knee cartilage injury grading method and a storage medium thereof. The knee cartilage MRI image of a patient is acquired, and image region segmentation is performed on the knee cartilage MRI image to obtain a first image representing a patellofemoral joint region, a second image representing a medial femorotibial joint region, and a third image representing a lateral femorotibial joint region in the patient. Feature extraction is performed on the first image, the second image, and the third image to obtain a first feature set. The first feature set is input into a radiomics model, and the first feature set is subjected to cartilage injury grading evaluation and evaluation explainability analysis by the radiomics model to obtain a knee injury score and a knee injury grade of the patient and a visual evaluation report for explaining the generation of the knee injury score and the knee injury grade. The knee cartilage injury grading accuracy and explainability evaluation are realized, and the grading accuracy and the clinical application reliability are improved.