484 results about "Surgical therapy" patented technology

A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.

This invention provides a process and system for a comprehensive surgical assist system, called a Therapy Imaging and Model Management System (TIMMS), which combines and integrates all of the necessary information and communication technology; workflow analysis, data processing and data synthesis; interactive interfaces between surgeon and mechatronic devices; and, cognitive agents; to provide comprehensive assistance and guidance throughout complex medical and surgical therapies, such as image guided surgery. The components of this invention, which are modular, scalable and may be distributed in location, act synergistically to provide functionality and utility that exceeds the sum of its individual parts.

A method of performing surgery on a patient comprising the step of comparing a chosen patient's data to statistical data in a repository of patient data to develop a patient specific model, wherein the data comprises information from two or more sub databases selected from the group consisting of workflow data, electronic medical records, diagnostic data, biological data, measurement data, anatomical data, physiological data, genetic data, molecular data, imaging data, chemical data, clinical laboratory data, simulated data, coordinate data and surgical result and wherein the patient specific model aids in the preoperative, operative or post operative phase of surgery performed in real time on the patient.

A tissue protective system and method having particular application in thermoablative surgical therapies where heat or cold is used to create a kill zone for treating cancer cells as well as malignant or benign tumors in a targeted internal tissue area (e.g., the prostate) of a patient while sparing an adjacent benign internal tissue area (e.g., a neurovascular bundle). One of a hollow sheath or a balloon that is carried by a balloon catheter is located within an access opening that is made by a needle trocar inserted between the targeted tissue area in need of treatment and the benign tissue area to be protected in order to hold the protected tissue area off the targeted tissue area and away from the lethal temperature of the kill zone. The balloon of the balloon catheter is inflated in the access opening via a balloon channel which runs longitudinally through the catheter. At least one temperature sensor is mounted on the balloon and responsive to the temperature near the benign tissue area to be protected. Heat or cold is provided to the balloon from a heating wire or a circulating fluid, depending upon the temperature that is sensed by the temperature sensor.

An improvement in a method for closed-chest, video-assisted diagnostic or surgical treatment of a patient is provided. The improvement comprises draping a video monitor with a transparent sterile surgical drape and positioning the draped monitor within the surgical field so that a surgeon can perform an internal surgical or diagnostic procedure and view it on the monitor to provide improved visual alignment for the surgeon. A flexible, sterile drape for covering the video monitor is disclosed. An apparatus for assisting the surgeon in performing closed-chest, video-assisted surgical or diagnostic treatment of a patient is disclosed which comprises a movable cabinet having an adjustable arm to which is affixed a video monitor that can be extended into the surgical field of an operating room to improve the visualization of the surgery performed by the surgeon. An improved operating table for assisting a surgeon in performing closed-chest, video-assisted surgical or diagnostic treatment of a patient is also disclosed along with endoscopic visualization apparatus and an improved design of a view scope that allows the doctor to get closer to a patient during the operation.

Aspects of the present disclosure are presented for a single surgical instrument configured to grasp, seal, and/or cut tissue through application of therapeutic energy, and also detect nerves through application of non-therapeutic electrical energy. A medical device may include two jaws at an end effector, used to apply therapeutic energy and to perform surgical procedures. The therapeutic energy may be in the form of ultrasonic vibrations or higher voltage electrosurgical energy. One of the jaws may be configured to cut tissue through application of the blade. In addition, one or both of the two jaws may be configured to apply nontherapeutic energy for nerve stimulation probing. The application of therapeutic energy may be disabled while the nontherapeutic nerve stimulation energy is applied, and vice versa. The nontherapeutic nerve stimulation energy may be applied to the use of one or more probes positioned near one or both of the jaws.

Disclosed is a device and method which provide a surgical therapy for in situ treatment and repair of intra-articular cartilage lesions and/or defects. The device is an implantable laminate cartilage repair patch which is bio-compatible and physiologically absorbable. The cartilage repair patch has a first outer cell occlusive layer; a second outer, cell porous layer adapted to be disposed proximate a subchondral bone wound site; and a cartilagenic matrix disposed between the first and second layers. The cartilagenic matrix is a sink for diffusion of autologous stem cells and includes chemical components promoting generation of hyaline-like cartilage in the presence of the autologous stem cells. The method of the present invention provides the autologous compositions, which when used in combination with the repair patch provides a therapeutic system to regenerate replacement hyaline-like intraarticular cartilage.

A composite medicine for treating tumor by locally putting it in the tumor is composed of the active anticancer components (topoenzyme inhibitor and its symergist chosen from taxol-type anticancer medicnie, antineoplastic antibiotic and antimetabolitic medicine) and the medicinal auxiliary (biocompatible and biodegradable high-molecular polymer).

The present invention relates to methods for perioperative genomic screening of subjects, in particular to perioperative screening for markers indicative of responses to anesthesia and other perioperative or operative treatments and procedures. The present invention also provides compositions for use in screening methods. The methods and compositions of the present invention find use in tailoring a subject's medical or surgical treatment to reflect genetic information that predicts a subject's response to medications or techniques used in the procedure.

An anticancer in vivo implant applied locally is prepared from the anticancer nitrosourea-type medicine, the anticancer synergist chosen from nitrogen mustard compound, mitotic inhibitor and antimetabolic anticancer medicine, and the biocompatible and biodegradable high-molecular polymer as medicinal additive.

The invention combines a novel combination with two especially important aspects: first, the invention proposes to simultaneously stimulate response in white blood cells and a patient's tumor cells with a mitogen-challenging compound, preferably a lectin, in the preferred mode the selected lectin being phytohemagglutin ("PHA"), and second, to generate heat shock protein. A method of treatment is set out. The method of manufacturing proposed utilizes a system calculated to better insure sterility and streamline production of the cytokine modulator. A method of testing in conjunction with the therapy is also claimed utilizing clinical assessment of disease activity, patient performance status, and quality of life questionnaire. Should efficacy of a treatment fall off, particularly because of mutation or adaption, the composition and method may be re- applied. The invention is not limited to humans, but is also applicable to mammals. The composition is usable as a stand-alone composition, but preferably is used in conjunction with standard therapy such as radiation, chemotherapy or surgery, particularly surgical therapy, and in conjunction with the administration of cystine, as later defined, to enhance immune system competency.

A device for removing tissue by means of laparoscopy or thoracoscopy with an operating part and an optionally partially open hollow tube with a guide for operating a removing part. The removing part has the form of a zeppelin with one or more ribs. The removing part is provided on the upper side with longitudinal connecting elements.

Further described is an application of such a device in a surgical treatment wherein, by use of the operating part, the removing part with the form of a zeppelin is opened out, the removed tissue is collected in the expanded bag of the removing part, and the removing part with tissue is pulled optionally at least partially into the open part of the hollow tube. The connecting elements of the removing part can then be brought together and snapped or zipped closed.

Disclosed is an anti-cancer drugs slow release agent containing Epothilone which comprises slow release microspheres and dissolvent, wherein the slow release microballoons comprise anti-cancer active constituents and slow release auxiliary materials, the dissolvent being specific dissolvent containing suspension adjuvant. The anticancer active constituents include Epothilone, Epothilone derivatives, Epothilone B, Epothilone D and combination of anti-cancer drugs selected from phosphoinositide-3-kinase inhibitor, of pyrimidine analogues and/or DNA restoring enzyme inhibitor, the slow release auxiliary materials include polylactic acid and its copolymer, polyethylene glycol, PLA-COOH copolymer, di-aliphatic acid and sebacylic acid copolymer, poly(erucic aciddipolymer-sebacylic acid), poly(fumaric acid-sebacylic acid), Polifeprosan, polylactic acid and other biocompatible high polymers, the viscosity of the suspension adjuvant is 100-3000cp (at 20-30 deg C), and is selected from sodium carboxymethylcellulose. The anticancer active constituents and the slow release microspheres can also be prepared into slow release implanting agent for intra-tumor or around-tumor injection or placement for the effective suppression of tumor growth and for the appreciable enhancement for curative effects of non-operative treatments such as chemotherapy.

Disclosed is a pharmaceutical composition for solid tumour which comprises anticancer available composition and medicinal adjuvant, the anticancer available composition is platinum compounds, and the medicinal adjuvant mainly employs biological compactable, degradable and absorbable macromolecular polymer. The composition can lower down the whole body toxicity reaction of the medicament when locally dispensing on the tumor, selectively increase the tumor local medicinal concentration, and improve the treatment effect of the non-operative treatment methods such as chemotherapy, medicament and radiation.

The invention relates to a focused ultrosound therapy combined array element phased array and multifocal shear wave imaging system for focused ultrosound non-invasive surgical therapy, belonging to the technical field of biomedical instrument, in particular to a combined array element phased array transducer used for multifocal focused ultrosound therapy and radial force excitation imaging and also relates to a multifocal plane shear wave imaging system by using the combined array element phased array transducer. In the transducer, the combined array element is formed by compactly placing 2*2 or 3*3 basic matrix array elements in rows according to spherical rectangle mode, all basic matrix array elements in each combined array element are in parallel electrically and share one power driven channel; a basic matrix array element distance is left between the centers of two adjacent combined array elements along at least one direction, and each combined array element is matched with the phase and amplitude of one power driven channel so as to significantly expand the focal scanning area.

This distraction device comprises a rod (1), a second rod (2) and means to control the translation of one rod relative to the other (3), so as to cause the desired distraction or compression. Each rod (1) and (2) has a first end, respectively (11) and (21), which receive means to link to a part of the organism such as hooks or screws for vertebra, ribs or the pelvis, and a second end, respectively (12) and (22), linked to the means to control the translation of one rod relative to the other (3) such that the direction of the first end (11) toward the second end (12) of the first rod (1) is roughly the same as the direction of the first end (21) toward the second end (22) of the second rod (2). The distraction device thus roughly forms a J, the bulging and rigid part of which is located outside the area concerned by the surgical treatment, facilitating its implantation. It is useful for straightening of the spine and bone lengthening, deformity correction or transport, depending on the means used to link to the organism.

The invention provides a liver image segmentation quality evaluation method and device and computer equipment. Inputting the acquired liver CT sequence diagram into an image segmentation model; obtaining a blood vessel mask and a liver mask contained in each liver CT image; carrying out connected domain analysis on each blood vessel mask; utilizing the obtained blood vessel connected domain; veinregions contained in the blood vessel masks are determined; and obtaining and outputting a liver blood vessel segmentation quality evaluation result of the liver CT sequence diagram acquired this timeby utilizing the determined liver mask and vein region. The medical personnel are informed of the liver blood vessel segmentation quality of the liver CT sequence diagram; therefore, it is avoided that under the condition that the liver blood vessel segmentation quality of the liver CT sequence diagram is poor, medical staff continue to refer to the liver CT sequence diagram to diagnose and treata patient, and the auxiliary effect of the liver auxiliary diagnosis system on liver disease diagnosis and surgical treatment is greatly improved.

The invention provides a discharge-controllable shock wave balloon catheter system which comprises a shock wave treatment host, a balloon, a catheter and a plurality of electrode pairs, wherein one end of the catheter penetrates through the balloon; the other end of the catheter is connected with the shock wave treatment host, and the electrode pair is contained in the balloon and installed on the catheter. The shock wave treatment host comprises a plurality of pulse switch modules, the single electrode pairs are electrically connected with the single pulse switch modules in a one-to-one correspondence mode, or the plurality of electrode pairs are independently electrically connected with the same pulse switch module. According to the shock wave balloon catheter system, by arranging the electrode pairs of different sizes, precise treatment of calcified blood vessels can be achieved easily; herein, the multiple electrode pairs are not connected in series, the magnitude and frequency of shock wave energy released by each electrode pair can be independently controlled, synchronous high-voltage pulse discharge can be achieved and asynchronous high-voltage pulse discharge can also be achieved, so that the flexibility of a discharge control mechanism is improved, the discharge efficiency is improved, and the surgical treatment time of vascular calcification is shortened.

The slow released anticancer injection containing methotrexate and its synergist consists of slow released microballoon and solvent. The slow released microballoon includes effective anticancer component and slow releasing supplementary material, and the solvent is common solvent or special solvent containing suspending agent. The effective anticancer component is methotrexate synergist or the composition of methotrexate and its synergist; the methotrexate synergist is selected from phosphorinositide 3-kinase (PI3K) inhibitor, pyrimidine analogue and DNA repair enzyme inhibitor; the slow releasing supplementary material is PLA, PLGA, EVAc, etc or their composition; and the suspending agent is sodium carboxymethyl cellulose, etc. The slow released microballoon may be also prepared into slow released implantation preparation. Implanting or injecting the slow released preparation to local tumor part can lower the systematic toxic reaction of the medicine and raise the medicine concentration of local tumor part selectively to raise the treating effect.

An anticancer pharmaceutical composition composed of pharmaceutic adjuvant and anti-metabolism medicine is disclosed. Wherein, the anti-metabolism medicine can effectively destroy DNA and/or protein synthesis and repairing function inside the tumor cell so as to inhibit the tumor cell growth, while the pharmaceutic adjuvant can mainly be biological compatible, degradable and absorbable macromolecule polymer, which can make the anti-metabolism drug to release slowly in the local tumor region in the degradation and absorption process, therefore it can both decrease considerably the whole body toxic reaction and sustain the local tumor effective drug level.

A crosslinked elastin, a water-soluble crosslinking agent to be used for crosslinking, molded elastin articles, medical instruments and regeneration tissues using the crosslinked elastin, and a surgical therapy method and regeneration treatment wherein the medical instruments are employed. There is provided a biocompatible functional material having elasticity suitable for transplantation into the body without causing detachment of cell adhesion proteins.