66results about How to "Powerful tool" patented technology

A method for communicating data is provided that includes collecting data associated with an individual using an accelerometer. The accelerometer is operable to monitor activity associated with the individual. The method also includes communicating the data to a computing device, which can receive the data and perform any number of operations.

An image processing method for use in dentistry or orthodontic is provided. Two images of teeth, one being a two-dimensional image and one a three-dimensional image are combined in a manner to allow the use of information obtained from one to the other. In order to combine the two images a set of basic landmarks is defined in one, identified in the other and then the two images are registered.

The present invention is directed to microparticles, to microparticle compositions containing the same, to methods of forming the same, and to uses for the same, including use for a vaccine, for raising an immune response, for treatment of a disease and for diagnosis of a disease. The microparticles comprise a biodegradable polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, or a polycyanoacrylate, and a detergent selected from a cationic detergent and an anionic detergent. The microparticles further comprise an antigen adsorbed on the surface of the microparticle.

A method for the development of gene panels for diagnostic and therapeutic purposes comprising the steps of: (a) isolating at least one biological sample from each of at least two groups of biological material containing mRNA and / or proteins; (b) analyzing the expression level of at least one gene in the at least one biological sample; (c) selecting the gene(s) exhibiting a different expression level between the at least two groups of biological material, whereby a first knowledge base is generated; (d) analyzing the level of cytosine methylation in the methylation relevant regions of at least one gene of at least one of the biological samples of step (a), wherein the gene is selected on the basis of the first knowledge base; (e) selecting the gene(s) exhibiting a different level of cytosine methylation between the at least two groups of biological material, whereby a second knowledge base is generated; and (f) adding selected genes from the second knowledge base to a gene panel.

A plurality of computing appliances, each used by a respective user, provide for collaboration on a common project having an associated base image display. Data is stored in each of a plurality of separate respective data layers, of respective user data associated with a respective display for a respective user, responsive to user input. The user data is comprised of event content data (comprised of change reference data, and change content data, wherein the event content data is representative of a unique event, for each input by the respective user) generated in a defined order of entry relative to other of the events. Mapping logic defines a mapping of event content to corresponding respective data layers. A plurality of events is selected as a selected set of events. Event content data for said events in the selected set are retrieved from respective data layers, and used to generate presentation data.

An integrated system is described in which digital image data of a patient, obtained from a variety of image sources, including CT scanner, X-Ray, 2D or 3D scanners and color photographs, are combined into a common coordinate system to create a virtual three-dimensional patient model. Software tools are provided for manipulating the virtual patient model to simulation changes in position or orientation of craniofacial structures (e.g., jaw or teeth) and simulate their affect on the appearance of the patient. The simulation (which may be pure simulations or may be so-called “morphing” type simulations) enables a comprehensive approach to planning treatment for the patient. In one embodiment, the treatment may encompass orthodontic treatment. Similarly, surgical treatment plans can be created. Data is extracted from the virtual patient model or simulations thereof for purposes of manufacture of customized therapeutic devices for any component of the craniofacial structures, e.g., orthodontic appliances.

A database query optimizer includes an access plan storage mechanism that stores execution detail corresponding to a query statement in an access plan cache. By storing execution detail in the access plan cache along with the query statement, the execution detail is available when needed to debug database problems, even after a problem occurs. The execution detail stored in the access plan cache may be mined and analyzed after-the-fact, producing a very powerful tool for debugging database problems. Snapshots of the execution detail may also be created by a user. In addition, the user may setup autonomic snapshots and comparisons so that a user may be alerted from a degradation in database performance between two snapshots.

A data handling method combines search capabilities with analytical functionality. The invention provides advantages when dealing with structured documents (such as electronic catalogs, XML documents, text documents, HTML documents, Internet documents, etc.) and other data stored in a computer system. Various embodiments include simplified ways to express search / analysis requests of a data set and also to express results to such requests.

A system and method of reporting and displaying field survey data related to particular features located at remote sites that includes generating GPS data related to a feature with a handheld device, generating at least one image of the location, entering text data related to the location on the handheld device, and uploading the GPS data, image and text data into a database located at a central location. The photograph can be optionally transferred wirelessly from a camera to the handheld device. In particular, the transfer can be on a wireless network (WiFi). Data can be post-processed at the database location before entry into the database. GIS maps and reports can be made from the processed data for use in a project. These maps and reports can be placed on a web server for access by authorized personnel. The maps can contain an aerial photograph of the remote sites with symbols representing features overlaid on the aerial photograph. Each feature on the map can be linked to the GPS data, image data and text data related to that feature.

The invention includes a method of tracking distributed content within a computer network. The method includes the step of identifying the delivery of a set of Network Information Monitors (NIMs). Information about each NTM within the set of NIMs is tracked. The information includes a first time at which a user opens a selected NIM, a second time at which the user closes the selected NW, and an identifier for the selected NIM. The information is used to determine sub-sets of NIMs that are displayed simultaneously. The invention also includes a method of identifying the delivery of a Network Information Monitor (NIM) to a user. Content information for the NIM is recorded. NIM use activity is tracked the user for a set of NIMs. The content information is correlated with the NIM use activity.

The present invention provides a membrane-permeable complex for facilitating the delivery of a double-stranded ribonucleic acid molecule into a cell. Specifically, the invention provides a membrane-permeable complex that comprises a double-stranded ribonucleic acid molecule, such as a small interfering RNA, a cell-penetrating peptide, and a covalent bond linking the double-stranded ribonucleic acid to the cell-penetrating peptide. Also provided are methods of using the membrane-permeable complex of the present invention to deliver the double-stranded ribonucleic acid molecule to a cell or to inhibit expression of a gene product by a cell.

The present invention provides compositions comprising colorimetric assay liposomes. The present invention also provides methods for producing colorimetric liposomes and calorimetric liposome assay systems. In preferred embodiments, these calorimetric liposome systems provide high levels of sensitivity through the use of dopant molecules. As these dopants allow the controlled destabilization of the liposome structure, upon exposure of the doped liposomes to analyte(s) of interest, the indicator color change is facilitated and more easily recognized.

Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and / or microemulsions of the invention, are also provided.

A method for communicating data is provided that includes collecting data associated with an individual using an accelerometer. The accelerometer is operable to monitor activity associated with the individual. The method also includes communicating the data to a computing device, which can receive the data and perform any number of operations.

Unification of a programming language with a definition language creates a powerful tool for object-oriented programming. A programming language is extended to include definition language constructs. In a compiler environment, a compiler recognizes the definition language constructs in programming language code. The compiler environment unifies representation of the definition language information and programming language code in a unified parse tree, and derives semantic meaning from definition language information. The compiler environment also checks for lexical, syntax, and semantic errors.

A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a pharmaceutically acceptable excipient is disclosed.

A computing appliances for use by a user, provide for collaboration on a common project having an associated base image display. User data representative of a respective display of annotations responsive to user input is stored. The user data is comprised of event content data for respective events that are generated in a defined order of entry relative to other of the events. Presentation assembly logic, selectively retrieves respective said event content data for said events in the selected set responsive to the mapping logic, and generates presentation data responsive to processing the event content data for said events in the selected set, in a respective defined order of entry relative to other of the events.

An image processing method for use in dentistry or orthodontic is provided. Two images of teeth one being a two-dimensional image and one a three-dimensional image are combined in a manner to allow the use of information obtained from one to the other. In order to combine the two images a set of basic landmarks is defined in one, identified in the other and then the two images are registered.

Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and / or microemulsions of the invention, are also provided.

A plurality of computing appliances, each used by a respective user, provide for collaboration on a common project having an associated base image display. Data is stored in each of a plurality of separate respective data layers, of respective user data associated with a respective display for a respective user, responsive to user input. The user data is comprised of event content data (comprised of change reference data, and change content data, wherein the event content data is representative of a unique event, for each input by the respective user) generated in a defined order of entry relative to other of the events. Mapping logic defines a mapping of event content to corresponding respective data layers. A plurality of events is selected as a selected set of events. Event content data for said events in the selected set are retrieved from respective data layers, and used to generate presentation data.

There is provided a method of securitizing a pension fund associated with a pension scheme, comprising: calculating, using data processing apparatus, the expected liabilities of a pension scheme to at least a portion of its members taking into account an expected mortality of the scheme members; issuing from a securities issuing entity a financial instrument which undertakes to pay to an investor a cash flow according to a payment schedule, said expected liabilities being establishing as the initial payment schedule of a financial instrument; exchanging financial instrument with assets held by pension fund; and supporting the securities issuing entity in issuing the financial instrument by providing risk capital to the securities issuing entity; wherein the risk capital is initially provided by at least three separate equity investor entities. One of the equity investor entities may be the corporate sponsor of the pension scheme. Alternatively the risk capital is initially provided by the corporate sponsor of the pension scheme.

A method for locating competence in relation to a given subject in a group of users that are connected to an electronic communications network, includes sending a message to a user via said network, the message inviting the user to return a response message containing a reference to one or more other users who, in the opinion of the responding user, might have competence in relation to the subject; upon receipt of the response message, sending a message analogous to the one in the first sending step to each user who has been referred to in the response message; iterating the second sending step for all response messages, with the exception of those users who had already been referred to in a preceding iteration step; and storing competence data on the basis of the self-assessments and references as established in the above steps. The competence data may further be enhanced by adding a self-assessment of the user's competence in relation to the subject, to the response message.

The present invention provides monoclonal antibodies which are highly specific for Bacillus spores. Also provided are peptides derived from those monoclonal antibodies. Both the antibodies and peptides are highly specific and can discriminate between spores of potentially lethal organisms such as Bacillus anthracis and other harmless but closely related bacilli and provide a very powerful tool in the construction of detection instruments as counter measures.

A data handling method combines search capabilities with analytical functionality. The invention provides advantages when dealing with structured documents (such as electronic catalogs, XML documents, text documents, HTML documents, Internet documents, etc.) and other data stored in a computer system. Various embodiments include simplified ways to express search / analysis requests of a data set and also to express results to such requests.