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Pharmaceutical composition for solid tumour

A technology of tumor drugs and compositions, which is applied in the field of medicine, can solve the problems of local formation of effective drug concentrations and limitations in difficult tumors, and achieve the effects of prolonging local drug concentrations, reducing systemic toxic reactions, and enhancing anticancer effects

Inactive Publication Date: 2005-07-06
DASEN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. See Kong Qingzhong "Intratumoral placement of cisplatin plus systemic carmustine in the treatment of rat brain tumors" "Journal of Surgical Oncology" 69 pages 76-82 (1998) (KongQ et al., J Surg Oncol.1998 Oct; 69 (2 ):76-82), simply increasing the dosage is limited by systemic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Put 90 mg of polylactic acid (PLGA) with a molecular weight of 10,000 into a container, add 100 ml of dichloromethane, dissolve and mix, add 10 mg of oxaliplatin, re-shake, and then vacuum-dry to remove the organic solvent. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain an anti-solid tumor pharmaceutical composition containing 10% by weight of oxaliplatin. The drug release time of the anti-solid tumor pharmaceutical composition in physiological saline in vitro is 15-20 days, and the drug release time in mouse subcutaneous is 30-40 days.

Embodiment 2

[0054] Embodiment 2. As described in embodiment 1, the difference is that the contained anticancer active ingredients are:

[0055] 0.1-30% Heptaplatin, Denaplatin, Enloplatin, Cycloplatin, Cispiroplatin, Dexomaplatin, Isoproplatin, Lobaplatin, Miplatin, Nedaplatin, Omaplatin, Siplatin, Spiroplatin or zeniplatin. All are percentages by weight.

Embodiment 3

[0057] Put 80mg of polyphenylpropane (p-CPP: 20:80 of sebacic acid (SA)) copolymer into a container, add 100ml of dichloromethane, dissolve and mix well, then add 20mg Oxaliplatin, shake again and dry in vacuo to remove organic solvent. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain an anti-solid tumor pharmaceutical composition containing 20% ​​oxaliplatin. The drug release time of the anti-solid tumor pharmaceutical composition in physiological saline in vitro is 15-20 days, and the drug release time in mouse subcutaneous is 30-40 days.

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PUM

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Abstract

Disclosed is a pharmaceutical composition for solid tumour which comprises anticancer available composition and medicinal adjuvant, the anticancer available composition is platinum compounds, and the medicinal adjuvant mainly employs biological compactable, degradable and absorbable macromolecular polymer. The composition can lower down the whole body toxicity reaction of the medicament when locally dispensing on the tumor, selectively increase the tumor local medicinal concentration, and improve the treatment effect of the non-operative treatment methods such as chemotherapy, medicament and radiation.

Description

(1) Technical field [0001] The invention relates to a pharmaceutical composition for resisting solid tumors, belonging to the technical field of medicines. (2) Background technology [0002] The treatment of solid tumors mainly includes surgery, radiotherapy and chemotherapy. Among the various chemotherapeutic drugs used, the effect of platinum compounds is more obvious, and has been widely used in various malignant tumors. However, further studies have found that blood vessels, connective tissue, matrix proteins, fibrinoproteins, and collagen in the tumor stroma not only provide scaffolds and essential nutrients for the growth of tumor cells, but also affect the effect of chemotherapy drugs on tumor cells. Infiltration and diffusion in the surrounding and tumor tissues (see Netti et al. "The influence of the status of the extracellular matrix on the delivery of drugs in solid tumors" "Cancer Research" 60 pp. 2497-503 (2000) (Netti PA, Cancer Res .2000, 60(9): 2497-503). D...

Claims

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Application Information

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IPC IPC(8): A61K31/282A61K31/555A61P35/00
Inventor 孔庆忠
Owner DASEN BIOLOGICAL PHARMA CO LTD
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