3 results about "Tumor stroma" patented technology

The present application relates to the technical field of digital image processing, in particular to a tumor interstitial proportion quantitative evaluation system based on pathological images. The present application automatically obtains tumor epithelial region, tumor interstitial region, tumor region and tumor infiltration front region based on image segmentation, without pre-selecting histological evaluation position for visual evaluation by artificial selection, avoiding the subjective experience dependence of traditional methods, and improving the efficiency of tumor interstitial proportion evaluation. In addition, the present application comprehensively quantitatively evaluates the first tumor interstitial proportion under the overall scale of the to-be-tested pathological image, the second tumor interstitial proportion under the scale of the tumor infiltration front region and the third tumor interstitial proportion under the scale of the tumor region, and finally obtains the tumor interstitial proportion score value which can reflect the tumor interstitial proportion characteristics of different anatomical positions, further improving the accuracy of the evaluation result. The preset rule is to select the window tumor interstitial proportion with the highest tumor interstitial proportion value.

The application provides a pancreatic cancer deep penetration ferroptosis nano preparation and a preparation method and application thereof, the nano preparation comprises a drug-loaded core and a MOF shell, the drug-loaded core is formed by polymerization of a ferroptosis inducer Erastin and a polymer material, and the MOF is formed by coordination of iron ions and tannic acid. The preparation method is as follows: iron ions, the polymer material and Erastin are mixed to form an organic phase solution, the solution is slowly dropped into a tannic acid aqueous phase solution, and the nano preparation is obtained through ultrasonic and stirring. The nano preparation constructed in the application can regulate the re-polarization of tumor-associated macrophages, thereby reducing the activation and collagen deposition of tumor-associated fibroblasts to regulate the dense tumor stroma, achieving deep penetration of the nano preparation, after reaching the deep part of the tumor, the iron ions and Erastin synergistically act to destroy the redox balance of tumor cells, improve the ferroptosis effect of tumor cells, and realize ferroptosis treatment of pancreatic cancer cells.

A method for preparing biomimetic nanocomposite materials based on thylakoid membranes is disclosed, belonging to the field of bionanomaterials technology. This invention addresses the problems of existing nano-manganese oxide, which is easily cleared by the immune system, has difficulty penetrating complex tumor matrixes, and suffers from complex synthesis methods and high costs; it also addresses the issues of insufficient rigidity, instability, inability to accurately reach tumor sites, and limited functionality in existing single-membrane structures. The method comprises: 1. Dispersing a thylakoid membrane in pure water, then heating and adding hydrochloric acid solution to obtain a Mg-removed Nks system; 2. Adding an aqueous manganese chloride solution to the Mg-removed Nks system, then adjusting the pH and continuing stirring. This invention is used for the preparation of biomimetic nanocomposite materials based on thylakoid membranes.