528results about How to "Improve anti-cancer effect" patented technology

The invention relates to anti-integrin antibodies which are covalently linked to nanoparticles, wherein these nanoparticles were prior loaded with chemotherapeutic / cytotoxic agents. The antibody-chemotherapeutic agent-nanoparticle conjugates according to the invention, especially wherein the antibody is MAb DI17E6 and the cytotoxic agent is doxorubicin show a significant increase of tumor cell toxicity.

The invention provides a health-care soybean milk powder for men, which relates to a health-care drinking product. The health-care soybean milk powder for men is characterized by comprising the following components, by weight percent: 50-90% of soybean milk powder or black bean milk powder or pease milk powder or mung bean milk powder, 1-10% of licorice powder, 1-30% of broccoli powder, 1-30% of tomato powder, 1-10% of gynostemma pentaphylla powder, 1-30% of Chinese chestnut powder and 1-30% of oryzanol. The health-care soybean milk powder for men has the main aim of enhancing the physical health of men, is added with the licorice powder, the broccoli powder, the tomato powder, the gynostemma pentaphylla powder, the Chinese chestnut powder and the oryzanol which are processed, and has better effects of strengthening the body, protecting the kidney and resisting cancers.

The invention relates to a composition for enhancing immunity and a preparation method of the composition for enhancing the immunity. The composition comprises the following raw materials: cordyceps sinensis powder, marine fish oligopeptide, corn oligopeptides, wheat oligopeptides, American ginseng extract, ganoderma extract, medlar extract and ganoderma spore powder. According to the preparation method, the cordyceps sinensis powder and three short peptide materials with biological activity are combined, and are supplemented with the plant extract capable of improving the immunity, therefore, the effect of enhancing the immunity can be achieved.

The invention relates to a method for producing green tea soycheese, which is characterized in that 5-15% parts by weight of the green tea, 85-95% parts by weight of the water and sopped bean are gridded to be green tea pulp and soya-bean milk; the green tea pulp and the soya-bean milk are filtered through 100 screen mesh filter screen; the filtered pulp liquid is heated up to be 85-95 DEG C; the pulp liquid is beat to be grain with salt water; the pulp grain is pressed to be plates by sanitized cotton cloth; the shaped plates are rough green tea soycheese; the rough green tea soycheese is cut to be small square blocks; the small square blocks are put into a cleaned and sanitized cage in sequence; the surfaces of the small square blocks of the rough green tea soycheese are sterilized by means of jetting; the small square blocks are put into a temperature control room with temperature being 30 DEG C to be fermented till that the surfaces of the rough green tea soycheese have cotton-shaped white mucor; the surface of the rough green tea soycheese is coated with a layer of slat; the rough green tea soycheese is put into a container with normal temperature for 12-24 hours; the rough green tea soycheese is extracted from the container to be filled into a bottle; alcohol with alcoholic strength being 16-18% is poured into the bottle; and the bottle is sealed for 10-30 days to prepare the green tea soycheese. The method improves the additional value of the green tea, increases the tea polyphenol, the coffeic alkali and the amino acid of the green tea and the red tea, and improves human body immunity as well as anticancer effect.

The invention discloses an oxaliplatin liposome glucose preparation and the preparation method and application, relating to an oxaliplatin liposome glucose solution preparation used for tumor resistance and the preparation method and application. An oxaliplatin liposome glucose preparation is formed by liposome which prepared by oxaliplatin, hydrogenated phosphorus, cholesterol and DSPE-PEG2000, and is dissolved in glucose solution; wherein the weight ratio of the hydrogenated phosophorus and the oxaliplatin is 1:1-50; the weight ratio of the hydrogenated phosophorus, cholesterol and the DSPE-PEG2000. The preparation method is that the hydrogenated phosophorus, cholesterol and the DSPE-PEG2000 are weighed according to proportioning by weight in a description and then fixed together; tertiary butyl alcohol is added into the fixture for the fixture to be stirred and dissolved, then the fixture is precooled; the oxaliplatin saturated water solution with 4-10 percent of glucose after cooling and drying is stirred, dissolved and emulsified by an emulsion balancing machine and then prepared into liposome solution by a homogenizer and a nanometer extruder, separated and refined through a filter column to prepare the oxaliplatin liposome glucose solution.

This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.

The invention provides a preparation method of porphyrin photosensitizer and anticarcinogen diad, relates to a preparation method of the diad and solves the technical problems that the porphyrin photosensitizers cannot kill all cancer cells under the light irradiation, the targeting of the anticarcinogen is insufficient, and toxic or side effects are generated. The method comprises the following steps of: 1, preparing midbodies; and 2, preparing the porphyrin photosensitizer and anticarcinogen diad. Because porphyrin and the metal complex compounds thereof have special affinity on the cancer cells, the photosensitizers of 4-hydroxyphenyl porphyrin and anticarcinogen are prepared into the diad, the affinity of the porphyrin on the cancer cells is utilized, so the targeting of the anticarcinogen can be improved, the anti-cancer capability is improved, and in addition, the toxic or side effect is reduced. The anti-cancer effect of the anticarcinogen overcomes the defect of insufficient anti-cancer capability of the porphyrin photosensitizer. Under the conditions of light illumination and dark light, two different anti-cancer mechanisms realize the cooperative effect, the advantage complementation of the anti-cancer effects of the two compounds is realized, the toxic or side effects are reduced under the use condition of the same quantity, and the anti-cancer capability is improved.

Disclosed is an anticancer pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof, and a glycolysis inhibitor, particularly, 2-deoxy-D-glucose as active ingredients. These ingredients act in synergy with each other, thus exhibiting more potent inhibitory activity against the growth of cancer cells, compared to individual ingredients. Also, the synergistic anticancer activity allows the individual drugs to be used in lower amounts, which leads to a reduction in the occurrence of adverse effects. In addition, the time-lag release or administration of the ingredients decreases blood lactic acid levels to significantly mitigate the adverse effect of lactic acidosis, as well as exerting high anticancer effects. Particularly, the pharmaceutical composition can be formulated to dosage forms effective for therapy, increasing the drug compliance of the subject.

The invention discloses anti-cancer selenium-enriched soy sauce. In the anti-cancer selenium-enriched soy sauce, the amino acid nitrogen content is 0.70 to 0.75 g / 100ml; and the organic selenium content is 50 to 100 ug / kg. The anti-cancer selenium-enriched soy sauce is prepared by the following steps of inoculating aspergillus oryzae into raw materials comprising soybean and wheat to prepare yeast; adding saline into the yeast; fermenting; pouring oil in the completely fermented sauce paste; adding traditional Chinese medicine soup cooked by the organic selenium and a traditional Chinese composition to anti-cancer selenium-enriched soy sauce; or adding traditional Chinese medicine soup cooked by the traditional Chinese composition into the completely fermented sauce paste, inoculating salt-tolerance lactic acid bacteria and salt-tolerance saccharomycetes, performing secondary fermentation, pouring oil after the fermentation is finished, and adding the organic selenium to prepare the anti-cancer selenium-enriched soy sauce. The organic selenium and the traditional Chinese composition can enhance the anti-cancer effect; and the traditional composition has the effects of tonifying spleen, soothing the nerves, replenishing blood and tonifying qi.

The invention discloses a coordination compound comprising (1,2-diaminocyclohexane)platinum (II) moiety and poly(ethylene glycol)-block-poly(glutamic acid) copolymer moiety; and its use as an anti-cancer agent. The characteristic feature lies in the use of a copolymer whose poly(glutamic acid) segment has a chain length consisting of, on an average, less than 35 repeating units.

The invention relates to a purple sweet potato beverage which is prepared from the following raw materials in parts by weight: 10-70 parts of fresh purple sweet potato, 10-80 parts of water, 0.5-1.5 parts of stabilizer and 0-5 parts of sweetener. The beverage is prepared by the following method: pre-boiling the fresh purple sweet potato and fishing out; mixing the pre-boiled purple sweet potato with water and slurrying with a colloid mill; adding high temperature resistant alpha-amylase into the obtained slurry for enzymolysis; filtering the slurry after enzyme deactivation to obtain filtrate; adding the stabilizer, sweetener and the balance of water into the filtrate; and mixing uniformly, then homogenizing, degassing, filling and sterilizing to obtain the finished product. The obtained purple sweet potato beverage is purplish red turbid liquid without precipitation, has a thick purple sweet potato taste and pure mouthfeel, and maintains the original nutrient components of purple sweet potato to the greatest degree; and after long-time drinking, the purple sweet potato beverage can supplement various mineral elements necessary to human body, eliminate body fatigue and improve immunity, and has a relatively good caner resisting and preventing effect, thereby being an excellent anti-aging healthcare beverage.

The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and / or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.

The invention provides a novel Irinotecan carrier which is circulating nano liposome and a novel preparation method thereof which is an ethanol injection-ammonium sulfate active medicament-loading method. The preparation process comprises: a, dissolving a lipid material for forming the liposome in ethanol to prepare solution; b, dissolving a polyethylene glycol compound in solution of ammonium sulfate to prepare a hydration medium; c, injecting solution obtained by the step a into the hydration medium obtained by the step b with stirring in a water bath, stirring at a constant temperature for a certain period under a condition of introducing N2 to form circulating blank liposome; d, dialyzing the blank liposome obtained by the step c in physiological saline; and e, adding solution of Irinotecan into the blank liposome, regulating the pH value of an external phase, and performing incubation and medicament loading at a certain temperature to obtain the Irinotecan circulating nano liposome. The process is simple, the particle size is 80 to 150 nanometers, the coating rate is over 95 percent, the sterile preparation can be obtained easily, and an industrialization requirement is met.

The invention discloses a sweet potato-based functional cake and a preparation method thereof. Most of sweet potatoes are utilized for extracting a sweet potato protein fluid and preparing a dietary fiber in the preparation process, so that the content of sweet potato protein and the dietary fiber in the obtained cake is increased; the cake prepared by the method has the efficacies of preventing and treating constipation, is rich in sweet potato protein and dietary fiber, can play a role in preventing bowel cancer and hyperlipidemia without being greatly taken, and does not cause discomfort symptoms such as abdominal distension and heartburn; meanwhile, liver function damage can be effectively prevented; the abdominal pain symptoms caused by constipation are relieved; and the sweet potato-based functional cake is abundant and balanced in nutrient, easy to digest and absorb, free of a toxic or side effect, and suitable for being taken for a long period of time.

The invention relates to a tumor treatment method and particularly provides joint use of immunologic effector cells and radiation in tumor treatment, and a method of treating an individual with tumorsby joint use of immunologic effector cells and local radiation. The method provides no lymphocyte removal for the individual; the immunologic effector cells comprise a receptor to recognize tumor antigens to tumors. Tests prove that the method provided herein has significant antitumor effect for solid tumors; at the premise of pretreatment without removing lymphocytes, the joint treatment of CAR-T cell therapy and local radiotherapy with no lymphocyte removal helps attain better treatment effect than CAR-T treatment with lymphocyte removal; antitumor treatment effect is improved greatly.

The present invention relates to pharmaceutical combinations comprising dual Angiopoietin-2 / Dll4 binders and anti-VEGF agents for use in treating diseases like cancer and ocular diseases.

The present invention relates to food processing method and producing process of mulberry fruit vinegar. The mulberry fruit vinegar is produced with fresh mulberry and through the steps of sorting mulberry, cleaning, scalding in hot water, crushing, alcohol fermentation via adding alcohol yeast liquid in temperature controlling fermentation tank, continuous deep acetic fermentation via adding acetic acid yeast, blending, ageing in sealed acetification tank at 19 deg.c for 6 months, non-heating sterilizing with 100-800 W RE ultrasonic transducer, and packing. The present invention adopts low temperature fermentation and mycose protection to maintain the antioxidant matter, amino acids and other nutritious components. The mulberry fruit vinegar has the health functions of promoting blood circulation, softening blood vessel, improving gastrointestinal function, moistening skin, etc.

The invention provides a compound having anticancer activity, which is obtained by cooperation of Norabieta cantharidin and platinum (IV) and modification of a piperazine derivative. The compound is characterized in that a Norabieta cantharidin piperazine derivative ligand is introduced, thereby cytotoxicity of a platinum (IV) compound is reduced, and high antineoplastic activity is provided. The result of the cytotoxicity experiments shows that the provided platinum (IV) compound has less destruction to normal mice fibroblast L929, but has good killing effect to cancer cells such as human breast cancer MCF-7 cell, human cervical carcinoma HeLa cell and human lung adenocarcinoma A549 cell, so that the compound having anticancer activity is capable of reducing the system toxicity and having equal anticancer activity with cisplatin. The compound having anticancer activity has good killing effect by aiming at cisplatin resistance human lung adenocarcinoma A549 / DDP cell. Therefore, the toxicity is reduced, the cisplatin resistance can be reversed, and anticancer effect of the platinum medicines can be increased.

The invention discloses an anticancer nano medicament loading an arsenical and a preparation method thereof, and relates to a nano medicament. The anticancer nano medicament loading the arsenical comprises an arsenite complex and a carrier, wherein the arsenite complex is loaded on the carrier and formed by As ions and most transition metal ions; the most transition metal ions comprise one of Mn, Fe, Ni, Zn, Pt, Co, Pb and the like; and the carrier is a silicon dioxide nano material with a pore structure. Hollow silicon dioxide nano spheres are synthesized first, then mesoporous silicon dioxide nano spheres are synthesized, and finally, the anticancer nano medicament loading the arsenical is prepared. The process steps are simple, the operation is convenient, the yield is relatively high, and amplified preparation is facilitated; and the anticancer nano medicament loading the arsenical has a strong anticancer effect, and can effectively control the growth and migration of tumors on the premise that cancer cells are effectively killed so as to effectively treat the cancer.

The invention relates to a preparation method for alpha-TOS-loaded and dendrimer-wrapped gold nanoparticles. The method comprises the following steps: (1) adding EDC and an NH2-PEG-COOH solution into an alpha-TOS solution and reacting to obtain TOS-PEG-COOH; (2) adding the EDC and the NH2-PEG-COOH solution into folic acid and reacting to obtain FA-PEG-COOH; (3) adding a poly amidoamine dendrimer solution into an FI solution and reacting to obtain G5.NH2-FI; (4) adding the TOS-PEG-COOH and FA-PEG-COOH solution into the EDC for activation, adding into the G5.NH2-F1 water solution, and reacting to obtain a dendrimer solution; and (5) adding chloroauric acid, NaBH4, N(C2H5)3 and acetic anhydride into the above solution, and reacting to obtain the gold nanoparticles. The method is simple in preparation process, and is easy to implement.

The invention relates to complex paclitaxel and its derivates docetaxel intralipid which includes the following ingredients: paclitaxel or docetaxel, vegetable oil, solubilizing agent, lecithin, glycerine, and water for injection at a ratio of 0.5-10:10-100:10-100:10-20:20-25:700-950. The preparing method includes the following steps: stirring with high speed homogenating machine or ultrasonic oscillating to get the protogala; preparing the complex paclitaxel intralipid with high pressure homogenizer. The preparation is intralipid in O / W type which packages paclitaxel or docetaxel into the compound oil phase. The compound oil phase has good solubility for paclitaxel or docetaxel which has prevented the phenomenon of precipitation after diluting the emulsion; the ingredients of compound oil has the function of coordinated antitumous effect; it can also release the injecting irritative response, haemolysis and hypersensitiveness; it has the function of targeting which has increased the drug action.

The invention discloses a method for preparing curcumin polymer, which comprises the following steps: dissolving curcumin and a monomer into organic solvent to carry out condensation polymerization under the action of a catalyst at 0-100 DEG C for 1 hour to 48 hours and carrying out purification processing to obtain a curcumin polymer, wherein the monomer is one or more of diacid monomer, anhydride monomer, dichloride monomer, diene monomer and diol monomer. The method is simple and has convenient operation, and the prepared and obtained curcumin polymer has favorable thermal stability, storage stability and controllable molecular weight and degradation rate; compared with curcumin, the curcumin polymer not only obviously improves the stability and the biological utilization ratio of the curcumin, but also obviously improves the cytotoxicity and the cancer resistance of the curcumin on cancer cells.

The invention discloses an adriamycin nano drug delivery system as well as a preparation method and application thereof. The drug delivery system comprises the following components in percentage by weight: 0.02%-1.5% of active ingredient containing adriamycin, 1%-20% of solid lipid, 0.1%-20% of liquid lipid, 0.5%-20% of emulsifier and 0.1%-5% of isoosmotic adjusting agent, wherein the solid lipid and the liquid lipid form nanoparticles to cover the active ingredient containing the adriamycin. The preparation method comprises the following steps: (1), uniformly dispersing the active ingredient containing the adriamycin, the solid lipid, the liquid lipid and fat-soluble emulsifier in an organic solvent, evaporating the organic solvent to obtain an oil phase; (2), uniformly dispersing other emulsifiers and the isoosmotic adjusting agent in water to obtain a water phase; (3), adding the water phase into the oil phase for emulsifying drop by drop; (4), homogenizing under high pressure; (5), cooling and degerming. The adriamycin nano drug delivery system disclosed by the invention can be used for realizing co-transporting of the adriamycin and a chemosensitizer, so that the killability of the adriamycin on liver cancer cells is strengthened.

An emulsified injection for treating cancers is prepared from brucea fruit oil, medical emulsifier, isotonic agent and water through respectively dissolving oil phase and water phase, emulsifying and homogenizing.

The invention relates to a TPGS modified docetaxel liposome nano-drug delivery system, a preparation method and an application thereof. The TPGS modified docetaxel liposome nano-drug delivery system uses phospholipid and cholesterol as membrane materials, Surfactant TPGS modified liposomes and docetaxel (DTX) as anticancer drug were prepared by membrane dispersion ethanol injection ultrasonic dispersion reverse evaporation and freeze drying. The particle size of nano-doxetaxel liposomes modified by TPGS is 80-200 nm, the zeta potential is 0+30 mV or 0-30 mV, the encapsulation efficiency is 75-99%, with a drug loading of 3-15%. The in vitro cell experiment and in vivo pharmacodynamic experiment of the TPGS modified docetaxel liposome nano-drug delivery system prepared by the invention showthat the nano-drug delivery system can inhibit P. Overexpression of gp, decrease of drug efflux, increase of drug enrichment in tumor cells, increase of cytotoxicity and apoptosis rate, increase of tumor therapeutic effect and reversal of multidrug resistance.

The invention discloses a nanometer preparation system method based on a supercritical carbon dioxide technology. The nanometer preparation system method comprises: dissolving curcumin into a polymer-containing organic solvent according to a certain ratio to prepare a mixed solution having a certain concentration; pumping liquefied CO2 into a high pressure crystallization kettle, adjusting the temperature and the pressure to preset values, and pumping the mixed solution at a certain flow rate through a HPLC pump; after completely pumping the mixed solution, continuously introducing CO2, maintaining the stable temperature and the stable pressure until the organic solvent is completely taken away by CO2, stopping the pumping of CO2, decreasing the pressure to a normal pressure to obtain a dried sample, and storing in a 4 DEG C refrigerator so as to be used for the subsequent anti-cancer effect detection. According to the present invention, the product has the nanometer structure, the regulation is easily achieved by changing the parameters, a variety of the curcumin nanometer systems can be prepared, and comprise nanoparticles and nano-fiber matrixes, the anticancer effect of curcumin can be substantially improved, the organic reagent residue is low, the treatment conditions are mild and controllable, the operation is simple, the continuous operation can be achieved, and the yield is high.

The invention discloses a preparation method of coix lacryma-jobi and black tea wine. The coix lacryma-jobi and black tea wine comprises the following components in percentage by weight: 50 to 53% of high-quality sticky rice, 30 to 36% of coix lacryma-jobi, 4% of red yeast rice, 5% of bee honey, and 5 to 8% of black tea. The preparation method comprises the following steps of: preprocessing the black tea, the sticky rice and the coix lacryma-jobi; mixing; stewing; fermenting; managing the temperature in a fermenting room; precipitating; and filling to obtain the coix lacryma-jobi black tea wine. According to the preparation method, the beneficial substances in the black tea are effectively and scientifically blended in the coix lacryma-jobi, the sticky rice and other raw materials; the bee honey is adopted to reduce the amount of added red yeast rice, so that the prepared tea wine has the alcohol content 2 to 3 degrees less than that of the tea wine prepared from the raw materials without bee honey and tastes more delicately; and the tea wine integrates the functions of invigorating stomach, activating blood, clearing damp, beautifying and the like of the black tea and the bee honey, gains the special health preservation effects of eliminating dampness and heat, eliminating wind-damp, inducing urination, benefiting lung and expelling pus, strengthening spleen and stomach and strengthening bones and muscles of the coix lacryma-jobi and also has the capability of strengthening the organic immunity and cancer-fighting ability after long-term drinking.

The invention discloses a method capable of promoting migration of dendritic cells to lymph nodes and achieving multi-mode imaging simultaneously. The method is implemented by mDCs (mature dendritic cells) carrying magnetic fluorescent nanoparticles in an externally applied magnetic field. The magnetic fluorescent nanoparticles are formed by organically combining oleate-magnetic iron oxide particles, two phospholipids, near-infrared probes and an antigen fusion peptide with lipid binding capability through self-assembly. The method has the advantages that efficiency of DC living migration to a lymphoid tissue can be improved effectively, tumor prevention and treatment effects after DCs absorb antigen peptides are promoted, and multi-mode living imaging detection can be performed.

The anti-cancer combined preparation containing sulforaphane and platinum drugs is used for the treatment of cancer, especially lung cancer, and the components can be administered simultaneously, separately or sequentially. Among them, sulforaphane increases the anticancer effect of platinum anticancer drugs.

The invention provides medicated tea for conditioning and treating diabetes, and a preparation method thereof. The medicated tea comprises the following drug substances in parts by weight according to the formula: 1-5 parts of fructus momordicae, 7-12 parts of herba gynostemmatis pentaphylli, 3-12 parts of hawthorn fruit, 3-8 parts of radix ophiopogonis, 2-6 parts of lotus leaves, 1-6 parts of ganoderma lucidum, 3-8 parts of fragrant solomonseal rhizome, 2-6 parts of fructus momordicae flower, 2-6 parts of barbary wolfberry fruit, 1-4 parts of liquorice, 1-5 parts of capillary wormwood herb and 2-6 parts of membranous milkvetch roots. The medicated tea can maintain weight aiming at the situation that weight gradually declines, improves metabolic parameters, reduces hyperglycemia on an empty stomach and after dinner, prevents or reduces complications of diabetes, and reduces hypertriglyceridemia on an empty stomach and after dinner.