The invention discloses a nanometer preparation system method based on a supercritical carbon dioxide technology. The nanometer preparation system method comprises: dissolving curcumin into a polymer-containing organic solvent according to a certain ratio to prepare a mixed solution having a certain concentration; pumping liquefied CO2 into a high pressure crystallization kettle, adjusting the temperature and the pressure to preset values, and pumping the mixed solution at a certain flow rate through a HPLC pump; after completely pumping the mixed solution, continuously introducing CO2, maintaining the stable temperature and the stable pressure until the organic solvent is completely taken away by CO2, stopping the pumping of CO2, decreasing the pressure to a normal pressure to obtain a dried sample, and storing in a 4 DEG C refrigerator so as to be used for the subsequent anti-cancer effect detection. According to the present invention, the product has the nanometer structure, the regulation is easily achieved by changing the parameters, a variety of the curcumin nanometer systems can be prepared, and comprise nanoparticles and nano-fiber matrixes, the anticancer effect of curcumin can be substantially improved, the organic reagent residue is low, the treatment conditions are mild and controllable, the operation is simple, the continuous operation can be achieved, and the yield is high.