The invention relates to the technical fields of
medicine, food and health products, and discloses a highly efficient preparation method of antitumor
drug sodium cantharidinate. Add
cantharidin essence into
sodium hydroxide aqueous solution, heat to dissolve, add
activated carbon to
reflux for decolorization for 0.5-1 hour, heat filter, wash with water, concentrate under reduced pressure, add
ethanol, cool to
room temperature, precipitate
solid and dry to obtain
white powder. Wherein the equivalent ratio of
cantharidin fines and
sodium hydroxide is 1:2-3, and the weight ratio of
cantharidin and
ethanol is 1:3-10. The synthesis of sodium cantharidinate and the decolorization and refining of
activated carbon are completed simultaneously, and the
crystallization is carried out with
ethanol-water
system. The invention provides a synchronous method for synthesizing sodium cantharidate and decolorizing and refining
activated carbon, the preparation process is simpler, the reaction cycle is shortened, the application of a large amount of
acetone and isopropanol is omitted in the reaction process, the production cost is reduced, and The
pollution to the environment is small, the
quality control is simpler, the production efficiency is improved, and the industrial production is convenient.