11 results about "Cantharidin" patented technology

The invention belongs to the field of agricultural bactericides, and particularly relates to a colza sclerotinia rot sterilization composition containing green biocontrol bacteria and application of the colza sclerotinia rot sterilization composition. The colza sclerotinia rot sterilization composition comprises a bacillus amyloliquefaciens WHIG fungicide and cantharidin; the mass ratio of the bacillus amyloliquefaciens WHIG microbial inoculum to the cantharidin is (20: 1)-(1: 20). A biological control strategy is adopted, the application amount of chemical agents can be reduced, the stability of biological control is improved, the effect of effectively controlling diseases can be achieved, and the composition shows a remarkable synergistic effect.

The invention discloses a cantharidin in-situ release pharmaceutical composition and a preparation method thereof. The pharmaceutical composition contains 0.1-2% of an active component, 0.5-3% of a gel matrix, 0.1-3% of a stabilizer, 0.1-1% of a bacteriostatic agent and a solvent, the active component comprises cantharidin or a derivative thereof. The in-situ gel preparation provided by the invention can be an injection preparation and also can be applied externally. The injection preparation is liquid at normal temperature, when the injection preparation is injected subcutaneously, due to temperature rise, the liquid injection preparation is converted into a gel state, the release time of the medicine in local warts is prolonged, and the treatment effect is enhanced. During external administration, the medicine is coated on a molluscum contagiosum body, and the medicine can be quickly converted into gel under the action of temperature, so that the medicine is convenient to smear and can be effectively prevented from overflowing, and the damage of the medicine to surrounding skin is reduced.

The invention provides an Mcic000159 gene of a CYP450 family gene participating in cantharidin biosynthesis, the nucleotide sequence of the Mcic000159 gene is as shown in SEQ ID NO. 1, and the coded amino acid sequence is as shown in SEQ ID NO. 2. When the expression of the Mcic000159 gene of the CYP450 family gene in the Eye spot Brassica rapa larva is interfered, the content of juvenile hormone III in the Eye spot Brassica rapa larva is not influenced, the content of cantharidin is reduced, and the relative expression quantity of the upstream genes McicHMGR, McicFPPS and McicJHEH for synthesizing the cantharidin is up-regulated. The Mcic000159 gene of the CYP450 family gene acts between the downstream metabolite of the juvenile hormone III and the cantharidin, so that the blank of the stage from the juvenile hormone III to the cantharidin in the synthetic route of the cantharidin is filled.

The invention discloses a multifunctional feed additive for improving yolk chromaticity and whole egg quality, and belongs to the technical field of feed additives. The additive is prepared by mixing the following dry substances in parts by weight: 300-500 parts of pine needle meal, 100-150 parts of hermetia illucens powder, 2-8 parts of cantharides yellow, 0.5-5 parts of protoporphyrin and 0.3-1 part of vitamin E. The feed additive disclosed by the invention is added into daily ration of laying hens at the dosage of 1-5%, so that the chromaticity of egg yolk can reach 11-12 grades, the egg yolk is still effective after 10 days after the addition is stopped, the feed additive is obviously superior to an existing single or binary compound colorant, and meanwhile, the egg shell strength is improved, the Hough unit is increased, and the problem of quality decline of eggs laid by the laying hens in the later period of egg laying is solved. The technical problems that an existing egg yolk coloring agent is single in function, short in coloring effect lasting time and incomplete in egg quality improvement are solved, and the egg yolk coloring agent has safety, economical efficiency and practicability.

The application provides a CYP450 family gene Mcic000159 gene involved in cantharidin biosynthesis, the nucleotide sequence of the Mcic000159 gene is shown as SEQ ID NO. 1, and the coded amino acid sequence is shown as SEQ ID NO. 2. When the expression of the CYP450 family gene Mcic000159 gene in the application is interfered in the body of the L. decemnotata larva, the content of juvenile hormone III in the body of the L. decemnotata larva has no influence, the content of cantharidin is reduced, and the relative expression amount of the upstream genes McicHMGR, McicFPPS and McicJHEH of cantharidin synthesis is up-regulated. The CYP450 family gene Mcic000159 gene in the application acts on the metabolic product downstream of juvenile hormone III to cantharidin, and fills the blank of the stage from juvenile hormone III to cantharidin in the cantharidin synthesis route.

This invention discloses a pH-sensitive norcantharidin solid self-microemulsion, its preparation method, and its applications, belonging to the field of pharmaceutical technology. It comprises the following components in parts by weight: 0.1–3 parts norcantharidin, 1–10 parts pH-sensitive polymer, 30–80 parts solid adsorbent, and 87–98.9 parts blank self-microemulsion. The pH-sensitive norcantharidin solid self-microemulsion of this invention can improve the solubility and permeability of the drug. Due to the amide bond cleavage of the pH-sensitive polymer under acidic conditions, the drug is released systematically from the interior of the nano-solid self-microemulsion, resulting in targeted release at the tumor site. Animal experiments show that the pH-sensitive norcantharidin solid self-microemulsion of this invention can effectively improve the absorption rate constant and apparent permeability coefficient of norcantharidin at the colon tumor site, thereby enhancing its ability to inhibit tumor growth, migration, and invasion, and thus significantly improving the therapeutic effect of colon tumors.

The invention discloses a preparation method of a traditional Chinese medicine external liniment for treating viral warts, and relates to the technical field of traditional Chinese medicine external preparations, and the preparation method sequentially comprises the following steps: raw material pretreatment: respectively taking seven medicinal materials including horsetail, prepared cantharides, cyperus rotundus, prepared arisaema consanguineum schott, raw rhubarb, angelica dahurica and wild agastache rugosus, washing, and drying at 50-65 DEG C until the moisture content is less than or equal to 10% to obtain dried medicinal materials; the formula aims at the pathogenesis of heat toxin accumulation and qi and blood stasis of virus warts, the compatibility of monarch, minister, assistant and guide is rigorous, the core medicines such as the processed cantharides and the raw rhubarb have the effects of directly corroding warts and inhibiting viruses, and the alkalization auxiliary materials are combined, so that the medicine can more effectively act on wart tissues with abnormal hyperplasia, and the effect of treating the warts is achieved. The process route of low-temperature drying, co-crushing, alkalization and long-time cold soaking is adopted, the damage of high-temperature decoction to effective components (especially cantharidin and the like) is avoided, the efficient and sufficient extraction of the active components is realized through long-time soaking and alkalization environment, and the stability of the efficacy of the preparation is ensured.

The application belongs to the technical field of medicine, and particularly relates to a medicine for treating tumors, a liposome, a preparation method and use; comprising cantharidin and staurosporine, and the weight ratio of the cantharidin and the staurosporine is 350-2500:1; the application effectively improves the effect of treating tumors.

Provided herein are devices, systems, kits and methods for treating skin conditions, ailments or diseases, such as skin warts. In some examples, a device for treating warts comprises a reservoir that includes a cantharidin formulation, and an applicator device in fluid communication with the reservoir that delivers the cantharidin formulation to a subject.

The invention belongs to the field of agricultural fungicides, and particularly relates to a composition for preventing and treating rice sheath blight disease and application of the composition, active ingredients comprise cantharidin and validamycin, and the mass ratio of the cantharidin to the validamycin is 1: 1-1: 20. The composition has a remarkable synergistic effect on rice sheath blight disease, the application amount of chemical agents can be reduced, and the effect of effectively controlling diseases can be achieved.

Abstract Methods of treating skin lesions using cantharidin as well as associated compositions treatment regimens, kits, devices and systems are provided. Abstract