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Process for preparing sodium cantharidinate

A technology of sodium cantharidinate and cantharidin, applied in the direction of organic chemistry, etc., to achieve the effect of high purity and stable properties

Active Publication Date: 2010-01-27
江苏睿玻生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This application has also adopted a large amount of acetone in steps such as extraction, degreasing, therefore there is the same shortcoming as CN1166669C

Method used

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  • Process for preparing sodium cantharidinate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) The treatment of the cantharidin body.

[0024] Pick the dried cantharidin bodies that meet the standards of the National Pharmacopoeia, remove debris such as soil clods, and pulverize them so that the fineness of the cantharidin body powder is 20 mesh to 40 mesh.

[0025] (2) Extraction of cantharidin.

[0026] Put 100 kg of cantharidin body powder into a stainless steel extraction tank of 700 kg to 2000 liters of ethyl acetate saturated with hydrochloric acid in advance, soak for 16 hours, and stir once every half hour for the first 10 hours. Drain the leachate into storage tanks. Repeat the above operations, and then add 700 kg of ethyl acetate saturated with hydrochloric acid in advance to soak and extract once. Release the leaching liquid and combine it into the recoverer, heat it with steam to 50°C to concentrate, stop heating, and the recovered solvent will be used for the next extraction. After the leachate is drained, the insect residues are taken out an...

Embodiment 2

[0034] (1) The treatment of the cantharidin body.

[0035] Pick the dried cantharidin bodies that meet the national pharmacopoeia standards, remove soil clods and other sundries, and crush them so that the fineness of the cantharidin body powder is 20 mesh to 30 mesh.

[0036] (2) Extraction of cantharidin.

[0037] Put 100 kg of cantharidin body powder into a stainless steel extraction tank of 800 kg to 2000 liters of ethyl acetate saturated with hydrochloric acid in advance, soak for 16 hours, and stir once every half hour for the first 10 hours. Drain the leachate into storage tanks. Repeat the above operations, and then add 700 kg of ethyl acetate saturated with hydrochloric acid in advance to soak and extract once. Release the leaching liquid and combine it into the recoverer, heat it with steam to 50°C to concentrate, stop heating, and the recovered solvent will be used for the next extraction. After the leachate is drained, the insect residues are taken out and colle...

Embodiment 3

[0045] (1) The treatment of the cantharidin body.

[0046] Pick the dried cantharidin bodies that meet the standards of the national pharmacopoeia, remove soil clods and other sundries, and crush them so that the fineness of the cantharidin body powder is 30 mesh to 40 mesh.

[0047] (2) Extraction of cantharidin.

[0048] The formula ratio is:

[0049] Put 100 kg of cantharidin body powder into a stainless steel extraction tank of 900 kg to 2000 liters of ethyl acetate saturated with hydrochloric acid in advance, soak for 16 hours, and stir once every half hour for the first 10 hours. Drain the leachate into storage tanks. Repeat the above operations, and then add 700 kg of ethyl acetate saturated with hydrochloric acid in advance to soak and extract once. Release the leaching liquid and combine it into the recoverer, heat it with steam to 50°C to concentrate, stop heating, and the recovered solvent will be used for the next extraction. After the leachate is drained, the ...

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Abstract

The invention discloses a process for preparing sodium cantharidinate, which comprises the following steps: treating cantharis; extracting cantharidin; purifying; refining; synthesizing the sodium cantharidinate; purifying and refining the sodium cantharidinate, and the like. The invention has the advantages of simplicity, practicability, good safety, high purity of prepared finished products, stable quality, low production cost, and the like and can be applied to the production of various dosage forms of big injections, big transfusions, tablets, granules, capsules, oral liquid, ointments, and the like.

Description

technical field [0001] The present invention relates to a kind of preparation technology of medicine for treating tumor, in particular to a kind of preparation technology of sodium cantharidate. Background technique [0002] Traditional Chinese medicine in my country began to use mylabris to treat tumors very early: as early as the 13th century, it was recorded in "Renzhai Zhizhi Fang" that mylabris has the effect of treating breast cancer and abdominal cancer. The ancients often used the folk prescription of "boiling eggs with mylabris, discarding mylabris and eating eggs" to treat liver cancer and other digestive system cancers, and it is still used by the people today. This medicine is pungent in nature and hot in taste; it is highly toxic and can attack poison and erode sores, and returns to the liver, stomach and kidney meridians. Possessing the blood to eliminate {symptom}, gong toxin erosion sores, and the function of causing redness and foaming. It is used for the t...

Claims

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Application Information

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IPC IPC(8): C07D493/08
Inventor 郝守祝
Owner 江苏睿玻生物科技有限公司
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