Preparation method of cantharidin-loaded tumor cell membrane-encapsulated tellurium elementary substance nanoparticles

A nanoparticle and cell membrane technology, applied in the direction of anti-tumor drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of inability to meet the needs of drug loading, no specific targeting, and bioavailability Low efficiency and other issues, to achieve high photothermal conversion performance, inhibition of expression, and simple preparation process
CN110623939AActive Publication Date: 2019-12-31DALIAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN UNIV OF TECH
Publication Date
2019-12-31

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Abstract

The present invention provides a preparation method of cantharidin-loaded tumor cell membrane-encapsulated tellurium elementary substance nanoparticles and belongs to the field of nano biomedicine. The nanoparticles prepared from tellurium elementary substance as a core, cantharidin as a model drug and tumor cell membranes as an outer layer coating. The tellurium nano-material and the cantharidinhaving toxic and side effects on organisms are encapsulated by the tumor cell membranes in the nanoparticles, so that biocompatibility of the nanoparticles is improved, immune cells are effectively prevented from being cleared, and the nanoparticles have homologous targeting capability; after intravenous injection, the nanoparticles are massively gathered at tumor sites through an EPR effect and ahomologous targeting property, the tellurium elementary substance is rapidly heated under near-infrared stimulation to cause outer cell membrane rupture, and the leaked cantharidin inhibits a heat shock reaction of tumor cells, enhances a photo-thermal treatment effect of the tellurium elementary substance, and kills tumor cells. The method is reasonable in design, simple in preparation technology and wide in application prospect, and lays a foundation for design and development of a corresponding drug delivery system.
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Description

technical field

[0001] The invention belongs to the field of nano-biomedicine, and relates to a method for preparing cantharidin-loaded tumor cell membrane-encapsulated tellurium single-substance nanoparticles, and in particular to a tellurium nanoparticle that utilizes near-infrared laser and tumor-treating drug cantharidin to achieve combined treatment of tumors. Particles and methods for their preparation. Background technique

[0002] Tellurium nanomaterials (Te) are widely used in many fields, such as gas sensing, optoelectronic devices and photonic crystals, due to their unique optoelectronic properties, including photoconductivity, nonlinear optical response, pyroelectric and piezoelectric properties, etc. But in the biomedical field, tellurium applications are far from being explored. Due to the different preparation methods, tellurium nanomaterials display various forms, such as nanodots, nanorods, nanowires, nanotubes, etc. Tellurium nanomaterials of different sha...

Claims

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