75results about How to "Improve biocompatibility" patented technology

The invention discloses a preparation method of a self-adhering super strong hydrogel, and is characterized in that the preparation method comprises the steps: adding dopamine grafted modified hyaluronic acid into an acrylamide aqueous solution, adding N,N-methylene bisacrylamide and ammonium persulfate, fully stirring evenly, and carrying out sealed vacuumization for 10-15 min; in an ice water bath and under a stirring condition, adding tetramethylethylenediamine, placing at the temperature of 0-4 DEG C, and crosslinking for 12-16 h, to obtain the self-adhering super strong polyacrylamide hydrogel. The prepared self-adhering super strong hydrogel has the following advantages: 1, the adhesion strength is large, is up to 12.3 kPa and is 3-4 times that of a pure polyacrylamide gel; and during use, an auxiliary adhesive or adhesive tape and the like does not need, and the self-adhering super strong hydrogel can adhere onto the surface of any material; and 2, the self-adhering super stronghydrogel has self-healing and self-repairing properties and can be self-healed in 20-30 min.

Nitroxide mediated free radical polymerization of vaporized vinyl monomers, including acrylic acid (AAc), styrene (St), N-2-(hydroxypropyl)methacrylamide (HPMA) and N-isopropyl acrylamide (NIPAAm), on silicon wafers is demonstrated. FTIR, ellipsometry and contact angle goniometry were used to characterize the chemical structures, thickness and hydrophilicity of the films. The growth of film is linearly proportional to its reaction time, leading to the easy and exact control of polymer film thickness from nanometers to submicrons. The capability of polymerizing various monomers allows us to fabricate various functional polymer brushes. The reversible thermo-responsiveness of a 200 nm thick grafted poly(NIPAAm) film in aqueous solution is demonstrated with over 50% change in thickness at its lower critical solution temperature. A tri-block copolymer of poly(AAc)-b-polySt-b-poly(HPMA) is successfully synthesized, proving the renewability of TEMPO-mediated polymerization at vapor phase. Surface polymer composition and morphology is thus controlled at nanoscale by utilizing vapor phase surface-initiated controlled polymerization.

The invention discloses an injectable filling material of particle tissues, wherein particulate acellular bio-derived materials are mixed with drug-containing release microspheres, after the filling material is evenly mixed with a gel solution before use, the filling material is injected into a recipient site, an operator can arbitrarily model the particle tissue before gel is solidified according to the condition of the recipient site so as to achieve a satisfactory cosmetic effect. The particle tissue material which can be moulded rapidly is implanted in the body to fill defective soft tissues and promote wound healing. Compared with the prior art, the injectable filling material of the particle tissues has high biocompatibility, and is capable of rapid arbitrarily modeling and rapid filling the defect of tissue organs, and can promote fibroblast ingrowth, the formation of new capillary, generation of granulation tissue and wound healing. The injectable filling material of the particle tissues has the following clinical functions that the injectable filling material can be used as a filler of defective soft tissues which is used for repairing body depression deformity; for filling wrinkles or ruga of skins; and for demands of cosmetic surgeries, such as soft tissue arthroplasty and so on.

The invention discloses an antimicrobial fabric supported with nano silver core-shell polymer microspheres and a preparation method thereof. According to the preparation method, amphipathic polyethylene glycol-maleic anhydride-octadecylamine (PEG-Ma-OC) is synthesized at first, and the polymerized styrene is emulsified and dispersed by utilizing the hydrophily and lipophilicity of PEG-Ma-OC, so as to obtain core-shell polymer microspheres; and silver is supported on the surface of the core-shell polymer microspheres, thereby achieving the dispersion uniformity of nano silver particles and well solving the agglomeration problem of the nano particles; by utilizing the high surface activity of the antimicrobial fabric on the surface of which the nano silver core-shell polymer microspheres are supported, the nano silver core-shell polymer microspheres are added in the fabric, thereby improving the biocompatibility of the antimicrobial fabric; polystyrene in the inner core is used, so thatthe strength of the fabric is improved, and the washing fastness and weather resistance of the antimicrobial fabric are enhanced; and the preparation process of the antimicrobial fabric is suitable for batch production and is easy to industrialize.

The invention discloses a biodegradable medical magnesium alloy which consists of the following matters in percentage by weight: 1.0-3.0% of Zn, 0.20-1.50% of Y, 0.40-1.50% of Nd, 0.30-0.50% of Zr and the balance of Mg and inevitable impurity elements. Meanwhile, the invention discloses a preparation method of the alloy. The magnesium alloy is smelted to prepare common magnesium alloy. The use level of Zn, Y and Nd in furnace burden is 1.2-1.4 times the content of Zn, Y and Nd in the magnesium alloy, and the use level of Zr is 2-2.5 times the content of Zr in the magnesium alloy. According to the invention, the magnesium alloy overcomes the problems of cytotoxicity, excessively high corrosion rate and the like by adding rare earth elements Y, Nd and Zr into a magnesium-zinc alloy, and the potential difference with a matrix is reduced due to a lot of uniformly dispersed and distributed nano MgZn particle phases in the matrix by extrusion and processing, so that the corrosion resistance of the alloy is greatly improved, and the alloy has better mechanical properties.

The invention relates to a method for preparing cross-linked hyaluronic acid, which comprises the step of ensuring that a cross-linking reaction of solution containing hyaluronic acid is performed for more than about 48 hours at the low temperature of between about 10 and about 30 DEG C. The method can reduce the content of a cross-linking agent without a purification step.

An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.

The invention relates to a biological composite patch for female pelvic floor and a manufacturing method thereof, and according to the patch, a surface of a polypropylene mesh is coated with a bladder acellular matrix of an animal donor. A bladder obtained from an animal donor needs to be treated by decellularization and freeze-drying; after disinfection, the treated bladder is preserved by plastic packaging at a low temperature; then the obtained bladder acellular matrix is coated onto a surface of a polypropylene mesh. The invention effectively combines biomaterials with inorganic materials, and with the integration of the advantages of both materials, obviously excellent using effect is obtained. Thereinto, the external bladder matrix has the effect of insulating the polypropylene mesh from host tissue, and can significantly improve the biocompatibility. After the patch is implanted, fibrous tissue of a patient is induced to grow into the patch, and finally the restoration of the fibrous tissue of the patient itself is realized.

The invention discloses a preparation method of a modified polysaccharide hydrogel and a prepared modified polysaccharide hydrogel, and belongs to the field of gel preparation. The preparation methodcomprises following steps: (1) preparing double bond modified polysaccharide; (2) preparing zwitter-ion thiol polymer (CB-SH); and (3) preparing click-chemistry hydrogel. The provided hydrogel can beformed under physiological conditions, the reaction conditions are simple and mild; through the cooperation between hyaluronic acid and zwitter-ion polymer, the biocompatibility of the hydrogel is improved; and the hydrogel has a high equilibrium water content, an anti-protein property, and a self-healing performance.

The invention relates to a bilirubin adsorbent for blood perfusion. The bilirubin adsorbent is based on a molecular imprinting principle, oligomeric macromolecules and the like which have the molecular weight similar to that of human serum albumin are taken as pore-foaming agents, polystyrene-divinyl benzene is taken as a basic framework, and the bilirubin adsorbent with oversized aperture and high specific surface area is prepared according to a free radical suspension polymerization method. The bilirubin adsorbent not only has ultrahigh specific surface area, but also has a pore passage suitable for the free diffusion of bilirubin conjugated with albumin, and has a good adsorbing effect on the conjugated and non-conjugated bilirubin. Furthermore, compared with the traditional bilirubin adsorbent, the bilirubin adsorbent for blood perfusion has the characteristics of being simple in preparation technology, good in biocompatibility, large in adsorption capacity, and free from risk of electrolyte disorder, thus being not only used for plasma perfusion, but also used for removing the bilirubin by all-blood perfusion.

The invention provides soil activating powder; the components are as follows in parts by weight: 50 to 70 parts of organic fermentation product, 10 to 25 parts of sucrose, 15 to 35 parts of straw green powder, 5 to 10 parts of bacterial cellulose, 3 to 7 parts of Xanthan, 5 to 15 parts of humic acid, 0.05 to 0.2 part of pH buffer, and 0.1 to 0.5 part of soil disinfectant. The soil activating powder can comprehensively improve and control the physical structure, the fertility, the microbial activity, the water characteristics, the cohesion anti-erosion capability and the like of the soil, has the advantages of strong functions, low cost, simple use, applicability to the improvement of various poor degraded soil and the like, and is mainly used for the improvement of various poor soil.

The invention relates to a hyaluronic acid modified surface plasma resonance spectrometer chip and a preparation method thereof. The structure of the hyaluronic acid modified chip is orderly composed of a glass layer, a chromium layer, a gold film layer, a mercapto-alcohol monomolecular layer and a hyaluronic acid layer. The surface of the gold film is modified by use of mercaptoundecanol and then a self-assembly single layer can be formed; next, the self-assembly single layer is epoxidized by use of epoxy chloropropane and then immersed into a hyaluronic acid solution, covalently modified with a layer of hyaluronic acid and further subjected to carboxylation by use of bromoacetic acid, and finally, the hyaluronic acid-based surface plasma resonance spectrometer chip can be obtained. The chip has excellent antifouling property in a single protein, a natural complex sample and 10% blood serum, and has high immobilization capacity and excellent compatibility for biomacromolecular antibodies, and high-specificity sensitive quick detection on target molecules in a complex protein system is realized. The chip has excellent antifouling property, and is low in raw material cost; the preparation method of the chip is easy to operate; the chip has excellent economic feasibility and practicability.

A method of preparing a nano-structured hydroxyapatite [Ca₁₀(PO₄)₆(OH)₂, HA] coating layer with improved biocompatibility is provided. The preparation method includes: (S1) putting hydroxyapatite [Ca₁₀(PO₄)₆(OH)₂, HA] powder in a powder chamber, placing a metal substrate in a deposition chamber, and keeping the chamber in vacuum state by using a vacuum pump; (S2) injecting carrier gas into the powder chamber and mixing with hydroxyapatite powder; (S3) spraying the mixture of the powder and the carrier gas onto the surface of metal substrate in the deposition chamber through a nozzle and depositing hydroxyapatite coating layer on the metal substrate; (S4) hydrothermal-treating the deposited hydroxyapatite coating layer; and (S5) rinsing the hydrothermal-treated hydroxyapatite coating layer and drying the layer. Additionally, a thermal-treated, nano-structured hydroxyapatite [Ca₁₀(PO₄)₆(OH)₂, HA] coating layer with improved biocompatibility fabricated by the above preparation method is provided.

The invention relates to the field of pharmacy and provides a preparation method of targeting and photo-thermal integrated erythrocyte bionic nanoparticles. The method comprises the following steps: firstly, extracting erythrocyte membranes, then loading indocyanine green to a polylactic acid-hydroxyl acetic acid solution, burying adriamycin amycin to the system, and preparing an indocyanine greenpolylactic acid-hydroxyl acetic acid solution buried with adriamycin amycin through a secondary emulsification-solvent evaporation method; then carrying out a reaction on folic chitosan oligosaccharide and the indocyanine green polylactic acid-hydroxyl acetic acid solution to obtain an adriamycin amycin-folic chitosan oligosaccharide-indocyanine green-polylactic acid-hydroxyl acetic acid solution; and finally, extruding the adriamycin amycin-folic chitosan oligosaccharide-indocyanine green-polylactic acid-hydroxyl acetic acid solution into the erythrocyte membranes to obtain the erythrocyte bionic nanoparticles.

The invention discloses a tumor-targeting albumin nano-lyophilized powder injection preparation and a preparation method thereof. The preparation comprises the following components: an insoluble antitumor drug (for example, taxol), albumin, tricaprylin, tributyrin, polyethylene glycol-12-hydroxy stearate and phospholipid. The tumor-targeting albumin nano-lyophilized powder injection preparation provided by the invention can spontaneously form a nanoemulsion with the particle size of about 100nm after being diluted by normal saline, and the drug can target the tumor tissues after intravenous injection, thus improving the effectiveness and safety. In addition, the tumor-targeting albumin nano-lyophilized powder injection preparation provided by the invention is simple in preparation process and suitable for industrialized production.

The invention relates to a polyether-ether-ketone material and a surface modification method thereof. The method comprises the steps of performing plasma immersion ion implantation of the surface of the polyether-ether-ketone material with argon as an ion source, and then, soaking the polyether-ether-ketone material treated by plasma immersion ion implantation in a hydrogen peroxide aqueous solution. The surface of the modified polyether-ether-ketone material has a shallow hole-shaped nanometer structure.

The invention discloses a novel fluorescence lipidosome nano probe. The fluorescence lipidosome nano probe contains water-soluble CdTe quantum dots, dipalmitoyl phosphatidyl choline, cholesterol, polyethylene glycol-distearoyl phosphoethanolamine and folic acid-polyethylene glycol-distearoyl phosphoethanolamine. The fluorescence lipidosome nano probe has the advantages of being good in fluorescence property, target property and stability, and high in biocompatibility.

The invention discloses polysiloxane modified polyamide-amine as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, adding allyl glycidyl ether, end-hydrogen-containing polysiloxane and chloroplatinic acid into a reactor for reflux reaction, thereby obtaining single-ended epoxy polysiloxane; and further adding single-ended epoxy polysiloxane and first generation polyamidoamine into a reactor, and stirring to react and purify, thereby obtaining polysiloxane grafted polyamide-amine (PAMAM-Si) of an arborization-linear structure. The preparation method disclosed by the invention is simple and relatively high in yield. The prepared polysiloxane grafted polyamide-amine contains multi-ended amino and can be solidly bonded with leather and dye; due to the grafted polysiloxane long chain, the leather can be good in waterproof softness; due to the arborization-linear structure, a certain filling effect can be achieved, and a product obtained when the polysiloxane modified polyamide-amine is used in leather retanning procedures can meet multiple functions of leather retanning.

The invention belongs to the technical field of medical contrast agents, and particularly relates to a KMnF3 nuclear magnetic resonance imaging contrast agent, a preparation method and application thereof. The contrast agent has an extremely high relaxivity (23.15mM.S<-1>) and a low r2/r1 ratio (3.23), and primary animal nuclear magnetic resonance imaging experiments by using a colloidal solution which is prepared by the method indicate that the contrast agent can be used in contrast enhanced imaging of a mouse brain. Furthermore, the contrast agent can stay in a body for a proper period, and can become a novel medical nuclear magnetic resonance imaging contrast agent.

The invention relates to a method for preparing nanometer composite resin mouth repair material. Wherein, it comprises that: prepare water-mellow system; hydrolyzing the silane coupler in acetic acid catalyst to be water-mellow system with coupler; modifying the surface of inorganic nanometer stuff; adding the nanometer inorganic powder into the water-mellow system to be dispersed by ultrasonic wave; washing and drying to obtain the modified inorganic nanometer stuff; preparing resin substrate; adding resin monomer into some dilute agent to be diluted, to form resin substrate; preparing nanometer composite resin; in shade, adding the resin substrate into light initializer and share initializer, to be mixed and added with modified inorganic nanometer stuff; mixing and removing the bubble, to obtain the final product. The invention has simple process and short time, while the product has high mechanical strength.

The invention provides a bismuth selenide nanocomposite material and a preparation method and application thereof. The bismuth selenide nanocomposite material comprises polyvinylpyrrolidone, selenocysteine, and bismuth selenide coated by the polyvinylpyrrolidone and the selenocysteine. The bismuth selenide nanocomposite material has a good light-heat conversion function, can achieve effective combination of thermotherapy and radiotherapy to play a synergistic effect, and can overcome respective defects of the two therapy methods to obtain the optimal tumor treatment effect; after completion of the radiotherapy, the selenocysteine is degraded from the surface of the material and can effectively enter a living body to participate in synthesis of selenium protein, so that the body immunity is enhanced, and the side effects caused by the radiotherapy are reduced.

The invention relates to a brush-type hydrazine-polymer functionalized magnetic nano-material, preparation and application thereof to enriching of glycopeptide or glycoprotein. After a reversible addition-fragmentation chain transfer (RAFT) reagent is introduced into the surface of a nano-material, an organic polymerization reaction functional monomer and an organic polymerization reaction initiator are added, the organic functional monomer is subjected to controllable free-radical polymerization under the regulation and control of the reversible addition-fragmentation chain transfer reagent, so that the brush-type polymer organic-inorganic hybrid nano-material is prepared. The organic-inorganic hybrid nano-material is simple in preparation process and mild in reaction conditions, and is applicable to enriching of glycopeptide or glycoprotein in a complex biological sample.

The invention discloses a laser interference nanolithography system for one-step titanium alloy implant surface texturing and modification. The laser interference nanolithography system comprises a high-power laser, a beam-splitting system, a wave plate and a polarizer. The laser interference nanolithography system is characterized in that two light beams are intervened, interference light beam parameters are controlled according to different implantation positions, a groove pattern produced through laser interference of the two light beams is utilized for directly processing the surface of a titanium alloy implant, a groove structure with the characteristic dimension adjustable from 100nm to 20 microns is formed, the geometrical morphology and the roughness of the surface of a material are changed, bio-mechanical bonding property of the titanium alloy implant with a bone is improved, osteoblast chemotaxis is guided, the biocompatibility of the implant is improved, and one-step titanium alloy implant surface texturing and modification is realized.

The invention provides a method for preparing palladium and copper alloy nanowires through heliothis armigera nuclear polyhedrosis protein. According to the method, mainly, heliothis armigera nuclear polyhedrosis protein freeze-drying powder is taken, and a polyhedrosis protein solution with the concentration being 0.001-0.01 mg/mL is prepared; a Na2PdCl4 and CuCl2 mixed solution with the ratio of Pd atoms to Cu atoms being 1-4:1-4 is added in the polyhedrosis protein solution, nitrogen is introduced for 5-30 min to remove oxygen in the solution, at room temperature, sodium borohydride is added in the above solution for reduction, the molar ratio of a reduction agent to the precursor mixed solution is 1:2-1:4, and the palladium and copper alloy nanowires with the network structure can be obtained. The method is simple in technology and fast in operating process, the raw materials are low in price, easy to obtain and environment-friendly, industrial production is easily achieved, and the prepared network-shaped palladium and copper alloy nanowires are uniform in shape, stable in structure and good in dispersion performance and can bear overspeed centrifugal treatment and ultrasonic treatment.

The invention discloses a surface modifying method for a biological material. The surface modifying method comprises the step of carrying out oxygen gas plasma activation treatment on the material surface and then carrying out surface self-assembling; then, alternatively immobilizing chemical molecules with different functional groups in sequence by adopting a micro-contact printing technology, so that the biological active molecules with different biological functions are immobilized on the material surface to obtain the biological material with multifunctional biological activity. The method disclosed by the invention is adopted to treat the material surface, so that multifunctional biological activity is provided for the material surface, and therefore, the surface modifying method is applied to the fields such as biological materials, tissue engineering and implantable medical device research.

The invention discloses an anti-infection hemodialysis tube, which relates to the field of medical equipment. The anti-infection hemodialysis tube of the present invention comprises a dialysis outer tube, a dialysis inner tube, and a dialysis membrane. Covering the outer wall of the dialysis inner tube; the dialysis inner tube has a U-shaped or V-shaped structure, and the openings are respectively a liquid inlet and a liquid outlet; the tubes of the dialysis outer tube and the dialysis inner tube are made of polyester Tetrafluoroethylene-polyurethane-nanosilver composite. In the present invention, the dialysis tube is directly placed in the blood vessel, without taking the blood out of the body and then performing hemodialysis through a machine. The nano-silver of the tube can effectively reduce the risk of infection in the hemodialysis process, and the chitosan quaternary ammonium salt in the dialysis membrane Make the composite membrane positively charged, form a positively charged barrier, effectively resist the bacteria in the dialysate from entering the blood, and further reduce the chance of blood infection during dialysis.

The invention discloses a graphene, CNT (carbon nano tube) and bio-based nylon ternary composite material and a preparation method thereof. The surface of a CNT/graphene is modified, so that the solubility of the CNT/graphene in an organic solvent is improved; then the CNT/graphene is linked with diamine and diacid, finally, in-site polymerization is performed, and the graphene, CNT and bio-based nylon ternary composite material is synthesized. Compared with the prior art, the composite material shows more excellent performance than any single materials, such as better isotropic heat conductivity, isotropic electrical conductivity, a three-dimensional space microporous network and better mechanical performance. Besides, the method is simple to operate and easy to popularize.

The invention discloses a compound oil paint flocculating agent where bacterial cellulose shell-core structures are added. The following steps including the first step of strain separation and purification, the second step of strain screening, the third step of strain fermentation and cultivation and the fourth step of compound magnetic microsphere preparation are included. The preparation process is simple, the compound oil paint flocculating agent can be suitable for industrialized large-scale production, can be repeatedly used and can reduce cost, the problems that the flocculating efficiency is poor and sediment sinks in circulating water are effectively solved, and the long-term effective safe operation of the circulating water is ensured.

The invention relates to a method for carrying drugs or nano particles into specific target cells based on aptamer and cell-penetrating peptide. The method comprises the following steps: preparing cell-penetrating peptide modified by distearoyl phosphoethanolamine-polyethylene glycol, and preparing lipidosome wrapping the drug or the nano particles and the cell-penetrating peptide TAT and aptamer connected onto the lipidosome. According to the method, the lipidosome is used to carry the drugs or nano particles, and the appropriate aptamer and the cell-penetrating peptide are modified on the lipidosome, so that the drug delivery and target treatment can be improved, an effective means is provided for the diagnosis and treatment of diseases, and the application prospect is wide. The lipidosome is used to carry the drugs or nano particles, so that the biological compatibility of the drugs or nano particles is improved, and the uptake rate of tumor cells for the drugs or nano particles is improved. The method is simple and easy in modification, and the used materials are natural, easy to get, easy to degrade in the body and good in biological compatibility.

The invention discloses an injectable double-drug-loading compound chitosan hydrogel. The compound chitosan hydrogel contains liposomes, a chitosan solution, antibiotics, hydroxyapatite and a cross-linking agent, wherein the liposomes contain lipoids and osteoporosis drugs in a mass ratio of (0.5-1.5) to (0.01-0.5), the chitosan solution consists of chitosan and acetic acid; and the hydroxyapatiteis prepared from inorganic minerals and an alkaline solution. The invention further discloses a preparation method of the injectable double-drug-loading compound chitosan hydrogel. By virtue of different cross-linking degrees of the hydrogel prepared by virtue of the method, the hydrogel can be released in different stages, is capable of resisting inflammations and treating osteoporosis for a long time and has good application prospects in the biomedical field.