44 results about "Fibrous tissue" patented technology

A reagent kit, staining method, and application for combining dual immunohistochemistry with elastin fiber staining. The reagent kit includes a combination of primary antibodies, consisting of anti-CK7 and anti-CD34 monoclonal antibodies from different species, such as rabbit anti-human CK7 monoclonal antibody and mouse anti-human CD34 monoclonal antibody. By selecting CK7 and CD34 as the primary antibody combination, the growth pattern of tumor epithelium can be accurately indicated, and the proliferation and thickening of alveolar septal fibrous tissue caused by tumors can be clearly revealed, as opposed to structural changes of alveoli induced by other factors. Combined with independent Victoria blue staining, the elastin fibers of the walls of arteries and veins, as well as the pleura of the lungs, can be clearly visualized, aiding in the assessment of the integrity of elastin fibers on the lung surface and in determining the extent of tumor infiltration.

A pressure-sensitive stacking structure for a sports training device of the present invention that is able to detect a pressure with which a player grips a grip portion may include: a conductive layer that is pressure-sensitive; a circuit layer disposed to face the conductive layer and having a plurality of conductive patterns; and a separating layer disposed between the conductive layer and the circuit layer and formed of a fibrous tissue including a plurality of fibers, wherein, when a pressure is generated, the conductive layer and the circuit layer may come into contact, and the pressure may be detected.

The invention discloses an operation method for splitting an oral implant bone, which comprises the following steps of: preparing an ultrathin bone sheet of which the buccal side is less than 1mm, reserving physiological connection between periosteum and the bone sheet, and constructing a periosteum bone flap. The periosteum flap is of a natural barrier membrane structure, and integrates the function of a bone sheet rigid support and the semi-permeable membrane characteristic of the periosteum. The buccal ultrathin bone sheet is connected with the basal bone, is a rigid support structure, supports an osteogenesis space, and can provide bone marrow stroma cells to participate in bone defect repair. Physiological attachment of periosteum is not only a blood supply source of an inner side bone sheet, but also exerts the characteristics of a semi-permeable membrane, replaces an artificial barrier membrane to stop fiber tissue from growing in, and follows the PASS principle of the GBR technology, so that the operation risk is reduced, the use of the artificial barrier membrane is reduced, the adaptation disease of bone splitting is widened, the absorption of buccal side bones is reduced, and the bone splitting effect is improved. And the clinical effect of bone defect repair is improved.

The invention discloses bioactive porous high-density polyethylene foam and a preparation method thereof, and belongs to the technical field of medical implant materials. The preparation method comprises the following steps: (1) mixing high-density polyethylene powder and template particles, carrying out hot press molding, ultrasonically removing the template particles in a solvent, and finally washing and drying to obtain porous high-density polyethylene foam; and (2) sequentially soaking and modifying the porous high-density polyethylene foam in a hydrophilic improver, a biological active agent and an antibacterial agent, and drying to obtain the porous high-density polyethylene foam. The preparation method disclosed by the invention is simple, and the obtained bioactive high-density polyethylene foam with the porous structure has good biological activity, hydrophilicity and excellent mechanical properties, is beneficial to cell adhesion, material exchange, fibroblast ingrowth and angiogenesis, can be used as a craniomaxillofacial non-bearing area bone defect repair material, and has wide application prospects. And the method has a huge practical application prospect.

Provided are microRNA from a Rhodiola root and uses thereof in the prevention and / or the treatment of a fibroplasia medical sign and / or syndrome.

Compared with the prior art, the short straight type ultrasonic suction scalpel head structure comprises a hollow scalpel head main body, the tool bit interface structure is arranged on the hollow tool bit main body and is used for being connected with a handle; the through pipeline is arranged in the hollow tool bit main body in a penetrating manner; the penetrating through hole structure is arranged in the hollow tool bit body in a penetrating mode, the penetrating through hole structure is perpendicular to and intersects with the central axis of the hollow tool bit body, and the penetrating through hole structure is communicated with the middle through pipeline; the through pipeline is arranged on the tool bit body section structure, the tool bit operation end structure and the cutting tool bit structure in a penetrating mode. Compared with the prior art, the short straight type ultrasonic suction scalpel head structure has the advantages that the stability is high, high-density tissue or fiber tissue can be efficiently cut, the risk of blockage of the scalpel head can be reduced, and in addition, the short straight type ultrasonic suction scalpel head structure also has the technical effects.

The utility model relates to a multifunctional warm mattress. The multifunctional warm mattress comprises a mattress body and a controller, the mattress body is provided with a heating wire and a red light LED, and the controller is connected with the electrode plates through wires; wherein a main control board and a power supply module are arranged in the controller, one path of external power supply is connected with the heating wire through a temperature control circuit and a temperature control switch on the main control board, and the other path of external power supply is connected with the MCU microprocessor through the power supply module; one output end of the MCU microprocessor is connected with a red light LED through a lamp control circuit; the other output end of the MCU microprocessor is connected with an electrode plate through an intermediate frequency signal generator, a modulator and a current controller; and the signal input end of the MCU microprocessor is connected with the temperature sensor. According to the multifunctional warm mattress, on the basis of the warm effect, the red light near-illumination and electrical stimulation functions are expanded, so that the multifunctional warm mattress has the effects of promoting fiber tissue repair and relieving local pain, and meanwhile, the hidden danger of product overheating is eliminated through double protection of feedback temperature control adjustment and overtemperature hard breakage.

The present disclosure relates to systems, devices, and methods for subcutaneously cutting and treating tissue and cellulite with non-invasive acoustic waves. Embodiments of the present disclosure refer to systems, devices, and methods that use unfocused or planar, non-cavitating acoustic waves to induce physical effects in tissue such as dermis, fat, muscle, bone, blood vessels, liver tissue, etc. The physical effects include disruption of the fibrous extracellular matrix of the target tissue. Embodiments of the present disclosure include the application of multiple rapid acoustic pulses (e.g., shockwaves) to cause the breakdown of the fibrous extracellular matrix to reduce the appearance of cellulite or scarring in the treated area. Such unfocused or planar, non-cavitating acoustic waves can induce tissue responses such as reduced fibrosis, induction of angiogenesis or lymphangiogenesis, etc.

A fibrous tissue repair device includes first and second tubular anchors having corresponding longitudinal passages. The tissue repair device includes corresponding first and second inserters. Each inserter has a shaft with a distal portion received in the longitudinal passage of the corresponding tubular anchor. A flexible strand couples the first and second anchors.

This application proposes a traditional Chinese medicine composition and preparation method for treating atrophic gastritis of spleen deficiency and blood stasis type, involving the field of traditional Chinese medicine. It utilizes Bupleurum chinense, stir-fried Paeonia lactiflora, Citrus reticulata peel, Pinellia ternata, Codonopsis pilosula, Poria cocos, stir-fried Atractylodes macrocephala, prepared Glycyrrhiza uralensis, Agrimonia pilosa, and Curcuma zedoaria, and establishes a water extraction and decoction preparation process. A rat model of precancerous gastric lesions was established using MNNG combined with multiple factors. Normal control group, model group, folic acid group, and traditional Chinese medicine group were set up to observe the morphological and pathological changes of the gastric mucosa. The results showed that the traditional Chinese medicine composition can reduce gastric mucosal atrophy, inflammatory cell infiltration, and fibrous tissue hyperplasia, alleviate intestinal metaplasia, downregulate the expression of AKT and mTOR proteins in the gastric mucosa, and inhibit abnormal mucosal proliferation. Its effect is superior to that of folic acid, providing experimental evidence for clinical treatment.

The invention relates to the technical field of keloid resection, and discloses a minimally invasive surgery device for keloid core resection, which comprises a body, and further comprises an outer sleeve fixedly connected to the front end of the body, the outer sleeve is of a slender hollow structure and is used for being inserted into keloid tissues through a skin tiny incision; the inner cutting tube is coaxially arranged in the outer sleeve and can rotate relative to the outer sleeve, and an annular cutting edge used for cutting keloid fibrous tissue is formed at the far end of the inner cutting tube; according to the minimally invasive surgery device for keloid core excision, the outer sleeve and the inner excision tube are coaxially arranged, and the annular cutting edge used for cutting keloid fibrous tissue is formed at the far end of the inner excision tube, so that the device can enter the keloid through a tiny incision of the skin; on the premise of reducing skin wounds, effective treatment of keloid core tissues is realized, and improvement of postoperative healing effect and appearance recovery are facilitated.

The application provides a traditional Chinese medicine external application method for reducing the risk of fistula fibrosis in dialysis patients, relates to the technical field of clinical application of traditional Chinese medicine, is suitable for the prevention of autologous arteriovenous fistula fibrosis of maintenance hemodialysis patients, can effectively reduce the incidence of complications such as fistula peripheral tissue fibrosis and vascular stenosis, and prolongs the service life of the fistula. The drug stability and skin permeability are improved through optimization of adjuvants, and based on the grouping intervention of maintenance hemodialysis patients, the fistula blood flow and fibrosis improvement are evaluated in combination with color Doppler ultrasound. The application takes the principles of promoting blood circulation to remove blood stasis, dredging collaterals and resolving knots, and detoxification and swelling reduction as the therapeutic principles, prepares a fistula protection ointment by screening and optimizing a traditional Chinese medicine formula, realizes the effects of improving local microcirculation of the fistula, inhibiting fibrous tissue proliferation and reducing inflammatory reactions through external application intervention, thereby reducing the incidence of fistula fibrosis and related complications, prolonging the fistula patency time, simultaneously reducing the treatment cost, and improving the patient tolerance and life quality.

According to the lung fibrous tissue removing device, starting from the source, abnormal fibrous grids in a pleural cavity are safely and effectively broken, ablated or cut off in a physical or energy mode, all separated small rooms are broken through, and a plurality of independent areas are fused into a whole. Therefore, all effusion in the thoracic cavity can be thoroughly drained only through one-time puncture or a few times of puncture. The operation time can be remarkably shortened, the pain of a patient can be relieved, lung trauma and various complications caused by multiple times of puncture can be fundamentally avoided, the treatment effect and safety of pleural effusion, especially complex atrial effusion, are greatly improved, and important clinical value and social significance are achieved.

The utility model provides a tissue grinding tube capable of quickly purifying RNA (Ribonucleic Acid), which relates to the technical field of RNA extraction, and comprises a grinding tube body, an auxiliary grinding piece and a plurality of grinding raised lines, two ends of the grinding tube body are concave inwards to form a grinding cavity, the plurality of grinding raised lines are fixed on the inner wall of the grinding cavity in an annular array, the auxiliary grinding piece is connected with the inner wall of a sealing cover, and the sealing cover is connected with the grinding cavity. When the grinding pipe body is placed in a grinding instrument for use, the auxiliary grinding piece is used for crushing a tissue sample in a grinding cavity during grinding; according to the utility model, during grinding, the movable rod provided with the crushing cutter rotates in an uncertain direction, the crushing cutter can continuously impact a tissue sample with different forces, and by virtue of the high-frequency cutting and crushing actions of the crushing cutter in different directions, the deep disintegration can be carried out on tough fiber tissues, high-toughness meat structures and the like; the internal cell structure and fiber framework are fully destroyed, so that the crushing effect is better realized, and the grinding process is greatly accelerated.

The invention discloses a personalized implantation structure and method for improving insufficient chin anterior movement in a chin shaping surgery, the personalized implantation structure comprises an implant and a chin anterior movement osteotomy matched with the implant, and the implant is fixed on the chin anterior movement osteotomy. Compared with the prior art, osteotomy forward movement and the implant are combined together to be applied to the chin forming operation, and when the chin bone mass of a patient is insufficient, supplementation can be conducted through the implant. Compared with an autogenous bone or an artificial bone for transplantation, the implant does not need to face the problems of absorption, rejection and the like, and the risk of a secondary operation cannot be increased; meanwhile, compared with the mode that the prosthesis is completely adopted for implantation, the burden of mandibular fibrous tissue can be relieved, and the risk of implant displacement can also be reduced.

The invention discloses an ascites drainage control device, and belongs to the technical field of medical instruments, the ascites drainage control device comprises a control assembly, the front end of the control assembly is connected with a first drainage tube, the rear end of the control assembly is connected with a second drainage tube, the first drainage tube is used for being placed in an abdominal cavity, and the second drainage tube is used for being connected with a drainage ball. Complications such as abrupt pressure drop of the abdominal cavity, hypotension and hepatic encephalopathy caused by out-of-control flow velocity of traditional equipment are effectively avoided through the flow velocity adjusting mechanism; through magnetic positioning and fixing buckle design, it is guaranteed that the adjusting state is stable, the pipeline is fixed reliably, and the risks of drainage tube disengagement, displacement, folding, winding and infection are reduced; two-way dredging of the pipeline can be completed without additional instruments, the problem of blood clot and fiber tissue blockage is solved quickly, and drainage interruption is avoided.

A spinal implant is provided that is configured to receive a fill material is provided that includes a wall that defines an interior chamber. The wall has an interior side, an exterior side, and a wall thickness that extends between the interior side and the exterior side. The wall has a porosity that permits fluid passage through the wall thickness and permits blood vessels and fibrous tissue to extend through the wall thickness. The interior chamber has a first chamber segment and a second chamber segment. In the first chamber segment, the wall has a first wall configuration. In the second chamber segment, the wall has a second wall configuration. The first chamber segment has a first volumetric expansion ratio and the second chamber segment has a second volumetric expansion ratio. The second volumetric expansion ratio is greater than the first volumetric expansion ratio.

Methods of making fibrous tissue derived materials, as well as such materials and compositions comprising them, are provided. In addition to resizing, decellularizing, and delipidizing, tissue samples are subjected to one or more milling steps which are performed within certain parameters and using selected substances to control, retain, enhance, or a combination thereof, the fibrous quality of the resulting fibrous tissue derived material. Such fibrous tissue derived materials should provide beneficial handling properties, such as being a moldable putty when rehydrated, but having a fibrous texture, which is expected to be more cohesive than tissue derived materials subjected to more or longer milling steps, or those involving different substances during milling. The fibrous tissue derived materials and compositions comprising them provide a porous matrix or scaffold to support healing and remodeling of a subject's treatment, wound, defect, or reconstruction site.

A novel system and method for accurate detection and quantification of fibrous tissue produces a virtual medical image of tissue treated with a second stain based on a received medical image of tissue treated with a first stain using a computer-implemented trained deep learning model. The model is trained to learn the deep texture patterns associated with collagen fibers using conditional generative adversarial networks to detect and quantify fibrous tissue.

Modulation of foreign body responses in living tissue, and more particularly, devices and related methods for light-based modulation of foreign body responses in living tissue are disclosed. Light sources are disclosed that provide light with characteristics for modulation of foreign body responses that may be elicited by percutaneous and / or subcutaneous devices, including medical devices and other consumer electronic devices. Light delivery structures are disclosed that propagate light from the light sources to irradiate associated subcutaneous tissues. Modulation of foreign body responses may include inhibiting collagen and fibrous tissue generation, modulating inflammation and healing, and / or increasing nitric oxide production and / or release. By modulating foreign body responses associated with percutaneous and / or subcutaneous devices, performance characteristics and lifetimes of such devices may be improved.

The invention discloses an external traditional Chinese medicine ointment for treating thyroid nodules as well as a preparation method and application thereof, and relates to the field of medicines. The external traditional Chinese medicine ointment comprises traditional Chinese medicine micro powder and a matrix, wherein the traditional Chinese medicine micro powder comprises nidus vespae, dung beetle, cowherb seed, garden balsam seed, ephedra, ground beetle, radix ranunculi ternati, prepared arisaema consanguineum schott, semen momordicae, leech, curcuma zedoary, borneol and selfheal. According to the traditional Chinese medicine micro powder, various insect medicines contain components such as chitinase or enzyme, fiber tissue or cyst can be degraded, targeted knot breaking can be achieved, various plant medicines contain volatile oil or alkaloid components, blood circulation can be improved, and nodule absorption can be promoted. Meanwhile, borneol and ephedra are used for enhancing transdermal absorption of drugs, a matrix promotes drug release, the ointment can directly act on a thyroid nodule focus area, the bioavailability is high, the treatment effect of removing stasis is improved, the burden of liver and kidney is reduced through external administration, skin irritation is small, safety is high, and operation is easy and convenient.

Provided is an ophthalmic surgical instrument for cutting an intraocular fibrous tissue, including: a rod body having a long axis; and a cutting portion protruding in a direction away from the length direction of the rod body. The rod body includes: a rod body front surface located in the protruding direction of the cutting portion; and a rod body rear surface located on the opposite side of the protruding direction. The cutting portion includes: a tip end located in the protruding direction of the cutting portion and having a minimum thickness in the length direction of the rod body; a top surface as a connecting surface between the tip end and the rod body front surface; and a bottom surface as a connecting surface between the tip end and the rod body rear surface. When viewed from the side, the center point of a reference cross section that is orthogonal to a horizontal tangent line in a tangent line of a surface or a point that transitions from the top surface to the rod body front surface and that is initially parallel to a horizontal axis extending in the length direction of the rod body and that passes through a tangent point of the horizontal tangent line and the top surface is closer to the rod body rear surface side than a first axis that passes through a center point of a plurality of reference cross sections parallel to the reference cross section that overlaps the most when viewed from the front.

Disclosed is a dispersible adhesively bonded wet tissue laminate and more particularly a dispersible wet wipe comprising two or more adhesively bonded tissue plies. Generally, the wipe comprises first, and second tissue plies adhesively bonded to one another by an adhesive, particularly a triggerable binder, disposed at the interface of the plies. The first and second tissue plies preferably comprise fibrous tissue plies and more preferably wet-laid tissue plies consisting essentially of conventional papermaking fibers. The adhesively bonded laminates are generally strong enough to withstand use, such as having a geometric mean wet tensile strength (GMWT) greater than about 250 g / in, but disperse quickly in water, such as having a Slosh Time less than about 60 minutes.

There is provided a surgical instrument for releasing soft tissue from fibrous tissue comprising: a body having a distal end configured to be inserted into an incision formed in the soft tissue and a handle end opposite to the distal end for gripping by a user; a hook member located at the distal end of the body to extend laterally from the body; and a blade pivotally mounted adjacent an opening of the hook member at a proximal end so as to be movable between an open position where opening of the hook member can freely receive fibrous tissue therethrough and a closed position where the blade is positioned across the opening of the hook member; wherein, the body is firstly inserted into the soft tissue and advanced such that the opening of the hook member is open to receive fibrous tissue therein for testing, and upon the test determining that the fibrous tissue requires release, the blade is activated to move from the open position to the closed position thereby performing a cutting action that passes through the fibrous tissue located within the hook member to cut and release the soft tissue therefrom.

1. The name of the design product: erbium laser treatment instrument (OEM-LSP501). 2. The use of the design product: instrument for treating fibrous tissue repair and beauty. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The invention provides a striae gravidarum hexagonal matrix therapy method. Firstly, laser energy penetrates through dermis, melanin is smashed, pigment molecules are metabolized, and purplish red lines are eliminated to improve the skin color; secondly, targeted anti-aging is carried out aiming at grain fibroblasts, the dermal matrix capacity is increased, skin circulation is remodeled, subcutaneous cracks are released, the fibroblast activity is stimulated, and collagen is induced to be generated so as to flatten the skin; thirdly, radio frequency energy is used for activating the deep layer of dermis and the epidermal layer, synthesis of collagen, elastin and hyaluronic acid is promoted, regeneration of skin fiber tissue is stimulated, and the fracture surface is repaired for deep renewal; fourthly, damaged skin soft tissues are repaired, red metabolism is accelerated, and epidermis repair is achieved; 5, aiming at postpartum abdominal fat accumulation, matching with proper tightening and shaping equipment to act on subcutaneous fat cells to enable the subcutaneous fat cells to be split, apoptotic and metabolized so as to reduce fat and shape; and finally, the dermal collagenous fibers are shrunk through deep three-dimensional heating, so that the tightening and lifting of abdomen tightening, pulling and anti-aging are realized.

To provide a tissue structure that facilitates administration of pluripotent stem cells to a disease site, and a method for forming the tissue structure.SOLUTION: A tissue structure formed by a partition wall 12 indwelled in an environment including a biological tissue, wherein the partition wall 12 includes an inner surface 14 surrounding a hollow portion 11 and a plurality of through-holes 13 opened in the inner surface 14, cells in the biological tissue enter the hollow portion 11 through the through-holes to form the tissue structure in the hollow portion 11, and the tissue structure includes a membranous fibrous connective tissue having one side surface peeled from the inner surface 14 and a sparse fibrous tissue spreading over the entire other side surface opposite to the one side surface and having pluripotent stem cells accumulated therein.SELECTED DRAWING: Figure 1

The present invention provides an apparatus, system and method for providing robotically assisted surgery that involves the removal of bone or non-fibrous type tissues during a surgical procedure, in particular with assistance from real-time ultrasound images from an ultrasound probe. The system utilizes a multi-axis robot having a reciprocating tool that is constructed and arranged to remove hard or non-fibrous tissues while leaving soft tissues unharmed. The multi-axis robot may be controlled via computer or telemanipulator, which allows the surgeon to complete a surgery from an area adjacent to the patient to thousands of miles away.

The application belongs to the technical field of covered stents, and relates to a tacrolimus / ZIF-8 airway covered stent and application of the tacrolimus / ZIF-8 airway covered stent in inhibiting airway cicatricial stenosis. Preparation of the tacrolimus / ZIF-8 airway covered stent comprises the following steps: loading tacrolimus on ZIF-8 to obtain tacrolimus@ZIF-8 particles; dissolving PLLA in hexafluoroisopropanol to prepare a PLLA solution; dissolving the tacrolimus@ZIF-8 particles in the PLLA solution to obtain a tacrolimus@ZIF-8 / PLLA solution; and electrospinning the tacrolimus@ZIF-8 / PLLA solution and spraying the solution on a metal bare stent to obtain the tacrolimus / ZIF-8 airway covered stent. The obtained tacrolimus / ZIF-8 airway covered stent has good biocompatibility, a low degree of foreign body reaction, a broad-spectrum antibacterial effect and a multi-pathway inhibition of fibrous tissue proliferation, and can be used for benign airway cicatricial stenosis and prevention of airway restenosis.

An implantable medical device for treating reflux disease includes a movement restriction device configured to be anchored to the stomach wall to prevent movement of the lower esophageal sphincter relative to the thoracic diaphragm. The movement restriction device includes a first portion, a second portion, and a first distance element. The first and second portions are configured to be connected to each other to form at least a portion of a functional movement restriction device. The first and second portions are detachable from each other to allow the first and second portions to pass independently through the gastrointestinal tract, and the first distance element is configured to form a space between the first and second portions, the space being configured to allow fibrous tissue ingrowth between the first and second portions.