63 results about "Fibrous tissue" patented technology

The invention discloses a porcine fibroblast line capable of being passaged for a long time and application of the porcine fibroblast line. According to the invention, pig fibroblast tissues are taken as a source, pig fibroblasts at different parts are obtained through a tissue block separation method, in-vitro long-term passage is carried out, the cells are triggered to break through the Harike limit, monoclonal screening is further carried out through a limited dilution method, and a pig fibroblast line with a single source is obtained. After screening, porcine fibroblasts with two parts can be subjected to long-term passage in vitro, namely ear edge fibroblasts and rear leg fibroblasts, have collagen secretion capability and are preserved in China Center for Type Culture Collection with preservation numbers of CCTCC NO: C202511 and CCTCC NO: C202512, the cell line breaks through the Harike limit, is already transferred to 42 generations at present, and has the advantages of being capable of secreting collagen, capable of secreting collagen, capable of secreting collagen and capable of secreting collagen. The cells are in a healthy and full long fusiform state, the proliferation level is not influenced after long-term passage, and the method can be applied to preparation of cell culture meat.

A knife-shaped needle for loosening the shoulder and neck envelope fascia, relates to a tool for crushing fibrous tissue under the skin, wherein cross bars (1) perpendicular to the side walls of the support rod are provided on opposite side walls of the top of a support rod (2), triangular blades A (3) are provided on each side wall of the two cross bars in a manner that is rotationally symmetrical around the support rod and is located at the front ends of the two cross bars when the support rod rotates clockwise, and triangular blades B (4) are provided at the outer ends of the two cross bars at positions on the same side as the two triangular blades A; the utility model arranges two cross bars opposite to each other at the upper end of the support rod, and rotatably arranges the triangular blades A on the two cross bars, and rotatably arranges the triangular blades B at the ends of the two cross bars, so that after the electric spiral knife drills a hole in the hymenoplasty and simply crushes the tissue inside the hymenoplasty, the utility model can effectively crush the interspinous process space, the fibrous sclerotic tissue on both sides of the spinous process, and the envelope fascia.

A machine learning system makes medical predictions based, at least in part, on pathomic features indicating collagen fiber organization extracted from pathology images that include lesions. The pathomic features are extracted from pathology images. The pathology images may be routine clinical images gathered in the course of diagnosis and treatment, such as hematoxylin and eosin (H&E)-stained whole slide images (WSIs) of tissue. The medical predictions may concern, e.g., the diagnosis, prognosis, genotype, or phenotype of a lesion, and may include disease-free survival (DFS) and overall survival (OS) of patients known or suspected of having malignant lesions. Methods for training a machine model to make, and for making, such predictions are also disclosed.

A reagent kit, staining method, and application for combining dual immunohistochemistry with elastin fiber staining. The reagent kit includes a combination of primary antibodies, consisting of anti-CK7 and anti-CD34 monoclonal antibodies from different species, such as rabbit anti-human CK7 monoclonal antibody and mouse anti-human CD34 monoclonal antibody. By selecting CK7 and CD34 as the primary antibody combination, the growth pattern of tumor epithelium can be accurately indicated, and the proliferation and thickening of alveolar septal fibrous tissue caused by tumors can be clearly revealed, as opposed to structural changes of alveoli induced by other factors. Combined with independent Victoria blue staining, the elastin fibers of the walls of arteries and veins, as well as the pleura of the lungs, can be clearly visualized, aiding in the assessment of the integrity of elastin fibers on the lung surface and in determining the extent of tumor infiltration.

A pressure-sensitive stacking structure for a sports training device of the present invention that is able to detect a pressure with which a player grips a grip portion may include: a conductive layer that is pressure-sensitive; a circuit layer disposed to face the conductive layer and having a plurality of conductive patterns; and a separating layer disposed between the conductive layer and the circuit layer and formed of a fibrous tissue including a plurality of fibers, wherein, when a pressure is generated, the conductive layer and the circuit layer may come into contact, and the pressure may be detected.

The invention relates to 900MPa-grade high-strength steel as well as a preparation method and application thereof. The method comprises the following steps: obtaining a plate blank with set chemical components; heating the plate blank, controlling technological parameters of heating to refine grains in the plate blank, and then performing hot rolling, cooling and coiling to obtain a hot-rolled coil; the hot-rolled coil is subjected to acid pickling, then cold rolling is conducted in a reciprocating rolling mode, the reduction rate of cold rolling is controlled, so that the interior of the hot-rolled coil subjected to acid pickling has sufficient recrystallization driving force, and a cold hard coil is obtained; and the cold hard coil is subjected to continuous complete annealing, technological parameters of a soaking section of continuous complete annealing are controlled so as to eliminate fibrous structures in the structure of the cold hard coil, then flattening is conducted, and the 900MPa-grade high-strength steel is obtained. The 900MPa-grade high-strength steel prepared by the preparation method disclosed by the invention has excellent forming performance.

The invention discloses an operation method for splitting an oral implant bone, which comprises the following steps of: preparing an ultrathin bone sheet of which the buccal side is less than 1mm, reserving physiological connection between periosteum and the bone sheet, and constructing a periosteum bone flap. The periosteum flap is of a natural barrier membrane structure, and integrates the function of a bone sheet rigid support and the semi-permeable membrane characteristic of the periosteum. The buccal ultrathin bone sheet is connected with the basal bone, is a rigid support structure, supports an osteogenesis space, and can provide bone marrow stroma cells to participate in bone defect repair. Physiological attachment of periosteum is not only a blood supply source of an inner side bone sheet, but also exerts the characteristics of a semi-permeable membrane, replaces an artificial barrier membrane to stop fiber tissue from growing in, and follows the PASS principle of the GBR technology, so that the operation risk is reduced, the use of the artificial barrier membrane is reduced, the adaptation disease of bone splitting is widened, the absorption of buccal side bones is reduced, and the bone splitting effect is improved. And the clinical effect of bone defect repair is improved.

The present invention discloses a porcine fibroblast cell line capable of long-term passage and its application. The present invention uses porcine fibroblast tissue as a source, obtains porcine fibroblasts from different parts through tissue block separation, performs long-term in vitro passage, and induces the cells to break through the Hayflick limit. Further, monoclonal screening is performed through limiting dilution to obtain a single-source porcine fibroblast cell line. After screening, porcine fibroblasts from two parts, ear margin fibroblasts and hind leg fibroblasts, can be long-term passaged in vitro and have the ability to secrete collagen. These cells have been deposited with the China Center for Type Culture Collection under the accession numbers CCTCC NO: C202511 and CCTCC NO: C202512. This cell line has broken through the Hayflick limit and has been passaged to 42 generations. The cells exhibit a healthy, plump, long spindle shape. Long-term passage does not affect proliferation levels, and the cell line can be used in the preparation of cell-cultured meat.

To provide a method of reducing the formation of fibrotic tissue in a uterus of a subject in need thereof, and a method of increasing myometrial regeneration in a uterus of a subject in need thereof.SOLUTION: A method of reducing the formation of fibrotic tissue in a uterus comprises applying a mesenchymal stem cell (MSC) sheet to a uterus of a subject, where the MSC sheet comprises one or more layers of aggregated confluent mesenchymal stem cells (MSCs), and where applying the MSC sheet to the uterus reduces the formation of fibrotic tissue in the uterus relative to a uterus to which the MSC sheet is not applied.SELECTED DRAWING: Figure 1

The utility model discloses a deep soft soil field stiff pile composite foundation grouting device based on a soilbag, which comprises an expanded-base grouting pipeline and a flexible soilbag, the center of the expanded-base grouting pipeline is provided with a grouting channel penetrating up and down, the lower end of the expanded-base grouting pipeline is provided with the flexible soilbag, and the flexible soilbag is arranged in the expanded-base grouting pipeline. And an opening in the upper end of the flexible geotechnical bag is communicated with the grouting channel. Grouting is conducted in the grouting channel of the expanded-base grouting pipeline, the flexible soil engineering bag installed at the lower end of the expanded-base grouting pipeline is used for receiving grouting, and the overall forming shape of grouting slurry is intervened and controlled, so that it is guaranteed that the final shape reaches the ideal state, the grouting construction problem of the expanded head is solved, and the construction quality of the expanded head is guaranteed. And meanwhile, after grouting is completed in the flexible soil bag, the fiber tissue of the flexible soil bag becomes the internal tissue of the expanded head, the structural stability of the expanded head can be further improved, and therefore the structural stability of the whole stiff composite pile is improved.

The invention discloses bioactive porous high-density polyethylene foam and a preparation method thereof, and belongs to the technical field of medical implant materials. The preparation method comprises the following steps: (1) mixing high-density polyethylene powder and template particles, carrying out hot press molding, ultrasonically removing the template particles in a solvent, and finally washing and drying to obtain porous high-density polyethylene foam; and (2) sequentially soaking and modifying the porous high-density polyethylene foam in a hydrophilic improver, a biological active agent and an antibacterial agent, and drying to obtain the porous high-density polyethylene foam. The preparation method disclosed by the invention is simple, and the obtained bioactive high-density polyethylene foam with the porous structure has good biological activity, hydrophilicity and excellent mechanical properties, is beneficial to cell adhesion, material exchange, fibroblast ingrowth and angiogenesis, can be used as a craniomaxillofacial non-bearing area bone defect repair material, and has wide application prospects. And the method has a huge practical application prospect.

Provided are microRNA from a Rhodiola root and uses thereof in the prevention and / or the treatment of a fibroplasia medical sign and / or syndrome.

A multi-chamber spinal implant is provided that includes at least a first chamber and a second chamber. The first chamber is defined by a first wall having a first wall thickness disposed therebetween. The first chamber has an interior cavity and the first wall has a first porosity. The second chamber is defined by a second wall having a second wall thickness disposed therebetween. The second chamber has an interior cavity and the second wall has a second porosity. The first porosity permits passage of fluids through the first wall thickness and permits blood vessels and fibrous tissue to extend therethrough the first wall thickness. The second porosity is configured to permit passage of fluids through the second wall thickness and permit blood vessels and fibrous tissue to extend therethrough. The first and second chambers are both disposable in a collapsed state and in an expanded state.

Compared with the prior art, the short straight type ultrasonic suction scalpel head structure comprises a hollow scalpel head main body, the tool bit interface structure is arranged on the hollow tool bit main body and is used for being connected with a handle; the through pipeline is arranged in the hollow tool bit main body in a penetrating manner; the penetrating through hole structure is arranged in the hollow tool bit body in a penetrating mode, the penetrating through hole structure is perpendicular to and intersects with the central axis of the hollow tool bit body, and the penetrating through hole structure is communicated with the middle through pipeline; the through pipeline is arranged on the tool bit body section structure, the tool bit operation end structure and the cutting tool bit structure in a penetrating mode. Compared with the prior art, the short straight type ultrasonic suction scalpel head structure has the advantages that the stability is high, high-density tissue or fiber tissue can be efficiently cut, the risk of blockage of the scalpel head can be reduced, and in addition, the short straight type ultrasonic suction scalpel head structure also has the technical effects.

Provided are a stable cross-linking curing agent, and a walnut dreg-derived fibrous tissue protein prepared by a multi-stage temperature-variable moderate extrusion device in conjunction with a green stable cross-linking curing agent. The stable cross-linking curing agent includes inulin, sodium carboxymethyl cellulose, a sea buckthorn dreg-derived polysaccharide, and a resistant dextrin. The walnut dreg-derived fibrous tissue protein includes a walnut dreg, a vital wheat gluten, and the stable cross-linking curing agent.

The utility model relates to a multifunctional warm mattress. The multifunctional warm mattress comprises a mattress body and a controller, the mattress body is provided with a heating wire and a red light LED, and the controller is connected with the electrode plates through wires; wherein a main control board and a power supply module are arranged in the controller, one path of external power supply is connected with the heating wire through a temperature control circuit and a temperature control switch on the main control board, and the other path of external power supply is connected with the MCU microprocessor through the power supply module; one output end of the MCU microprocessor is connected with a red light LED through a lamp control circuit; the other output end of the MCU microprocessor is connected with an electrode plate through an intermediate frequency signal generator, a modulator and a current controller; and the signal input end of the MCU microprocessor is connected with the temperature sensor. According to the multifunctional warm mattress, on the basis of the warm effect, the red light near-illumination and electrical stimulation functions are expanded, so that the multifunctional warm mattress has the effects of promoting fiber tissue repair and relieving local pain, and meanwhile, the hidden danger of product overheating is eliminated through double protection of feedback temperature control adjustment and overtemperature hard breakage.

The present disclosure relates to systems, devices, and methods for subcutaneously cutting and treating tissue and cellulite with non-invasive acoustic waves. Embodiments of the present disclosure refer to systems, devices, and methods that use unfocused or planar, non-cavitating acoustic waves to induce physical effects in tissue such as dermis, fat, muscle, bone, blood vessels, liver tissue, etc. The physical effects include disruption of the fibrous extracellular matrix of the target tissue. Embodiments of the present disclosure include the application of multiple rapid acoustic pulses (e.g., shockwaves) to cause the breakdown of the fibrous extracellular matrix to reduce the appearance of cellulite or scarring in the treated area. Such unfocused or planar, non-cavitating acoustic waves can induce tissue responses such as reduced fibrosis, induction of angiogenesis or lymphangiogenesis, etc.

A fibrous tissue repair device includes first and second tubular anchors having corresponding longitudinal passages. The tissue repair device includes corresponding first and second inserters. Each inserter has a shaft with a distal portion received in the longitudinal passage of the corresponding tubular anchor. A flexible strand couples the first and second anchors.

This application proposes a traditional Chinese medicine composition and preparation method for treating atrophic gastritis of spleen deficiency and blood stasis type, involving the field of traditional Chinese medicine. It utilizes Bupleurum chinense, stir-fried Paeonia lactiflora, Citrus reticulata peel, Pinellia ternata, Codonopsis pilosula, Poria cocos, stir-fried Atractylodes macrocephala, prepared Glycyrrhiza uralensis, Agrimonia pilosa, and Curcuma zedoaria, and establishes a water extraction and decoction preparation process. A rat model of precancerous gastric lesions was established using MNNG combined with multiple factors. Normal control group, model group, folic acid group, and traditional Chinese medicine group were set up to observe the morphological and pathological changes of the gastric mucosa. The results showed that the traditional Chinese medicine composition can reduce gastric mucosal atrophy, inflammatory cell infiltration, and fibrous tissue hyperplasia, alleviate intestinal metaplasia, downregulate the expression of AKT and mTOR proteins in the gastric mucosa, and inhibit abnormal mucosal proliferation. Its effect is superior to that of folic acid, providing experimental evidence for clinical treatment.

The present invention discloses a staining method for co-staining of three fibrous tissues, which includes the steps of successively using Victoria blue staining and Gordon-Sweets silver ammonia solution staining on the processed tissue sections; the staining method of the present invention combines Victoria blue staining and silver ammonia solution staining, and can clearly present the staining of three fibrous tissues on the same section, clearly show the relationship between the cell nucleus structure and elastic fibers, significantly improve the diagnostic accuracy of the degree of tumor invasion, reduce the demand for tissue samples, and the staining method of the present invention has the advantages of clear color contrast, rich levels, accurate positioning, simple operation, etc., and has important significance for clinical pathological diagnosis and is worthy of popularization and application.

The invention relates to the technical field of keloid resection, and discloses a minimally invasive surgery device for keloid core resection, which comprises a body, and further comprises an outer sleeve fixedly connected to the front end of the body, the outer sleeve is of a slender hollow structure and is used for being inserted into keloid tissues through a skin tiny incision; the inner cutting tube is coaxially arranged in the outer sleeve and can rotate relative to the outer sleeve, and an annular cutting edge used for cutting keloid fibrous tissue is formed at the far end of the inner cutting tube; according to the minimally invasive surgery device for keloid core excision, the outer sleeve and the inner excision tube are coaxially arranged, and the annular cutting edge used for cutting keloid fibrous tissue is formed at the far end of the inner excision tube, so that the device can enter the keloid through a tiny incision of the skin; on the premise of reducing skin wounds, effective treatment of keloid core tissues is realized, and improvement of postoperative healing effect and appearance recovery are facilitated.

The application provides a traditional Chinese medicine external application method for reducing the risk of fistula fibrosis in dialysis patients, relates to the technical field of clinical application of traditional Chinese medicine, is suitable for the prevention of autologous arteriovenous fistula fibrosis of maintenance hemodialysis patients, can effectively reduce the incidence of complications such as fistula peripheral tissue fibrosis and vascular stenosis, and prolongs the service life of the fistula. The drug stability and skin permeability are improved through optimization of adjuvants, and based on the grouping intervention of maintenance hemodialysis patients, the fistula blood flow and fibrosis improvement are evaluated in combination with color Doppler ultrasound. The application takes the principles of promoting blood circulation to remove blood stasis, dredging collaterals and resolving knots, and detoxification and swelling reduction as the therapeutic principles, prepares a fistula protection ointment by screening and optimizing a traditional Chinese medicine formula, realizes the effects of improving local microcirculation of the fistula, inhibiting fibrous tissue proliferation and reducing inflammatory reactions through external application intervention, thereby reducing the incidence of fistula fibrosis and related complications, prolonging the fistula patency time, simultaneously reducing the treatment cost, and improving the patient tolerance and life quality.

According to the lung fibrous tissue removing device, starting from the source, abnormal fibrous grids in a pleural cavity are safely and effectively broken, ablated or cut off in a physical or energy mode, all separated small rooms are broken through, and a plurality of independent areas are fused into a whole. Therefore, all effusion in the thoracic cavity can be thoroughly drained only through one-time puncture or a few times of puncture. The operation time can be remarkably shortened, the pain of a patient can be relieved, lung trauma and various complications caused by multiple times of puncture can be fundamentally avoided, the treatment effect and safety of pleural effusion, especially complex atrial effusion, are greatly improved, and important clinical value and social significance are achieved.

The utility model provides a tissue grinding tube capable of quickly purifying RNA (Ribonucleic Acid), which relates to the technical field of RNA extraction, and comprises a grinding tube body, an auxiliary grinding piece and a plurality of grinding raised lines, two ends of the grinding tube body are concave inwards to form a grinding cavity, the plurality of grinding raised lines are fixed on the inner wall of the grinding cavity in an annular array, the auxiliary grinding piece is connected with the inner wall of a sealing cover, and the sealing cover is connected with the grinding cavity. When the grinding pipe body is placed in a grinding instrument for use, the auxiliary grinding piece is used for crushing a tissue sample in a grinding cavity during grinding; according to the utility model, during grinding, the movable rod provided with the crushing cutter rotates in an uncertain direction, the crushing cutter can continuously impact a tissue sample with different forces, and by virtue of the high-frequency cutting and crushing actions of the crushing cutter in different directions, the deep disintegration can be carried out on tough fiber tissues, high-toughness meat structures and the like; the internal cell structure and fiber framework are fully destroyed, so that the crushing effect is better realized, and the grinding process is greatly accelerated.

The invention discloses a personalized implantation structure and method for improving insufficient chin anterior movement in a chin shaping surgery, the personalized implantation structure comprises an implant and a chin anterior movement osteotomy matched with the implant, and the implant is fixed on the chin anterior movement osteotomy. Compared with the prior art, osteotomy forward movement and the implant are combined together to be applied to the chin forming operation, and when the chin bone mass of a patient is insufficient, supplementation can be conducted through the implant. Compared with an autogenous bone or an artificial bone for transplantation, the implant does not need to face the problems of absorption, rejection and the like, and the risk of a secondary operation cannot be increased; meanwhile, compared with the mode that the prosthesis is completely adopted for implantation, the burden of mandibular fibrous tissue can be relieved, and the risk of implant displacement can also be reduced.

The invention discloses an ascites drainage control device, and belongs to the technical field of medical instruments, the ascites drainage control device comprises a control assembly, the front end of the control assembly is connected with a first drainage tube, the rear end of the control assembly is connected with a second drainage tube, the first drainage tube is used for being placed in an abdominal cavity, and the second drainage tube is used for being connected with a drainage ball. Complications such as abrupt pressure drop of the abdominal cavity, hypotension and hepatic encephalopathy caused by out-of-control flow velocity of traditional equipment are effectively avoided through the flow velocity adjusting mechanism; through magnetic positioning and fixing buckle design, it is guaranteed that the adjusting state is stable, the pipeline is fixed reliably, and the risks of drainage tube disengagement, displacement, folding, winding and infection are reduced; two-way dredging of the pipeline can be completed without additional instruments, the problem of blood clot and fiber tissue blockage is solved quickly, and drainage interruption is avoided.

A spinal implant is provided that is configured to receive a fill material is provided that includes a wall that defines an interior chamber. The wall has an interior side, an exterior side, and a wall thickness that extends between the interior side and the exterior side. The wall has a porosity that permits fluid passage through the wall thickness and permits blood vessels and fibrous tissue to extend through the wall thickness. The interior chamber has a first chamber segment and a second chamber segment. In the first chamber segment, the wall has a first wall configuration. In the second chamber segment, the wall has a second wall configuration. The first chamber segment has a first volumetric expansion ratio and the second chamber segment has a second volumetric expansion ratio. The second volumetric expansion ratio is greater than the first volumetric expansion ratio.

Methods of making fibrous tissue derived materials, as well as such materials and compositions comprising them, are provided. In addition to resizing, decellularizing, and delipidizing, tissue samples are subjected to one or more milling steps which are performed within certain parameters and using selected substances to control, retain, enhance, or a combination thereof, the fibrous quality of the resulting fibrous tissue derived material. Such fibrous tissue derived materials should provide beneficial handling properties, such as being a moldable putty when rehydrated, but having a fibrous texture, which is expected to be more cohesive than tissue derived materials subjected to more or longer milling steps, or those involving different substances during milling. The fibrous tissue derived materials and compositions comprising them provide a porous matrix or scaffold to support healing and remodeling of a subject's treatment, wound, defect, or reconstruction site.

A novel system and method for accurate detection and quantification of fibrous tissue produces a virtual medical image of tissue treated with a second stain based on a received medical image of tissue treated with a first stain using a computer-implemented trained deep learning model. The model is trained to learn the deep texture patterns associated with collagen fibers using conditional generative adversarial networks to detect and quantify fibrous tissue.

Modulation of foreign body responses in living tissue, and more particularly, devices and related methods for light-based modulation of foreign body responses in living tissue are disclosed. Light sources are disclosed that provide light with characteristics for modulation of foreign body responses that may be elicited by percutaneous and / or subcutaneous devices, including medical devices and other consumer electronic devices. Light delivery structures are disclosed that propagate light from the light sources to irradiate associated subcutaneous tissues. Modulation of foreign body responses may include inhibiting collagen and fibrous tissue generation, modulating inflammation and healing, and / or increasing nitric oxide production and / or release. By modulating foreign body responses associated with percutaneous and / or subcutaneous devices, performance characteristics and lifetimes of such devices may be improved.