292 results about "Fibrous tissue" patented technology

A device is described that can be used by surgeons to provide quick and accurate face-lifting maneuvers that minimize the amount of tissue that has to be removed. The device is comprised of a shaft with a relatively planar but possibly lenticulate and even slightly curved tip that can divide and energize various tissue planes causing contraction especially via the fibrous tissues. Various forms of energy can be delivered down the shaft to heat and cause desirable tissue contraction. The device can also include a temperature sensor that can be used to control power output.

A device is described that can be used quickly and accurately by surgeons to provide uniform facial tissue planes that are tunnel-free and wall-free thus optimizing face lifting, tightening, and implant delivery. The device is comprised of a shaft with a substantially planar tip further comprised of relative protrusions and energized relative recession lysing segments. Forward motion of the device precisely divides and energizes various tissue planes causing contraction, especially via the fibrous tissues. Other forms of energy and matter can be delivered down the shaft to further enhance desirable tissue modification and contraction.

Described herein are methods of remodeling the base of a ventricle. In particular, methods of remodeling a valve annulus by forming a new fibrous annulus are described. These methods may result in a remodeled annulus that corrects valve leaflet function without substantially inhibiting the mobility of the leaflet. The methods of remodeling the base of the ventricle include the steps of securing a plurality of anchors to the valve annulus beneath one or more leaflets of the valve, constricting the valve annulus by cinching a tether connecting the anchors, and securing the anchors in the cinched conformation to allow the growth of fibrous tissue. The annulus may be cinched (e.g., while visualizing the annulus) so that the mobility of the valve leaflets is not significantly restricted. The remodeled annulus is typically constricted to shorten the diameter of the annulus to correct for valve dysfunction (e.g., regurgitation).

A device is described that can be used by surgeons to provide accurate tissue-lifting and tightening maneuvers that uses minimal external incisions, enhances accuracy, reduces inadvertent consequences while speeding the procedure. The device is comprised of a shaft with a relatively planar but possibly lenticulate or even slightly curved tip that can divide and energize various tissue planes causing net contraction via the fibrous tissue modification. Various forms of energy can also be delivered to cause desirable tissue alterations.

Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to / from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.

A resorbable implant for interposition arthroplasty which is intended to fill a void between two adjacent bone ends, providing a cushion between the bone ends to prevent impingement of the bone ends while providing time for tissue to infiltrate into the space occupied by the implant. It has a protracted resorption time of preferably at least three months to allow time for the proliferation of load-bearing host fibrous tissue in place of the resorbed implant material. The implant preferably is porous with a pore size of greater than about 80 microns in order to enhance infiltration of fibrous tissue. The implant has a modulus in the range of 0.8 to 20 MPa which is soft enough to allow it to conform to surface irregularities of the adjacent bone surfaces while being hard enough to maintain a desired separation between those bones while tissue infiltration replaces the resorbable implant material. The implant may be preformed to the desired shape or alternatively may be formable by the surgeon by methods such as carving with a scalpel. A preferred application for the implant is as a trapezium bone replacement.

A breast implant has at least an outer shell which is composed of a resorbable material. The implant, which can be formed entirely of bioresorbable material such as a collagen foam, is sized and shaped to replace excised tissue. The implant supports surrounding tissue upon implantation, while allowing for in-growth of fibrous tissue to replace the implant. According to various alternative embodiments, the implant is elastically compressible, or can be formed from self-expanding foam or sponges, and can be implanted through a cannula or by injection, as well as by open procedures. The implant can carry therapeutic and diagnostic substances.

A tissue marking implant includes a matrix material and a dye marker. The implant, which can be formed entirely of bioresorbable material such as a collagen foam, is sized and shaped to replace excised tissue. The implant supports surrounding tissue upon implantation, while allowing for in-growth of fibrous tissue to replace the implant. According to various alternative embodiments, the implant is elastically compressible, or can be formed from self-expanding foam or sponges, and can be implanted through a cannula or by injection, as well as by open procedures. The implant can carry therapeutic and diagnostic substances. The dye marker leaches from the implant such that a surgeon, upon subsequent surgical intervention, visibly recognizes the tissue marked by the dye marker.

A method and apparatus for facilitating transapical removal of a prosthetic heart valve, i.e., percutaneously implantable valve (PIV), without open-heart surgery. The apparatus includes a holding tool for holding the PIV, a cutting tool for separating the PrV from fibrotic tissue accumulating around the PIV, and a removal tool for extracting the PIV from the heart.

Described herein are methods of remodeling the base of a ventricle. In particular, methods of remodeling a valve annulus by forming a new fibrous annulus are described. These methods may result in a remodeled annulus that corrects valve leaflet function without substantially inhibiting the mobility of the leaflet. The methods of remodeling the base of the ventricle include the steps of securing a plurality of anchors to the valve annulus beneath one or more leaflets of the valve, constricting the valve annulus by cinching a tether connecting the anchors, and securing the anchors in the cinched conformation to allow the growth of fibrous tissue. The annulus may be cinched (e.g., while visualizing the annulus) so that the mobility of the valve leaflets is not significantly restricted. The remodeled annulus is typically constricted to shorten the diameter of the annulus to correct for valve dysfunction (e.g., regurgitation).

These are breast implant devices and methods of use. The breast implants are made of a matrix of collagen material having a porous structure for supporting surrounding tissue of a breast. The implants are also configured to provide a framework for the in-growth of fibrous tissue into the matrix. The matrix can be resilient and / or self-expanding. The methods of use include the steps of forming a cavity having surrounding breast tissue and forming a resorbable implant made up of collagen that is sized to occupy the cavity. The implant is then implanted into the cavity, thereby supporting the surrounding tissue and allowing for in-growth of fibrous tissue into and replacing the resorbable material. The resorbable material may also be elastically compressible, such that the step of implanting includes the step of compressing the resorbable material. The implants may also contain a medicinal, therapeutic, or diagnostic substance.

The invention relates to a tissue engineering material and a preparation method thereof, in particular to a nano fiber tissue engineering blood vessel and a preparation method thereof. The invention consists of a three-dimensional reticular non-woven film formed by an inner layer of nano fiber and an outer layer of nano fiber; the inner layer of the blood vessel is natural polymer, wherein, calculated by weight, 40 percent to 80 percent is fibroin, 20 percent to 50 percent is gelatine, 0 percent to 20 percent is extracellular matrix protein; while the outer layer of the blood vessel is synthetic polymer. The preparation method is that the natural polymer is dissolved in trifluroroethyl and other solution, while the synthetic polymer is dissolved in hexafluoroisopropanol and other solution, which are respectively prepared into spinning solution; the static electricity spinning technique is adopted to subsequently form the inner and the outer layers on a gather roller; cross-linked treatment is conducted after the inner and the outer layers are taken down, to prepare the nano fiber tissue engineering vessel. The inner layer can simulate the structure of the extracellular matrix, provide good environment for endothelial cells to grow, support adhesion, proliferation and differentiation of the cells, and is good for endothelization of the blood vessel; and the outer layer has good mechanical performance.

New methods of ultrasound imaging are presented that provide images with reduced reverberation noise and images of nonlinear scattering and propagation parameters of the object, and estimation of corrections for wave front aberrations produced by spatial variations in the ultrasound propagation velocity. The methods are based on processing of the received signal from transmitted dual frequency band ultrasound pulse complexes with overlapping high and low frequency pulses. The high frequency pulse is used for the image reconstruction and the low frequency pulse is used to manipulate the nonlinear scattering and / or propagation properties of the high frequency pulse. A 1st method uses the scattered signal from a single dual band pulse complex for filtering in the fast time (depth time) to provide a signal with suppression of reverberation noise and with 1st harmonic sensitivity and increased spatial resolution. In other methods two or more dual band pulse complexes are transmitted where the frequency and / or the phase and / or the amplitude of the low frequency pulse vary for each transmitted pulse complex. Through filtering in the pulse number coordinate and corrections of nonlinear propagation delays and optionally also amplitudes, a linear back scattering signal with suppressed pulse reverberation noise, a nonlinear back scattering signal, and quantitative nonlinear scattering and forward propagation parameters are extracted. The reverberation suppressed signals are further useful for estimation of corrections of wave front aberrations, and especially useful with broad transmit beams for multiple parallel receive beams. Approximate estimates of aberration corrections are given. The nonlinear signal is useful for imaging of differences in tissue properties, such as micro-calcifications, in-growth of fibrous tissue or foam cells, or micro gas bubbles as found with decompression or injected as ultrasound contrast agent.

Apparatus and methods for treating a wall of an aneurysm formed in a vessel includes introducing a tubular member into the body lumen until a distal end of the tubular member is located within the aneurysm. A fluid is delivered via a lumen of the tubular member into the aneurysm to at least partially de-endothelialize the wall of the aneurysm, thereby causing an endothelium of the wall to generate fibrous tissue to strengthen the wall of the aneurysm.

Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.

A closure device closes an opening in a body cavity. The closure device includes an elongate delivery member and a closure component which is removably connected to the distal end of the delivery member. The closure component has a collapsible backing movable between a non-collapsed position and a collapsed position. The closure component also includes a plurality of fibrous tissue engaging members disposed on the backing and oriented in a non-engaging orientation when traveling in a distal direction and in an engaging orientation when traveling in a proximal direction. The fibrous tissue engaging members become entangled in the backing when the backing is in the collapsed position.

A closure device closes an opening in a body cavity. The closure device includes an elongate delivery member and a closure component which is removably connected to the distal end of the delivery member. The closure component has a collapsible backing movable between a non-collapsed position and a collapsed position. The closure component also includes a plurality of fibrous tissue engaging members disposed on the backing and oriented in a non-engaging orientation when traveling in a distal direction and in an engaging orientation when traveling in a proximal direction. The fibrous tissue engaging members become entangled in the backing when the backing is in the collapsed position.

A tissue marking implant includes a matrix material and a dye marker. The implant, which can be formed entirely of bioresorbable material such as a collagen foam, is sized and shaped to replace excised tissue. The implant supports surrounding tissue upon implantation, while allowing for in-growth of fibrous tissue to replace the implant. According to various alternative embodiments, the implant is elastically compressible, or can be formed from self-expanding foam or sponges, and can be implanted through a cannula or by injection, as well as by open procedures. The implant can carry therapeutic and diagnostic substances. The dye marker leaches from the implant such that a surgeon, upon subsequent surgical intervention, visibly recognizes the tissue marked by the dye marker.

An implant for marking an area within a living body includes a matrix material and a marking material. The implant is formable to fit the shape and size of a cavity in the human body. The implant is configured to support tissue surrounding the cavity and to allow in-growth of fibrous tissue into and replace at least a portion of the matrix material.

An implant for marking an area within a living body includes a matrix material and a marking material. The implant is formable to fit the shape and size of a cavity in the human body. The implant is configured to support tissue surrounding the cavity and to allow in-growth of fibrous tissue into and replace at least a portion of the matrix material.

Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent to the patient, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver, kidney, lung, pancreas, endocrine, gastrointestinal and / or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.

The invention discloses methods for preparing shredded mushroom and mushroom dried meat floss by using stems of waste mushrooms generated during mushroom processing. The method for preparing shredded mushroom comprises the following steps of: sequentially carrying out softening process, acid soaking process, high-pressure saturated steam process and shredding process on the stems of mushrooms to prepare the shredded mushroom. The method for preparing mushroom dried meat floss comprises the following steps of: mixing the shredded mushroom with raw materials with different flavors, frying and twisting to be loose. Pyroligneous and high-pressure steam process in the method provided by the invention can soften and separate fibrous tissues of the stems of mushrooms furthest so that the fibers of the stems of the mushrooms are completely and thoroughly separated, and the diameter of the prepared shredded mushroom stem is between 0.4mm and 0.5mm. The mushroom dried meat floss prepared with the method provided by the invention is mellow and tasty, contains more dietary fibers, and has favorable practical value and popularization prospect.

An endovascular graft, having both an expandable stent portion and a stent cover portion positioned, the graft itself and / or a stent cover-portion coated with a bioactive agent adapted to promote initial thrombus formation, preferably followed by long term fibrous tissue ingrowth. The endovascular graft prevents endoleaking by promoting a short term hemostatic effect in the perigraft region. This short term effect can, in turn, be used to promote or permit long term fibrous tissue ingrowth. Particularly where the stent cover portion is prepared from a porous material selected from PET and ePTFE, the bioactive agent can include a thrombogenic agent such as collagen covalently attached in the form of a thin, conformal coating on at least the outer surface of the stent cover. An optimal coating of this type is formed by the activation of photoreactive groups.

The invention relates to a preparation method of peanut wire-drawing protein. The preparation method comprises the following steps: 1) preparing low-denaturalization peanut protein powder; 2) mixing uniformly; 3) hardening and tempering; 4) extruding and swelling; and 5) discharging. The product of the invention is pure white and has specific peanut aroma and rapid rehydration; when the product is torn, a structure as thin as hair can be formed; and moreover, the product has an obvious fibrous tissue, high fiber toughness, tensile force and elasticity, forms a ball without breakage when kneaded by hands, and disperses like fiber immediately after rehydration. The peanut wire-drawing protein ensures that the nutrition level of people is improved without increasing cholesterol, has a uniqueflavor without beany flavor or flatulence factor of soy protein, and is a high-quality resource of vegetable protein. Meanwhile, a proper amount of soy protein and wheat protein is added, and the three high-quality vegetable proteins are combined so that the allocation of essential amino acids for human contained in the peanut wire-drawing protein is more reasonable and better conforms to the nutrition requirements of the human.