151 results about "Wound closure" patented technology

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. A novel platinum catalyst comprising platinum tetramethyldivinyl disiloxane diethyl maleate complex for use in such compositions provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention relates to artificial skin, in particular to self-generating full-layer artificial skin for wound treatment and application of the self-generating full-layer artificial skin. The artificial epidermis has an epidermis-dermis structure similar to skin, and the artificial epidermis structure is composed of an electrostatic spinning nano-film with piezoelectric capacity and has the functions of sterilization, protection and bioelectricity generation of an epidermis layer; the artificial dermal structure is composed of a photo-crosslinking polysaccharide and enzyme crosslinking protein interpenetrating hydrogel skeleton, by adding bioactive components and loading living cells, the effects of releasing active components and cytokines, remodeling wound extracellular matrix and promoting cell proliferation are achieved, and finally healing of acute and chronic wounds is remarkably accelerated. The invention provides a simple, feasible, economical and effective treatment method for sealing a large-area wound, sterilizing the wound and promoting healing of the wound.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The present invention relates to super-contractible films, super-contractible wound dressings comprising the super-contractible films, methods of forming the super-contractible films, methods of treating wounds comprising steps of applying the super-contractible wound dressings, and uses of the super-contractible wound dressings. The super-shrinkable film comprises an alpha-cyclodextrin crystal domain; and oriented polyethylene oxide crystalline domains physically crosslinked by alpha-cyclodextrin crystalline domains wherein the polyethylene oxide has a number average molecular weight of from 200,000 to 10,000,000 Daltons; and after the super-shrinkable film is wetted by water, the shrinkage of the super-shrinkable film exceeds 50% of the original length of the super-shrinkable film.

The invention discloses a uniformly-stressed wound closer and a mounting device thereof, and belongs to the technical field of medical instruments, the uniformly-stressed wound closer comprises an annular tension reducing paste and further comprises a self-locking closing assembly; a plurality of groups of self-locking closing assemblies are distributed at equal intervals at the upper end of the annular post reduction sticker in a circumferential array; the self-locking closing assembly comprises a movable traction module and a limiting module. The movable traction module and the limiting module are symmetrically distributed on the two sides of the upper end of the annular tension reducing sticker; the device further comprises a fixing disc and a multidirectional synchronous screwing mechanism. And a multidirectional synchronous screwing mechanism is mounted in the fixed disc. By means of the mode, the device can close a round wound on a patient, and the phenomenon that the wound is unevenly closed in the wound healing process is avoided.

A novel integrated wound closure device for laparoscopy having an elongated body with a distal end and proximal end able to-use suture for closing surgical port wounds comprising a single sequential proximal activation means able to operate multiple internal systems sequentially such as: a distal anchoring system, a self-contained tissue piercing system, a suture staging means to position suture suitable for capture at a target zone, and a suture capturing system to capture and retract suture into said piercing system with all system functions configured internally of said elongated body which can be reused multiple times per patient.

1. Name of the designed product: packaging box (wound closure device). 2. Use of the designed product: for packaging products. 3. Design points of the designed product: in the combination of shape and pattern. 4. Picture or photo that best shows the design points: Design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention discloses a negative pressure sealing drainage device, and relates to the technical field of medical instruments, and the negative pressure sealing drainage device comprises an arm band assembly, a liquid storage assembly, a dressing assembly and a drug delivery assembly. The arm band assembly comprises an arm band, elastic binding bands, a control panel, a display screen and a storage battery, and the elastic binding bands are fixed to the upper end and the lower end of the arm band through hook-and-loop fasteners. The liquid storage assembly comprises a liquid storage box, a negative pressure pipe, an overflow floater and a negative pressure pump. The dressing assembly comprises a dressing bottom layer, an annular airbag ring, a polyimide substrate layer, a sensor and a top covering layer, the annular airbag ring is arranged at the bottom of the dressing bottom layer, and the sensor is arranged at the top of the polyimide substrate layer. The medicine delivery assembly comprises three medicine cavities, a conveying pipe, a micro peristaltic pump and a mixing pipe. And the end part of the negative pressure tube penetrates through each layer of the dressing to a wound position. The device is good in sealing effect, capable of monitoring the wound state in real time, capable of achieving independent control delivery of various drugs and convenient to carry.

The utility model relates to the technical field of skin anastomats, and discloses a skin anastomat convenient to position, which comprises a plurality of bottom plates, the bottom plates are arranged at intervals, side bottom plates are arranged on one sides of the bottom plates, movable connecting rods are connected between the two bottom plates and between the two side bottom plates, and the movable connecting rods are connected between the two bottom plates and between the two side bottom plates. An upper plate is fixed to one side of the upper portion of each bottom plate, a side upper plate is fixed to one side of the upper portion of each side bottom plate, and an adjusting mechanism is connected between each side upper plate and the corresponding upper plate. The multiple bottom plates and the multiple side bottom plates are pasted to the two sides of a wound respectively, the distances between the bottom plates and the side bottom plates can be adjusted and stretched through the adjusting mechanisms so that the wound can be closed, the positions between the two bottom plates and the two side bottom plates can be adjusted through the movable connecting rods, and therefore the wound can be closed. Therefore, the skin anastomat can be placed in different shapes, and wounds in different shapes can be conveniently positioned and anastomosed.

The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.

The invention provides an on-demand stripping hydrogel with high biological wet tissue adhesion and a preparation method of the on-demand stripping hydrogel. The hydrogel is obtained by combining a hydrophobic amino acid acrylamide derivative and a hydrophilic monomer with a temperature-sensitive monomer and polymerizing. According to the hydrophobic amino acid vinyl monomer phenylalanine derivative provided by the invention, carboxyl and a benzene ring are in a special structure of the same structural unit, so that a hydration layer of a tissue interface can be effectively damaged, and the strength of a matrix can be enhanced by forming stable multiple hydrogen bonds; and strong adhesion (60kPa) can be realized after the adhesive is contacted with wet biological tissues for 5 seconds. The biocompatibility is good, clinical application is facilitated, and a new choice is provided for replacing surgical suture to achieve wound closure and rapid hemostasis clinically.

The present invention relates to skin adhesive formulations. The skin adhesive formulations of the present invention may be useful in wound-closing applications and other medical applications. Ideally the skin adhesive formulations of the present invention exhibit higher viscosity than known skin adhesive formulations. Ideally the skin adhesive formulations of the present invention cause fewer allergic reactions and skin irritation issues in patients relative to known skin adhesives. Ideally the skin adhesive formulations are UV curable in the visible range of 400-500nm rather than moisture cure.

Disclosed are adhesive medical films incorporating one or more cationic steroidal antimicrobial (CSA) compounds. The adhesive medical film is in the form of a tape, dressing, or sheet, configured for contact against dermal tissue to provide securement of medical devices, wound care, wound closure, and / or scar prevention. The adhesive medical film includes (i) a polymer adhesive (e.g., pressure-sensitive adhesive) in which one or more CSA compounds are distributed, and (ii) optionally, a backing substrate upon which the polymer adhesive is disposed. Examples of polymer adhesives include polyacrylate and silicone adhesives. The adhesive medical films, when used, reduce microbial colonization and / or growth, both on the films during storage and at a dermal site, as compared to the same adhesive medical film without incorporated CSA compounds.

The application relates to a wound suture device for a neurosurgery drainage tube. The wound suture device for the neurosurgery drainage tube comprises a shell, two sliding units oppositely arranged on the shell and two pushing units oppositely arranged on the shell, each of the sliding units is provided with a clamping unit, and each of the pushing units is provided with a suture unit; the sliding unit comprises an arc-shaped groove arranged on the shell and an extension plate slidably arranged in the arc-shaped groove, the clamping unit is connected with the extension plate, and the extension plate can slide along the arc-shaped groove; the pushing unit comprises a sliding groove arranged on the shell and a suture plate slidably arranged in the sliding groove, the suture unit is connected with the suture plate, and the suture plate can slide along the sliding groove. The scheme provided by the application can timely suture the drainage hole and prevent infection.

This utility model relates to the field of minimally invasive postoperative wound dressing technology, specifically a minimally invasive postoperative wound dressing with wound closure function. It includes an adhesive layer, release paper installed on both sides of the bottom of the adhesive layer, low-sensitivity adhesive tape evenly installed on both sides of the top of the adhesive layer, and a sterilization layer embedded in the middle of the adhesive layer. The improved minimally invasive postoperative wound dressing adds a first elastic band and a second elastic band. When the wound dressing is applied to the wound surface, the first and second elastic bands can be pulled to traction the sides of the adhesive layer, thereby effectively closing the wound, reducing the risk of wound dehiscence, and promoting rapid wound healing. An absorbent layer made of highly absorbent resin is also added, allowing the absorbent layer to quickly absorb tissue fluid exudated from the wound during the healing process, helping to reduce the risk of wound infection and thus promoting wound healing.

A handheld tape applicator device (10) for tape-assisted wound closure for applying an adhesive tape (18) to the skin wherein a mechanical traction force is applied to the skin. The device (10) comprises: a housing (12); a reel (14) having a roll (16) of tape (18); and a tape cutting mechanism (20). A displaceable actuator (36) is pivotally mounted to the housing (12). The driven roller (28) frictionally engages the tape. The actuator includes a toothed pawl (46) that engages a toothed ratchet attached to a driven roller (28) to drive rotation of the roller and thereby dispense the tape. The application of the adhesive tape is initiated by discharging a length of adhesive tape from the device by means of rotation of the drive roller (28). The ratchet is positively engaged by a pawl (46) to provide resistance to tape feed, allowing tape tensioning. For greater traction, the device (10) comprises a brake pad (70) mounted to the actuator (36) for applying a braking force to the roller (28).

The invention belongs to the technical field of biological medicines, and particularly relates to application of human umbilical cord mesenchymal stem cells combined with metformin in preparation of anti-DFU medicines. By constructing a diabetic foot ulcer rat model and combining in-vivo and in-vitro experiments and signal analysis, it is confirmed for the first time that hUC-MSCs and metformin have a synergistic effect in treating diabetic foot ulcer. Combined treatment is beneficial to diabetic foot ulcer wound closure, reepithelization, matrix remodeling and proliferation of blood vessels and inflammation related cells, regulation and control of vascular endothelial cells PI3K-AKT and downstream signal channels thereof can be promoted through paracrine, so that the inhibited survival, proliferation, migration and vascularization capacities of the vascular endothelial cells PI3K-AKT in a hyperglycemia environment are recovered, and the vascular endothelial cells PI3K-AKT and the downstream signal channels of the vascular endothelial cells PI3K-AKT are promoted. Further, the dynamic regulation of enhancement, maturation and weakening of new angiogenesis of the wound of the DFU rat is promoted, and the wound healing is accelerated. The invention provides theoretical basis and experimental support for developing a more effective treatment scheme.

Disclosed herein are systems, devices, kits, and associated methods for excising tissue. A device for excising tissue may include a body, a first curved member coupled to the body and having a first tissue contact surface, a second curved member movable relative to the first curved member and comprising a second tissue contact surface, an actuator coupled to the body and configured to decrease a distance between the first and second curved members, and a cutting assembly configured to excise the tissue. The first tissue contact surface may have a first radius of curvature (ROC), while the second curved member may have a second, smaller ROC. Further, one or portions of the device, such as one or both of the first and second jaws, may be transparent and / or may include markings to facilitate accurate aligning of the device relative to a tissue excision site.

Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The present invention discloses a double-crosslinked hydrogel, which is formed by interweaving two crosslinked networks: poly(N-isopropylacrylamide) formed by free radical polymerization of N-isopropylacrylamide and N,N'-methylenebisacrylamide, and a crosslinked network formed by nucleophilic addition reaction of hyaluronic acid and glutaraldehyde. The double-crosslinked hydrogel of the present invention combines the multiple requirements of accelerating wound closure, promoting wound healing, and having tissue adhesion ability and temperature sensitivity to meet the needs of wound healing.

The invention discloses a hydrogel dressing containing pearl sac liquid as well as a preparation method and application of the hydrogel dressing, and belongs to the technical field of medical dressings. The hydrogel dressing is prepared by taking polyvinyl alcohol (PVA) and chitosan (CS) as gel matrixes and loading Markov pearl sac liquid through an in-situ crosslinking technology. The hydrogel dressing is of a three-dimensional porous network structure and is excellent in water absorption performance, the mechanical property of the hydrogel dressing meets the wound repairing requirement, the bacteriostasis rate of the hydrogel dressing on common burn pathogenic bacteria such as staphylococcus aureus and pseudomonas aeruginosa exceeds 90%, and the hydrogel dressing is free of obvious cytotoxicity. When being applied to burn infection wounds, the medical dressing can effectively inhibit bacterial proliferation of the wounds, relieve inflammatory response, promote angiogenesis and tissue regeneration and remarkably improve the closure rate of the wounds, solves the problems that existing burn dressings are narrow in antibacterial spectrum, limited in repair promoting capacity and the like, provides a safe and effective novel dressing choice for clinical treatment of burn infection, and has wide application prospects. Meanwhile, the effective utilization of the martensitic pearl sac liquid is realized.

The utility model relates to the technical field of medical equipment, in particular to a skin tension reduction patch which comprises first base cloth and second base cloth, a pull strip is fixed on the first base cloth, a rack box is fixed on the second base cloth, and the pull strip penetrates out of the rack box. Limiting teeth are elastically connected into the rack box and meshed with tooth grooves in the side edges of the brace. Meanwhile, a release mechanism is further arranged on the rack box and connected with the limiting teeth, and when the two fingers of a doctor hook the end, on the first base cloth, of the brace and the end of the release mechanism respectively and apply force to get close to each other, the limiting teeth are pulled through the release mechanism to move to release the meshing state with the brace, and then the brace is released; and after the wound is closed, the release mechanism is released, the limiting teeth can be reset to be meshed with the tooth grooves in the corresponding positions of the pulling strip again, and the wound is kept in a closed state.

The application discloses a kind of fusion polypeptide SynExo for targeted delivery and its engineering exosome preparation method.The fusion polypeptide includes PDGFR beta transmembrane domain (FIASFFLAVVTLLVLLYF), photocontrol cross-linking site 4-azidophenylalanine (AzF) and double-targeting peptide CRGDKGPDC, is connected in series by flexible linker GGGGS, realizes the efficient anchoring, accurate targeting and space-time controllable delivery of exosome.The high hydrophobicity (GRAVY value +2.3) of PDGFR beta transmembrane domain makes its anchoring efficiency increase by 2.7 times, AzF generates azinome intermediate under 365nm light to realize irreversible cross-linking, double-targeting peptide targets integrin αvβ3 and ECM1 by cRGD (Kd=25nM) and KGPDC (Kd=1.2nM) synergistically, and penetration depth reaches 180 μm.Engineering exosome realizes AzF accurate incorporation by lentivirus packaging combined with orthogonal tRNA system, and in diabetic ulcer model, targeted enrichment efficiency reaches 6.8 times of unmodified group, and wound closure rate is 92.5%, which is significantly better than that of control group.The application provides an innovative platform for targeted treatment of diseases such as tumors and diabetic ulcers.

Suture systems, devices, and methods to enhance the precision and efficiency of surgical procedures are disclosed herein. Exemplary sutures are integrated with length indicators along their length, providing surgeons with an immediate visual reference for measuring anatomical distances intra-operatively in open and key hole (e.g. arthroscopic and endoscopic) procedures, tissue dimensions, gauging suture tension, and determining the optimal or desired suture length required for closure. The length indicators, marked at predetermined intervals, allow for accurate measurement without the need for additional tools, thereby streamlining the surgical process and reducing operation time. This suture material is particularly beneficial in complex surgeries where precision is paramount, and can improve patient outcomes by enabling more accurate tissue approximation and wound closure. Exemplary embodiments enable a combination of functionality and convenience, providing a valuable addition to the medical field, particularly in surgical specialties that demand meticulous attention to detail.

The invention discloses a hydration-induced shrinkage medical dressing and a preparation method and application thereof, the design is ingenious, a hydration-induced shrinkage film is adopted as a composite framework of a driving layer and a polyacrylic acid-N-hydroxysuccinimide ester (PAA-NHS ester) adhesion layer, functional modularization and synergism are achieved, and the application range is wide. The hydration-induced shrinkage medical dressing has excellent mechanical properties, intelligent fluid responsiveness and strong wet tissue adhesion, can intelligently respond to wound exudate and spontaneously generate physical shrinkage, can actively promote wound closure, remarkably improves the wound repair effect, and has a good application prospect. And active mechanical closing of the wound surface is realized without external source energy driving.

A wound closure device includes a filamentary element having a proximal end and a distal end, and a plurality of barbs extending outwardly from the filamentary element. Each barb has a base connected with the filamentary element, a tip spaced from the base, and an outer edge that extends between the base and the tip. The outer edge includes a first section having a concave surface that extends between the base and a transition point of the barb and a second section having a convex surface that extends between the transition point of the barb and the tip of the barb. The outer edge transforms from the concave surface of the first section to the convex curve of the second section at the transition point of the barb. The tip of the barb has a convexly curved surface facing the distal end of the filamentary element. The unique dual radius shape of the outer edge of the barbs and the tips of the barbs minimizes resistance when the filamentary element is pulled in a first direction through tissue and maximizes resistance to movement when the filamentary element is pulled in an opposite, second direction through tissue for holding the wound closure device stationary.

The invention provides a copper calcium phosphate nano-enzyme fibroin antibacterial dressing as well as a preparation method and application thereof, and belongs to the technical field of material preparation. CCP HNS nano-enzyme with ascorbic acid oxidase is prepared through a coprecipitation method, nano-enzyme particles with controllable morphology, stable structure and excellent catalytic performance are obtained by regulating and controlling the ratio of copper to calcium and reaction conditions, and then the nano-enzyme particles are uniformly loaded on a natural protein material silk fibroin (SF), so that the nano-enzyme is prepared. The calcium copper phosphate nano-enzyme fibroin antibacterial dressing is obtained; the copper calcium phosphate nano-enzyme fibroin antibacterial dressing has an excellent antibacterial effect, is relatively low in cytotoxicity, maintains good cell viability and shows good biocompatibility; the copper calcium phosphate nano-enzyme fibroin antibacterial dressing has obvious advantages in the aspects of infection control, inflammation relief and tissue regeneration, can greatly shorten the wound closing time, shows good healing promoting ability, and has good practicability.

A wound closure system and a method of reducing the size of an open wound are disclosed. A suture line is sutured through body tissue adjacent an open wound, the suture line sutured so as to pass into the body tissue at an entry point and exit at an exit point, the suture line including a plurality of barbs extending outwardly at an acute angle with respect to a surface of the suture line. A biasing member applies a continuous pulling force on the suture line for stretching the body tissue toward the open wound, wherein the biasing member is configured to take up any slack of the suture line during stretching of the body tissue and keep the suture line taut.