225 results about "Wound closure" patented technology

The invention discloses a polyphenol-based tissue adhesive for promoting wound healing and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the tissue adhesive comprises the following steps: step 1, preparing a polyphenol compound and recombinant mussel mucin into a solution, and uniformly stirring for later use, namely a solution A; 2, preparing a temperature response type high polymer material into a solution for later use, namely a solution B; and 3, mixing the solution A prepared in the step 1 and the solution B prepared in the step 2, fully and uniformly mixing, shaking and centrifuging, and discarding the supernatant. By selecting the temperature response type high polymer material, the tissue adhesive is endowed with the characteristic of temperature sensitivity, so that the modulus of the adhesive at the human body temperature is improved, and the colloid contraction can further promote wound closure. The mussel mucin is introduced to stimulate collagen regeneration of the wound part, activate the immune mechanism and remodel the wound microenvironment so as to achieve the purpose of promoting healing.

The invention relates to the technical field of hydrogel microneedle preparation, in particular to a collagen microneedle patch loaded with copper-based antibacterial nanoparticles and a preparation method and application of the collagen microneedle patch loaded with the copper-based antibacterial nanoparticles. The microneedle patch is prepared from the copper-based antibacterial nanoparticles, recombinant XVII type collagen and sodium alginate; wherein the copper-based antibacterial nano particles are Cu-CpG (at) PDA composite nano particles; the recombinant XVII type collagen protein is rCol XVII; the preparation method of the microneedle patch comprises the following steps: firstly, preparing Cu-CpG (at) PDA nanoparticles from antibacterial copper ions, a nucleic acid immunologic adjuvant CpG oligonucleotide and polydopamine (PDA); then, the Cu-CpG (at) PDA nano-particles are doped into recombinant XVII type collagen (rCol XVII) and sodium alginate, and collagen hydrogel loaded with the Cu-CpG (at) PDA nano-particles is prepared; finally, the hydrogel is laid in a mold, and the collagen microneedle patch loaded with the copper-based antibacterial nanoparticles is prepared after vacuum treatment, centrifugation and drying. The collagen microneedle patch disclosed by the invention has good photo-thermal conversion capacity, antibacterial property and skin regeneration capacity, and can be used for treating bacterial infection and promoting wound closure.

The invention discloses an intelligent bandage integrating wound monitoring, drug administration and electrical stimulation. The intelligent bandage comprises a bandage body, a portable battery, a wound monitoring module, an intelligent drug administration module, an electrical stimulation module and a portable control module. The bandage body is of a double-layer structure, the inner layer is an antibacterial fiber layer, and the outer layer is a breathable waterproof layer. By means of the design, the wound can be kept dry, and external bacteria can be prevented from invading. The bandage body is further provided with a bandage elastic area which is used for adjusting the tightness of the bandage so as to meet the requirements of different wound parts. 3-6 sensors are arranged on the inner surface of the bandage body and used for monitoring key physiological indexes of a wound in real time, and accurate information is provided for treatment. The intelligent drug delivery module adopts a drug-loaded stimuli-responsive electroactive hydrogel fiber array and is arranged on the inner surface of the bandage body, and accurate drug delivery is achieved through a voltage modulation electrode. The electrical stimulation module adopts a pseudo convergence electric field configuration, is arranged on the inner surface of the bandage body, and is switched between the electrical stimulation electrodes through a timing relay so as to alternately push the wound to be closed. The portable battery supplies power to the portable control module, and the portable control module comprises an integrated microprocessor module, a wireless communication module and a lumped power management module and is connected with the intelligent drug delivery module, the wound monitoring module and the electrical stimulation module to achieve remote monitoring and personalized treatment.

The invention belongs to the technical field of biological medicines, and particularly discloses a lignin janus hydrogel patch as well as a preparation method and application thereof. The lignin janus hydrogel patch comprises a substrate layer and a tissue adhesion layer, wherein the substrate layer is pre-stretched, one surface of the substrate layer is subjected to hydroxylation treatment, and the tissue adhesion layer is attached to the hydroxylated surface of the substrate layer through lignin-based hydrogel and is subjected to photo-initiated free radical polymerization; the invention also discloses an application of the lignin janus hydrogel patch in preparation of a patch for promoting soft tissue defect or wound healing. In the lignin janus hydrogel patch disclosed by the invention, the lignin janus hydrogel patch has different adhesion properties, and the adhesion surface has excellent adhesion property, mechanical property and antibacterial property; after contacting with wet tissue of a wound, a strain program can be started to perform mechanical self-constriction, thereby effectively helping the wound to be closed and accelerating the repairing speed.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. A novel platinum catalyst comprising platinum tetramethyldivinyl disiloxane diethyl maleate complex for use in such compositions provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention relates to artificial skin, in particular to self-generating full-layer artificial skin for wound treatment and application of the self-generating full-layer artificial skin. The artificial epidermis has an epidermis-dermis structure similar to skin, and the artificial epidermis structure is composed of an electrostatic spinning nano-film with piezoelectric capacity and has the functions of sterilization, protection and bioelectricity generation of an epidermis layer; the artificial dermal structure is composed of a photo-crosslinking polysaccharide and enzyme crosslinking protein interpenetrating hydrogel skeleton, by adding bioactive components and loading living cells, the effects of releasing active components and cytokines, remodeling wound extracellular matrix and promoting cell proliferation are achieved, and finally healing of acute and chronic wounds is remarkably accelerated. The invention provides a simple, feasible, economical and effective treatment method for sealing a large-area wound, sterilizing the wound and promoting healing of the wound.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The present invention discloses a preparation method of CFS nanozyme. This nanozyme has broad-spectrum bactericidal property, has low toxicity to normal cells, and there is no problem of bacterial drug resistance, and is expected to be used in the field of antibiotic-free sterilization. The CFS-ion-MN wound repair microneedle patch provided by the present invention, as a wound dressing, can transdermally deliver the antibacterial CFS nanozyme to the deep part of the wound, effectively kill bacteria. The CFS nanozyme can also inhibit inflammation in the body through its superoxide dismutase-like activity, promote wound healing, and promote the antibacterial and healing of the wounds of mice infected with Staphylococcus aureus. Among them, Co 2+ and Fe 3+ can inhibit the IL-17 and NF-κB signaling pathways, thereby accelerating wound closure.

A wound management assembly includes a belt configured to partially wrap around the body of a patient in the area of a wound. First and second base members are configured to contact the patient on opposing sides of the wound and to grip opposing end regions of the belt to permit engagement, tensioning and detensioning of the belt relative to the base members. At least one cord is provided for connecting the base members to each other across the wound. The cord is adjustable to increase and decrease the pressure applied to the body of the patient. A pressure monitoring assembly is provided for monitoring the pressure applied to the body of the patient. The pressure monitoring assembly includes a bladder positionable between the at least one cord and the body of the patient, and a pressure gauge for displaying a pressure associated with the bladder.

The invention discloses a laparoscopic surgery suture device, which relates to the technical field of medical instruments, and comprises a shell, a forceps seat arranged at the front end of the shell, a forceps clip assembly arranged on the forceps seat, and a movable handle, a fixed handle and a reset reed which are arranged at the rear end of the shell, the forceps clip assembly comprises a rotating shaft rotationally mounted on the forceps seat, and a first forceps clip arm and a second forceps clip arm which can be relatively rotationally mounted on the rotating shaft; the forceps clip assembly is provided with a squeezing assembly used for squeezing a notch, and the squeezing assembly comprises a driving part which is installed on the arc-shaped outer wall of the first forceps clip arm and the arc-shaped outer wall of the second forceps clip arm in a mirror image mode; and the driven piece is slidably connected to the first forceps clip arm and the second forceps clip arm, and the bottom surface of the driven piece is fixedly connected with a supporting spring. Effective extrusion of an incision can be achieved in the suturing process, the situation that the incision is sutured only through the pulling force of a suture line is avoided, and therefore the wound closing stability and the healing effect are remarkably improved, and tissue damage is reduced.

A skin closure system includes a surgical mesh, a topical skin adhesive, and a strip that may be secured relative to the surgical mesh. The surgical mesh includes an upper side and a lower side, with the lower side capable of adhering to a section of the patient skin that surrounds a wound. The topical skin adhesive can be applied to the upper side of the surgical mesh and cure within the surgical mesh to form a protective layer over the wound. The strip has an elongated body impregnated with an active pharmaceutical ingredient. The strip extends longitudinally along a central portion of the lower side of the elongated mesh and can diffuse the active pharmaceutical integrated toward the wound after the protective layer is formed over the wound.

The present invention provides a preparation process of a wound closure repair component and a stretcher adapter film, which relates to the technical field of medical devices, and includes: a first fixed body and a stretcher adapter component; the first fixed body is used to be fixed on human skin, and a fixing groove is formed between the first fixed body and the human skin; the stretcher adapter component has a wound contact layer, and the stretcher adapter component can be inserted into the fixing groove so that the wound contact layer fits on the human skin wound. By fixing the first fixed body on human skin, the stretcher adapter component is inserted into the fixing groove formed between the first fixed body and the human skin, so that the wound contact layer on the stretcher adapter component is moved to the wound position and covers the human wound position, which alleviates the technical problem that the wound care film in the prior art is difficult to directly care on the skin, and the wound care film can only be covered on the stretcher, which has the risk of infection.

The present invention relates to super-contractible films, super-contractible wound dressings comprising the super-contractible films, methods of forming the super-contractible films, methods of treating wounds comprising steps of applying the super-contractible wound dressings, and uses of the super-contractible wound dressings. The super-shrinkable film comprises an alpha-cyclodextrin crystal domain; and oriented polyethylene oxide crystalline domains physically crosslinked by alpha-cyclodextrin crystalline domains wherein the polyethylene oxide has a number average molecular weight of from 200,000 to 10,000,000 Daltons; and after the super-shrinkable film is wetted by water, the shrinkage of the super-shrinkable film exceeds 50% of the original length of the super-shrinkable film.

The invention discloses a uniformly-stressed wound closer and a mounting device thereof, and belongs to the technical field of medical instruments, the uniformly-stressed wound closer comprises an annular tension reducing paste and further comprises a self-locking closing assembly; a plurality of groups of self-locking closing assemblies are distributed at equal intervals at the upper end of the annular post reduction sticker in a circumferential array; the self-locking closing assembly comprises a movable traction module and a limiting module. The movable traction module and the limiting module are symmetrically distributed on the two sides of the upper end of the annular tension reducing sticker; the device further comprises a fixing disc and a multidirectional synchronous screwing mechanism. And a multidirectional synchronous screwing mechanism is mounted in the fixed disc. By means of the mode, the device can close a round wound on a patient, and the phenomenon that the wound is unevenly closed in the wound healing process is avoided.

A novel integrated wound closure device for laparoscopy having an elongated body with a distal end and proximal end able to-use suture for closing surgical port wounds comprising a single sequential proximal activation means able to operate multiple internal systems sequentially such as: a distal anchoring system, a self-contained tissue piercing system, a suture staging means to position suture suitable for capture at a target zone, and a suture capturing system to capture and retract suture into said piercing system with all system functions configured internally of said elongated body which can be reused multiple times per patient.

1. Name of the designed product: packaging box (wound closure device). 2. Use of the designed product: for packaging products. 3. Design points of the designed product: in the combination of shape and pattern. 4. Picture or photo that best shows the design points: Design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention discloses a negative pressure sealing drainage device, and relates to the technical field of medical instruments, and the negative pressure sealing drainage device comprises an arm band assembly, a liquid storage assembly, a dressing assembly and a drug delivery assembly. The arm band assembly comprises an arm band, elastic binding bands, a control panel, a display screen and a storage battery, and the elastic binding bands are fixed to the upper end and the lower end of the arm band through hook-and-loop fasteners. The liquid storage assembly comprises a liquid storage box, a negative pressure pipe, an overflow floater and a negative pressure pump. The dressing assembly comprises a dressing bottom layer, an annular airbag ring, a polyimide substrate layer, a sensor and a top covering layer, the annular airbag ring is arranged at the bottom of the dressing bottom layer, and the sensor is arranged at the top of the polyimide substrate layer. The medicine delivery assembly comprises three medicine cavities, a conveying pipe, a micro peristaltic pump and a mixing pipe. And the end part of the negative pressure tube penetrates through each layer of the dressing to a wound position. The device is good in sealing effect, capable of monitoring the wound state in real time, capable of achieving independent control delivery of various drugs and convenient to carry.

The utility model relates to the technical field of skin anastomats, and discloses a skin anastomat convenient to position, which comprises a plurality of bottom plates, the bottom plates are arranged at intervals, side bottom plates are arranged on one sides of the bottom plates, movable connecting rods are connected between the two bottom plates and between the two side bottom plates, and the movable connecting rods are connected between the two bottom plates and between the two side bottom plates. An upper plate is fixed to one side of the upper portion of each bottom plate, a side upper plate is fixed to one side of the upper portion of each side bottom plate, and an adjusting mechanism is connected between each side upper plate and the corresponding upper plate. The multiple bottom plates and the multiple side bottom plates are pasted to the two sides of a wound respectively, the distances between the bottom plates and the side bottom plates can be adjusted and stretched through the adjusting mechanisms so that the wound can be closed, the positions between the two bottom plates and the two side bottom plates can be adjusted through the movable connecting rods, and therefore the wound can be closed. Therefore, the skin anastomat can be placed in different shapes, and wounds in different shapes can be conveniently positioned and anastomosed.

The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.

The invention provides an on-demand stripping hydrogel with high biological wet tissue adhesion and a preparation method of the on-demand stripping hydrogel. The hydrogel is obtained by combining a hydrophobic amino acid acrylamide derivative and a hydrophilic monomer with a temperature-sensitive monomer and polymerizing. According to the hydrophobic amino acid vinyl monomer phenylalanine derivative provided by the invention, carboxyl and a benzene ring are in a special structure of the same structural unit, so that a hydration layer of a tissue interface can be effectively damaged, and the strength of a matrix can be enhanced by forming stable multiple hydrogen bonds; and strong adhesion (60kPa) can be realized after the adhesive is contacted with wet biological tissues for 5 seconds. The biocompatibility is good, clinical application is facilitated, and a new choice is provided for replacing surgical suture to achieve wound closure and rapid hemostasis clinically.

The invention discloses gelatin hydrogel containing skin cell component seeds as well as a preparation method and application of the gelatin hydrogel, and belongs to the technical field of biomedicine. The iPSCs are used as raw materials, are differentiated into components with full-thickness skin structures and cells, then are coated with gelatin hydrogel, and are transplanted into SD rat bodies, so that inflammatory cells and inflammatory factors can be reduced, the number of epidermal stem cells is increased, fibroblast expression related to scar formation is reduced, and advanced scar formation can be inhibited. The treatment effect of the method is most obvious on the third day, the size of the wound is obviously smaller than that of a frostbite group, and the wound of a treatment group is completely healed on the seventh day, which shows that wound closure can be accelerated and infection can be reduced after treatment by the method.

A system for performing any of extracorporeal or intracorporeal wound closure, includes a suture cartridge 100 configured to be detachably coupled to a distal end of a handle of the system extracorporeal wound closure, or to a shaft assembly that is coupled to distal end of the handle for intracorporeal wound closure. On being coupled to any of the shaft assembly or the handle, a driving pulley 112A of the cartridge 100 gets operatively coupled to a driving mechanism in the handle to drive a belt 110 of the suture cartridge 100 to drive a suturing needle 106 for suturing tissues for the extracorporeal or intracorporeal wound closure. The cartridge 100 can be coupled with any of a robotic system, a hand held system and a minimal invasive surgical system.

Excess skin removal and wound closure devices, such as blepharoplasty devices and methods, are provided. An exemplary device for resecting excess skin (e.g., eyelid skin) and creating wound closure includes a base, a lever mechanism coupled to the base via a lever pivot, a locking mechanism, an elongated curved first jaw member in fixed relationship with the base and having a lower serrated tissue contact surface, and an elongated curved second jaw member in movable relationship with the base and having an upper serrated tissue contact surface. The upper serrated tissue contact surface of the second jaw member can face toward the lower serrated tissue contact surface of the first jaw member. The locking mechanism can be releasably engagable with the second jaw member. Pivoting movement of the lever mechanism can cause linear movement of the second jaw member relative to the first jaw member.

A surgical incision cover cloth (10) includes a flexible substantially flat area substrate (20) having an upper side (22) and an opposing tissue-facing side having a longitudinal axis (21) and a pressure-sensitive adhesive (40) disposed on the tissue-facing side; at least one hollow microtubular compartment (30) containing a flowable agent (100), the hollow microtubular compartment (30) being positioned to intersect the longitudinal axis (21) and embedded in or positioned on the substrate (20).

The present invention relates to skin adhesive formulations. The skin adhesive formulations of the present invention may be useful in wound-closing applications and other medical applications. Ideally the skin adhesive formulations of the present invention exhibit higher viscosity than known skin adhesive formulations. Ideally the skin adhesive formulations of the present invention cause fewer allergic reactions and skin irritation issues in patients relative to known skin adhesives. Ideally the skin adhesive formulations are UV curable in the visible range of 400-500nm rather than moisture cure.

The invention relates to an integrated dressing change device for pulling out a closed drainage tube, and aims to solve the problems of low breathing matching degree of a patient, poor wound closing effect and the like in the traditional tube pulling operation. The device comprises a dressing change bag, a pair of sterile scissors, tweezers, gauze, a gauze ball, a mouth-nose closed breathing auxiliary mask, elastic tension adhesive tape dressing and a medical garbage bag. The breathing assisting mask forces the patient to hold breath through the air bag and the pressing device, subjective cooperation of the patient is not needed, the tube drawing success rate is remarkably increased, and the breathing assisting mask is particularly suitable for children, old people and other patients with low adaptability. The elastic tension adhesive tape dressing adopts a sterile dressing, an elastic cloth, a non-woven fabric and an adhesive layer structure, and can provide 5-10N transverse tension after being stretched, so that the folding of the edges of the wound is promoted, the seepage is reduced, and the dressing change period is prolonged. By means of the integrated design, the preoperative preparation time is shortened, the operation standardization level is improved, the medical cost is reduced, and the medical efficiency and quality are improved.

Disclosed are adhesive medical films incorporating one or more cationic steroidal antimicrobial (CSA) compounds. The adhesive medical film is in the form of a tape, dressing, or sheet, configured for contact against dermal tissue to provide securement of medical devices, wound care, wound closure, and / or scar prevention. The adhesive medical film includes (i) a polymer adhesive (e.g., pressure-sensitive adhesive) in which one or more CSA compounds are distributed, and (ii) optionally, a backing substrate upon which the polymer adhesive is disposed. Examples of polymer adhesives include polyacrylate and silicone adhesives. The adhesive medical films, when used, reduce microbial colonization and / or growth, both on the films during storage and at a dermal site, as compared to the same adhesive medical film without incorporated CSA compounds.

The application relates to a wound suture device for a neurosurgery drainage tube. The wound suture device for the neurosurgery drainage tube comprises a shell, two sliding units oppositely arranged on the shell and two pushing units oppositely arranged on the shell, each of the sliding units is provided with a clamping unit, and each of the pushing units is provided with a suture unit; the sliding unit comprises an arc-shaped groove arranged on the shell and an extension plate slidably arranged in the arc-shaped groove, the clamping unit is connected with the extension plate, and the extension plate can slide along the arc-shaped groove; the pushing unit comprises a sliding groove arranged on the shell and a suture plate slidably arranged in the sliding groove, the suture unit is connected with the suture plate, and the suture plate can slide along the sliding groove. The scheme provided by the application can timely suture the drainage hole and prevent infection.

This utility model relates to the field of minimally invasive postoperative wound dressing technology, specifically a minimally invasive postoperative wound dressing with wound closure function. It includes an adhesive layer, release paper installed on both sides of the bottom of the adhesive layer, low-sensitivity adhesive tape evenly installed on both sides of the top of the adhesive layer, and a sterilization layer embedded in the middle of the adhesive layer. The improved minimally invasive postoperative wound dressing adds a first elastic band and a second elastic band. When the wound dressing is applied to the wound surface, the first and second elastic bands can be pulled to traction the sides of the adhesive layer, thereby effectively closing the wound, reducing the risk of wound dehiscence, and promoting rapid wound healing. An absorbent layer made of highly absorbent resin is also added, allowing the absorbent layer to quickly absorb tissue fluid exudated from the wound during the healing process, helping to reduce the risk of wound infection and thus promoting wound healing.