188 results about "Wound closure" patented technology

The invention discloses a polyphenol-based tissue adhesive for promoting wound healing and a preparation method thereof, and relates to the technical field of medical tissue adhesives. The preparation method of the tissue adhesive comprises the following steps: step 1, preparing a polyphenol compound and recombinant mussel mucin into a solution, and uniformly stirring for later use, namely a solution A; 2, preparing a temperature response type high polymer material into a solution for later use, namely a solution B; and 3, mixing the solution A prepared in the step 1 and the solution B prepared in the step 2, fully and uniformly mixing, shaking and centrifuging, and discarding the supernatant. By selecting the temperature response type high polymer material, the tissue adhesive is endowed with the characteristic of temperature sensitivity, so that the modulus of the adhesive at the human body temperature is improved, and the colloid contraction can further promote wound closure. The mussel mucin is introduced to stimulate collagen regeneration of the wound part, activate the immune mechanism and remodel the wound microenvironment so as to achieve the purpose of promoting healing.

The invention discloses an intelligent bandage integrating wound monitoring, drug administration and electrical stimulation. The intelligent bandage comprises a bandage body, a portable battery, a wound monitoring module, an intelligent drug administration module, an electrical stimulation module and a portable control module. The bandage body is of a double-layer structure, the inner layer is an antibacterial fiber layer, and the outer layer is a breathable waterproof layer. By means of the design, the wound can be kept dry, and external bacteria can be prevented from invading. The bandage body is further provided with a bandage elastic area which is used for adjusting the tightness of the bandage so as to meet the requirements of different wound parts. 3-6 sensors are arranged on the inner surface of the bandage body and used for monitoring key physiological indexes of a wound in real time, and accurate information is provided for treatment. The intelligent drug delivery module adopts a drug-loaded stimuli-responsive electroactive hydrogel fiber array and is arranged on the inner surface of the bandage body, and accurate drug delivery is achieved through a voltage modulation electrode. The electrical stimulation module adopts a pseudo convergence electric field configuration, is arranged on the inner surface of the bandage body, and is switched between the electrical stimulation electrodes through a timing relay so as to alternately push the wound to be closed. The portable battery supplies power to the portable control module, and the portable control module comprises an integrated microprocessor module, a wireless communication module and a lumped power management module and is connected with the intelligent drug delivery module, the wound monitoring module and the electrical stimulation module to achieve remote monitoring and personalized treatment.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. A novel platinum catalyst comprising platinum tetramethyldivinyl disiloxane diethyl maleate complex for use in such compositions provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention relates to artificial skin, in particular to self-generating full-layer artificial skin for wound treatment and application of the self-generating full-layer artificial skin. The artificial epidermis has an epidermis-dermis structure similar to skin, and the artificial epidermis structure is composed of an electrostatic spinning nano-film with piezoelectric capacity and has the functions of sterilization, protection and bioelectricity generation of an epidermis layer; the artificial dermal structure is composed of a photo-crosslinking polysaccharide and enzyme crosslinking protein interpenetrating hydrogel skeleton, by adding bioactive components and loading living cells, the effects of releasing active components and cytokines, remodeling wound extracellular matrix and promoting cell proliferation are achieved, and finally healing of acute and chronic wounds is remarkably accelerated. The invention provides a simple, feasible, economical and effective treatment method for sealing a large-area wound, sterilizing the wound and promoting healing of the wound.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The present invention discloses a preparation method of CFS nanozyme. This nanozyme has broad-spectrum bactericidal property, has low toxicity to normal cells, and there is no problem of bacterial drug resistance, and is expected to be used in the field of antibiotic-free sterilization. The CFS-ion-MN wound repair microneedle patch provided by the present invention, as a wound dressing, can transdermally deliver the antibacterial CFS nanozyme to the deep part of the wound, effectively kill bacteria. The CFS nanozyme can also inhibit inflammation in the body through its superoxide dismutase-like activity, promote wound healing, and promote the antibacterial and healing of the wounds of mice infected with Staphylococcus aureus. Among them, Co 2+ and Fe 3+ can inhibit the IL-17 and NF-κB signaling pathways, thereby accelerating wound closure.

A wound management assembly includes a belt configured to partially wrap around the body of a patient in the area of a wound. First and second base members are configured to contact the patient on opposing sides of the wound and to grip opposing end regions of the belt to permit engagement, tensioning and detensioning of the belt relative to the base members. At least one cord is provided for connecting the base members to each other across the wound. The cord is adjustable to increase and decrease the pressure applied to the body of the patient. A pressure monitoring assembly is provided for monitoring the pressure applied to the body of the patient. The pressure monitoring assembly includes a bladder positionable between the at least one cord and the body of the patient, and a pressure gauge for displaying a pressure associated with the bladder.

The present invention relates to super-contractible films, super-contractible wound dressings comprising the super-contractible films, methods of forming the super-contractible films, methods of treating wounds comprising steps of applying the super-contractible wound dressings, and uses of the super-contractible wound dressings. The super-shrinkable film comprises an alpha-cyclodextrin crystal domain; and oriented polyethylene oxide crystalline domains physically crosslinked by alpha-cyclodextrin crystalline domains wherein the polyethylene oxide has a number average molecular weight of from 200,000 to 10,000,000 Daltons; and after the super-shrinkable film is wetted by water, the shrinkage of the super-shrinkable film exceeds 50% of the original length of the super-shrinkable film.

The invention discloses a uniformly-stressed wound closer and a mounting device thereof, and belongs to the technical field of medical instruments, the uniformly-stressed wound closer comprises an annular tension reducing paste and further comprises a self-locking closing assembly; a plurality of groups of self-locking closing assemblies are distributed at equal intervals at the upper end of the annular post reduction sticker in a circumferential array; the self-locking closing assembly comprises a movable traction module and a limiting module. The movable traction module and the limiting module are symmetrically distributed on the two sides of the upper end of the annular tension reducing sticker; the device further comprises a fixing disc and a multidirectional synchronous screwing mechanism. And a multidirectional synchronous screwing mechanism is mounted in the fixed disc. By means of the mode, the device can close a round wound on a patient, and the phenomenon that the wound is unevenly closed in the wound healing process is avoided.

A novel integrated wound closure device for laparoscopy having an elongated body with a distal end and proximal end able to-use suture for closing surgical port wounds comprising a single sequential proximal activation means able to operate multiple internal systems sequentially such as: a distal anchoring system, a self-contained tissue piercing system, a suture staging means to position suture suitable for capture at a target zone, and a suture capturing system to capture and retract suture into said piercing system with all system functions configured internally of said elongated body which can be reused multiple times per patient.

1. Name of the designed product: packaging box (wound closure device). 2. Use of the designed product: for packaging products. 3. Design points of the designed product: in the combination of shape and pattern. 4. Picture or photo that best shows the design points: Design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention discloses a negative pressure sealing drainage device, and relates to the technical field of medical instruments, and the negative pressure sealing drainage device comprises an arm band assembly, a liquid storage assembly, a dressing assembly and a drug delivery assembly. The arm band assembly comprises an arm band, elastic binding bands, a control panel, a display screen and a storage battery, and the elastic binding bands are fixed to the upper end and the lower end of the arm band through hook-and-loop fasteners. The liquid storage assembly comprises a liquid storage box, a negative pressure pipe, an overflow floater and a negative pressure pump. The dressing assembly comprises a dressing bottom layer, an annular airbag ring, a polyimide substrate layer, a sensor and a top covering layer, the annular airbag ring is arranged at the bottom of the dressing bottom layer, and the sensor is arranged at the top of the polyimide substrate layer. The medicine delivery assembly comprises three medicine cavities, a conveying pipe, a micro peristaltic pump and a mixing pipe. And the end part of the negative pressure tube penetrates through each layer of the dressing to a wound position. The device is good in sealing effect, capable of monitoring the wound state in real time, capable of achieving independent control delivery of various drugs and convenient to carry.

The utility model relates to the technical field of skin anastomats, and discloses a skin anastomat convenient to position, which comprises a plurality of bottom plates, the bottom plates are arranged at intervals, side bottom plates are arranged on one sides of the bottom plates, movable connecting rods are connected between the two bottom plates and between the two side bottom plates, and the movable connecting rods are connected between the two bottom plates and between the two side bottom plates. An upper plate is fixed to one side of the upper portion of each bottom plate, a side upper plate is fixed to one side of the upper portion of each side bottom plate, and an adjusting mechanism is connected between each side upper plate and the corresponding upper plate. The multiple bottom plates and the multiple side bottom plates are pasted to the two sides of a wound respectively, the distances between the bottom plates and the side bottom plates can be adjusted and stretched through the adjusting mechanisms so that the wound can be closed, the positions between the two bottom plates and the two side bottom plates can be adjusted through the movable connecting rods, and therefore the wound can be closed. Therefore, the skin anastomat can be placed in different shapes, and wounds in different shapes can be conveniently positioned and anastomosed.

The present invention discloses an instant-adhesive strong-tough wet tissue tape and a preparation method thereof. The preparation of the instant-adhesive strong-tough wet tissue tape comprises the following steps: S1, reacting 3,4-dihydroxyphenylacetic acid with glycidyl methacrylate to synthesize 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate; S2, dissolving chitosan in an acrylic acid aqueous solution, then adding 2-(2-(3,4-dihydroxyphenyl)acetoxy)-3-hydroxypropyl methacrylate and a photoinitiator to obtain a mixed solution; S3, applying the mixed solution to the surface of a polymer film treated with a plasma cleaner, and then curing under ultraviolet light to obtain the instant-adhesive strong-tough wet tissue tape. This invention designs and synthesizes novel catechol compounds with long alkyl side chains and uses them to manufacture an instantly adhesive, strong, and resilient wet tissue tape. This tape is thin, flexible, and optically transparent, conforming to various substrates and allowing visual inspection of the substrate's state. Prior to use, the tape is dry and non-sticky, but upon contact with water or blood, it rapidly bonds to wet biological tissue. The tape exhibits exceptionally strong interfacial toughness and adhesion strength to wet biological tissue, far exceeding existing commercial adhesives and some other wet tissue adhesives. Therefore, the instantly adhesive, strong, and resilient wet tissue tape can be used for wound closure and hemostasis.

The invention provides an on-demand stripping hydrogel with high biological wet tissue adhesion and a preparation method of the on-demand stripping hydrogel. The hydrogel is obtained by combining a hydrophobic amino acid acrylamide derivative and a hydrophilic monomer with a temperature-sensitive monomer and polymerizing. According to the hydrophobic amino acid vinyl monomer phenylalanine derivative provided by the invention, carboxyl and a benzene ring are in a special structure of the same structural unit, so that a hydration layer of a tissue interface can be effectively damaged, and the strength of a matrix can be enhanced by forming stable multiple hydrogen bonds; and strong adhesion (60kPa) can be realized after the adhesive is contacted with wet biological tissues for 5 seconds. The biocompatibility is good, clinical application is facilitated, and a new choice is provided for replacing surgical suture to achieve wound closure and rapid hemostasis clinically.

A system for performing any of extracorporeal or intracorporeal wound closure, includes a suture cartridge 100 configured to be detachably coupled to a distal end of a handle of the system extracorporeal wound closure, or to a shaft assembly that is coupled to distal end of the handle for intracorporeal wound closure. On being coupled to any of the shaft assembly or the handle, a driving pulley 112A of the cartridge 100 gets operatively coupled to a driving mechanism in the handle to drive a belt 110 of the suture cartridge 100 to drive a suturing needle 106 for suturing tissues for the extracorporeal or intracorporeal wound closure. The cartridge 100 can be coupled with any of a robotic system, a hand held system and a minimal invasive surgical system.

Excess skin removal and wound closure devices, such as blepharoplasty devices and methods, are provided. An exemplary device for resecting excess skin (e.g., eyelid skin) and creating wound closure includes a base, a lever mechanism coupled to the base via a lever pivot, a locking mechanism, an elongated curved first jaw member in fixed relationship with the base and having a lower serrated tissue contact surface, and an elongated curved second jaw member in movable relationship with the base and having an upper serrated tissue contact surface. The upper serrated tissue contact surface of the second jaw member can face toward the lower serrated tissue contact surface of the first jaw member. The locking mechanism can be releasably engagable with the second jaw member. Pivoting movement of the lever mechanism can cause linear movement of the second jaw member relative to the first jaw member.

The present invention relates to skin adhesive formulations. The skin adhesive formulations of the present invention may be useful in wound-closing applications and other medical applications. Ideally the skin adhesive formulations of the present invention exhibit higher viscosity than known skin adhesive formulations. Ideally the skin adhesive formulations of the present invention cause fewer allergic reactions and skin irritation issues in patients relative to known skin adhesives. Ideally the skin adhesive formulations are UV curable in the visible range of 400-500nm rather than moisture cure.

The invention relates to an integrated dressing change device for pulling out a closed drainage tube, and aims to solve the problems of low breathing matching degree of a patient, poor wound closing effect and the like in the traditional tube pulling operation. The device comprises a dressing change bag, a pair of sterile scissors, tweezers, gauze, a gauze ball, a mouth-nose closed breathing auxiliary mask, elastic tension adhesive tape dressing and a medical garbage bag. The breathing assisting mask forces the patient to hold breath through the air bag and the pressing device, subjective cooperation of the patient is not needed, the tube drawing success rate is remarkably increased, and the breathing assisting mask is particularly suitable for children, old people and other patients with low adaptability. The elastic tension adhesive tape dressing adopts a sterile dressing, an elastic cloth, a non-woven fabric and an adhesive layer structure, and can provide 5-10N transverse tension after being stretched, so that the folding of the edges of the wound is promoted, the seepage is reduced, and the dressing change period is prolonged. By means of the integrated design, the preoperative preparation time is shortened, the operation standardization level is improved, the medical cost is reduced, and the medical efficiency and quality are improved.

Disclosed are adhesive medical films incorporating one or more cationic steroidal antimicrobial (CSA) compounds. The adhesive medical film is in the form of a tape, dressing, or sheet, configured for contact against dermal tissue to provide securement of medical devices, wound care, wound closure, and / or scar prevention. The adhesive medical film includes (i) a polymer adhesive (e.g., pressure-sensitive adhesive) in which one or more CSA compounds are distributed, and (ii) optionally, a backing substrate upon which the polymer adhesive is disposed. Examples of polymer adhesives include polyacrylate and silicone adhesives. The adhesive medical films, when used, reduce microbial colonization and / or growth, both on the films during storage and at a dermal site, as compared to the same adhesive medical film without incorporated CSA compounds.

The application relates to a wound suture device for a neurosurgery drainage tube. The wound suture device for the neurosurgery drainage tube comprises a shell, two sliding units oppositely arranged on the shell and two pushing units oppositely arranged on the shell, each of the sliding units is provided with a clamping unit, and each of the pushing units is provided with a suture unit; the sliding unit comprises an arc-shaped groove arranged on the shell and an extension plate slidably arranged in the arc-shaped groove, the clamping unit is connected with the extension plate, and the extension plate can slide along the arc-shaped groove; the pushing unit comprises a sliding groove arranged on the shell and a suture plate slidably arranged in the sliding groove, the suture unit is connected with the suture plate, and the suture plate can slide along the sliding groove. The scheme provided by the application can timely suture the drainage hole and prevent infection.

This utility model relates to the field of minimally invasive postoperative wound dressing technology, specifically a minimally invasive postoperative wound dressing with wound closure function. It includes an adhesive layer, release paper installed on both sides of the bottom of the adhesive layer, low-sensitivity adhesive tape evenly installed on both sides of the top of the adhesive layer, and a sterilization layer embedded in the middle of the adhesive layer. The improved minimally invasive postoperative wound dressing adds a first elastic band and a second elastic band. When the wound dressing is applied to the wound surface, the first and second elastic bands can be pulled to traction the sides of the adhesive layer, thereby effectively closing the wound, reducing the risk of wound dehiscence, and promoting rapid wound healing. An absorbent layer made of highly absorbent resin is also added, allowing the absorbent layer to quickly absorb tissue fluid exudated from the wound during the healing process, helping to reduce the risk of wound infection and thus promoting wound healing.

Compositions and methods for treatment of burns and other wounds. A unitary product containing all ingredients of the compositions may deliver composition ingredients to a surface of a burn / wound treatment site. The unitary product may include an ointment. The unitary product may include a cream. The unitary product may include a hydrogel. The compositions may include antibiotic ethacridine lactate. The compositions may include metal-containing species. The compositions may include a moisture-modulating agent. The compositions, when applied to the site, may constitute a barrier overlying the surface. The unitary product may deliver the antibiotic onto the surface. The unitary product may deliver the metal-containing species onto the surface. Each of the antibiotic and the metal-containing species may positively modulate wound bed and perilesional cellular processes supportive of healing. Initial testing and use studies have yielded good wound closures, with minimal-to-no scarring and high regain of function of repaired tissues.

The utility model belongs to the field of medical instruments, and discloses a wound closer used after cesarean section, which comprises a fixing plate. The fixing plate is vertically placed, and a sliding groove which is vertically placed downwards is formed in the middle section of any side wall of the fixing plate; a pair of sliding blocks which are symmetrically arranged up and down are clamped in the sliding groove in a sliding mode, a screw which is coaxially arranged is rotationally connected in the sliding groove, the spiral directions of threads, located on the two sides of the symmetrical plane of the two sliding blocks, of the screw are opposite, and the sliding blocks are arranged on the screw in a sleeving mode and are in threaded connection with the screw; horizontal strip-shaped plates are fixed to the ends, away from the fixing plate, of the sliding blocks, medical proof fabric is arranged on the sides, away from the fixing plate, of the strip-shaped plates, and the sides, away from the fixing plate, of the medical proof fabric are used for pasting the abdominal skin of a patient; the two ends of the fixing plate are provided with a pair of symmetrically-arranged bandages in the axis direction of the strip-shaped plate. The two medical adhesive tapes are adhered to the two sides of the wound, and the wound is closed by pulling the two medical adhesive tapes, so that the problem that the skin at the wound is pressed and damaged for a long time when the wound closer is used in the prior art is solved.

A handheld tape applicator device (10) for tape-assisted wound closure for applying an adhesive tape (18) to the skin wherein a mechanical traction force is applied to the skin. The device (10) comprises: a housing (12); a reel (14) having a roll (16) of tape (18); and a tape cutting mechanism (20). A displaceable actuator (36) is pivotally mounted to the housing (12). The driven roller (28) frictionally engages the tape. The actuator includes a toothed pawl (46) that engages a toothed ratchet attached to a driven roller (28) to drive rotation of the roller and thereby dispense the tape. The application of the adhesive tape is initiated by discharging a length of adhesive tape from the device by means of rotation of the drive roller (28). The ratchet is positively engaged by a pawl (46) to provide resistance to tape feed, allowing tape tensioning. For greater traction, the device (10) comprises a brake pad (70) mounted to the actuator (36) for applying a braking force to the roller (28).

The invention belongs to the technical field of biological medicines, and particularly relates to application of human umbilical cord mesenchymal stem cells combined with metformin in preparation of anti-DFU medicines. By constructing a diabetic foot ulcer rat model and combining in-vivo and in-vitro experiments and signal analysis, it is confirmed for the first time that hUC-MSCs and metformin have a synergistic effect in treating diabetic foot ulcer. Combined treatment is beneficial to diabetic foot ulcer wound closure, reepithelization, matrix remodeling and proliferation of blood vessels and inflammation related cells, regulation and control of vascular endothelial cells PI3K-AKT and downstream signal channels thereof can be promoted through paracrine, so that the inhibited survival, proliferation, migration and vascularization capacities of the vascular endothelial cells PI3K-AKT in a hyperglycemia environment are recovered, and the vascular endothelial cells PI3K-AKT and the downstream signal channels of the vascular endothelial cells PI3K-AKT are promoted. Further, the dynamic regulation of enhancement, maturation and weakening of new angiogenesis of the wound of the DFU rat is promoted, and the wound healing is accelerated. The invention provides theoretical basis and experimental support for developing a more effective treatment scheme.

Disclosed herein are systems, devices, kits, and associated methods for excising tissue. A device for excising tissue may include a body, a first curved member coupled to the body and having a first tissue contact surface, a second curved member movable relative to the first curved member and comprising a second tissue contact surface, an actuator coupled to the body and configured to decrease a distance between the first and second curved members, and a cutting assembly configured to excise the tissue. The first tissue contact surface may have a first radius of curvature (ROC), while the second curved member may have a second, smaller ROC. Further, one or portions of the device, such as one or both of the first and second jaws, may be transparent and / or may include markings to facilitate accurate aligning of the device relative to a tissue excision site.

Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The present invention discloses a double-crosslinked hydrogel, which is formed by interweaving two crosslinked networks: poly(N-isopropylacrylamide) formed by free radical polymerization of N-isopropylacrylamide and N,N'-methylenebisacrylamide, and a crosslinked network formed by nucleophilic addition reaction of hyaluronic acid and glutaraldehyde. The double-crosslinked hydrogel of the present invention combines the multiple requirements of accelerating wound closure, promoting wound healing, and having tissue adhesion ability and temperature sensitivity to meet the needs of wound healing.