99 results about "Wound closure" patented technology

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention discloses a uniformly-stressed wound closer and a mounting device thereof, and belongs to the technical field of medical instruments, the uniformly-stressed wound closer comprises an annular tension reducing paste and further comprises a self-locking closing assembly; a plurality of groups of self-locking closing assemblies are distributed at equal intervals at the upper end of the annular post reduction sticker in a circumferential array; the self-locking closing assembly comprises a movable traction module and a limiting module. The movable traction module and the limiting module are symmetrically distributed on the two sides of the upper end of the annular tension reducing sticker; the device further comprises a fixing disc and a multidirectional synchronous screwing mechanism. And a multidirectional synchronous screwing mechanism is mounted in the fixed disc. By means of the mode, the device can close a round wound on a patient, and the phenomenon that the wound is unevenly closed in the wound healing process is avoided.

1. Name of the designed product: packaging box (wound closure device). 2. Use of the designed product: for packaging products. 3. Design points of the designed product: in the combination of shape and pattern. 4. Picture or photo that best shows the design points: Design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention discloses a negative pressure sealing drainage device, and relates to the technical field of medical instruments, and the negative pressure sealing drainage device comprises an arm band assembly, a liquid storage assembly, a dressing assembly and a drug delivery assembly. The arm band assembly comprises an arm band, elastic binding bands, a control panel, a display screen and a storage battery, and the elastic binding bands are fixed to the upper end and the lower end of the arm band through hook-and-loop fasteners. The liquid storage assembly comprises a liquid storage box, a negative pressure pipe, an overflow floater and a negative pressure pump. The dressing assembly comprises a dressing bottom layer, an annular airbag ring, a polyimide substrate layer, a sensor and a top covering layer, the annular airbag ring is arranged at the bottom of the dressing bottom layer, and the sensor is arranged at the top of the polyimide substrate layer. The medicine delivery assembly comprises three medicine cavities, a conveying pipe, a micro peristaltic pump and a mixing pipe. And the end part of the negative pressure tube penetrates through each layer of the dressing to a wound position. The device is good in sealing effect, capable of monitoring the wound state in real time, capable of achieving independent control delivery of various drugs and convenient to carry.

The present invention relates to skin adhesive formulations. The skin adhesive formulations of the present invention may be useful in wound-closing applications and other medical applications. Ideally the skin adhesive formulations of the present invention exhibit higher viscosity than known skin adhesive formulations. Ideally the skin adhesive formulations of the present invention cause fewer allergic reactions and skin irritation issues in patients relative to known skin adhesives. Ideally the skin adhesive formulations are UV curable in the visible range of 400-500nm rather than moisture cure.

Disclosed are adhesive medical films incorporating one or more cationic steroidal antimicrobial (CSA) compounds. The adhesive medical film is in the form of a tape, dressing, or sheet, configured for contact against dermal tissue to provide securement of medical devices, wound care, wound closure, and / or scar prevention. The adhesive medical film includes (i) a polymer adhesive (e.g., pressure-sensitive adhesive) in which one or more CSA compounds are distributed, and (ii) optionally, a backing substrate upon which the polymer adhesive is disposed. Examples of polymer adhesives include polyacrylate and silicone adhesives. The adhesive medical films, when used, reduce microbial colonization and / or growth, both on the films during storage and at a dermal site, as compared to the same adhesive medical film without incorporated CSA compounds.

The application relates to a wound suture device for a neurosurgery drainage tube. The wound suture device for the neurosurgery drainage tube comprises a shell, two sliding units oppositely arranged on the shell and two pushing units oppositely arranged on the shell, each of the sliding units is provided with a clamping unit, and each of the pushing units is provided with a suture unit; the sliding unit comprises an arc-shaped groove arranged on the shell and an extension plate slidably arranged in the arc-shaped groove, the clamping unit is connected with the extension plate, and the extension plate can slide along the arc-shaped groove; the pushing unit comprises a sliding groove arranged on the shell and a suture plate slidably arranged in the sliding groove, the suture unit is connected with the suture plate, and the suture plate can slide along the sliding groove. The scheme provided by the application can timely suture the drainage hole and prevent infection.

This utility model relates to the field of minimally invasive postoperative wound dressing technology, specifically a minimally invasive postoperative wound dressing with wound closure function. It includes an adhesive layer, release paper installed on both sides of the bottom of the adhesive layer, low-sensitivity adhesive tape evenly installed on both sides of the top of the adhesive layer, and a sterilization layer embedded in the middle of the adhesive layer. The improved minimally invasive postoperative wound dressing adds a first elastic band and a second elastic band. When the wound dressing is applied to the wound surface, the first and second elastic bands can be pulled to traction the sides of the adhesive layer, thereby effectively closing the wound, reducing the risk of wound dehiscence, and promoting rapid wound healing. An absorbent layer made of highly absorbent resin is also added, allowing the absorbent layer to quickly absorb tissue fluid exudated from the wound during the healing process, helping to reduce the risk of wound infection and thus promoting wound healing.

A handheld tape applicator device (10) for tape-assisted wound closure for applying an adhesive tape (18) to the skin wherein a mechanical traction force is applied to the skin. The device (10) comprises: a housing (12); a reel (14) having a roll (16) of tape (18); and a tape cutting mechanism (20). A displaceable actuator (36) is pivotally mounted to the housing (12). The driven roller (28) frictionally engages the tape. The actuator includes a toothed pawl (46) that engages a toothed ratchet attached to a driven roller (28) to drive rotation of the roller and thereby dispense the tape. The application of the adhesive tape is initiated by discharging a length of adhesive tape from the device by means of rotation of the drive roller (28). The ratchet is positively engaged by a pawl (46) to provide resistance to tape feed, allowing tape tensioning. For greater traction, the device (10) comprises a brake pad (70) mounted to the actuator (36) for applying a braking force to the roller (28).

Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention discloses a hydrogel dressing containing pearl sac liquid as well as a preparation method and application of the hydrogel dressing, and belongs to the technical field of medical dressings. The hydrogel dressing is prepared by taking polyvinyl alcohol (PVA) and chitosan (CS) as gel matrixes and loading Markov pearl sac liquid through an in-situ crosslinking technology. The hydrogel dressing is of a three-dimensional porous network structure and is excellent in water absorption performance, the mechanical property of the hydrogel dressing meets the wound repairing requirement, the bacteriostasis rate of the hydrogel dressing on common burn pathogenic bacteria such as staphylococcus aureus and pseudomonas aeruginosa exceeds 90%, and the hydrogel dressing is free of obvious cytotoxicity. When being applied to burn infection wounds, the medical dressing can effectively inhibit bacterial proliferation of the wounds, relieve inflammatory response, promote angiogenesis and tissue regeneration and remarkably improve the closure rate of the wounds, solves the problems that existing burn dressings are narrow in antibacterial spectrum, limited in repair promoting capacity and the like, provides a safe and effective novel dressing choice for clinical treatment of burn infection, and has wide application prospects. Meanwhile, the effective utilization of the martensitic pearl sac liquid is realized.

The utility model relates to the technical field of medical equipment, in particular to a skin tension reduction patch which comprises first base cloth and second base cloth, a pull strip is fixed on the first base cloth, a rack box is fixed on the second base cloth, and the pull strip penetrates out of the rack box. Limiting teeth are elastically connected into the rack box and meshed with tooth grooves in the side edges of the brace. Meanwhile, a release mechanism is further arranged on the rack box and connected with the limiting teeth, and when the two fingers of a doctor hook the end, on the first base cloth, of the brace and the end of the release mechanism respectively and apply force to get close to each other, the limiting teeth are pulled through the release mechanism to move to release the meshing state with the brace, and then the brace is released; and after the wound is closed, the release mechanism is released, the limiting teeth can be reset to be meshed with the tooth grooves in the corresponding positions of the pulling strip again, and the wound is kept in a closed state.

The application discloses a kind of fusion polypeptide SynExo for targeted delivery and its engineering exosome preparation method.The fusion polypeptide includes PDGFR beta transmembrane domain (FIASFFLAVVTLLVLLYF), photocontrol cross-linking site 4-azidophenylalanine (AzF) and double-targeting peptide CRGDKGPDC, is connected in series by flexible linker GGGGS, realizes the efficient anchoring, accurate targeting and space-time controllable delivery of exosome.The high hydrophobicity (GRAVY value +2.3) of PDGFR beta transmembrane domain makes its anchoring efficiency increase by 2.7 times, AzF generates azinome intermediate under 365nm light to realize irreversible cross-linking, double-targeting peptide targets integrin αvβ3 and ECM1 by cRGD (Kd=25nM) and KGPDC (Kd=1.2nM) synergistically, and penetration depth reaches 180 μm.Engineering exosome realizes AzF accurate incorporation by lentivirus packaging combined with orthogonal tRNA system, and in diabetic ulcer model, targeted enrichment efficiency reaches 6.8 times of unmodified group, and wound closure rate is 92.5%, which is significantly better than that of control group.The application provides an innovative platform for targeted treatment of diseases such as tumors and diabetic ulcers.

Suture systems, devices, and methods to enhance the precision and efficiency of surgical procedures are disclosed herein. Exemplary sutures are integrated with length indicators along their length, providing surgeons with an immediate visual reference for measuring anatomical distances intra-operatively in open and key hole (e.g. arthroscopic and endoscopic) procedures, tissue dimensions, gauging suture tension, and determining the optimal or desired suture length required for closure. The length indicators, marked at predetermined intervals, allow for accurate measurement without the need for additional tools, thereby streamlining the surgical process and reducing operation time. This suture material is particularly beneficial in complex surgeries where precision is paramount, and can improve patient outcomes by enabling more accurate tissue approximation and wound closure. Exemplary embodiments enable a combination of functionality and convenience, providing a valuable addition to the medical field, particularly in surgical specialties that demand meticulous attention to detail.

The invention discloses a hydration-induced shrinkage medical dressing and a preparation method and application thereof, the design is ingenious, a hydration-induced shrinkage film is adopted as a composite framework of a driving layer and a polyacrylic acid-N-hydroxysuccinimide ester (PAA-NHS ester) adhesion layer, functional modularization and synergism are achieved, and the application range is wide. The hydration-induced shrinkage medical dressing has excellent mechanical properties, intelligent fluid responsiveness and strong wet tissue adhesion, can intelligently respond to wound exudate and spontaneously generate physical shrinkage, can actively promote wound closure, remarkably improves the wound repair effect, and has a good application prospect. And active mechanical closing of the wound surface is realized without external source energy driving.

The invention provides a copper calcium phosphate nano-enzyme fibroin antibacterial dressing as well as a preparation method and application thereof, and belongs to the technical field of material preparation. CCP HNS nano-enzyme with ascorbic acid oxidase is prepared through a coprecipitation method, nano-enzyme particles with controllable morphology, stable structure and excellent catalytic performance are obtained by regulating and controlling the ratio of copper to calcium and reaction conditions, and then the nano-enzyme particles are uniformly loaded on a natural protein material silk fibroin (SF), so that the nano-enzyme is prepared. The calcium copper phosphate nano-enzyme fibroin antibacterial dressing is obtained; the copper calcium phosphate nano-enzyme fibroin antibacterial dressing has an excellent antibacterial effect, is relatively low in cytotoxicity, maintains good cell viability and shows good biocompatibility; the copper calcium phosphate nano-enzyme fibroin antibacterial dressing has obvious advantages in the aspects of infection control, inflammation relief and tissue regeneration, can greatly shorten the wound closing time, shows good healing promoting ability, and has good practicability.

The technology presented herein, in general, relates to the use of biosurfactants, such as rhamnolipids, for the treating wounds. More particularly, the present technology relates to a method for reducing or inhibiting the development of biofilm during to promote wound closure, by applying a composition comprising a mixture of specific rhamnolipids to the wound.

The invention relates to a fusion polypeptide for diabetes wound repair and a pharmaceutical composition thereof, and discloses a sequence design and a preparation method of the fusion polypeptide FP-DW01-Chol, and a temperature-sensitive hydrogel composition containing the polypeptide and MitoQ. The fusion polypeptide contains a TREM2 agonist domain, an AGE-RAGE blocking domain, an MMP9 recognition cleavage site, an Angiopoietin-2 mimic peptide fragment and a cholesterol modification terminal, and can activate anti-inflammatory polarization of macrophages, block a chronic inflammation pathway and respond to a wound enzyme environment to release an angiogenesis promoting fragment. The pharmaceutical composition takes poloxamer 407 / 188 as a temperature-sensitive carrier, realizes cooperative delivery of polypeptide and MitoQ, and has the advantages of slow release, skin retention and stability. In-vitro and db / db mouse model experiments prove that the composition can remarkably promote high-glucose damaged cell activity recovery, inhibit inflammatory factor release, accelerate wound closure, promote angiogenesis and tissue remodeling, provides a multi-mechanism synergistic and local long-acting treatment scheme for diabetic refractory wounds, and has important clinical transformation value.

The invention relates to a wound surface treatment agent and a preparation method thereof, and relates to the technical field of medical instruments, polyvinylpyrrolidone (PVP) is adopted to carry out organic molecule inclusion and stabilization on chlorine dioxide, so that chlorine dioxide keeps a dissolved state and chemical stability in a physiologically compatible weakly alkaline solution, and can be directly used without acidic activation; therefore, chemical stimulation of acid to the wound surface is avoided. When the stable system is in contact with wound exudate, the stable system can gradually release chlorine dioxide molecules with strong oxidation activity under the action of a body fluid ion environment, and a broad-spectrum and efficient antibacterial effect is locally played on a wound. Meanwhile, the released chlorine dioxide can promote the local blood coagulation process through the oxidation effect, and the healing process is facilitated. On the basis, the comprehensive performance is further enhanced through dosage form design, the effects of rapidly astringing wounds, reducing infection and promoting healing are achieved, and meanwhile the skin wound dressing is suitable for nursing skin wounds with different characteristics.

The invention relates to a preparation method of a biodegradable medical suture with gradient mechanical properties, and belongs to the field of medical materials. Adding the polylactic acid suture line into absolute ethyl alcohol for ultrasonic treatment; putting the pretreated polylactic acid suture into a serine protease solution, adding cassia oil and baking soda, sealing, performing constant-temperature oscillation treatment, fully washing with distilled water, airing, and drying; the serine protease surface modified polylactic acid suture line is twisted by using twisting equipment, and the mechanical property of the suture line is adjusted by adjusting the number of twists to form a gradient. According to the biodegradable medical suture with the gradient mechanical property, the high-strength end has the high mechanical property, and wound closure can be effectively maintained; the mechanical property of the low-strength end is low, the degradation rate is gradually increased, and wound healing is promoted.

The application provides a wound suture device, which comprises a suture fixing assembly and a suture tightness adjusting assembly, the suture tightness adjusting assembly comprises a first bottom plate, a locking mechanism and an adjusting rod, the adjusting rod is connected with the suture fixing assembly through a suture, the adjusting rod is adapted to rotate axially along a first direction to make the suture in a tension state and rotate axially along a second direction to make the suture in a slack state. The adjusting rod is locked and unlocked through the locking mechanism, when the wound needs to be closed, the adjusting rod only needs to be rotated axially along the first direction to make the suture in the tension state; when the wound needs to be ventilated, drained, changed or observed, the adjusting rod only needs to be unlocked through the locking mechanism and rotated axially along the second direction to make the suture in the slack state. The wound suture device provided by the embodiment of the application can realize quick closing of a deep and large wound and simultaneously facilitate ventilation, drainage, change or observation of the wound.

A fluid adhesive dispenser device includes a housing having a passageway through the housing and a port at a distal end of the passageway. The dispenser device also includes a container at least partially within the housing configured to contain a single-use amount of the fluid adhesive. The container is configured to be opened allowing the fluid adhesive contained therein to be actively expelled from the container through the passageway and the port of the housing. A method of manufacture of the fluid adhesive dispenser device includes providing the dispenser device filled with the single-use amount of the fluid adhesive and sterilizing the filled device.

Excess skin removal and wound closure devices, such as blepharoplasty devices and methods, are provided. An exemplary device for excising excess skin (e.g. eyelid skin) and creating wound closure includes a base, a lever mechanism coupled with the base via a lever pivot, a locking mechanism, an elongate curved first jaw member in fixed relationship with the base and having a lower serrated tissue contacting surface, an elongate curved second jaw member in movable relationship with the base and having an upper serrated tissue contacting surface. The upper serrated tissue contacting surface of the second jaw member can face toward the lower serrated tissue contacting surface of the first jaw member. The locking mechanism can be releasably engageable with the second jaw member. The pivoting actuation of the lever mechanism can cause linear movement of the second jaw member relative to the first jaw member.

A wound closure treatment system includes a dressing member having an at least partially hard or rigid body, the body having a base portion and one or more wings extending upwardly from the base portion. The base portion has a top surface and a bottom surface. The dressing member is positionable atop a wound to be closed in a pressure application configuration where the bottom surface is adapted to apply pressure to the wound to help stop bleeding of the wound. The dressing member is also positionable atop the wound to be closed in a protection configuration where the top surface faces the wound in a manner where the dressing member protects the wound during healing. In one version, the wings are bendable relative to the base portion to cause the base portion to apply pressure to the wound. A method of using the wound closure treatment system is also disclosed.

This invention discloses an ultrasonic-responsive modular acoustic printing ink, a printing platform, and their applications, relating to the fields of biomedical engineering and biomanufacturing. The ultrasonic-responsive element of this invention is a hollow nanocage composed of fluorinated silk fibroin, and the critical response sound pressure can be set by adjusting the degree of fluorination. The modular acoustic printing ink includes this ultrasonic-responsive element, a biopolymer prepolymer matrix, and optional functional additives. The printing platform integrates a focused ultrasonic transducer, an ink application device, an ultrasonic imaging module, and a control system. This invention uses an ultrasonic triggering method, breaking through the depth limitations of traditional photopolymer printing, to achieve minimally invasive in-situ printing of subcutaneous tissues several centimeters deep. It also features high spatiotemporal resolution, good biocompatibility, and mechanical adaptability, and can flexibly realize functions such as conductivity and drug loading. It is suitable for scenarios such as bioelectrode preparation, visceral wound closure, and controlled drug release, providing a new tool for precision medicine.

This invention provides a stem cell preparation for skin repair and its application, belonging to the field of biomedical technology. The stem cell preparation is obtained by inducing stem cells in a composite culture medium containing sodium butyrate, L-carnosine, and quercetin, followed by short-term pulsed hypoxia treatment, ultrasonic disruption, deep freeze-thaw rehydration, and vacuum freeze-drying to obtain a lyophilized stem cell powder. Experimental results show that the stem cell preparation of this invention significantly promotes the proliferation of human skin fibroblasts and significantly promotes the migration of human keratinocytes. In a mouse full-thickness skin defect model, local application after reconstitution in PBS buffer containing 0.1% sodium hyaluronate (concentration ≥100 μg / mL) significantly accelerates wound closure. In summary, the preparation of this invention exhibits high activity, strong stability, and broad prospects for clinical translation.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2 -5 minutes.

Suture systems, devices, and methods to enhance the precision and efficiency of surgical procedures are disclosed herein. Exemplary sutures are integrated with length indicators along their length, providing surgeons with an immediate visual reference for measuring anatomical distances intra-operatively in open and key hole (e.g. arthroscopic and endoscopic) procedures, tissue dimensions, gauging suture tension, and determining the optimal or desired suture length required for closure. The length indicators, marked at predetermined intervals, allow for accurate measurement without the need for additional tools, thereby streamlining the surgical process and reducing operation time. This suture material is particularly beneficial in complex surgeries where precision is paramount, and can improve patient outcomes by enabling more accurate tissue approximation and wound closure. Exemplary embodiments enable a combination of functionality and convenience, providing a valuable addition to the medical field, particularly in surgical specialties that demand meticulous attention to detail.

The present invention relates to a pharmaceutical composition comprising a supernatant of a peripheral blood mononuclear cell (PBMC) culture for use in the treatment of a wound and / or for promoting wound healing or wound closure, wherein the composition applied topically per cm2 wound area comprises the components present in 1 ml of the supernatant, which is obtainable by cultivating PBMCs in a culture medium at a concentration of 20x106 to 50x106 PBMCs / ml culture medium for at least 4 h, wherein the PBMCs are subjected to ionizing radiation at a dose of at least 10 Gy before or during cultivation.