370results about How to "Controlled release rate" patented technology

A sustained-release composition containing a hydroxynaphthoic acid salt of a biologically active substance and a biodegradable polymer, a method of its production, and a pharmaceutical composition containing said sustained-release composition.

The invention relates to sutures and surgical staples useful in anastomoses. Various aspects of the invention include wound closure devices that use amphiphilic copolymer or parylene coatings to control the release rate of an agent, such as a drug or a biological material, polymerizing a solution containing monomers and the agent to form a coating, using multiple cycles of swelling a polymer with a solvent-agent solution to increase loading, microparticles carrying the agent, biodegradable surgical articles with amphiphilic copolymer coatings, and sutures or surgical staples the deliver a drug selected from the group consisting of triazolopyrimidine, paclitaxol, sirolimus, derivatives thereof, and analogs thereof to a wound site.

One aspect of the invention relates to a graft, a surface of which is coated with an amphiphilic block copolymer that includes both hydrophobic and hydrophilic polymer chains. An amphiphilic block copolymer coating according to the invention can serve as a carrier for a very broad range of drugs, possibly including every drug presently used, being considered for use, or likely to be used in the future to inhibit stenosis. The release rates of the drugs can be controlled, for example, through the length of the polymer chains, through their ratio, or through the degree of cross-linking.

This invention relates to novel calcium phosphate-coated implantable medical devices and processes of making same. The calcium-phosphate coatings are designed to minimize the immune response to the implant (e.g. restenosis in stenting procedures) and can be used to store and release a medicinally active agent in a controlled manner. Such coatings can be applied to any implantable medical devices and are useful for a number of medical procedures including (but not limited to) balloon angioplasty in cardiovascular stenting, ureteral stenting and catheterisation. The calcium phosphate coatings can be applied to a substrate as one or more coatings by a sol-gel deposition process, an aerosol-gel deposition process, a biomimetic deposition process, a calcium phosphate cement deposition process, an electro-phoretic deposition process or an electrochemical deposition process. The coating can contain and elude a drug in an engineered manner.

Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed.

The invention relates generally to a medical device, such as an intravascular stent, for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. More particularly, the invention pertains to a medical device having a metal oxide or metal material with a plurality of pores therein disposed on the surface of the medical device and a polymer disposed on the metal oxide or metal material. The invention also relates to medical devices having a surface and an outer region comprising a metal oxide or metal material having a plurality of pores therein and a polymer disposed on the metal oxide or metal material.

A wiper having a controlled release anti-microbial agent therein for providing anti-microbial cleansing of surfaces is provided. The wiper is formed from an absorbent base web to which an anti-microbial formulation is adhered. The formulation includes an anti-microbial agent that is capable of being controllably released from the wiper. In some embodiments, a polymer mixture may be employed to control the rate of release of the anti-microbial agent. Various anti-microbial agents, such as metal ions and organic compounds may be employed.

The present invention relates to a product for at least one of medicinal, cosmetic, coloring or dermatologic use. The product comprises a fibrous plant product and a plant extract which is applied thereto. Further, the invention relates to a corresponding method for producing said product and its use in at least one of medicinal, cosmetic, coloring or dermatologic products or applications or treatments. The plants used may be all plants comprising one or more substances of interest to achieve a desired medicinal, cosmetic, coloring or dermatologic effect.

The invention provides a granular pesticide fertilizer, and a preparation method and application thereof. The granular pesticide fertilizer comprises the following components expressed in mass percent: on the basis that the total mass of the granular pesticide fertilizer is 100%, 0.001 to 20% of a pesticide active component, 70 to 99% of a granular fertilizer carrier, 0.05 to 9% of an organic solvent, 0.05 to 0.5% of a surfactant and 0.05 to 0.5% of a coating agent. According to embodiments in the invention, the pesticide active component and the granular fertilizer carrier in the granular pesticide fertilizer are reasonably combined, which allows the problem of damage by diseases and insects to soil in agricultural production to be effectively overcome and enables soil fertility to be improved and labor and time to be saved. The granular pesticide fertilizer is produced by using a normal temperature spraying adsorption process and a cladding process, so the preparation method for the granular pesticide fertilizer has the advantages of a simple process, low energy consumption, reduction in production cost, easiness in controlling and operating and suitability for industrial production.

The present invention relates to a biodegradable polymeric nanocapsule composition, adaptable for encapsulation of an agent of therapeutic interest for enhancing the in vivo circulation time of thereof and uses thereof.

The present invention provides a composition controlling a pH range of release and/or a release rate, which contains (i) a thienotriazolodiazepine compound of the formula (I)

and (ii) at least one kind of ingredient selected from the group consisting of a water-soluble polymer, an enteric polymer, a water-insoluble polymer and a porous polymer and/or a surfactant, as well as a production method thereof.

The present invention relates to a controlled delivery system that can be incorporated in liquid, as well as, dry granular, or powder, household products, such as dishwashing detergents, surface cleaners, deodorizers, animal litters and cleaning wipes The system also prolongs the release rate of the active agents over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance “burst” upon heat treatment. The controlled delivery system of the present invention is a nano-sphere, having an average sphere diameter of from about 0.01 microns to about 10 microns. The nano-sphere comprises hydrophobic materials, cationic conditioning agent or, cationic conditioning agent in conjunction with a cationic charge booster to assist in adhering the spheres onto a surface.

The present invention relates to an edible product, which comprises a fibrous plant product and a plant extract applied thereto. Further, the invention relates to a corresponding method for producing said edible product and its use in at least one of food, food supplement, medicinal, cosmetic, well-being, nutraceutical or phytotherapeutical applications. The plants used may be all plants comprising one or more substances of interest for an edible product.

The invention discloses a kernel-shell structural nanofiber membrane, a preparation method thereof and an application; the preparation method includes steps of (1), preparation of spinning; dissolving sodium alginate, polyoxyethylene and poloxamer F127 in distilled water, stirring evenly and acquiring shell layer spinning solution; mixing the chitosan nanoparticle solution loaded with active matters with polyving akohol solution evenly, and acquiring the kernel layer spinning solution; (2), coaxial electrostatic spinning: respectively injecting the shell layer spinning fluid and kernel layer spinning fluid in a static spinning device containing a coaxial needle, performing the coaxial electrostatic spinning under room temperature, performing solvent evaporation in the spinning process, and acquiring the kernel-shell structural nanofiber membrane loaded with the nanoparticle. The preparation method is simple in operation and gentle in reaction condition and can well control the slow release of the active matter; moreover, the prepared colon targeting controlled release system has obvious colon targeting property, thereby improving the utilization degree of the active matter. The colon targeting controlled release system can be applied to functional food domain.

The bed bug trap has a base, and a lid sealable against the base but leaving a gap in at least a portion around the periphery between the base and the lid. The base has a recess therein containing a glue pad, preferably on a removable and replaceable tray. The outer portion of the base is sufficiently textured for a bed bug to be able to climb into and enter the trap through the gap. A carbon dioxide generator is connectable to the trap. A heat pad may be clipped to the trap. A travel kit includes the bed bug trap and other items which may include the carbon dioxide generator, the heat pack, and other accessories.

The invention discloses a hepatic targeted temperature sensitive microsphere and a preparation method therefor, and belongs to the functional polymer material field, and especially relates to a drug sustained release and targeted drug delivery material and a preparation method therefor. The temperature response range of the material is 25 DEG C-37 DEG C, and the particle size of the microsphere is about 500nm. The microsphere can be prepared through the following method: glycyrrhetinic acid (GA) is modified by ethylene diamine and acrylic acid (AAc) and vinyl monomers are generated; ammonium persulfate (APS) is employed as an initiator, N,N-methylene bisacrylamide (MBA) is employed as a cross-linking agent, hepatic targeted temperature sensitive microspheres are prepared through a semicontinuous soap-free emulsion polymerization method. The preparation method has simple technological processes, and mild experiment conditions, needs no special devices, has a low investment cost, and has good operability. The reagents are all common reagents. The reaction residues are easy to remove. The preparation method is convenient for industrial implementation.

The invention discloses pH-responsive comb-like copolymer and preparation and application thereof. The preparation includes obtaining pH-responsive group by ARGETATRP (activator regeneration by electron transfer and atomic transfer radical polymerization), obtaining hydrophobic group by ROP (ring opening polymerization), using the pH-responsive group and the hydrophobic group to form block copolymer, using the block copolymer as macroinitiator to initiate ARGETATRP of hydrophobic macromers, and obtaining the pH-responsive amphipathic comb-like copolymer by selective hydrolysis reaction. The proportion of functional groups in the polymer molecule is easy to regulate. The synthetic process is simple, and yield is high. The hydrophobic group and the pH-responsive group obtained by dialysis form polymeric micelles of a shell, drug slightly soluble in water can be entrapped in a core of the polymeric micelles, the drug is kept to release slowly in the presence of gastric juice, and the drug is quickly and controllably released in intestines.

Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

Pharmaceutical compositions and methods of using the composition are provided. The pharmaceutical composition comprises an inert core surrounded by an active coating containing one or more bisphosphonic acids or salts thereof, a seal coating surrounding the active coating and an enteric coating surrounding the seal coating. Alendronic acid and alendronate sodium trihydrate are the preferred active ingredients. The composition may be provided in the form of pellets in a capsule or Peltabs. The invention further provides methods for the treatment of disorders caused by the abnormal dissolution or deposition of calcium salts using the inventive compositions.