74 results about "Ertapenem" patented technology

The invention discloses a method for preparing ertapenem in a non-palladium system. A docking reaction occurs under the action of ertapenem to generate protected ertapenem; 2) Add zinc powder as a reducing agent to remove the protecting group at pH=3.0-6.5; 3) Extract the ertapenem solution and crystallize to obtain Ertapenem. The method has relatively mild reaction conditions, is easy to operate, does not involve heavy metals in the whole process, and the product can be crystallized and separated out in post-treatment, with high purity.

The invention provides a preparation method of an ertapenem intermediate or pharmaceutically acceptable salts thereof. The method provided by the invention comprises the following steps: carrying out condensation reaction on ertapenem side chain dimer or pharmaceutically acceptable salts thereof and carbapenem mother nuclide in the presence of a compound R3P and alkali to prepare the ertapenem intermediate or pharmaceutically acceptable salts thereof. The preparation method provided by the invention has the advantages of high reaction activity and high speed, can shorten the working hours and lower the cost in industrial production, and avoids using the ertapenem side chain ES', which can easily absorb moisture, can be easily oxidized and can not be easily preserved due to unstable properties, thereby being beneficial to industrial production.

The invention relates to an ertapenem purification method, which comprises the following steps: dissolving a crude product of ertapenem by water; using a chromatographic column adopting a porous polystyrene copolymer resin as a separation filler to carry out adsorption; carrying out eluting by using phosphate buffers with different organic phase ratios; and carrying out post treatment on the obtained eluent to obtain an ertapenem purified product. The method has simple operation and high product purity and yield and is suitable for industrial products.

The invention relates to an ertapenem derivative which contains heter-thioureido sulfhydryl pyrrolidine, the ester which is easy to be hydrolyzed, the salt acceptable in pharmacy, the isomer thereof, the hydrate thereof and the hydrate of ester or salt thereof shown in the formula (I) and a preparing method of the compound shown in the formula (I). The compounds are used as active materials, in particular to be used for preparing the medicine for curing or preventing infectious diseases and to be used as a drug combination containing the compound shown in the formula (I). In the formula (I), the definitions of R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, and n are elaborately described in an introduction.

The invention relates to the technical field of clinical microorganism bacterial detection, in particular to a method for simultaneously classifying and detecting carbapenemase, AmpC enzyme and extended-spectrum beta-lactamase. The method includes the steps that antibiotic test paper and EDTA test paper are selected for use, detected drug-resistant to-be-detected bacteria are prepared into a 0.5 McFarland unit bacterium suspension and evenly smeared to the surface of an M-H plate, the test paper containing EDTA is placed in the center of the surface of the M-H plate coated with the to-be-detected bacteria, ceftazidime (CAZ) antibiotic test paper, ertapenem (ETP) antibiotic test paper, piperacillin / tazobactam (TZP) antibiotic test paper, ceftazidime / clavulanic acid (CAZ / CLAV) antibiotic test paper, imipenem (IMP) antibiotic test paper, and cefoxitin (FOX) antibiotic test paper are attached around the EDTA test paper, gaps are reserved between the EDTA test paper and other antibiotic test paper and between every two pieces of antibiotic test paper, incubation is conducted for 16-18 h at 35 DEG C, and antibacterial zone diameters of the EDTA test paper and other antibiotic test paper are observed and recorded respectively. Cost is low, the detection rate is high, and application and popularization in a clinical laboratory are easy.

The invention discloses a dual-protection ertapenem crystal and a preparation method thereof. The dual-protection ertapenem crystal has a powder X-ray diffraction spectrogram shown as a Figure 1 and is prepared according to the following steps of: firstly, performing condensation reaction of carbapenems mother nucleus MAP and an ertapenem side chain, pouring a reaction liquid into a mixed solvent which is prepared from a buffer solution with a pH value of 4 to 6 and an ester solvent after reaction, extracting and layering; and secondly, adding the buffer solution into an organic layer for washing; and finally, drying the organic layer by using anhydrous sodium sulfate, filtering, stirring and crystallizing at the temperature of 0 to 30 DEG C, filtering, washing a filter cake, and performing vacuum drying. The dual-protection ertapenem crystal provided by the invention is high in stability and purity, and establishes a foundation and provides a guarantee for subsequent preparation of high-purity and stable-quality ertapenem. Moreover, the preparation method is simple, is easy for realizing mass production, meets industrial production requirement and has practical and promotional values, and raw materials are cheap and readily available.

Intermediates of Ertapenem of formula 2a wherein Np represents (I) or (II), and P1 and P2 represent carboxyl protecting groups, and their preparation methods. Compound 2a prepared by the present methods in solid form is amorphous. The present invention also relates to a composition comprising at least 95% of the intermediate of Ertapenem of formula 2a.