Penem derivative containing sulfhydryl nitrogen heterocyclic ring and vinyl nitrogen heterocyclic ring

Abstract

The invention belongs to the technical field of medicine, and more particularly relates to ertapenem derivatives which are shown in general formula (I) and contain hydrosulphonyl nitrogen heterocyclic ring ethylene azacyclonol, salt which can be accepted by the derivatives on pharmacy, ester of the derivatives that is easy to hydrolyze, and isomer of the derivatives; wherein, R1, R2, R3, R4, m, n and are defined as instruction; the invention also relates to a method used for preparing the compounds, medicine combinations containing the compounds, and the application of the compounds in the preparation of the medicine for treating and / or preventing infectious diseases.

Description

1. Technical field The present invention belongs to the technical field of medicine, and in particular relates to penem derivatives containing mercapto nitrogen heterocycles vinyl nitrogen heterocycles, pharmaceutically acceptable salts thereof, easily hydrolyzed esters thereof, isomers thereof, and methods for preparing these compounds. A pharmaceutical composition containing these compounds, and the use of these compounds in the preparation of medicines for treating and / or preventing infectious diseases. 2. Background technology Penem antibiotics are new broad-spectrum, enzyme-resistant, highly efficient β-lactam antibiotics developed in the 1970s. Its structural feature is that the sulfur at the 1-position of the penicillane core is replaced by carbon, and the 2-position has a double bond, which combines the five-membered ring of penicillin and the conjugated double bond of cephalosporin to activate the β-lactam ring. At present, such drugs that have been marketed includ...

AI Technical Summary

Problems solved by technology

Due to the excessive amount of penem antibiotics currently used in clinical practice, bacterial resistance is increasing continuously, and at the same time, due to the limitation of injection administration, it can no longer meet the clinical needs