1508 results about "Lactam" patented technology

The invention discloses a green phosphorus-free and nitrogen-free corrosion and scale inhibitor, and relates to the technical field of energy-saving and environment-friendly water treatment agents. The corrosion and scale inhibitor is prepared from polyaspartic acid, hydrolytic polymaleic acid, acrylic acid / hydroxypropyl acrylate copolymer, polyepoxysuccinic acid, delta-valerolactam, sodium borate, zinc sulfate heptahydrate and benzotriazole according to a specific proportion. The preparation method comprises the following steps: preparing the modified polyaspartic acid, adding other components, mixing the modified polyaspartic acid and other components, adjusting the pH value, homogenizing, filtering, filling and the like. The corrosion and scale inhibitor has excellent corrosion and scale inhibition performance, the corrosion inhibition efficiency of the corrosion and scale inhibitor reaches up to 88.6%, and the scale inhibition rate ranges from 90.5% to 92.4%. Compared with a contrast agent, the efficient corrosion and scale inhibition performance is provided, meanwhile, the water treatment agent has the advantages of being environmentally friendly, economical and the like, and is a green water treatment agent with great application prospects.

The invention discloses an antibacterial nylon material as well as a preparation method and application thereof, relates to the technical field of antibacterial high polymer materials, and solves the problems of poor antibacterial performance and difficulty in industrial production of existing antibacterial nylon 6. The preparation method comprises the following steps: mixing a seven-membered cyclic lysine derivative monomer with lactam, and carrying out hydrolytic polymerization by taking water as an initiator to obtain copolyamide; and placing the copolyamide in an acid solution, heating and stirring to carry out protonation reaction, and purifying the reaction product to obtain the antibacterial nylon material. The seven-membered cyclic lysine derivative monomer is an unprotected cyclic lysine monomer (aminocaprolactam), a single protected cyclic lysine monomer or a salified cyclic lysine monomer. The method can be widely applied to the fields with antibacterial requirements, such as fabrics, plates, pipes, packaging and various panels.

The invention discloses a flame-retardant nylon material as well as a preparation method and application thereof, relates to the technical field of flame-retardant high polymer materials, and solves the problems that a flame-retardant nylon material prepared by a blending method is unstable in flame-retardant effect and a flame-retardant nylon material prepared by a copolymerization method is complex in process. The preparation method comprises the following steps: carrying out ring-opening copolymerization on a seven-membered ring lysine derivative monomer formed by ring formation of lysine and other lactam monomers to obtain copolyamide with a functional group on a side chain, and reacting a reagent containing a flame-retardant group with the functional group to prepare the flame-retardant nylon material. The flame-retardant nylon material prepared by the invention can effectively avoid migration and loss of the flame retardant, improve the dispersity of the flame retardant and enhance the flame-retardant effect. Meanwhile, a renewable lysine resource is used for partially replacing a petroleum resource, so that the method has the advantages of resource conservation, environmental friendliness, simple process, low production cost and the like. The flame-retardant nylon material disclosed by the invention has lasting and stable flame-retardant performance and can be widely applied to the fields of automobiles, textiles, electronics and electricity, buildings, packaging and the like.

The invention provides a preparation method of a nylon elastomer with good dyeing property, antibacterial property and antistatic property. The preparation method comprises the following steps: S1, preparing a dicarboxyl-terminated nylon hard segment from binary acid, diamine or lactam and an end-capping reagent; s2, reacting the dicarboxyl-terminated nylon hard segment with polyether polyol to generate a dicarboxyl-terminated nylon elastomer with a certain molecular weight; s3, reacting the double-carboxyl-terminated nylon elastomer with the double-amino-terminated aminoguanidine compound to generate a double-amino-terminated nylon elastomer with a guanidyl group; and S4, dipping the double-amino-terminated nylon elastomer with the guanidyl group by using an anionic antistatic agent solution. The novel nylon elastomer prepared by the invention has higher molecular weight, the dyeing property of the novel nylon elastomer is favorably improved by diamino-terminated end, guanidyl is introduced in a copolymerization manner, so that the novel nylon elastomer has good antibacterial property, and meanwhile, the guanidyl is combined with the anionic antistatic agent through an ionic bond, so that the nylon elastomer has firmer antistatic property.

Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

The present invention relates to a process for producing ε-caprolactam by depolymerization of polycaprolactam (PA6), which comprises: a. contacting a composite material comprising PA6 and at least one fibrous reinforcement with a solvent comprising at least one polyol at a temperature in the range of 130°C to 200°C, thereby obtaining a solution comprising solubilized PA6 and an insoluble fraction comprising at least said fibrous reinforcement; b. separating the insoluble fraction from the solution; c. combining the solution with a coagulation liquid comprising water to obtain coagulated partially depolymerized PA6 dispersed in a liquid phase; d. separating the solidified PA6 from the liquid phase; e. subjecting the coagulated PA6 separated in phase d to further depolymerization by hydrolysis to obtain ε-caprolactam; Includes.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

The present invention relates to the field of oilfield chemical drilling fluid treatment agents, and disclosed are a chitosan graft copolymer, a preparation method therefor, and a drilling fluid. The chitosan graft copolymer has a structure as shown in formula (I), the number average molecular weight is 200,000-600,000, m is 1,200-3,500, and X and Z are each independently H, -R1COOM1 or a polymer segment; R1 is an alkylene group of C1-C5, and M1 is H, Na or K; the polymer segment comprises a structural unit A and a structural unit B, the structural unit A comprising at least two -COOM2, M2 being H, Na or K, the structural unit B comprising a cyclic lactam structure, and Y being H or a quaternary ammonium salt structure having an ester group. The chitosan graft copolymer provided by the present invention has good wall-fixing performance and filtration loss reduction performance, thereby ensuring well wall stability in easily collapsed formations in shale fracture zones by means of both wall-fixing and reducing filtrate infiltration.

The invention relates to the technical field of drilling fluids, and discloses a 240 DEG C saturated salt resistant high-density environment-friendly polymer water-based drilling fluid as well as a preparation method and application thereof. The water-based drilling fluid contains a micro-crosslinked heterocyclic polymer filtrate reducer, a hyperbranched strong-adsorption filtrate reducer, a nano-intercalation composite shear strength improving agent, a microsphere blocking agent with soft outside and rigid inside and water, and the micro-crosslinked heterocyclic polymer filtrate reducer is prepared from sodium p-styrenesulfonate, N, N, N-trimethyl-3-(2-methylallylamido)-1-propylammonium chloride, N, N, N-trimethyl-3-(2-methylallylamido)-1-propylammonium chloride, N, N, N-trimethyl-3-(2-methylallylamido)-1-propylammonium chloride and water. The polymer is prepared from N, N-diethylacrylamide, N-vinyl caprolactam, tetramethylethylenediamine and phenyltriethoxysilane through a reaction. The 240 DEG C saturated salt resistant high-density environment-friendly polymer water-based drilling fluid disclosed by the invention can show good performance under high-temperature and high-salt conditions, is good in weighting capability, and can meet the requirements of deep oil and gas formation drilling.

The invention relates to the field of oilfield chemical drilling fluid treatment agents, and discloses a chitosan grafted copolymer, a preparation method thereof and a drilling fluid, the chitosan grafted copolymer has a structure as shown in formula (I), and the number-average molecular weight is 200000-600000; m is 1200 to 3500, and X and Z are respectively and independently H or-R1COOM1 or a polymeric chain segment; wherein R1 is alkylene of C1-C5, and M1 is H, Na or K; the polymeric chain segment contains a structural unit A and a structural unit B, the structural unit A contains at least two-COOM2, M2 is H, Na or K, and the structural unit B contains a cyclic lactam structure; y is H or a quaternary ammonium salt structure with an ester group. The chitosan grafted copolymer provided by the invention has relatively good wall fixing performance and filtrate loss reduction performance, and ensures well wall stability of easy-to-collapse stratum of shale fracture zone from two aspects of wall fixing and filtrate invasion reduction, # imgabs0 #

The invention relates to the technical field of antibacterial high polymer materials, in particular to an antibacterial nylon material as well as a preparation method and application thereof. The method comprises the following steps: carrying out anion ring-opening copolymerization on a seven-membered ring lysine monomer obtained by ring formation of lysine and a lactam monomer to obtain copolyamide, dissolving the copolyamide, and carrying out complete quaternization reaction by using halogenated hydrocarbon to obtain the antibacterial nylon material. The preparation method provided by the invention effectively avoids the problems of insufficient antibacterial property, obvious mechanical property reduction, poor thermal stability and the like of an antibacterial nylon material prepared by hydrochloric acid protonation in the prior art. Meanwhile, the seven-membered cyclic lysine monomer can be copolymerized without alkylation, the synthesis process is greatly simplified, the production efficiency is high, and the production cost is low. The prepared antibacterial nylon material has the characteristics of lasting and efficient antibacterial performance, high safety, environment friendliness, excellent mechanical property and thermal stability and the like, and can be widely applied to the fields of textiles, daily necessities, packaging materials, panels and the like.

The invention discloses flame-retardant anti-fouling copolymer nylon 6 and a preparation method and application thereof, and the preparation method comprises the following steps: adding a phosphorus-containing flame-retardant monomer, a silicon-containing reaction monomer, lactam, an initiator and a catalyst into a polymerization reaction kettle, and introducing nitrogen to replace air in the kettle; under the protection of nitrogen, firstly raising the temperature to 180-220 DEG C to carry out prepolymerization reaction, and then raising the temperature to 240-260 DEG C to carry out polymerization reaction; and after the polymerization reaction, removing water vapor in the system to react in a normal pressure state, then vacuumizing to react, filling nitrogen to recover to normal pressure after the reaction is finished, and discharging and cooling to obtain the flame-retardant and anti-fouling copolymer nylon 6. The phosphorus-containing comonomer and the silicon-containing comonomer are introduced into the copolymerized nylon, the intrinsic flame-retardant nylon material with high flame-retardant efficiency and permanent flame retardance is prepared through melt copolymerization at a relatively low introduction amount, and the intrinsic flame-retardant nylon material has certain hydrophobic and anti-fouling properties and also retains good mechanical properties and spinnability of the nylon material.

The invention provides a beta '-sulfo-alpha, beta-unsaturated gamma-lactam derivative as well as a preparation method and application thereof, and belongs to the technical field of organic chemical synthesis. The beta '-thio-alpha, beta-unsaturated gamma-lactam derivative has a structure as shown in a formula I. According to the method disclosed by the invention, cesium carbonate is taken as alkali, and a molecular skeleton of the beta'-thio-alpha, beta-unsaturated gamma-lactam derivative is constructed through free radical coupling and olefin isomerization processes under the condition of blue light irradiation. Bioactivity evaluation shows that the beta '-sulfo-alpha, beta-unsaturated gamma-lactam derivative prepared by the method disclosed by the invention has an inhibition effect on MDA-MB-231 human breast cancer cells.

The invention discloses a method for synergistically removing nitrate and degrading antibiotics through sulfur autotrophy-heterotrophy, which comprises the following steps: (1) taking an SBR (sequencing batch reactor), inoculating anoxic sludge of a sewage treatment plant, adding CH3NaS, Na2S2O3 and NaHCO3 into influent water containing nitrate, and domesticating the sludge; and (2) after domestication in the step (1) is completed, carrying out anoxic stirring, introducing nitrate-containing wastewater, adding a solution containing CH3NaS and antibiotics into the reactor, carrying out a stirring reaction, determining a first-order derivative of ORP, when the first-order derivative dORP / dt is less than or equal to r, repeating the steps of adding the solution containing CH3NaS and antibiotics, carrying out a stirring reaction, and determining the first-order derivative of ORP for many times, and when the last first-order derivative dORP / dt is less than or equal to r, stopping adding the solution containing CH3NaS and antibiotics. Carrying out anaerobic stirring, precipitating, draining and stopping to complete domestication of the sludge; and (3) introducing wastewater to be treated to remove nitrate and antibiotics. The method provided by the invention can realize sulfur autotrophy-heterotrophy synergistic efficient removal of nitrate and tolerate beta-lactam antibiotic stress.

The invention provides a polyamide elastomer with high gas barrier property and high resilience and a preparation method thereof, and belongs to the technical field of polyamide elastomer preparation. The preparation method of the polyamide elastomer comprises the following steps: mixing cyclic lactam with water, heating, and carrying out a ring-opening reaction; then adding a predetermined amount of diamine and furandicarboxylic acid, and carrying out a prepolymerization reaction to obtain a prepolymer; and mixing the prepolymer with diisocyanate and polyether glycol, and carrying out chain extension reaction to obtain the polyamide elastomer. Through the mode, the polyamide elastomer prepared by the preparation method provided by the invention has high toughness, high rebound resilience and better gas barrier property, the application field of the polyamide elastomer can be effectively expanded, and the additional value of the polyamide elastomer is improved. The preparation method provided by the invention is simple in process, easy to regulate and control and relatively low in cost, and has relatively high practical application value.

The invention discloses an omariglitazone intermediate as well as a synthesis method and application thereof, and belongs to the technical field of pharmaceutical chemistry synthesis. The invention provides a synthesis method of an omarigliflozin intermediate and application of the intermediate in synthesis of omarigliflozin. The key of the synthesis method provided by the invention lies in the deprotection process of polycyclic indole amide, nitrile groups are not hydrolyzed, indole carboxylic acid is generated with high selectivity, molecular lactamization is avoided in the condensation process with polycyclic imine B, and expensive amidation reagents such as HATU are not needed in the process, so that the synthesis method is simple and easy to implement. And the purpose of preparing omariglitazone with low cost and high yield is achieved. The synthesis method has the advantages of easily available raw materials, mild reaction conditions, small side reaction influence, simplicity and convenience in operation and high yield, improves the yield, is easy to purify, and is suitable for industrial production of omariglitazone.

The invention relates to the technical field of organic synthesis, in particular to a synthesis method and application of functional caprolactam and functional nylon-6. The synthesis method comprises the following steps: in the presence of a catalyst and a solvent, enabling amino caprolactam and / or a derivative thereof to contact and react with benzaldehyde, so as to obtain functional caprolactam which is bis (benzyl) amino caprolactam, wherein the reaction conditions are as follows: the temperature is 150-350 DEG C; the hydrogen pressure is 0.1 to 10 MPa; the time is 5-15 hours. The synthesis method not only has the advantages of high reaction efficiency, high catalytic efficiency, adjustable target product selectivity and the like, but also simplifies process conditions, and realizes green large-scale production.

The invention provides a method for asymmetrically synthesizing an ubugepam chiral intermediate, which comprises the following steps: by taking N-Boc protected ketone ester as a raw material, forming an intermediate II through enamination of ketone and molecular lactam cyclization, obtaining an intermediate III through trifluoroethylation, removing Boc under an acidic condition to obtain an intermediate IV, and carrying out asymmetric synthesis on the intermediate IV under crystallization induction of 5-nitrosalicylaldehyde and chiral acid to obtain the ubugepam chiral intermediate. According to the present invention, the target of dynamic kinetic chiral resolution is achieved through the imine intermediate state, the selective construction of C-3 chirality is achieved, and the chirality of C-5 and C-6 sites is selectively controlled during double-bond cis-catalytic hydrogenation through the chirality of the C-3 site of the substrate so as to obtain the fragment A; the method is efficient, mild and suitable for large-scale production, high performance liquid chromatography chiral resolution is avoided, an expensive metal catalytic coupling step is avoided, application of enzyme catalytic reaction conditions with high technical barriers is avoided, and the amplification performance and the industrial production efficiency of the process are greatly improved.

The invention provides copolymerized flame-retardant nylon containing nitrogen and phosphorus as well as a preparation method and application of the copolymerized flame-retardant nylon. The copolymerized flame-retardant nylon containing nitrogen and phosphorus is formed by copolymerizing a structural unit I and lactam or copolymerizing the structural unit I, diamine and binary acid, the nitrogen and phosphorus-containing copolymerized flame-retardant nylon belongs to a halogen-free flame-retardant environment-friendly high polymer material and is intrinsic flame-retardant nylon, so that the problems of flame retardant migration, compatibility with a base material and the like do not exist, excellent flame-retardant performance can be achieved under the condition of relatively low introduction amount of a flame-retardant structural unit, and meanwhile, excellent mechanical property and spinnability can be kept.

The invention discloses a nylon 12 material with high gas barrier property, a nylon pipeline and application. The nylon 12 material is prepared from the following raw materials in percentage by weight: 76.0%-90.3% of nylon 12; 0.1 to 0.8 percent of laurolactam; 8%-20% of a grafting toughening agent; 0.1%-1.0% of a lubricant; 0.5-1.2% of an antioxidant and 1-2% of other processing aids. The nylon 12 material disclosed by the invention has excellent gas barrier property and mechanical property, high melt strength and good long-term hydrostatic resistance, and can be applied to sub-high pressure gas pipelines, carbon dioxide pipelines, oil and gas pipelines, hydrogen delivery pipelines and the like.

The invention belongs to the technical field of biology, and discloses penicillin acylase or a mutant thereof, a constructed strain and a method for synthesizing beta-lactam antibiotics by an enzymic method. The penicillin acylase obtained by the invention can catalyze beta-lactam antibiotic parent nucleus and an acyl donor to generate acylation reaction, is used for preparing beta-lactam antibiotics, and has good industrial application prospects in synthesis of cephalosporin drug intermediates catalyzed by a biological enzyme method.

In some embodiments of the present disclosure, a solid dispersion is provided, comprising: lurasidone or its pharmaceutically acceptable salt and a carrier. The material of the carrier comprises polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methycellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethyl cellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.

This application provides cross-linked block copolymers comprising at least one block comprising repeating units derived from monomers comprising lactam and acryloyl moieties. The application further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The application furthermore provides Pickering emulsion compositions comprising the block copolymers.

The invention provides a beta-lactam inhibitor and cephalosporin medicine composition as well as a preparation method and application thereof, and belongs to the technical field of pharmacy. The composition disclosed by the invention is prepared from the following components in parts by weight: 5 to 90 parts of beta-lactamase inhibitor and 0.01 to 50 parts of cephalosporin medicine. The antibacterial activity of the composition on gram-positive bacteria and gram-negative bacteria is remarkably improved, the antibacterial spectrum is expanded, and meanwhile the clinical application range is widened.

The present invention discloses an α-aminocaprolactam flame retardant containing a substituted P-C-N functional group, and a preparation method and application thereof. The flame retardant is prepared by a two-step reaction of three components, namely, α-aminocaprolactam, an aldehyde-containing compound, and an organophosphorus compound containing a P-H bond. First, the aldehyde-containing compound is reacted with the α-aminocaprolactam to obtain a Schiff base intermediate, which is then subjected to nucleophilic addition with the organophosphorus compound containing a P-H bond to obtain an α-aminocaprolactam substituted with a P-C-N functional group. The flame retardant of the present invention can introduce a variety of flame retardant elements including phosphorus, nitrogen, halogen, silicon and the like through the aldehyde-containing compound and the organophosphorus compound containing a P-H bond, thereby giving it good flame retardant properties; at the same time, the caprolactam group contained can be copolymerized with a variety of monomers or exchanged with a variety of polymers to prepare a variety of intrinsic flame-retardant polymers, and has broad application prospects.

The present disclosure relates to a method that includes hydrolyzing a polyamide by contacting the polyamide with a hydrolase. In some embodiments of the present disclosure, the polyamide may include nylon-6, nylon 6,6, or a combination thereof. In some embodiments of the present disclosure, the hydrolyzing may produce aminohexanoic acid, an oligomer of aminohexanoic acid, ε-caprolactam, or combinations thereof.

The invention discloses a lactam ring compound and application thereof, and belongs to the technical field of chemical medicines. The lactam ring compound as shown in the formula I provided by the invention can be used as a PARP1 inhibitor, has the advantages of high activity and high selectivity, and also has excellent pharmacokinetic properties and safety. # imgabs0 #

There is provided a method of at least partially inhibiting the function of Klebsiella pneumoniae carbapenemase-2 (KPC-2) or a variant thereof, the method comprising reacting said KPC-2 with a compound selected from the group consisting of 5-chloro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-chloro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-chloro-1, 3-dihydro-1-hydroxy-2, 1- The present invention relates to a method for contacting a beta-lactam antibiotic-resistant bacterium with a benzoxaborolane selected from the group consisting of 1, 1-benzoxaborolane and mixtures thereof, which can be used to treat an infection with a beta-lactam antibiotic-resistant bacterium in a subject.

The present disclosure provides siloxane derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized with a siloxane group to form a compound that is surface-active and has surfactant characteristics. The compounds have low critical micelle concentrations (CMC) as well as the ability to lower the surface tension of a liquid.

The present invention discloses a wear-resistant and tear-resistant polyamide elastomer composition and a preparation method and application thereof, and belongs to the technical field of modified materials. The wear-resistant and tear-resistant polyamide elastomer composition is prepared by weight from 87.1 to 95.9 parts of polyamide elastomer, 3 to 10 parts of wear-resistant agent, 0.2 to 1 part of cross-linking agent, 0.4 to 1 part of antioxidant, 0.1 to 0.6 parts of nucleating agent, 0.2 to 0.6 parts of dispersant, 0 to 2 parts of masterbatch, and 0 to 0.01 parts of fluorescent brightener. The present invention adopts polyamide elastomer as a substrate, and generates a cross-linking structure through a trifunctional cross-linking agent and an amide bond and / or an end group (amino, carboxyl, hydroxyl) in a polyamide elastomer molecular chain to improve the tear strength of the composition, and adds a polymer wear-resistant agent (PTFE and / or POM powder) to improve the wear resistance and resilience of the composition, so that the badminton racket line nails prepared by the composition of the present invention have playability and durability.