618 results about "Lactam" patented technology

The invention provides a beta '-sulfo-alpha, beta-unsaturated gamma-lactam derivative as well as a preparation method and application thereof, and belongs to the technical field of organic chemical synthesis. The beta '-thio-alpha, beta-unsaturated gamma-lactam derivative has a structure as shown in a formula I. According to the method disclosed by the invention, cesium carbonate is taken as alkali, and a molecular skeleton of the beta'-thio-alpha, beta-unsaturated gamma-lactam derivative is constructed through free radical coupling and olefin isomerization processes under the condition of blue light irradiation. Bioactivity evaluation shows that the beta '-sulfo-alpha, beta-unsaturated gamma-lactam derivative prepared by the method disclosed by the invention has an inhibition effect on MDA-MB-231 human breast cancer cells.

The invention discloses an omariglitazone intermediate as well as a synthesis method and application thereof, and belongs to the technical field of pharmaceutical chemistry synthesis. The invention provides a synthesis method of an omarigliflozin intermediate and application of the intermediate in synthesis of omarigliflozin. The key of the synthesis method provided by the invention lies in the deprotection process of polycyclic indole amide, nitrile groups are not hydrolyzed, indole carboxylic acid is generated with high selectivity, molecular lactamization is avoided in the condensation process with polycyclic imine B, and expensive amidation reagents such as HATU are not needed in the process, so that the synthesis method is simple and easy to implement. And the purpose of preparing omariglitazone with low cost and high yield is achieved. The synthesis method has the advantages of easily available raw materials, mild reaction conditions, small side reaction influence, simplicity and convenience in operation and high yield, improves the yield, is easy to purify, and is suitable for industrial production of omariglitazone.

The invention provides copolymerized flame-retardant nylon containing nitrogen and phosphorus as well as a preparation method and application of the copolymerized flame-retardant nylon. The copolymerized flame-retardant nylon containing nitrogen and phosphorus is formed by copolymerizing a structural unit I and lactam or copolymerizing the structural unit I, diamine and binary acid, the nitrogen and phosphorus-containing copolymerized flame-retardant nylon belongs to a halogen-free flame-retardant environment-friendly high polymer material and is intrinsic flame-retardant nylon, so that the problems of flame retardant migration, compatibility with a base material and the like do not exist, excellent flame-retardant performance can be achieved under the condition of relatively low introduction amount of a flame-retardant structural unit, and meanwhile, excellent mechanical property and spinnability can be kept.

The present disclosure provides siloxane derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized with a siloxane group to form a compound that is surface-active and has surfactant characteristics. The compounds have low critical micelle concentrations (CMC) as well as the ability to lower the surface tension of a liquid.

The invention discloses a full-bio-based multifunctional antibacterial nylon material as well as a preparation method and application thereof, relates to the technical field of high-molecular polymers, and solves the problems that the preparation process of a nylon material in the prior art depends on petroleum resources, the function is single and the application scene is limited. The method comprises the following steps: reacting an aminocaprolactam solution with corresponding aldehyde / carboxylic acid / halogenated alkane, and purifying to obtain a cyclic lysine derivative monomer M; the preparation method comprises the following steps: mixing and heating a cyclic lysine derivative monomer M, an initiator and a catalyst, reacting, and purifying to obtain a nylon material PM; and carrying out quaternization reaction on the nylon PM solution and alkyl halide, and purifying to obtain the full-bio-based multifunctional nylon material P. The preparation method completely abandons the use of petroleum-based raw materials, realizes the multifunctional synergistic effect of antibacterial property, biocompatibility, antibacterial biofilm property, thermosensitivity and the like, and can be applied to the fields of antibacterial materials, biomedical materials, antibacterial biofilms and thermosensitivity materials.

The invention provides a polyamide elastomer and a preparation method thereof. The method comprises the following steps: (1) under the action of a first catalyst, carrying out condensation polymerization on a poly-diol compound and a binary acid monomer in a solvent to obtain an end-capping reagent; (2) under the action of a second catalyst, an end-capping reagent and a comonomer are subjected to a contact reaction, and a polyamide block is obtained; and (3) in the presence of a stabilizer and under the action of a third catalyst, carrying out contact reaction on the soft segment and the polyamide block to obtain the polyamide elastomer, wherein the polydihydric alcohol compound is polyalkylene ether glycol with the number-average molecular weight of 150-2000, and the stoichiometric ratio of the polydihydric alcohol compound to the binary acid monomer is 1: (2.0-2.4); the comonomer is C4-C12 lactam and / or C4-C12 amino carboxylic acid; and the soft segment is a hydroxyl-terminated diol polymer. According to the invention, the performance loss of the hard-segment-dominated material is not caused on the basis of improving the soft-segment-dominated material mechanical property of the product, and the polyamide elastomer product with excellent comprehensive performance is obtained.

Provided is an ink composition for ultraviolet-curable inkjet printing comprising polymerization components, a resin component, and a photopolymerization initiator, wherein the polymerization components include (A) a polyfunctional amine-modified oligomer, (B) a nitrogen-containing monomer, (C) an aromatic ring-containing monomer, and (D) a polyfunctional monomer, wherein the resin component includes a hydroxyl group-containing resin, wherein (A) comprises an acrylated amine compound having two photopolymerizable functional groups and two amino groups in a molecule, wherein (B) comprises vinyl caprolactam, wherein (C) comprises benzyl acrylate and phenoxyethyl acrylate, wherein (D) comprises at least one of propoxylated neopentyl glycol diacrylate, dipropylene glycol diacrylate, or 1,6-hexanediol diacrylate, wherein a content of (A) is 0.1 to 13.0% by mass, wherein a content of (C) is 35.0 to 75.0% by mass, wherein a content of (D) is 2.0 to 16.0% by mass, and wherein the hydroxyl group-containing resin includes a ketone resin having a hydroxyl group.

The invention discloses a method for improving the self-luminous intensity of a plant, which is characterized in that an AroGL175Q gene or an RgTAL gene and a PtC3H gene or the AroGL175Q gene, the RgTAL gene and the PtC3H gene are expressed in a plant containing a fungus bioluminescence system FBP, so that a transgenic plant of which the caffeic acid content, the milk tree alkali content and the luminous intensity are obviously increased is obtained. According to the invention, through metabolic network optimization and transformation, phenylpropane metabolites required by middle and upper streams of a fungus bioluminescence pathway are increased, and synthesis of caffeic acid and milk tree alkali in plants is increased, so that bioluminescence enhancement is realized. The precursor supply bottleneck of a fungus bioluminescence system is broken through, and an innovative solution is provided for creating efficient self-luminous plants.

The invention belongs to the technical field of microbiological detection, and particularly relates to a primer and a method for detecting salmonella and a drug-resistant gene thereof and application of the primer and the method. The gene of the salmonella is invA, and the drug resistance genes are blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA; the gene of the salmonella is invA, and the drug resistance genes of the salmonella are blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA; the primers comprise inner primers and outer primers of invA, blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA, a primer group is designed according to conserved regions of a salmonella invA gene and part of beta-lactam drug-resistant genes blaNDM-1, blaTEM-1, blaOXA and blaCTX-M, a detection method of SYBR-LAMP and HNB-LAMP technologies is established, and screening of part of beta-lactam drug-resistant genes carried by animal-derived pathogenic strains is realized.

The present invention provides a method for recovering ε-caprolactam and polyether polyurethane from a material comprising nylon 6 and polyether polyurethane in a plant, wherein the plant comprises a separation section [B], a depolymerization section [C], a recovery section [D], and a purification section [E].

The present disclosure provides siloxane derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized with a siloxane group to form a compound that is surface-active and has surfactant characteristics. The compounds have low critical micelle concentrations (CMC) as well as the ability to lower the surface tension of a liquid.

Provided are a thiazololactam compound, and the use thereof in the preparation of a drug for treating ERK-related diseases. Specially, the present invention provides a compound as shown in formula (III) or a pharmaceutically acceptable salt thereof.

Disclosed herein is a compound that is (R)-(2-(3-((((2-ethylbutanoyl)oxy)methoxy)carbonyl)-2-hydroxyphenyl)-1-propionamidoethyl)boronic acid citrate coordination complex, or a pharmaceutically acceptable salt or solvate thereof. Also disclosed herein are methods of treating a bacterial with a compound that is (R)-(2-(3-((((2-ethylbutanoyl)oxy)methoxy)carbonyl)-2-hydroxyphenyl)-1-propionamidoethyl)boronic acid citrate coordination complex, or a pharmaceutically acceptable salt or solvate thereof in combination with ceftibuten.

The application belongs to the technical field of drug dissolution and dispersion, and particularly relates to a bunazosin water-based solution preparation and a preparation method. The bunazosin water-based solution preparation provided by the application comprises the following components: bunazosin, gamma-cyclodextrin, lecithin, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, aspartame and water. The above components are mixed to be homogeneous to prepare an oral solution which is uniform, clear and can be stored for a long time. The scheme of the application further enriches the dosage form of bunazosin, improves the convenience of taking bunazosin, and is expected to help improve the oral bioavailability and absorption efficiency of bunazosin. The scheme of the application also provides a reference direction for the mechanism research on the dissolution and dispersion behavior of the insoluble bunazosin macromolecule in a water medium.

The present disclosure provides a liquid cryoprotectant having a lactam moiety structure of wherein the lactam having at least one hydroxyl functional group; wherein Y is an alkylene or alkenylene group comprising 2 to 50 carbon atoms; wherein 2 to 4 carbon atoms reside in the lactam ring between the I group and the II group; Q is selected from the group consisting of functionalized and unfunctionalized alkylenes of linear, branched, or cyclic structure, rylenes, and combinations thereof, wherein the aforementioned groups may or may not contain oxygen atom(s); and R is selected from the group consisting of hydrogen and functionalized and unfunctionalized alkyl, cycloalkyl, alkenyl, and aryl groups, wherein the alkyl, cycloalkyl, alkenyl, and aryl groups may or may not contain heteroatoms. The present disclosure also provides a composition for cryopreservation having a lactam moiety structure.

The present invention provides a solid dispersion of compound 1 or a pharmaceutical salt thereof, comprising the compound 1 or the pharmaceutical salt thereof as an active ingredient and a carrier material, wherein the carrier material is selected from one, two, or more of polyvinylpyrrolidone (PVP), copovidone, polyvinylpyrrolidone-vinyl acetate copolymer, hydroxypropyl methylcellulose acetate succinate, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, hydroxypropyl methylcellulose, polyethylene glycol, and ethyl cellulose, enabling the drug to have good stability, dissolution, and therapeutic effects. The formulation of the present invention provides rapid drug release and can reduce the oral burden of large-dose tablets on menopausal patients, thereby improving treatment compliance and treatment efficiency.

Compounds to treat various infections, including infections caused by Clostridioides difficile, particularly the compounds α-methylene and α-aminomethyl lactones, lactams, iminolactones, and iminolactams, thiolactones, thionolactones, thiolactams, and thionolactams; pharmaceutical compositions; and methods for treating those infections.

The present invention relates to a polymer composition, a polymer slurry, a separator for a battery, and a battery, wherein the polymer composition may comprise a polymer component comprising: a first polymerization unit derived from an N-unsubstituted (meth)acrylamide group-containing monomer; a second polymerization unit derived from an N-2 substituted (meth)acrylamide group-containing monomer; and a third polymerization unit derived from a lactam group-containing monomer having 6 or more ring atoms.

The present application discloses lactam ring compounds and uses thereof, which have a rapid antidepressant effect.

This invention relates to an antibacterial copolyamide and its preparation method. The antibacterial copolyamide comprises a polyamide A structure formed by hexamethylenediamine and a dodecanoic acid, at least one polyamide B structure other than polyamide A, and an antibacterial agent C structure. The polyamide B structure is formed by at least one diacid b1 and at least one diamine b2, and / or by ring-opening of a lactam b3. The antibacterial agent C structure contains a quaternary phosphonium salt group and is formed by a quaternary phosphonium salt antibacterial agent containing a carboxylic acid group and the diamine b2. The melting point of the antibacterial copolyamide is 180℃~210℃. The antibacterial copolyamide of this invention exhibits good antibacterial stability, possesses highly efficient and long-lasting antibacterial effects, and does not affect the transparency of the polyamide itself.

This invention discloses a method for preparing a three-dimensional integrated lumbar support cushion. The raw materials of the lumbar support cushion include: ethylene-vinyl acetate copolymer, polyether-type thermoplastic polyurethane elastomer, physically foamed microspheres, azodicarbonamide, caprolactam-blocked 4,4'-diphenylmethane diisocyanate, surface-modified copper nanowires, and silver-loaded silicone composite components. The preparation process is as follows: the matrix resin and modified copper nanowires are melt-blended at high temperature, and then mixed with the foaming system, crosslinking agent, and composite components at low temperature to obtain a blended base material; the blended base material is injection molded, followed by static differential temperature field for pressure holding and curing, and finally cooled and demolded. This invention utilizes copper nanowires to construct a thermally conductive network, which, combined with the external temperature difference, forms a continuous foaming ratio and crosslinking density gradient inside, eliminating the physical phase interface of traditional multi-material splicing, significantly improving the tear resistance and fatigue life of the transition zone; and utilizes cooling phase separation to form an anti-slip and antibacterial skin layer.

The invention relates to high-stability amoxicillin powder for livestock. 100 kg of the amoxicillin powder mainly comprises the following raw materials by weight: 10 to 30 kg of amoxicillin, 2.5 to 7.5 kg of potassium clavulanate, 0.6 to 0.7 kg of a hydroxypropyl-beta-cyclodextrin-baicalin and chlorogenic acid compound inclusion body, 1.8 to 2.4 kg of citric acid and calcium carbonate controlled release microspheres, 23.7 to 45 kg of oat beta-glucan, 18 to 25 kg of pre-gelatinized cassava starch, 3 to 4 kg of mannitol, 8 to 12.7 kg of silanized microcrystalline cellulose, and the balance of water. The coating comprises the following components by weight: 0.8 to 1.2 kg of nano silicon dioxide, 2.0 to 2.5 kg of hydroxypropyl methylcellulose and 0.6 to 1.0 kg of zinc diricinoleate. The powder is dried at low temperature, so that the degradation rate of beta-lactam rings is reduced, the stability of amoxicillin is improved, and the bioavailability of the medicine is improved.

The invention discloses an anti-scraping thin coating type powder coating plate and a preparation method thereof, and relates to the technical field of coating materials and metal surface treatment. According to the scheme, the method comprises the following steps: forming a film on the surface of a degreased, alkali-washed and passivated metal substrate by adopting an interface modification liquid containing a silane coupling agent KH-590; and performing melt extrusion on a powder coating prepared from a hydroxyl-terminated polyether-ether-ketone / bisphenol A type epoxy silane grafted composite resin matrix, a triglycidyl isocyanurate / caprolactam composite curing agent and a titanate modified nano composite filler, and then performing electrostatic spraying and curing to obtain a coated plate with a dry film thickness of 20-40 [mu] m, wherein the powder coating is prepared from the hydroxyl-terminated polyether-ether-ketone / bisphenol A type epoxy silane grafted composite resin matrix, the triglycidyl isocyanurate / caprolactam composite curing agent and the titanate modified nano composite filler. The invention has the following beneficial effects: the interface modification layer and the silicon-containing grafted resin cooperate to improve the interface bonding force, boiling resistance and salt spray resistance; the multi-scale hard filler constructs a reinforced skeleton in the film, so that the scratch resistance is improved while the mechanical property is maintained, and thin coating and powder saving are realized under the condition of ensuring the decoration and durability.

Pharmaceutical compositions of the invention comprise functionalized lactam derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

The application belongs to the field of compound synthesis, and discloses a kind of compound containing seven-membered lactam and pyrone skeleton and its construction and application, and the chemical structure is shown in the following, wherein R1 is selected from any one of hydrogen, alkyl, halogen;R2 is selected from any one of alkyl, aryl;R3 is selected from any one of hydrogen, phenyl.The seven-membered lactam and pyrone skeleton has good drug activity, and can be used for preparing antitumor drugs.The application also discloses a construction method of the seven-membered lactam and pyrone skeleton.The construction method of the seven-membered lactam and pyrone skeleton has the advantages that raw materials and catalysts are cheap and easy to obtain, operation is simple and convenient, and the universality of substrates is wide.

The present application belongs to the field of microbial technology, and particularly relates to a fungus in promoting growth of Nauclea officinalis and increasing yield of active substance in a microbial agent. The fungus has a preservation number of GDMCC No: 66543, and belongs to Cladosporium herbarum Cladosporium tenuissimum. Researches show that the fungus can well colonize in the roots of Nauclea officinalis, promote growth of the plant, and increase the yield of vinosamycin lactam in the leaves of Nauclea officinalis, thereby facilitating further improvement of availability of medicinal substance vinosamycin lactam and promoting cultivation of Nauclea officinalis.

According to the pigment red 254 kneading inducer and the application thereof, the aromatic amide lactam compound is used as the pigment red 254 kneading inducer, so that the content of an alpha crystal form of the pigment red 254 kneading inducer can be effectively increased, the alpha crystal form is stabilized, and the pigment red 254 kneading inducer has the advantages that the pigment dispersity and resin compatibility are improved, and grain growth and reaggregation are inhibited; the pigment red 254 overcomes many defects of pigment red 254 in the prior art, and has a remarkable application prospect.

This invention discloses a chiral [oxyindole-pyrrolidine-β-lactam] bispirocyclic compound containing trifluoromethyl groups, with the following structural formula: The preparation includes the following steps: 1. Sequentially adding a metal catalyst, a chiral ligand, a base, indigo-derived trifluoromethylimine ylide, and 3-methylene β-lactam, followed by the addition of an organic solvent to obtain a mixture. The mixture is stirred at a reaction temperature of 0℃ to 50℃. 2. After the reaction is complete, the chiral [oxyindole-pyrrolidine-β-lactam] bispirocyclic compound containing trifluoromethyl groups is obtained through post-processing. The chiral [oxyindole-pyrrolidine-β-lactam] bispirocyclic compound containing trifluoromethyl groups prepared in this application lays a material foundation for in-depth drug activity research based on new drug development.