1072 results about "Lactam" patented technology

The invention discloses an antibacterial nylon material as well as a preparation method and application thereof, relates to the technical field of antibacterial high polymer materials, and solves the problems of poor antibacterial performance and difficulty in industrial production of existing antibacterial nylon 6. The preparation method comprises the following steps: mixing a seven-membered cyclic lysine derivative monomer with lactam, and carrying out hydrolytic polymerization by taking water as an initiator to obtain copolyamide; and placing the copolyamide in an acid solution, heating and stirring to carry out protonation reaction, and purifying the reaction product to obtain the antibacterial nylon material. The seven-membered cyclic lysine derivative monomer is an unprotected cyclic lysine monomer (aminocaprolactam), a single protected cyclic lysine monomer or a salified cyclic lysine monomer. The method can be widely applied to the fields with antibacterial requirements, such as fabrics, plates, pipes, packaging and various panels.

The invention discloses a flame-retardant nylon material as well as a preparation method and application thereof, relates to the technical field of flame-retardant high polymer materials, and solves the problems that a flame-retardant nylon material prepared by a blending method is unstable in flame-retardant effect and a flame-retardant nylon material prepared by a copolymerization method is complex in process. The preparation method comprises the following steps: carrying out ring-opening copolymerization on a seven-membered ring lysine derivative monomer formed by ring formation of lysine and other lactam monomers to obtain copolyamide with a functional group on a side chain, and reacting a reagent containing a flame-retardant group with the functional group to prepare the flame-retardant nylon material. The flame-retardant nylon material prepared by the invention can effectively avoid migration and loss of the flame retardant, improve the dispersity of the flame retardant and enhance the flame-retardant effect. Meanwhile, a renewable lysine resource is used for partially replacing a petroleum resource, so that the method has the advantages of resource conservation, environmental friendliness, simple process, low production cost and the like. The flame-retardant nylon material disclosed by the invention has lasting and stable flame-retardant performance and can be widely applied to the fields of automobiles, textiles, electronics and electricity, buildings, packaging and the like.

The invention provides a preparation method of a nylon elastomer with good dyeing property, antibacterial property and antistatic property. The preparation method comprises the following steps: S1, preparing a dicarboxyl-terminated nylon hard segment from binary acid, diamine or lactam and an end-capping reagent; s2, reacting the dicarboxyl-terminated nylon hard segment with polyether polyol to generate a dicarboxyl-terminated nylon elastomer with a certain molecular weight; s3, reacting the double-carboxyl-terminated nylon elastomer with the double-amino-terminated aminoguanidine compound to generate a double-amino-terminated nylon elastomer with a guanidyl group; and S4, dipping the double-amino-terminated nylon elastomer with the guanidyl group by using an anionic antistatic agent solution. The novel nylon elastomer prepared by the invention has higher molecular weight, the dyeing property of the novel nylon elastomer is favorably improved by diamino-terminated end, guanidyl is introduced in a copolymerization manner, so that the novel nylon elastomer has good antibacterial property, and meanwhile, the guanidyl is combined with the anionic antistatic agent through an ionic bond, so that the nylon elastomer has firmer antistatic property.

The invention relates to the technical field of antibacterial high polymer materials, in particular to an antibacterial nylon material as well as a preparation method and application thereof. The method comprises the following steps: carrying out anion ring-opening copolymerization on a seven-membered ring lysine monomer obtained by ring formation of lysine and a lactam monomer to obtain copolyamide, dissolving the copolyamide, and carrying out complete quaternization reaction by using halogenated hydrocarbon to obtain the antibacterial nylon material. The preparation method provided by the invention effectively avoids the problems of insufficient antibacterial property, obvious mechanical property reduction, poor thermal stability and the like of an antibacterial nylon material prepared by hydrochloric acid protonation in the prior art. Meanwhile, the seven-membered cyclic lysine monomer can be copolymerized without alkylation, the synthesis process is greatly simplified, the production efficiency is high, and the production cost is low. The prepared antibacterial nylon material has the characteristics of lasting and efficient antibacterial performance, high safety, environment friendliness, excellent mechanical property and thermal stability and the like, and can be widely applied to the fields of textiles, daily necessities, packaging materials, panels and the like.

The invention discloses flame-retardant anti-fouling copolymer nylon 6 and a preparation method and application thereof, and the preparation method comprises the following steps: adding a phosphorus-containing flame-retardant monomer, a silicon-containing reaction monomer, lactam, an initiator and a catalyst into a polymerization reaction kettle, and introducing nitrogen to replace air in the kettle; under the protection of nitrogen, firstly raising the temperature to 180-220 DEG C to carry out prepolymerization reaction, and then raising the temperature to 240-260 DEG C to carry out polymerization reaction; and after the polymerization reaction, removing water vapor in the system to react in a normal pressure state, then vacuumizing to react, filling nitrogen to recover to normal pressure after the reaction is finished, and discharging and cooling to obtain the flame-retardant and anti-fouling copolymer nylon 6. The phosphorus-containing comonomer and the silicon-containing comonomer are introduced into the copolymerized nylon, the intrinsic flame-retardant nylon material with high flame-retardant efficiency and permanent flame retardance is prepared through melt copolymerization at a relatively low introduction amount, and the intrinsic flame-retardant nylon material has certain hydrophobic and anti-fouling properties and also retains good mechanical properties and spinnability of the nylon material.

The invention provides a beta '-sulfo-alpha, beta-unsaturated gamma-lactam derivative as well as a preparation method and application thereof, and belongs to the technical field of organic chemical synthesis. The beta '-thio-alpha, beta-unsaturated gamma-lactam derivative has a structure as shown in a formula I. According to the method disclosed by the invention, cesium carbonate is taken as alkali, and a molecular skeleton of the beta'-thio-alpha, beta-unsaturated gamma-lactam derivative is constructed through free radical coupling and olefin isomerization processes under the condition of blue light irradiation. Bioactivity evaluation shows that the beta '-sulfo-alpha, beta-unsaturated gamma-lactam derivative prepared by the method disclosed by the invention has an inhibition effect on MDA-MB-231 human breast cancer cells.

The invention discloses an omariglitazone intermediate as well as a synthesis method and application thereof, and belongs to the technical field of pharmaceutical chemistry synthesis. The invention provides a synthesis method of an omarigliflozin intermediate and application of the intermediate in synthesis of omarigliflozin. The key of the synthesis method provided by the invention lies in the deprotection process of polycyclic indole amide, nitrile groups are not hydrolyzed, indole carboxylic acid is generated with high selectivity, molecular lactamization is avoided in the condensation process with polycyclic imine B, and expensive amidation reagents such as HATU are not needed in the process, so that the synthesis method is simple and easy to implement. And the purpose of preparing omariglitazone with low cost and high yield is achieved. The synthesis method has the advantages of easily available raw materials, mild reaction conditions, small side reaction influence, simplicity and convenience in operation and high yield, improves the yield, is easy to purify, and is suitable for industrial production of omariglitazone.

The invention relates to the technical field of organic synthesis, in particular to a synthesis method and application of functional caprolactam and functional nylon-6. The synthesis method comprises the following steps: in the presence of a catalyst and a solvent, enabling amino caprolactam and / or a derivative thereof to contact and react with benzaldehyde, so as to obtain functional caprolactam which is bis (benzyl) amino caprolactam, wherein the reaction conditions are as follows: the temperature is 150-350 DEG C; the hydrogen pressure is 0.1 to 10 MPa; the time is 5-15 hours. The synthesis method not only has the advantages of high reaction efficiency, high catalytic efficiency, adjustable target product selectivity and the like, but also simplifies process conditions, and realizes green large-scale production.

The invention provides copolymerized flame-retardant nylon containing nitrogen and phosphorus as well as a preparation method and application of the copolymerized flame-retardant nylon. The copolymerized flame-retardant nylon containing nitrogen and phosphorus is formed by copolymerizing a structural unit I and lactam or copolymerizing the structural unit I, diamine and binary acid, the nitrogen and phosphorus-containing copolymerized flame-retardant nylon belongs to a halogen-free flame-retardant environment-friendly high polymer material and is intrinsic flame-retardant nylon, so that the problems of flame retardant migration, compatibility with a base material and the like do not exist, excellent flame-retardant performance can be achieved under the condition of relatively low introduction amount of a flame-retardant structural unit, and meanwhile, excellent mechanical property and spinnability can be kept.

The invention discloses a nylon 12 material with high gas barrier property, a nylon pipeline and application. The nylon 12 material is prepared from the following raw materials in percentage by weight: 76.0%-90.3% of nylon 12; 0.1 to 0.8 percent of laurolactam; 8%-20% of a grafting toughening agent; 0.1%-1.0% of a lubricant; 0.5-1.2% of an antioxidant and 1-2% of other processing aids. The nylon 12 material disclosed by the invention has excellent gas barrier property and mechanical property, high melt strength and good long-term hydrostatic resistance, and can be applied to sub-high pressure gas pipelines, carbon dioxide pipelines, oil and gas pipelines, hydrogen delivery pipelines and the like.

The invention provides a beta-lactam inhibitor and cephalosporin medicine composition as well as a preparation method and application thereof, and belongs to the technical field of pharmacy. The composition disclosed by the invention is prepared from the following components in parts by weight: 5 to 90 parts of beta-lactamase inhibitor and 0.01 to 50 parts of cephalosporin medicine. The antibacterial activity of the composition on gram-positive bacteria and gram-negative bacteria is remarkably improved, the antibacterial spectrum is expanded, and meanwhile the clinical application range is widened.

The present invention discloses an α-aminocaprolactam flame retardant containing a substituted P-C-N functional group, and a preparation method and application thereof. The flame retardant is prepared by a two-step reaction of three components, namely, α-aminocaprolactam, an aldehyde-containing compound, and an organophosphorus compound containing a P-H bond. First, the aldehyde-containing compound is reacted with the α-aminocaprolactam to obtain a Schiff base intermediate, which is then subjected to nucleophilic addition with the organophosphorus compound containing a P-H bond to obtain an α-aminocaprolactam substituted with a P-C-N functional group. The flame retardant of the present invention can introduce a variety of flame retardant elements including phosphorus, nitrogen, halogen, silicon and the like through the aldehyde-containing compound and the organophosphorus compound containing a P-H bond, thereby giving it good flame retardant properties; at the same time, the caprolactam group contained can be copolymerized with a variety of monomers or exchanged with a variety of polymers to prepare a variety of intrinsic flame-retardant polymers, and has broad application prospects.

The present disclosure relates to a method that includes hydrolyzing a polyamide by contacting the polyamide with a hydrolase. In some embodiments of the present disclosure, the polyamide may include nylon-6, nylon 6,6, or a combination thereof. In some embodiments of the present disclosure, the hydrolyzing may produce aminohexanoic acid, an oligomer of aminohexanoic acid, ε-caprolactam, or combinations thereof.

There is provided a method of at least partially inhibiting the function of Klebsiella pneumoniae carbapenemase-2 (KPC-2) or a variant thereof, the method comprising reacting said KPC-2 with a compound selected from the group consisting of 5-chloro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-fluoro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-chloro-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborolane, 5-chloro-1, 3-dihydro-1-hydroxy-2, 1- The present invention relates to a method for contacting a beta-lactam antibiotic-resistant bacterium with a benzoxaborolane selected from the group consisting of 1, 1-benzoxaborolane and mixtures thereof, which can be used to treat an infection with a beta-lactam antibiotic-resistant bacterium in a subject.

The present disclosure provides siloxane derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized with a siloxane group to form a compound that is surface-active and has surfactant characteristics. The compounds have low critical micelle concentrations (CMC) as well as the ability to lower the surface tension of a liquid.

The present invention discloses a wear-resistant and tear-resistant polyamide elastomer composition and a preparation method and application thereof, and belongs to the technical field of modified materials. The wear-resistant and tear-resistant polyamide elastomer composition is prepared by weight from 87.1 to 95.9 parts of polyamide elastomer, 3 to 10 parts of wear-resistant agent, 0.2 to 1 part of cross-linking agent, 0.4 to 1 part of antioxidant, 0.1 to 0.6 parts of nucleating agent, 0.2 to 0.6 parts of dispersant, 0 to 2 parts of masterbatch, and 0 to 0.01 parts of fluorescent brightener. The present invention adopts polyamide elastomer as a substrate, and generates a cross-linking structure through a trifunctional cross-linking agent and an amide bond and / or an end group (amino, carboxyl, hydroxyl) in a polyamide elastomer molecular chain to improve the tear strength of the composition, and adds a polymer wear-resistant agent (PTFE and / or POM powder) to improve the wear resistance and resilience of the composition, so that the badminton racket line nails prepared by the composition of the present invention have playability and durability.

The present disclosure provides derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized to form a compound that is surface-active and have advantageous surfactant characteristics. The compounds of the present disclosure have low critical micelle concentrations (CMC) as well as superior ability to lower the surface tension of a liquid.

The invention provides a penicillin G acylase AxPGA mutant, an expression plasmid, a genetically engineered bacterium and application, and belongs to the technical field of biocatalysts. The mutant is obtained by mutation of any one or more of the following sites of an amino acid sequence as shown in SEQ ID NO: 1: (1) methionine at the 103rd site is substituted by cysteine, (2) tyrosine at the 424th site is substituted by phenylalanine, (3) tyrosine at the 442nd site is substituted by phenylalanine, and (4) tyrosine at the 451st site is substituted by alanine. The obtained penicillin G acylase AxPGA mutant is relatively high in enzyme activity and can be applied to high-conversion-rate and high-yield synthesis of beta-lactam antibiotics such as benicillin and amoxicillin.

The invention discloses a bacteriostatic composition which comprises a synergist and a bacteriostatic agent, the synergist is ethyl phenylacetate or a derivative thereof, and the bacteriostatic agent is selected from hydrogen peroxide, beta-lactam antibiotics, macrolide antibiotics and aminoglycoside antibiotics. The synergist disclosed by the invention is wide in synergistic effect spectrum range, and has a remarkable synergistic bacteriostatic effect when being combined with hydrogen peroxide, amoxicillin, ampicillin, benzylpenicillin potassium, erythromycin, azithromycin and amikacin; the antibacterial effect is weak when the compound is independently used, but the virulence of staphylococcus aureus can be remarkably reduced, the formation of hemolysin, staphylococcus flavin, enterotoxin and a biofilm can be inhibited, and meanwhile, the selective pressure on bacteria is favorably reduced due to the relatively low antibacterial activity, so that the occurrence of drug resistance is delayed; the method is suitable for various application scenes such as food processing industry.

The invention provides a catalyst for one-step preparation of diamine from lactam and a preparation method and application of the catalyst. A catalyst carrier is sequentially subjected to sensitization treatment operation in the step S1, activation treatment operation in the step S2 so as to enable the catalyst carrier to load active metal, complexing treatment operation in the step S3, reduction treatment operation in the step S4 and acid treatment operation in the step S5; the catalyst can be coupled with an ammoniation reaction for preparing diamine from lactam and an aminonitrile hydrogenation reaction, so that the diamine is produced through one-step reaction of lactam, and the production process is greatly simplified.

The invention discloses a preparation method of a spiro [4.5] trienone compound containing difluoro gamma-lactam, which comprises the following steps: reacting an N-(4-methoxyphenyl)-N-methyl-3-phenylpropanamide compound and an N-allyl-2, 2-difluoro-2-bromo-N-aryl acetamide compound in an argon atmosphere under the action of a photocatalyst and alkali to obtain the spiro [4.5] trienone compound containing difluoro gamma-lactam. And reacting under the irradiation of 467 nm blue light to obtain the spiro [4.5] trienone compound containing difluoro gamma-lactam. The reaction operation is simple and convenient, the product specificity is high, the substrate application range is wide, and the price is low. The invention provides a simple and efficient preparation method of the spiro [4.5] trienone compound containing difluoro gamma-lactam for the first time.

The invention discloses a full-bio-based multifunctional antibacterial nylon material as well as a preparation method and application thereof, relates to the technical field of high-molecular polymers, and solves the problems that the preparation process of a nylon material in the prior art depends on petroleum resources, the function is single and the application scene is limited. The method comprises the following steps: reacting an aminocaprolactam solution with corresponding aldehyde / carboxylic acid / halogenated alkane, and purifying to obtain a cyclic lysine derivative monomer M; the preparation method comprises the following steps: mixing and heating a cyclic lysine derivative monomer M, an initiator and a catalyst, reacting, and purifying to obtain a nylon material PM; and carrying out quaternization reaction on the nylon PM solution and alkyl halide, and purifying to obtain the full-bio-based multifunctional nylon material P. The preparation method completely abandons the use of petroleum-based raw materials, realizes the multifunctional synergistic effect of antibacterial property, biocompatibility, antibacterial biofilm property, thermosensitivity and the like, and can be applied to the fields of antibacterial materials, biomedical materials, antibacterial biofilms and thermosensitivity materials.

The present application belongs to the field of pharmaceutical chemistry. The present application relates to a compound containing a lactam structure, in particular to a compound of Formula I, a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof in the treatment of related diseases (such as cancer). PTM-L-CLM Formula I

The invention relates to a method for synthesizing 1, 4-butanediamine and co-producing NMP (N-Methyl Pyrrolidone), which comprises the following steps: dissolving 1, 4-butanedinitrile in a solvent, and reacting with introduced hydrogen and carbon dioxide under the action of a bi-component composite catalyst to obtain a product containing 1, 4-butanediamine, carrying out separation and purification treatment on the obtained product containing 1, 4-butanediamine to obtain 1, 4-butanediamine and NMP (N-Methyl Pyrrolidone); the active components of the bi-component composite catalyst comprise nickel salt and copper salt. According to the method disclosed by the invention, the carbon dioxide carbon source is introduced, so that the conversion of the byproduct butyrolactam into the NMP product with a high added value is realized, the combined yield of the 1, 4-butanediamine and the NMP and the conversion rate of the 1, 4-butanedinitrile are relatively high, and the economic benefit is remarkably improved.

The present disclosure provides siloxane derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized with a siloxane group to form a compound that is surface-active and has surfactant characteristics. The compounds have low critical micelle concentrations (CMC) as well as the ability to lower the surface tension of a liquid.

The invention provides a polyamide elastomer and a preparation method thereof. The method comprises the following steps: (1) under the action of a first catalyst, carrying out condensation polymerization on a poly-diol compound and a binary acid monomer in a solvent to obtain an end-capping reagent; (2) under the action of a second catalyst, an end-capping reagent and a comonomer are subjected to a contact reaction, and a polyamide block is obtained; and (3) in the presence of a stabilizer and under the action of a third catalyst, carrying out contact reaction on the soft segment and the polyamide block to obtain the polyamide elastomer, wherein the polydihydric alcohol compound is polyalkylene ether glycol with the number-average molecular weight of 150-2000, and the stoichiometric ratio of the polydihydric alcohol compound to the binary acid monomer is 1: (2.0-2.4); the comonomer is C4-C12 lactam and / or C4-C12 amino carboxylic acid; and the soft segment is a hydroxyl-terminated diol polymer. According to the invention, the performance loss of the hard-segment-dominated material is not caused on the basis of improving the soft-segment-dominated material mechanical property of the product, and the polyamide elastomer product with excellent comprehensive performance is obtained.

The invention discloses a preparation method of a seven-membered cyclic lysine monomer and copolymerized polyamide, and relates to the field of organic synthesis. Alpha-amino-epsilon-caprolactam is obtained by taking lysine or lysine hydrochloride as an initial raw material, and then alpha-amino of an intermediate is alkylated by using alcohol under the catalysis of a catalyst to obtain a series of seven-membered cyclic lysine monomers. According to the preparation method provided by the invention, toxic and harmful reagents such as formaldehyde and halogenated hydrocarbon are not additionally introduced, and the green and environment-friendly requirements are met; meanwhile, the seven-membered cyclic lysine monomer can be copolymerized with lactam to obtain a series of copolymerized polyamides with various structures.

The invention discloses a method for detecting a beta-lactamase drug-resistant gene. The method comprises the following steps: extracting bacterial plasmids; the method comprises the following steps of: downloading sequences of TEM-1 and ampC from GenBank, comparing nucleotide sequences by utilizing Megaalign, finding out a gene conserved region, and designing a primer by utilizing Primer expansion V5; and adding reactants of a PCR reaction system by taking the extracted whole-genome DNA of the bacteria and the extracted plasmid DNA of the bacteria as templates, and carrying out PCR amplification according to the reaction temperature required by the corresponding amplified substances. According to the invention, plasmid-mediated beta-lactam drug resistance detection and analysis are carried out on bovine-derived escherichia coli, so that drug resistance detection rates of TEM-1 type and ampC type genes of a whole genome are 76% and 95% (n is equal to 38); the drug resistance detection rates of the plasmid DNA are 98% and 89% (n = 44), and the drug resistance detection rates of the plasmid DNA are both 100%. The invention provides a scientific basis for further prevention and control of bovine-derived bacterial infectious diseases and reasonable use of antibacterial drugs, and also provides valuable data support and theoretical reference for guiding livestock farm medication and veterinary clinical scientific medication.

Provided is an ink composition for ultraviolet-curable inkjet printing comprising polymerization components, a resin component, and a photopolymerization initiator, wherein the polymerization components include (A) a polyfunctional amine-modified oligomer, (B) a nitrogen-containing monomer, (C) an aromatic ring-containing monomer, and (D) a polyfunctional monomer, wherein the resin component includes a hydroxyl group-containing resin, wherein (A) comprises an acrylated amine compound having two photopolymerizable functional groups and two amino groups in a molecule, wherein (B) comprises vinyl caprolactam, wherein (C) comprises benzyl acrylate and phenoxyethyl acrylate, wherein (D) comprises at least one of propoxylated neopentyl glycol diacrylate, dipropylene glycol diacrylate, or 1,6-hexanediol diacrylate, wherein a content of (A) is 0.1 to 13.0% by mass, wherein a content of (C) is 35.0 to 75.0% by mass, wherein a content of (D) is 2.0 to 16.0% by mass, and wherein the hydroxyl group-containing resin includes a ketone resin having a hydroxyl group.

The invention discloses a method for improving the self-luminous intensity of a plant, which is characterized in that an AroGL175Q gene or an RgTAL gene and a PtC3H gene or the AroGL175Q gene, the RgTAL gene and the PtC3H gene are expressed in a plant containing a fungus bioluminescence system FBP, so that a transgenic plant of which the caffeic acid content, the milk tree alkali content and the luminous intensity are obviously increased is obtained. According to the invention, through metabolic network optimization and transformation, phenylpropane metabolites required by middle and upper streams of a fungus bioluminescence pathway are increased, and synthesis of caffeic acid and milk tree alkali in plants is increased, so that bioluminescence enhancement is realized. The precursor supply bottleneck of a fungus bioluminescence system is broken through, and an innovative solution is provided for creating efficient self-luminous plants.