380 results about "Staphylococcus aureus" patented technology

The invention discloses bacillus velezensis as well as fermentation product filtrate and a biological product thereof, and belongs to the technical field of microorganisms, a bacillus velezensis BTN-HB-F4 strain is separated and purified from prinsepia utilis royle in Harba snow mountain in Yunnan province, the fermentation product filtrate of the bacillus velezensis has excellent HAS inhibition capacity and remarkable DPPH and ABTS free radical scavenging capacity, and the biological product of the bacillus velezensis has the advantages that the biological product can be used for preparing biological products of the prinsepia utilis royle; a good anti-oxidation effect can be realized; secondly, under various concentrations, fermentation product filtrate can remarkably reduce the proportion of SA-beta-Gal positive cells, gene expression of matrix metalloproteinase 3 can be remarkably inhibited, and a good anti-aging effect is achieved; in addition, fermentation product filtrate can remarkably inhibit generation of zebra fish melanin and has a good whitening effect; the secretion amount of cell inflammatory factors IL-6 and TNF-alpha can be remarkably inhibited, and a good relieving effect is achieved; finally, the fermentation product filtrate can effectively inhibit the growth of pathogenic bacteria staphylococcus aureus, and has the potential of regulating the skin micro-ecology.

The invention provides an antibacterial peptide cAMP048 sourced from microorganisms in a deep sea environment and application of the antibacterial peptide cAMP048, and belongs to the technical field of peptide inhibitors. The antibacterial peptide cAMP048 has an amino acid sequence as shown in SEQ ID NO: 1 (Sequence Identity Number 1). The antibacterial peptide can inhibit the growth of acinetobacter baumannii at 64 mu M, inhibit the growth of multi-drug-resistant acinetobacter baumannii and multi-drug-resistant enterococcus faecium at 128 mu M and inhibit the growth of escherichia coli, staphylococcus aureus and multi-drug-resistant klebsiella pneumoniae at 256 mu M. The antibacterial peptide can be used for preparing products with antibacterial and / or bactericidal performance, and can be applied to preparation of antibacterial and / or bactericidal products. Such as food, skin care products or medical supplies.

The invention discloses an antibacterial peptide based on D-type amino acid and application of the antibacterial peptide, and the antibacterial peptide is characterized in that the amino acid sequence is w-r-r-w-r-r-w-w-r-k-r (dTrp-dArg-dArg-dTrp-dArg-dArg-dTrp-dTrp-dArg-dLys-dArg). The antibacterial peptide can be synthesized through an Fmoc solid-phase chemical method, the synthesis difficulty is low, and the in-vivo antibacterial activity is good. The antibacterial peptide especially has broad-spectrum killing activity on carbapenem-resistant pseudomonas aeruginosa, pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli, methicillin-resistant staphylococcus aureus and staphylococcus aureus, is low in hemolytic toxicity, can reach half or more of cell survival rate under medium and low concentration, almost has no toxic effect on cells, and can be used for preparing the antibacterial peptide with a broad-spectrum killing activity on carbapenem-resistant pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli, methicillin-resistant staphylococcus aureus and staphylococcus aureus. The stability is good, the operability is high, and the cost is low.

The invention discloses preparation and application of an anti-staphylococcus aureus IsdB antibody. The antibody comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3 in the heavy chain variable region as shown in SEQ ID NO: 8; the light chain variable region comprises LCDR1, LCDR2 and LCDR3 in the light chain variable region as shown in SEQ ID NO: 16. The invention also provides nucleic acid for coding the antibody, a vector containing the nucleic acid and a cell containing the vector. In addition, experiments prove that the antibody can inhibit systemic infection of MRSA and resist invasion of MRSA to pneumonia, and has a good clinical application prospect.

The invention relates to a norhalal-enoxacin conjugate as well as a preparation method and application thereof. The norhalal-enoxacin conjugate comprises a norhalal-enoxacin coupling compound, or a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a pharmaceutically acceptable ester or a pharmaceutically acceptable solvate selected from the compound. Compared with enoxacin, kanamycin, streptomycin, lincomycin and azithromycin, the norharmann-enoxacin conjugate disclosed by the invention has a smaller MIC (Minimum Inhibitory Concentration) value, which shows that the norharmann-enoxacin conjugate has a better anti-staphylococcus aureus effect.

The invention discloses an ultrashort-sequence antibacterial peptide rich in lysine and tryptophan, an antibacterial peptide hydrogel and application of the ultrashort-sequence antibacterial peptide and the antibacterial peptide hydrogel. The preparation method comprises the following steps: combining lysine and tryptophan to obtain polypeptide containing five or six amino acids; then amidation is carried out on the C terminal of the polypeptide, fatty acid chain modification is carried out on the N terminal and side chain amino groups, the ultra-short sequence antibacterial peptide rich in lysine and tryptophan is obtained, and the antibacterial peptide has broad-spectrum antibacterial activity for resisting gram-positive and gram-negative bacteria. An antibacterial peptide micelle self-assembly experiment shows that C12-2KW can be self-assembled into stable hydrogel in a 7.17 mu M PBS (Phosphate Buffer Solution), the hydrogel internally has a compact net-shaped structure, can completely cover the peritoneal injury surface and physically isolate the peritoneal injury surface from surrounding tissues, and has a good effect on treating wound infection caused by MRSA (Methicillin-Resistant Staphylococcus Aureus); meanwhile, the compound has the effect of resisting intestinal wall and abdominal wall adhesion after an operation, is low in toxicity, has a very good application prospect in the aspect of preparing clinical antibacterial drugs, and is expected to become a candidate drug of a novel antibiotic.

The present invention discloses a broad-spectrum antibacterial peptide, and the amino acid sequence of the antibacterial peptide is GECEGNNRPVKKPQPRKKLPRFKKC-NH2. Based on melittin, the present invention designs antibacterial peptides by predicting based on a deep learning model, and obtains antibacterial peptides with broad-spectrum bacteriostasis, thermal stability and low hemolytic property, which have good inhibitory effects on skin pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Propionibacterium acnes. Peptides predicted as AMP amino acid sequences by the deep learning model antibacterial peptide prediction tool amPEPpy are selected for screening, and by using a biosynthesis technique, they are expressed, extracted and purified in Escherichia coli, reducing the workload and screening period of screening, and increasing the probability of screening out broad-spectrum and thermally stable biosynthetic antibacterial peptides.

The invention relates to the technical field of preparation of viscose fibers, in particular to a preparation method of viscose fibers based on wormwood essential oil / paraffin double-layer microcapsules, which comprises the following preparation steps: S1, preparing the wormwood essential oil / paraffin double-layer microcapsules; s2, preparing a microcapsule spinning solution; s3, spinning and forming. According to the invention, the wormwood essential oil is coated in the double-layer microcapsule, so that the natural antibacterial property of the wormwood essential oil is fully exerted. Main active components (such as eucalyptol and flavonoid compounds) of the wormwood essential oil are continuously released through a microcapsule slow release mechanism, and growth of common pathogenic bacteria such as escherichia coli and staphylococcus aureus is remarkably inhibited. Meanwhile, due to the double-layer structure (the polyurethane inner shell and the polyurea outer shell) of the microcapsule, volatilization and oxidation of the wormwood essential oil in the spinning process are effectively avoided, and the long-acting antibacterial effect is ensured.

The invention discloses an antibacterial peptide as well as a preparation method and application thereof. The antibacterial peptide has an amino acid sequence as shown in any one of SEQ ID NO: 1-11. The antibacterial peptide prepared by the scheme provided by the invention has very strong bacteriostasis and sterilization capabilities on methicillin-resistant staphylococcus aureus and multidrug-resistant escherichia coli, has application potential of becoming an antibacterial agent, a preservative or a disinfectant, and is not easy to generate drug resistance.

The present invention provide novel immunofiber compositions for protein or peptide purification and simple and cost-efficient methods and systems using these compositions. In some embodiments, the immunofibers comprise a customized Z-33 peptide derived from Staphylococcus aureus Protein A which is used to construct immuno-amphiphile molecules that assemble into immunofibers in aqueous solution with bioactive epitopes on the surface and have peptide or protein binding ability.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an LL-37 derived antibacterial peptide and application thereof. According to the invention, 17-29aa of the LL-37 antibacterial peptide is used as a core fragment and is connected with an amino acid sequence shown as SEQ ID NO: 1 or SEQ ID NO: 2 through an amido bond, the antibacterial activity of the obtained antibacterial peptide is obviously higher than that of the LL-37 antibacterial peptide, and the antibacterial peptide shows an obvious bactericidal effect on clinical drug-resistant bacteria such as acinetobacter baumannii, pseudomonas aeruginosa, escherichia coli, staphylococcus aureus, klebsiella pneumoniae and the like; meanwhile, the cytotoxicity and hemolytic activity are weak, drug resistance is not prone to being generated, bacteria can be rapidly killed in vivo through multiple mechanisms, no obvious cytotoxicity exists, the bacterium load in tissue is remarkably reduced, and the lifetime of a bacterium-infected mouse is prolonged.

The invention discloses self-cleaning antibacterial domestic ceramic and glaze and a preparation process thereof. The preparation process comprises the following steps: step 1, early-stage research and innovative conception; 2, determining a core raw material and a formula; step 3, pretreating the raw materials; step 4, glaze preparation process; step 5, preparing a domestic ceramic green body; step 6, glazing and sintering process; the preparation method has the advantages that nano titanium dioxide added in the glaze can generate free radicals with strong oxidizing property under illumination, organic pollutants on the surface of ceramic can be decomposed, the self-cleaning function is achieved, meanwhile, nano silver and silver-loaded zirconium phosphate have good antibacterial performance, breeding of various bacteria can be effectively inhibited, the anti-bacterial performance is good, the service life of the glaze is prolonged, and the service life of the glaze is prolonged. The antibacterial rate on common bacteria such as escherichia coli and staphylococcus aureus can reach 95% or above, the raw materials are wide in source and meet the environment-friendly requirement, the conventional ball milling, forming, glazing and firing processes are adopted, industrial production is easy, the cost is low, and large-scale popularization of the product is facilitated.

This invention discloses a primer and probe set, a kit, and their applications for detecting Staphylococcus aureus L based on real-time fluorescence MIRA technology. The primer and probe set consists of single-stranded DNA sequences 1-3. Based on the aforementioned primer and probe set, this invention establishes and optimizes a real-time fluorescence MIRA detection method for Staphylococcus aureus L. Furthermore, the optimized real-time fluorescence MIRA method is innovatively combined with a simplified nucleic acid extraction method and a portable fluorescence detection device, significantly reducing extraction and time costs while enabling rapid on-site detection of the virus, making it particularly suitable for grassroots units and remote areas. In addition, the real-time fluorescence MIRA detection method for Staphylococcus aureus L established in this invention has advantages such as high specificity, high sensitivity, and simple operation. Moreover, the detection process does not require opening the lid, effectively avoiding aerosol contamination, providing an effective technical means for the differential diagnosis and rapid detection of Staphylococcus aureus L.

Method and kit for topical treatment of a skin infection, in particular of superficial skin infections, caused by Staphylococcus aureus. The method comprises the steps of applying a photosensitizer to at least a part of the skin affected by the infection, and subjecting said part of the skin to first photons with a majority energy between 2.8 eV and 3.5 eV at a first energy level; and second photons with a majority energy between 1.24 eV and 1.65 eV at a second energy level, the ratio between the first and the second energy levels being in the range from about 10:1 to 2:1. By the method efficient treatment of Staphylococcus aureus infections can be achieved without the administration of topical antibiotics.

The invention discloses pyridone endoperoxide with antibacterial and antiviral activity and application thereof, and belongs to the fields of organic compound synthesis and medical technology, food engineering and the like. The invention proves that the series of endoperoxides can effectively kill pathogenic bacteria, fungi and viruses, including propionibacterium acnes, escherichia coli, staphylococcus aureus, candida albicans, human papilloma viruses, herpes simplex viruses and the like. The internal peroxide designed by the invention has the capability of treating skin diseases, is expected to be developed into a first-line medicine for treating skin diseases caused by pathogen invasion, and mainly relates to bacterial skin diseases, fungal skin diseases and viral skin diseases caused by pathogen infection. Meanwhile, the series of endoperoxides can be used for treating oral infection, periodontitis, infection of shoulder and other joint operations, and bacterial infection such as pressure sores. In addition, the peroxides in the series can also be used in the fields of food preservation, disinfectant preparation and the like.

The invention discloses a Bacillus velez, a fermentation product filtrate thereof and a biological product thereof, belonging to the field of microbial technology. A Bacillus velez BTN-HB-F4 strain is obtained by isolating and purifying green prunes from Haba Snow Mountain in Yunnan Province. The fermentation product filtrate thereof has excellent HAS inhibition ability and significant DPPH and ABTS free radical scavenging ability, and can achieve good antioxidant effect. Secondly, at various concentrations, the fermentation product filtrate thereof can significantly reduce the proportion of SA-β-Gal-positive cells, can significantly inhibit the gene expression of matrix metalloproteinase 3, and has good anti-aging effect. In addition, the fermentation product filtrate thereof can significantly inhibit the production of zebrafish melanin, and has good whitening effect. The fermentation product filtrate can significantly inhibit the secretion of cellular inflammatory factors IL-6 and TNF-α, and has good soothing effect. Finally, the fermentation product filtrate thereof can also effectively inhibit the growth of pathogenic bacteria Staphylococcus aureus, and has the potential to regulate skin microecology.

The invention provides a rare earth loaded aluminum oxide composite antibacterial material, a preparation method and application, and belongs to the technical field of antibacterial materials. The antibacterial material shows an excellent antibacterial effect under a dark condition, and the antibacterial rate on staphylococcus aureus and escherichia coli reaches up to 100%. After being repeatedly used for multiple times, the antibacterial agent still keeps strong bactericidal ability, and the minimum antibacterial rate is 90%.

The present invention discloses a preparation method of CFS nanozyme. This nanozyme has broad-spectrum bactericidal property, has low toxicity to normal cells, and there is no problem of bacterial drug resistance, and is expected to be used in the field of antibiotic-free sterilization. The CFS-ion-MN wound repair microneedle patch provided by the present invention, as a wound dressing, can transdermally deliver the antibacterial CFS nanozyme to the deep part of the wound, effectively kill bacteria. The CFS nanozyme can also inhibit inflammation in the body through its superoxide dismutase-like activity, promote wound healing, and promote the antibacterial and healing of the wounds of mice infected with Staphylococcus aureus. Among them, Co 2+ and Fe 3+ can inhibit the IL-17 and NF-κB signaling pathways, thereby accelerating wound closure.

The invention belongs to the technical field of biomedicine and nano material electronics, and particularly relates to a low-voltage efficient sterilization electrode device based on local enhanced electric field treatment. According to the electrode device, vertically-oriented nanoneedles serve as a core functional layer, a nanoneedle array is arranged on a conductive substrate, the intensity of an electric field in a pinpoint area is amplified by multiple times through the lightning rod effect induced by the tips of the nanoneedles so as to achieve irreversible electroporation of a low-potential induced pathogen membrane, the length of the nanoneedles is 5-100 micrometers, and the length of the nanoneedles is 5-100 micrometers. The curvature radius of the needle tip is lt; and the sterilization device can realize nearly complete sterilization on escherichia coli and methicillin-resistant staphylococcus aureus within 5 minutes. The invention further provides a nanometer microneedle sterilization patch based on the local enhanced electric field, a self-power-supply or external-source-power-supply energy supply mode is adopted, and rapid sterilization of a wound can be achieved without medicine adding.

The invention discloses a novel bifidobacterium infantis strain and application of extracellular products of the novel bifidobacterium infantis strain in delaying skin aging and regulating skin micro-ecology, and bifidobacterium infantis is bifidobacterium infantis BSJM24L007 which is preserved in the China General Microbiological Culture Collection Center (CGMCC for short) and has the preservation number of CGMCC No.33258. The invention further discloses a preparation method of the novel bifidobacterium infantis strain and the application of the extracellular products of the novel bifidobacterium infantis strain. The bifidobacterium infantis extracellular product prepared by the invention has an ideal effect of delaying skin aging, enables the skin to be more compact and elastic, reduces the generation of wrinkles and maintains normal metabolism of the skin, has relatively high safety, can effectively reduce the skin infection problem caused by staphylococcus aureus and propionibacterium acnes, and has a good application prospect. Skin infection and inflammation are reduced, skin health is promoted, and skin micro-ecological balance is maintained. The requirements of a modern skin external preparation on functionality and safety are met.

The invention discloses a production method of a cool-feeling antibacterial PA66 chinlon filament, and belongs to the technical field of chemical fiber manufacturing. According to the method, PA66 slices are used as raw materials and matched with jade cool-feeling master batches and a septol antibacterial oil agent (the effective component is OPHB), and the PA66 polyamide filament with the cool-feeling antibacterial effect is prepared through the process steps of slice and master batch mixing, melt spinning, side blowing cooling, oiling, drafting and winding and the like. The cool-feeling antibacterial PA66 chinlon filament produced by the invention not only has excellent physical properties (the fineness is 40-50 dtex, the breaking strength is greater than or equal to 3.5 cN / dtex, and the elongation at break is 36-46%), but also has long-acting antibacterial property (the antibacterial rate to escherichia coli and staphylococcus aureus is greater than or equal to 99%, and the antibacterial rate after 50 times of washing is still greater than or equal to 98%) and stable cool feeling (the cool feeling value Q-max is greater than or equal to 0.2 W / (m.K)), and is safe, non-toxic, environment-friendly, simple in process and low in cost. The method is suitable for the field of close-fitting textiles such as warp knitting, weft knitting and hosiery knitting, and the industrial applicability is high.

The invention discloses a cassia seed antibacterial liquid for eyes and a preparation method thereof. The semen cassiae antibacterial liquid for the eyes is prepared from the following components in percentage by mass: 2.0 to 3.0 percent of semen cassiae extract, 2.0 to 3.0 percent of magnolia flower leaf extract, 2.0 to 3.0 percent of flos chrysanthemi indici extract, 2.0 to 3.0 percent of radix gentianae extract, 2.0 to 3.0 percent of flos eriocauli extract, 1.0 to 2.0 percent of radix ginseng extract, 2.0 to 3.0 percent of rhizoma polygonati extract, 1.0 to 2.0 percent of radix codonopsis extract and the balance of water. The traditional Chinese medicine composition has the beneficial effects that various eyesight-improving traditional Chinese medicine components are adopted, the traditional Chinese medicine composition does not contain any artificial hormone and antibiotic, has no toxic or side effect, has the effects of clearing liver and improving eyesight, resisting bacteria and inflammation, and improving retina microcirculation and blood flow volume, and is matched with chlorhexidine acetate, so that the traditional Chinese medicine composition has the effects of clearing liver and improving eyesight, resisting bacteria and inflammation, and improving retina microcirculation and blood flow volume. The eye drops have the advantages that the eye drops have strong inhibition effects on candida albicans, escherichia coli and staphylococcus aureus, the components of the eye drops do not contain any irritant component, irritation influence on eyes is avoided, the preparation method is simple, and the eye drops can be easily applied to large-scale production and processing processes.

The invention provides an antibiotic-free dry milk composition which comprises an effective amount of chitosan and baicalein, and further comprises a greasy carrier, a suspending aid, a wetting agent and an antioxidant. The dry milk composition disclosed by the invention has the effects of promoting dry cow mammary tissue repair, inhibiting milk secretion and enhancing milk region immunity, and can accelerate mammary epithelium renewal and reduce milk yield so as to reduce internal milk pressure; the synergistic effect is achieved in the aspects of promoting the antioxidant activity and inhibiting the sensitivity of staphylococcus aureus, escherichia coli and the like to drugs; the milk leakage rate of the dairy cows in the dry period can be obviously reduced, and the milk drying effect is obvious, especially the early-stage milk drying effect is obvious.

The invention discloses a Lactobacillus paracasei with an immunity regulating effect and application thereof, and relates to the technical field of microorganisms, the Lactobacillus paracasei Mei1104.1 obtained by separation is preserved in China General Microbiological Culture Collection Center (CGMCC) No.30334 on April 15, 2024, and the preservation number of the Lactobacillus paracasei Mei1104.1 is CGMCC No.30334. The Lactobacillus paracasei Mei1104.1 is CGMCC No.30334, and the preservation time of the Lactobacillus paracasei Mei1104.1 is 2024. The lactobacillus paracasei not only has the characteristics of excellent acid resistance, bile salt tolerance, surface hydrophobicity and self-aggregation force, but also has an inhibition effect on escherichia coli, staphylococcus aureus and listeria monocytogenes; the bacterium can improve intestinal health and enhance immunoregulation by repairing intestinal injury, increasing the abundance of intestinal beneficial flora and the like, is expected to be applied to the fields of nutrition and health as a safe and nontoxic supplement, and has a wide application prospect.

The invention discloses a medicine composition for treating atopic dermatitis, a preparation method and application, the medicine composition comprises inactivated malassezia sphaeroides, and the strain preservation number of the malassezia sphaeroides is ATCC 96807. The cream composition disclosed by the invention is externally applied to local treatment of skin lesions of specific dermatitis, supplements skin symbiotic bacteria, assists in recovering skin barriers of patients, remarkably inhibits growth and proliferation of staphylococcus aureus at the skin lesions of dermatitis and exocrine toxins, remarkably relieves inflammatory response, reduces the thickness of cuticles and reduces inflammatory cell infiltration; the traditional Chinese medicine composition assists the treatment of atopic dermatitis through the effects of the proinflammatory factors and the expression and secretion of the proinflammatory factors, has a remarkable treatment effect on the atopic dermatitis, is quick to take effect, small in toxic and side effects and good in safety, and has a good medicinal prospect.

The invention provides periorbital secretion inhibition gel containing natural plant polyphenols and a preparation method thereof, and relates to the field of pet eye care, the gel is chelated with iron ions through EGCG to block a porphyrin oxidation pathway, cooperates with zinc ions to inhibit bacterial growth and plays a role in multiple mechanisms of targeted removal of bacterial biofilms through antibacterial peptide LL-37; in-vitro tests prove that the functional components in the gel have a remarkable synergistic effect, proliferation of staphylococcus aureus can be effectively inhibited, deposition of porphyrin is remarkably inhibited, and formation of tear stains is relieved; animal experiment results show that the gel has a remarkable tear stain removal effect and good periorbital safety, after two weeks of treatment, the periorbital tear stain area is reduced by 75.97% compared with that of a bear dog, the eye McDonald-Shiadduck stimulation score is also remarkably reduced, corneal fluorescein staining detection results of all tested animals are negative, and the gel has a good clinical application prospect. A mild and effective new thought is provided for inhibiting the periocular secretions of the pets.

The invention discloses a copper-based multifunctional close-fitting textile and a preparation method thereof. The copper-based multifunctional close-fitting textile comprises a copper conductive fiber layer which is blended and woven with any other fibers; the natural fiber layer is selected from any natural fiber and is blended with the copper conductive fiber layer, the product integrates antifungal, deodorizing and dustproof synergy and is selectively applied to various use fields, and the blended spinning of the copper conductive fiber layer and the natural fiber layer can make the antistatic performance be improved in a breakthrough manner; in a dry environment, due to static electricity generated by friction in natural fibers, copper ions can quickly disperse electrostatic charges and guide the electrostatic charges to the ground through an electron conduction mechanism, and static electricity accumulation is eliminated. Dust prevention is realized by electrostatic adsorption of particles. The copper ions can destroy bacterial cell membranes and inhibit reproduction of the bacterial cell membranes, and can treat common bacteria such as escherichia coli and staphylococcus aureus and fungi such as trichophyton rubrum and trichophyton asthenia. The photocatalytic material is used for photothermal catalytic decomposition of peculiar smell molecules.

The invention discloses a modified chitosan-based antibacterial material as well as a preparation method and application thereof, and belongs to the technical field of antibacterial materials. The ciprofloxacin grafted quaternized chitosan is successfully synthesized by taking the chitosan as a raw material, and the water solubility and the antibacterial ability of the chitosan are effectively improved. The antibacterial diameters of the ciprofloxacin grafted quaternized chitosan prepared by the preparation method disclosed by the invention on escherichia coli and staphylococcus aureus are respectively 35.34 to 39.06 mm and 40.45 to 44.51 mm, and the minimum MIC (Minimum Inhibitory Concentration) and MBC (Minimum Mass Chitosan) can reach 0.0005 mg / mL. In addition, the antibacterial material has an obvious inhibition effect on colletotrichum gloeosporioides and aspergillus niger, and the highest antifungal rates respectively reach 53.81 + / -2.17% and 54.88 + / -1.3%. Compared with the raw materials, the antibacterial ability is greatly improved, and the grafted and modified composite material is environment-friendly and can be used for antibacterial food packaging materials.

The invention belongs to the technical field of oral care, and discloses a rhodiola rosea-containing composite antibacterial oral bacteriostatic paste, which is prepared by compounding rhodiola rosea, tea polyphenol and other five-compound antibacterial components with sorbitol and other auxiliary materials according to an accurate proportion. According to the invention, a triple system of'instant sterilization-lasting bacteriostasis-ecological restoration 'is constructed, third-party detection shows that the inhibition rate on oral pathogens such as escherichia coli, staphylococcus aureus and the like reaches 99.9% or above, and multiple effects of resisting bacteria, diminishing inflammation, protecting gingiva, preventing caries and the like are achieved. The problems that an existing product is single in antibacterial effect, narrow in antibacterial spectrum and low in rhodiola rosea utilization rate are solved, no heavy metal is detected, stability is excellent, irritation is low, and the rhodiola rosea antibacterial agent is suitable for long-term use and has remarkable innovativeness and industrial value.

We provide new monoclonal antibody inhibitors of coagulases, staphylocoagulase (“SC”) and von Willebrand factor-binding protein (“vWbp”) for treatment of S. aureus. The monoclonal antibodies are useful in targeting the SC N-terminus of SC and vWbp (respectively) and inhibiting prothrombin activation. The monoclonal antibodies are able to bind to and interfere with, modulate, and / or inhibit the binding interactions between the coagulase protein and its ligan protein prothrombin the activation of prothrombin.