12 results about "Gastro-" patented technology

A gastro-resistant high-strength unit dosage form includes a solid solution prepared by hot-melt extrusion, whereby the solid solution contains 300 mg posaconazole and an enteric polymer in a specific weight ratio. The unit dosage form may be a capsule or an optionally film-coated tablet.

The invention relates to floating drug delivery systems (FDDS) that provide solutions to the particular problems often encountered with floating drug delivery systems described in the art. On such generally recognized problem is the vulnerability of the systems, especially damage to the gas-filled compartment making it accessible to water so as to impair its buoyancy, ultimately resulting in insufficient gastric residence time. The invention, in an aspect, provides a self-repairing FDDS that maintains its floating capacity after damaging. The floating drug delivery systems of the invention, furthermore, allow for incorporation of high loads of active ingredients. The floating drug delivery systems can be designed in such a way that release of active ingredient from the system occurs entirely independent from the pH of the fluid surrounding the system. Furthermore, the procedure of manufacturing the floating drug delivery system of the invention is simple and straightforward, and therefore economically attractive.

An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

The present application relates to the technical field of veterinary medicine preparation, and particularly relates to a water-soluble medicine gastro-resistant and enteric-coated granule, a preparation method and application thereof, the coated granule comprising: an inner core of at least one water-soluble medicine active ingredient, a coating layer coated outside the inner core; and the coating layer is formed by a composite coating material of hydrogenated palm oil and lipophilic hydrophobic nano active light calcium carbonate. The present application has the advantages that the nano calcium carbonate is used to form pores in the true stomach by acid reaction and to produce gas by saponification with fatty acids in the intestinal tract, so that the water-soluble medicine is efficiently protected in the rumen and rapidly and completely released in the intestinal tract. In vitro tests show that the effective release rate can reach more than 79%, which is significantly better than the traditional coating, and has a broad clinical application prospect.

The present application relates to a kind of amoxicillin gastric retention sustained-release preparation, which contains amoxicillin, sustained-release material, swelling agent and other pharmaceutical adjuvant, preferably also contains stabilizer or ion regulator.The combination of the above-mentioned adjuvant can be retained in the stomach for up to 24 hours, the complete release time is 10-24h, which can significantly prolong the retention time of amoxicillin in the stomach, has the advantages of fast floating, high effective concentration of drug in the stomach, long stable concentration time, and is beneficial to reduce the frequency of drug administration of patients;Further preferably, it is made into a double-layer tablet containing immediate-release layer, which can quickly reach effective concentration and also can be released slowly and continuously, maintaining effective concentration for a long time;When combined with proton pump inhibitors such as vonolabian, etc., combination kit or compound, only 1-2 times per day is needed, which can further improve the therapeutic effect and patient compliance.

This invention discloses an extracellular vesicle derived from Gastrodia elata, its preparation method, and its use in preparing drugs for treating glaucoma, belonging to the field of biomedical technology. This invention claims protection for an extracellular vesicle prepared from dried Gastrodia elata. The extracellular vesicles provided by this invention have no significant cytotoxicity and good biocompatibility. Studies have shown that these extracellular vesicles can significantly inhibit apoptosis of R28 cells and loss of Brn3a⁺ cells in the mouse retina in a glutamate excitotoxicity model. In a glaucoma model, these extracellular vesicles can effectively protect the survival of retinal ganglion cells (RGCs) and retinal function, and can significantly reduce retinal neuroinflammatory responses in the glaucoma model. Therefore, the extracellular vesicles provided by this invention have a clear anti-glaucoma-related retinal damage effect and possess great potential for development into drugs for treating glaucoma.

The present invention provides non-invasive intraoral devices and methods for the detection of intraoral acid exposure, methods of making said devices, and their use in the diagnosis of disorders such as gastro-oesophageal reflux disease (GORD).

This invention relates to the field of intelligent medical device technology, specifically to an intelligent health patch system and its control method based on gastro-brain axis communication. The system includes an intelligent patch integrating a multimodal physiological sensing module for collecting gastric electrical signals and heart rate variability signals, and a biomimetic control execution module for performing transcutaneous electrical stimulation and tactile feedback; a mobile computing terminal configured with a gastro-brain axis state assessment model for evaluating the user's hunger drive level based on the physiological signals, and a personalized control decision engine for generating control instructions. The mobile computing terminal can, based on the output of the assessment model, achieve non-invasive closed-loop control of the gastro-brain axis: for the first time, closed-loop management of "ascending signal sensing" and "descending neural control" of the gastro-brain axis is realized on a consumer-grade wearable patch, making the intervention more physiologically targeted and scientific.

The invention provides different types of floating composition of diaminophenothiazine (DAPTZ) compounds such as methylene blue, which provide rapid-release in the stomach, or are gastro-retained. They further provide methods of making and using the same in the treatment and / or prevention of diseases. In one embodiment the invention provides an oral pharmaceutical composition which is a film-coated solid tablet comprising a DAPTZ compound as active ingredient in a gastro-retentive platform. In another embodiment the invention provides an oral pharmaceutical composition comprising an elongate hollow cylindrical capsule containing a weighting agent which is retained at one end, the capsule being buoyant and self-orientating, wherein the capsule is coated with an inner sustained release layer comprising a DAPTZ compound as active ingredient, and a further protective outer layer.

The invention relates to application of a gastric retention shape memory composite membrane. The gastric retention shape memory composite membrane is prepared by the following method: (1) mixing a polymer with dichloromethane to obtain a solution 1; (2) preparing a solution 2 by taking water as a solvent, wherein the solution 2 contains hydroxypropyl methyl cellulose and NaHCO3; and (3) mixing the solution 1 and the solution 2, stirring, adding the luteolin phospholipid complex, continuously stirring, and volatilizing dichloromethane and water. The gastro-retention shape memory composite membrane provided by the invention can be used for preparing a medicine for treating gastric cancer, has a good in-vivo expansion effect, has the deformation temperature closer to the temperature of a human body, and can enhance the permeation of luteolin to a biological membrane, improve the gastrointestinal absorption effect of luteolin, reduce stomach discomfort of a patient and improve the bioavailability of the medicine.

The invention relates to a gastric retention shape memory composite membrane. The gastric retention shape memory composite membrane is prepared by the following method: (1) mixing a polymer with dichloromethane to obtain a solution 1; (2) preparing a solution 2 by taking water as a solvent, wherein the solution 2 contains hydroxypropyl methyl cellulose and NaHCO3; and (3) mixing the solution 1 and the solution 2, stirring, adding the luteolin phospholipid complex, continuously stirring, and volatilizing dichloromethane and water. The gastro-retention shape memory composite membrane provided by the invention has a good in-vivo expansion effect, the deformation temperature of the gastro-retention shape memory composite membrane is closer to the temperature of a human body, and the gastro-retention shape memory composite membrane can enhance penetration of luteolin to a biological membrane, improve the gastrointestinal absorption effect of the luteolin, reduce stomach discomfort of a patient and improve the bioavailability of a medicine.

The present invention relates to an anti-reflux valve for preventing gastro-esophageal reflux disease and includes a body formed in a ring shape and fixed to an upper end of a gastro-esophagus; a reflux blocking plate coupled to an inner circumferential surface of the body to be rotatable in one direction; and a fixing clip coupled to an outer circumferential surface of the body to fix the body to the upper end of the gastro-esophagus.