3 results about "Gastro-" patented technology

The present application relates to the technical field of veterinary medicine preparation, and particularly relates to a water-soluble medicine gastro-resistant and enteric-coated granule, a preparation method and application thereof, the coated granule comprising: an inner core of at least one water-soluble medicine active ingredient, a coating layer coated outside the inner core; and the coating layer is formed by a composite coating material of hydrogenated palm oil and lipophilic hydrophobic nano active light calcium carbonate. The present application has the advantages that the nano calcium carbonate is used to form pores in the true stomach by acid reaction and to produce gas by saponification with fatty acids in the intestinal tract, so that the water-soluble medicine is efficiently protected in the rumen and rapidly and completely released in the intestinal tract. In vitro tests show that the effective release rate can reach more than 79%, which is significantly better than the traditional coating, and has a broad clinical application prospect.

This invention discloses an extracellular vesicle derived from Gastrodia elata, its preparation method, and its use in preparing drugs for treating glaucoma, belonging to the field of biomedical technology. This invention claims protection for an extracellular vesicle prepared from dried Gastrodia elata. The extracellular vesicles provided by this invention have no significant cytotoxicity and good biocompatibility. Studies have shown that these extracellular vesicles can significantly inhibit apoptosis of R28 cells and loss of Brn3a⁺ cells in the mouse retina in a glutamate excitotoxicity model. In a glaucoma model, these extracellular vesicles can effectively protect the survival of retinal ganglion cells (RGCs) and retinal function, and can significantly reduce retinal neuroinflammatory responses in the glaucoma model. Therefore, the extracellular vesicles provided by this invention have a clear anti-glaucoma-related retinal damage effect and possess great potential for development into drugs for treating glaucoma.

This invention relates to the field of intelligent medical device technology, specifically to an intelligent health patch system and its control method based on gastro-brain axis communication. The system includes an intelligent patch integrating a multimodal physiological sensing module for collecting gastric electrical signals and heart rate variability signals, and a biomimetic control execution module for performing transcutaneous electrical stimulation and tactile feedback; a mobile computing terminal configured with a gastro-brain axis state assessment model for evaluating the user's hunger drive level based on the physiological signals, and a personalized control decision engine for generating control instructions. The mobile computing terminal can, based on the output of the assessment model, achieve non-invasive closed-loop control of the gastro-brain axis: for the first time, closed-loop management of "ascending signal sensing" and "descending neural control" of the gastro-brain axis is realized on a consumer-grade wearable patch, making the intervention more physiologically targeted and scientific.