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20 results about "Prolonged-release tablet" patented technology
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Salmeterol sulfate sustained-release tablet and its preparation process
The application discloses a salbutamol sulfate sustained-release tablet and a preparation process thereof. The preparation process comprises the following steps: drug micronization treatment, drug and ion exchange resin compounding, granulation with hydrophilic gel matrix material, gradient temperature control drying, total mixing after whole granulation, tabletting, double controlled-release coating, ladder solidification treatment and screening and packaging. Through the synergistic sustained-release effect of the ion exchange resin and the hydrophilic gel matrix material, the double controlled-release coating and the ladder solidification process, the application effectively inhibits drug burst release, realizes smooth and long-lasting release, reduces impurity content, and improves product stability and batch reproducibility. The obtained sustained-release tablet releases 20%-40% in 2 hours and 80% or more in 8 hours in a pH 6.8 phosphate buffer, and the quality is controllable, so the sustained-release tablet is suitable for industrial production.
Owner:SUZHOU HOMESUN PHARMA CO LTD
A layered compression device for multi-layered sustained release tablets
The utility model discloses a kind of layered compression devices of multilayer sustained-release tablet, belong to pharmaceutical equipment technical field.This kind of layered compression device of multilayer sustained-release tablet, including processing table, the bottom end of processing table is equipped with support frame, the top end middle part of processing table is rotatably connected with pivot, the top end of pivot is equipped with carousel, the top end outside of carousel is equipped with several compression grooves, the inside bottom end of compression groove is equipped with ejection plate, the bottom end of pivot is through the bottom end of processing table, the bottom end of processing table is equipped with adjusting mechanism for rotating pivot, the top end of carousel is equipped with pusher mechanism, the bottom end side of processing table is equipped with first electric telescopic rod, the top end of processing table is through the output of first electric telescopic rod, the output of first electric telescopic rod and the bottom end of ejection plate are contacted, the side of processing table is equipped with stand, the side top end of stand is equipped with horizontal plate, the utility model can effectively realize automatic discharge function, improve discharging efficiency, with higher practical value.
Owner:YANTAI LUYIN PHARM CO LTD
A sustained-release upatin tablet and a preparation method thereof
This invention relates to an utpatinib sustained-release tablet and its preparation method, belonging to the field of pharmaceutical formulation technology. The sustained-release tablet comprises a core and a coating layer. The core is formed by mixing and pressing drug-containing sustained-release particles with excipients. The drug-containing sustained-release particles are prepared by wet granulation and drying of utpatinib hemihydrate, hydroxypropyl methylcellulose, and small-particle-size microcrystalline cellulose, with the residual moisture content of the particles controlled at 1.0%–3.0% (w / w). The excipients include anhydrous citric acid, large-particle-size microcrystalline cellulose, lubricant, flow aid, and mannitol. This invention effectively solves the problems of utpatinib solubility being greatly affected by pH, unstable release, and easy tablet cracking under high hardness by constructing a synergistic system of pH adjustment and gel density, and by utilizing anhydrous citric acid to create an acidic microenvironment and enhance the strength of the HPMC gel layer, combined with the internal and external division of labor between small-particle-size and large-particle-size microcrystalline cellulose.
Owner:GUANGZHOU YUDONG HEALTH PHARM CO LTD
A sustained-release upatin tablet and a preparation method thereof
PendingCN122297412AProlonged-release tabletMagnesium stearate
The present application relates to a kind of upatin sustained-release tablets and preparation method thereof.The present application uses mannitol, microcrystalline cellulose as filler, hydroxypropyl methyl cellulose as matrix material, malic acid as pH regulator, colloidal silicon dioxide as glidant, magnesium stearate as lubricant, after mixing raw drug with one or more excipients, dry granulation, solve the upatin preparation in the tabletting process due to the hygroscopicity of pH regulator and cause the problem of astringent, sticky and product quality change, shorten the drying time of moisture control in coating process, tablet is more stable in the process of acceleration test and influencing factor test.
Owner:SHANDONG YUXIN PHARMA CO LTD +3
Dihydroergotoxine mesylate sustained-release tablet controlled by complex network and preparation method thereof
This invention relates to the field of pharmaceutical technology, specifically to a sustained-release tablet of dihydroergot mesylate with composite network regulation and its preparation method. The sustained-release tablet comprises a composite structure consisting of a drug-resin composite core, an inner interface regulation structure, and an outer composite network. The key to its preparation lies in: forming a wet complex of dihydroergot mesylate with a strongly acidic cation exchange resin; sequentially introducing low-viscosity hydroxypropyl methylcellulose and a first portion of ethyl cellulose to construct the inner interface regulation layer; and after semi-drying, adding high-viscosity hydroxypropyl methylcellulose and a second portion of ethyl cellulose to form the outer composite network framework. This structure can significantly inhibit the burst release of the drug in gastric juice and achieve a stable and sustained release in intestinal juice, with stable tablet quality and good industrialization prospects.
Owner:宝利化(南京)制药有限公司
Sustained-release tablet comprising apixaban
Provided is a once-daily sustained-release tablet containing apixaban, the tablet comprising apixaban or a pharmaceutically acceptable salt thereof, polyethylene oxide as a sustained-release base and tocopherol polyethylene glycol succinate.
Owner:REXPHARMTECH CO LTD
Combustine sustained release tablet and its preparation method
PendingCN122251356AOrganic active ingredientsInorganic non-active ingredientsProlonged-release tabletPolyethylene glycol
This invention relates to a compustin sustained-release tablet and its preparation method. The compustin sustained-release tablet comprises a tablet core and a film coating layer covering the tablet core; the components of the compustin sustained-release tablet, by weight percentage, are 94.5%~98.3% sustained-release tablet core and 1.7%~5.5% film coating layer; the tablet core, by weight percentage, comprises the following raw material components: 32%~53% active ingredient, 30%~50% sustained-release material, 10%~30% filler, 1%~3% gliding agent, and 0.2%~1% lubricant, wherein the active ingredient is compustin; the film coating layer comprises a film-forming agent, polyethylene glycol, and additives, wherein the mass ratio of the film-forming agent, polyethylene glycol, and additives is (2~6.4):1:(1.7~5.3). Compared with the prior art, the preparation process of this invention is simple, and the obtained compustin sustained-release tablets have good release rate, stability, and bioequivalence, and are easy to industrialize.
Owner:SHANGHAI INST OF TECH
A rapid detection device for release rate of trazodone hydrochloride sustained-release tablets
The utility model discloses a kind of trazodone hydrochloride sustained-release tablets release rate rapid detection equipment, it is related to pharmaceutical detection technical field, including installation box, the installation box outside is fixedly connected with observation window, the installation box inside is fixedly connected with baffle, the installation box inside is provided with two detection barrels, the detection barrel top is provided with cover plate, the cover plate top is fixedly connected with handle, the cover plate top is provided with notched, the installation box top is provided with automatic sampling mechanism, and one of the detection barrel bottom is provided with analog motion mechanism. The utility model discloses a kind of trazodone hydrochloride sustained-release tablets release rate rapid detection equipment, by the design of analog motion mechanism, the motion state of sustained-release tablets in human body is simulated, so that detection result is more close to actual situation, and the reliability of detection is improved.
Owner:CHONGQING RUIEN PHARM CO LTD
Prussian blue-based positive electrode material and preparation method and application thereof
The application discloses a Prussian blue type positive material and a preparation method and application thereof. The preparation method mainly comprises the following steps: sequentially adding a manganese source, a nickel source, an iron source and a reducing agent into a sodium ferrocyanide solution, and heating to obtain the Prussian blue type positive material; wherein the sodium ferrocyanide solution comprises Na4Fe[CN]6 slow-release tablets and / or Na4Fe[CN]6 capsules. Through tabletting or surface coating of the raw material Na4Fe[CN]6 capsules, and by utilizing the difference in solubility product between manganese, nickel, iron and ferrocyanide, the adding sequence of the reaction raw materials is adjusted, the production efficiency of the Prussian blue type positive material is improved, and the prepared Prussian blue type positive material has excellent electrochemical performance.
Owner:SHANGHAI ELECTRICGROUP CORP
Shape memory antibacterial essential oil sustained-release tablet with multiple fixing mechanism and preparation method thereof
The application discloses a shape memory antibacterial essential oil slow-release tablet with a multiple fixing mechanism and a preparation method thereof. In the preparation process, one or more cyclic lactone compounds are used as comonomers to prepare polyester homopolymer or random copolymer with controllable and uniform performance. Further, isocyanate compounds, chain extenders and reversible cross-linking agents are introduced into the reaction system to synthesize polyester type reversible cross-linking polyurethane. The synthesized polymer has shape memory characteristics. Finally, essential oil is added to the polymer solution, so that the antibacterial essential oil can be uniformly mixed in the polymer solution. After molding, the essential oil slow-release tablet is obtained. The prepared polymer memory material has a porous feature, so that the antibacterial essential oil is released through the porous structure, and the antibacterial essential oil can be released from the inside to the outside by using the porous structure. The whole antibacterial cycle of the antibacterial essential oil is greatly improved.
Owner:SINOCHEM PETROCHEMICAL RESEARCH INSTITUTE (QUANZHOU) CO LTD +1
A double-layer material filling device for nicotinic acid sustained-release tablets
This utility model discloses a double-layer material filling device for nicotinic acid sustained-release tablets, relating to the technical field of material filling devices. It includes a base, with a U-shaped support chamber fixedly connected to the top of the base via a lifting mechanism. The inner walls at both ends of the U-shaped support chamber have first limiting grooves and are slidably connected to U-shaped support seats. The top two ends of the U-shaped support seats are fixedly connected to a drug storage tank and a coating storage tank. The base provided by this utility model efficiently fills the double-layer material while simultaneously protecting the core drug layer and the sustained-release coating layer material stored inside. This solves the problems of existing nicotinic acid sustained-release tablets lacking professional filling devices during the filling process, hindering efficient and rapid filling, and lacking corresponding auxiliary protection for the core drug layer and the sustained-release coating layer material during the filling process.
Owner:GUANGZHOU YUDONG HEALTH PHARM CO LTD
Sapropterin sustained-release tablets and preparation method thereof
This invention belongs to the field of pharmaceutical formulation technology, specifically relating to a sapropterin sustained-release tablet and its preparation method. This invention utilizes the effective binding of the sustained-release matrix material, Parteck® SRP 80, to extend the release time of sapropterin hydrochloride to 8-12 hours, maintaining a prolonged effective therapeutic concentration. The preparation method of this sustained-release tablet is simple to operate, has a stable process, and is suitable for industrial production.
Owner:SHANDONG NEW TIME PHARMA CO LTD
Gastroretentive double-layer sustained-release tablet, preparation method therefor, and use thereof
PCT designated stageWO2026137698A1Prolonged-release tabletImmediate release
Disclosed are a gastroretentive double-layer sustained-release tablet, a preparation method therefor, and use thereof. An active ingredient of the gastroretentive double-layer sustained-release tablet is 3-[4-[4-(lH-benzotriazol-1-yl)butyl]piperazin-1-yl]benzisothiazole hydrochloride. Said tablet consists of two drug release layers comprising an immediate-release layer and a sustained-release layer. The immediate-release layer comprises the active ingredient, a filler I, and a disintegrant, and the sustained-release layer comprises the active ingredient, a filler II, a swelling material, a release blocker, a swelling enhancer, and a stabilizer. Said tablet can prolong the in vivo absorption window of the drug, maintain the plasma concentration, and prolong the in vivo half-life of the active ingredient.
Owner:LIAONING ORIGINAL DRUG CENT LIFE SCI RES CO LTD
A sustained-release tablet multi-layer press tablet anti-sticking die
Owner:JINAN TONGLU PHARM TECH & DEV CO LTD
A method for detecting the effect of a combination of sitagliptin and metformin sustained-release tablets
The present application relates to a kind of siglitin metformin sustained-release tablets combined drug effect detection method in the field of pharmaceutical testing, in the application, by introducing intelligent terminal and monitoring terminal, real-time observation is realized using mechanical vision technology in the experiment process, the observation pressure of experimental personnel is reduced, the labor cost of experimental detection is greatly reduced, the detection efficiency is improved, at the same time, the identity of experimental personnel is identified using intelligent terminal, all experimental operations are bound with its experimental personnel, it is convenient to subsequent summary when experiment is summarized, the traceability work is carried out, the standardization of experimental detection is improved, at the same time, protection unit is set for monitoring terminal, when experimental organism touches trigger lever, a part of stored stimulating smell in slow-release unit is released, the expelling effect is strengthened, and experimental organism is formed to expel domestication, so that experimental organism forms the habit of keeping away from monitoring terminal.
Owner:JIANGSU XUANTAI PHARM CO LTD
Sacubitril valsartan sodium indapamide sustained-release tablets and a preparation method thereof
ActiveCN121606542BPharmaceutical non-active ingredientsPill deliveryPharmacy medicineProlonged-release tablet
The application provides a sacubitril valsartan sodium indapamide sustained-release tablet and a preparation method thereof. The tablet is a double-layer tablet structure, comprising a first layer of an indapamide sustained-release layer and a second layer of a sacubitril valsartan sodium immediate-release layer. By adjusting the type and amount of the sustained-release material in the indapamide sustained-release layer, the type and amount of the disintegrant in the sacubitril valsartan sodium immediate-release layer and the amount of the binder, the double-layer tablet process is stable, the release behavior is similar to that of single preparation, and the consistency of the drug efficacy is ensured.
Owner:TIANJIN HANKANG PHARMA BIOTECH CO LTD +1
Drug packaging box (Doxazosin mesylate sustained-release tablets, Perindopril amlodipine tablets (I), Perindopril amlodipine tablets (III), Indapamid sustained-release tablets)
ActiveCN310012482SDoxazosin mesilateProlonged-release tablet
1. The name of the design product: medicine packaging box (Doxazosin Mesylate Sustained Release Tablets, Perindopril Amlodipine Tablets (I), Perindopril Amlodipine Tablets (III), Indapamid Sustained Release Tablets). 2. The use of the design product: used for packaging medicine. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: design 1 perspective view. 5. The design protected contains color. 6. The specified basic design: design 1.
Owner:TIANJIN LISHENG PHARM CO LTD
Theophylline sustained-release tablets and their preparation method
ActiveCN117122573BAvoid the "peak and valley" phenomenonStable efficacyPharmaceutical non-active ingredientsPill deliveryProlonged-release tabletPharmaceutical formulation
This invention discloses a theophylline sustained-release tablet and its preparation method, belonging to the field of pharmaceutical formulation technology. The technical solution includes the following steps: 1) preparation of a pore-forming agent; 2) preparation of a blocking agent; 3) premixing: anhydrous theophylline and a hydrophilic gel framework material are premixed to obtain a premixed powder; 4) first granulation: the prepared pore-forming agent aqueous solution is added to the premixed powder, granulated, dried, and sized to obtain granules one; 5) second granulation: the prepared blocking agent ethanol solution is added to granules one, granulated, dried, and sized to obtain granules two; 6) tableting: a lubricant is added to granules two, and tablets are compressed using a tableting machine to obtain theophylline sustained-release tablets. This invention provides a theophylline sustained-release tablet and its preparation method with good sustained-release effect, long duration of action, and good batch-to-batch repeatability. The preparation method is simple and requires no heating; the prepared theophylline sustained-release tablets show good compatibility with the reference formulation.
Owner:SHANDONG XINHUA PHARMA CO LTD
A Minobalin Extended-Release Tablet and Its Preparation Method
The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a minoxidil sustained-release tablet and a preparation method thereof. The minoxidil sustained-release tablet provided by the application comprises a tablet core and a coating layer; the tablet core comprises minoxidil active ingredients and a matrix material; the matrix material comprises a high molecular polymer and a natural polysaccharide; and the mass ratio of the high molecular polymer to the natural polysaccharide is 1:1-3:1. The minoxidil sustained-release tablet provided by the application can realize once-a-day administration, reduces the administration frequency, improves patient compliance, and can be slowly released for 24 hours, thereby stabilizing the blood drug concentration and reducing toxic side effects.
Owner:BEIJING XINLINGXIAN MEDICAL TECH DEV CO LTD