8 results about "Sustained-Release Preparations" patented technology

The application discloses a sustained-release preparation of indobufen and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The application relates to a sustained-release preparation of indobufen and a preparation method and application thereof. The preparation has the characteristics of stable sustained-release effect, high bioavailability, good drug-taking compliance and small side effect, and is suitable for the prevention and / or treatment of diseases such as ischemic cardiovascular diseases, ischemic cerebrovascular diseases and venous thrombosis.

The present application relates to microspheres having a physiologically active substance uniformly dispersed therein and sustained-release preparations containing the same. In the present application, microspheres are provided, which are microspheres having a physiologically active substance uniformly dispersed therein with a lactic acid / glycolic acid copolymer (PLGA) as a main component, characterized in that the average volume-based particle diameter of the microspheres is 1 μm or more and 150 μm or less, and no lump or pore of the physiologically active substance of 1.5 μm or more is present in the microspheres. The microspheres of the present application can appropriately control the initial release amount of the physiologically active substance and the release rate during the period thereafter, and continuously release the physiologically active substance in vivo for a certain period.

The application belongs to the technical field of microbial preparation, and specifically discloses a kind of SA-MPN encapsulated bacteriophage preparation and its preparation method and application, its preparation method includes the following steps: take bacteriophage cocktail concentrate, add tannic acid solution, FeCl3·6H2O solution, phosphate buffer solution, obtain metal phenolic aldehyde network encapsulated bacteriophage;Subsequently, CaCl2 solution and sodium alginate solution are added to the metal phenolic aldehyde network encapsulated bacteriophage in sequence, to obtain sodium alginate-metal phenolic aldehyde network-bacteriophage mixture microcapsules.The application adopts the above-mentioned SA-MPN encapsulated bacteriophage preparation and its preparation method and application, which can effectively protect bacteriophage from gastric acid, high temperature and ultraviolet stress, realize intestinal targeting and slow release, has high encapsulation efficiency, good stability, antioxidant activity, significant antibacterial effect on salmonella and high biological safety.

The application discloses an oral preparation capable of improving 5-HT level in the brain and application thereof in improving insomnia, and belongs to the field of food science. The oral preparation uses starch and beta-cyclodextrin as nanoparticle carriers to wrap 5-HTP, can effectively control the release rate of 5-HTP, makes it slowly release in the gastrointestinal tract, and improves the defect that the half-life of 5-HTP is short. The preparation can significantly improve the content of 5-HT in the brain, and improve the metabolic kinetic characteristics of 5-HT, thereby effectively improving the insomnia symptoms. Experimental data shows that, compared with the traditional 5-HTP, the slow-release preparation has better bioavailability and longer brain drug efficacy duration. The innovative preparation not only has significant advantages in technology, but also opens up a new, safe and effective way for the treatment of 5-HT related nervous system diseases, and has important application value and research significance.

The application belongs to the field of pharmaceutical chemistry, and particularly relates to a glucocorticoid prodrug, a preparation method and application thereof. The glucocorticoid prodrug has low solubility, is suitable for preparation of a long-acting sustained-release preparation, and compared with existing dexamethasone palmitate preparations on the market, the compound of the application provides more excellent long-acting sustained-release effect, while effectively reducing systemic drug exposure, thereby minimizing or avoiding systemic side effects possibly caused by glucocorticoids.

The application belongs to the tobacco mildew prevention technical field, and particularly relates to application of essential oil slow-release beads in preparation of cigar leaf and cigarette mildew-proof products. The application provides application of essential oil slow-release beads in preparation of cigar leaf and cigarette mildew-proof products, wherein the essential oil slow-release beads comprise a bacteriostatic active substance and a slow-release carrier, the bacteriostatic component is continuously and slowly released through the coating effect of the slow-release carrier, thereby achieving a convenient mildew-proof method which does not need to be sprayed and can be directly placed with finished cigar cigarettes, the method does not affect the quality of cigars, can prolong the duration of the mildew-proof effect, and avoids the problem of short-term effect caused by one-time release; meanwhile, the mildew-proof slow-release preparation has a broad-spectrum bacteriostatic effect, can effectively inhibit the growth of various molds such as Aspergillus corntus, Aureobasidium pullulans and Scopulariopsis, and is suitable for long-term mildew-proof protection of the fermentation process of cigar leaves and the aging process of finished cigars.