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Effective part group in red sage mixture and its delayed release prepn. medicinal use and prepn process

A technology of effective parts and sustained-release preparations, applied in the field of medicine, can solve the problems of forgetting to take, easy to miss, and inconvenient to take.

Inactive Publication Date: 2002-05-22
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] "Compound Danshen" preparation is composed of Danshen, Panax notoginseng, and Borneol. As a drug for treating cardiovascular diseases, it has a wide range of clinical applications, has a broad clinical drug basis, and has a significant effect. Disadvantages such as inconvenience (too many times of taking, easy to miss and forget to take), poor stability, etc.

Method used

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  • Effective part group in red sage mixture and its delayed release prepn. medicinal use and prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Preparation of the effective part of Danshen: crush the medicinal material of Danshen into a coarse powder, add 10 times the weight of the medicinal material in water, heat and extract twice at 80°C for 1.5 hours each time, filter, combine the secondary extracts, and rapidly cool to room temperature. According to the ratio of the amount of the upper column sample (equivalent medicinal material) to the amount of wet resin (1:15 / W:V), perform polyamide adsorption column chromatography, and use water at 1-2ml / cm 2 / min flow rate eluted 10 column bed volumes, followed by 60% ethanol 1-2ml / cm 2 10 column bed volumes were eluted at a flow rate of / min, and the eluted part with 60% ethanol was the effective part of the total phenolic acid of salvia miltiorrhiza, and the solvent was recovered under reduced pressure at about 70°C to a liquid extract with a specific gravity of 1.09-1.11. The above liquid extract of salvia miltiorrhiza phenolic acid is dried under reduced pressure...

Embodiment 2

[0018] Preparation of effective part of Panax notoginseng

[0019] Take notoginseng medicinal material and crush it into coarse powder, add 70% ethanol 10 times the weight of the medicinal material, reflux extraction twice, each time for 2.5 hours, filter, combine the second extraction solution, and recover the solvent under reduced pressure at about 70°C until the specific gravity is 1.10 -1.12 liquid extract. Dilute it with water to a concentration of 1:1 (equivalent to medicinal material g / ml), and perform macroporous resin HPD100 adsorption column chromatography according to the ratio of the amount of the column sample (equivalent to medicinal material) to the amount of wet resin (1:15 / W:V), and use water at 1-2ml / cm 2 / min flow rate eluted 10 column bed volumes, followed by 90% ethanol-2ml / cm 2 10 column bed volumes were eluted at a flow rate of / min, followed by 90% ethanol to elute the crude product of Panax notoginseng saponins, reduce the solvent at about 70°C to a ...

Embodiment 3

[0021] Preparation of Bornean Cyclodextrin Inclusion Complex

[0022] Dissolve borneol in ethanol, add 1:15 cyclodextrin, recover the solvent, and dry it.

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PUM

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Abstract

The present invention relates to a compound salvia active component group and its slow-release preparation, medicinal application and preparation method. It features convenient administration and good stability. Said invention contains salvia active component (salvia total phenolic acid content is above 50%), notoginseng active component (notoginseng total saponin content is above 50%) and natural (or artifiical) borneol and its cyclodextrin inclusion. It can be made into various slow-release preparations, and is obtained by using water or pure water to make extraction, dissolving in water, removing impurity by using water to wash and recovering and drying. It can be used for making medicine for curing angiocardiopathy and cerebrovascular diseases.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically, it is a compound salvia miltiorrhiza effective fraction group and its slow-release preparation, medical use and preparation method which can be expected to have medical use as anti-cardiovascular and cerebrovascular disease drugs. Background technique: [0002] "Compound Danshen" preparation is composed of Danshen, Panax notoginseng, and Borneol. As a drug for treating cardiovascular diseases, it has a wide range of clinical applications, has a broad clinical drug basis, and has a significant effect. Disadvantages such as inconvenience (too many times of taking, easy to miss and forget to take), poor stability, etc. Invention content: [0003] The invention provides a compound salvia miltiorrhiza effective fraction group and its slow-release preparation, medical application and preparation method. The sustained-release preparations include sustained-release coated pellets, sust...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/28A61P9/10
Inventor 王金辉唐星潘文军赵怀清李铣
Owner SHENYANG PHARMA UNIVERSITY
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