1177 results about "Late stage" patented technology

Compositions and methods for treatment of conditions related to the overexpression of EZH2, such as late stage prostate cancer, using a DNA methylation inhibitor and/or a histone deacetylase inhibitor, optionally in combination with an EZH2 antagonist and/or an antineoplastic agent, to specifically target diseases associated with EZH2 over-expression. Further provided are reagents and kits for treatment of EZH2 overexpression.

The present invention relates to the preparation of hyperstable Y-type RE molecular sieve for the catalytic cracking of heavy oil and containnig vanadium resisting component. The preparation uses NaY-type molecular sieve as main material and chemical aluminum-eliminating complex containing oxalic acid and/or oxalate and its mixture and through introducing RE ion in the late stage of chemical aluminum elimination reaction to from RE precipitate and hydrothermal treatment to realize hyperstabilizing and introduce RE ion and independent phase Re oxide. The formed precipitate RE precursor includes RE oxalate. Compared with conventional REY, REHY and REUSY, the molecular sieve preparing process is simple and high in RE utilization, and has homogeneously distributed aluminum, more secondary pores high hydrothermal stability, high activity and high vanadium contamination resisting capacity.

The invention provides a localizable video file format which can integrates video information, audio information and space locating information into a whole and facilitates the quick search of late-stage space locating information. Based on the video format, the invention discloses a method for collecting data of the localizable video file format in real time, which comprises the following steps: the video information and the audio information are collected by a camera and a microphone and the space locating information is received by a GPS serial receiver; a video collecting platform performs compressed encoding on the collected video information and the video information and extraction on corresponding parameters of the space locating information in real time according to audio and video coding parameters provided by a user and the selected space locating parameter information, marks timestamps on the collected video information, the collected video information and the space locating information at corresponding position of a time axis of the video collecting platform according to the collecting time of the three information, and finally the three information is stored in a hard disk by the localizable video file format.

The invention provides a system for comprehensive utilization of three industrial wastes, mainly relating to the field of energy conservation and emission reduction, in particular to the comprehensive utilization of the three industrial wastes; to realize the objective of energy conservation and emission reduction required by the recycle economy, a system technology targeted at comprehensive utilization of the three industrial wastes of factories is adopted; in the invention, the reactor in the nuclear plant, the boiler in the coal-fired power plant and other types of supercritical boilers are utilized to provide a new cooling and turbine drive mode to solve the issue of industrial discharge of greenhouse gas and other polluting gases; in addition, collected emissions are utilized to produce nuclear fuel, compound chemical fertilizer or feedstuff and other chemical raw materials; moreover, to realize recycling of resources and sustainable utilization of energy, the original three wastes are innovatively applied to nuclear electric power generation. The system is characterized by comprising 10 major links and the beneficial effect thereof lies in utilizing new methods to realize energy conservation and emission reduction and production cost in the late stage of production can be reduced.

A matrix type sustained-release preparation and a manufacturing method therefor are provided wherein dissolution with low pH dependence of a basic drug or a salt thereof at the early stage of dissolution can be ensured in a dissolution test, and wherein as the dissolution test proceeds, a ratio of a dissolution rate of the basic drug or the salt thereof in an acidic test solution to a dissolution rate of the basic drug or the salt thereof in a neutral test solution (dissolution rate in the acidic test solution/dissolution rate in the neutral test solution) decreases with dissolution time at the late stage of dissolution, as compared to the early stage of dissolution. According to the present invention, the matrix type sustained-release preparation contains a basic drug or a salt thereof and at least one enteric polymer, in which solubility of the basic drug or the salt thereof in a 0.1 N hydrochloric acid solution and a neutral aqueous solution, pH 6.0 is higher than in a basic aqueous solution, pH 8.0.

The invention discloses a fast recording method with handwriting identifying function, which comprises the steps of collecting handwriting data that is hand input by a user, displaying the handwriting that is hand input by the user, identifying multiple handwritings that are hand input by the user, and editing identified results. The picture and text recording speed by using the fast recording method and the device thereof is almost same with the human recording speed when using papers and pens, and the fast recording method and the device thereof can realize novel automatic identifying and differentiating as well as late stage editing of the handwritings such as characters, diagrams and the like.

The invention provides a method and a process for spraying a composite anticorrosive coating system by electric arc for a steel structure, which belong to the method and the process for anticorrosion of the steel structure. In the anticorrosive coating system, first, rust removal and coarsing are carried out on the surface of the steel structure; then, an anode metal coating is sprayed by electric arc; then, a nanometer modified epoxy seal paint as a primer coating, an MIO epoxy paint or nanometer modified MIO epoxy paint as an intermediate paint coating, and a nanometer modified fluorine-containing polyurethane paint or fluorine-containing polysiloxane paint or siloxane modified acrylic polyurethane as a finishing coating are coated on the metal coating in sequence. The composite anticorrosive coating system has excellent performances of corrosion resistance, weather resistance, stain resistance, chemical product resistance, decoration and the like, and can obviously reduce or remit anticorrosive maintenance work and cost of the steel structure in late stage.

In sophisticated semiconductor devices, replacement gate approaches may be applied in combination with a process strategy for implementing a strain-inducing semiconductor material, wherein superior proximity of the strain-inducing semiconductor material and/or superior robustness of the replacement gate approach may be achieved by forming the initial gate electrode structures with superior uniformity and providing at least one cavity for implementing the strained channel regions in a very advanced manufacturing stage, i.e., after completing the basic transistor configuration.

The invention relates to a solar battery cuprum-indium-gallium-selenium film key target material and a preparation method thereof. The target material uses cuprum-indium-gallium-selenium element powders as raw material; CIGS powder is prepared by adopting solid phase synthesis and further isostatic compaction; finally a CIGS target material is prepared by high temperature sintering. The target material is used as raw material and a CIGS film can be achieved by further sputtering. In the invention, the four-element component key target material preparation technology is simplified from 'fractional deposition---selenizing optimization'to'one-step deposition', thereby solving the complex technological process of multiple target replacements and repeated depositions and the quality problem caused by late-stage selenylation; the adjustment of the components is carried out by the target material; the late-stage sputtering technology only needs to ensure the quality of film forming, thereby increasing the controllability of the technology.

The invention provides a cold region paddy seedling culture matrix and relates to a paddy seedling culture matrix, and the cold region paddy seedling culture matrix is used for solving the problems of slow seedling emergence of the earlier stage, more irrigation times, serious damping off during the mid-to-late stage of seedling growing and obvious fertilizer removal during the later stage of the seedling when the existing paddy seedling culture matrix is applied in paddy cultivating areas of cold regions. The cold region paddy seedling culture matrix is prepared from edible fungus residues, coal ash, grass carbon, vermiculite and perlite, or ground straw, the coal ash, the grass carbon, the vermiculite and the perlite. The paddy which uses the cold region paddy seedling culture matrix does not need disease preventing and weeding during the seedling culture period, only needs to be irrigated, is convenient to operate, time-saving and labor-saving, has high quality seedlings and stronger stress resistance, no damping off, bacterial wilt and other diseases are caused during the seedling stage, and the seedlings are short and strong, have wide leaves and bright green color. The cold region paddy seedling culture matrix is applied in the paddy field.

The invention relates to the technical field of antiseptic, in particular to a microcapsule food antiseptic and the preparation method thereof; the antiseptic comprises 30 percent to 99 percent of wall materials and 1 percent to 70 percent of antiseptic core materials accounting to part by weight, the antiseptic core materials are embedded by the wall materials to form the microcapsule antiseptic; the preparation method comprises the following steps: the wall materials are heated to dissolve, stirred and mixed with the antiseptic core materials; the mixture is uniformly stirred into suspended state under normal temperature, and spray congealing palletizing method is adopted to palletize, thus preparing the antiseptic of microcapsule state; the antiseptic is carried out microcapsule embedding to lead the antiseptic to release at fixed points at the late stage of the food processing, which can solve the problems that the antiseptic affects the fermentation of ferment food and causes big losses in the processing cycle, and overcomes the defects of low embedding efficiency and bad embedding effects of the water-soluble wall materials.

A control device and method of a spark-ignition gasoline engine is provided. An engine operates in a compression ignition model in a low load area and in a spark ignition model in a high load area. In the spark ignition model, within a retard period from a late stage of a compression stroke to an early stage of an expansion stroke, an external EGR is executed for control. In a switching area with comparatively lower load in an execution area in the spark ignition model, an EGR rate controlled by the external EGR is set higher than a load of the switching area and filling quantity control for making an intake filling quantity lower than an intake filling quantity of the compression ignition model. Accordingly, combustion stability in the spark ignition model can be raised and the load area for reducing intake filling quantity can be reduced as much as possible.

The invention provides a preparing method of reconstructing immunoregulatory protein of a ganoderma lucidum. The method includes the following steps: construction of engineering bacteria, wherein, LZ-8 protein gene is designed and coded, and is connected with a leading peptide coding sequence of saccharomyces cervisiae alpha-factor into fusion gene, which is transferred to a Pichia Pastoris expression system GS115 for reconstructing expression, high expressed rLZ-8 protein bacterial strain is acquired; the fermentation under the scale of 100L fermentation cylinder, wherein, improved seed culture medium and fermentation medium are used, additions of glycerol and methanol are regulated, 0.5M(NH4)2SO4 is added at the late stage of the fermentation; the purification on a column via centrifugal separation, wherein, salt is hyperfiltrated, powder is prepared after being frozen and dried. The method has large scale of fermentation, optimized technological condition and high production rate.

The invention discloses a method for preparing a nanoparticle water reducing agent, which belongs to the technical field of the preparation of building material admixtures. The water reducing agent at a certain doping amount can achieve the dispersing and water reduction effects at the early stage of cement paste; meanwhile, the water reducing agent has the functions of room-temperature film formation and emulsion modification, so the comprehensive performance of cement concrete such as late-stage waterproofness, compactness, chloride ion permeation resistance, mechanical properties, durability and the like can be greatly improved. The nanoparticle water reducing agent can be widely applied to the fields of railways, bridges, tunnels, dams, offshore engineering, remedial works and the like.

The invention relates to a method and a device for continuously measuring the moisture content of tobacco. The method is characterized by comprising the following steps: the initial moisture content of tobacco shreds is determined; the weight of the tobacco shreds is continuously measured under the environment of constant temperature and constant humidity; measured values are transmitted to a data analysis module which automatically processes the initial moisture content and obtained data, so as to form data points of the instant moisture content of a series of tobacco shreds with reference to the time; and a curve of the instant moisture content of the tobacco shreds with reference to the time is made, and the nuance of the moistening effect of tobacco humectant is compared according to the comparison of the slope coefficient in the earlier stage and the equilibrium moisture content in the late stage of the curve. The device comprises a climatic chamber, wherein the climatic chamber is provided with an air inlet and an air outlet; a weighing machine is arranged inside a chamber body, and is connected with the data analysis module which is arranged on the outside through a data wire; and the lower part of the chamber body is provided with a liquid storage tank. By utilization of the method and the device, the weight variation of the tobacco shreds can be monitored online in real time, and the difference of the moistening performance of the tobacco humectant can be compared by measurement of the nuance of the moisture content of the tobacco shreds, thereby providing scientific reference for evaluation of the moistening effect.

A mask ROM stores information by selecting the work function of the gates of each FET in an array of FETs at a late stage in the manufacture of the ROM. The polysilicon gates of some of the FETs are doped N-type and the gates of the other FETs are doped P-type to form gates having different work functions, thereby forming FETs having different threshold voltages. The ROM consists of a parallel array of buried N+ bit lines formed in the substrate, a gate oxide layer deposited over the bit lines and a layer of polysilicon deposited on the gate oxide. The polysilicon is blanket doped N-type, gate electrodes are defined by photolithography, and then self-aligned silicide layers are formed on the gate electrodes. An insulating layer is then formed over the gate electrodes. Programming of the ROM is accomplished by forming a mask on the insulating layer and then implanting ions through openings in the mask, through the insulating layer and the silicide layer, and into the polysilicon layer. The implantation converts individual gate electrodes from N-type to P-type to alter the threshold voltage of the selected transistors. Relatively few additional processing steps are needed after the programming to complete the ROM.

Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β-cell function, aiding in preventing β-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.

The present invention relates to a method for the diagnosis, prognosis, and monitoring of bladder cancer, such as early or late stage bladder cancer, by detecting in a urine sample from a subject at least one biomarker for bladder cancer identified herein, such as alpha-1B-glycoprotein, haptoglobin, serotransferrin, or alpha-1-antitrypsin. The biomarkers may be detected and, optionally, measured using an agent that detects or binds to the biomarker protein or an agent that detects or binds to encoding nucleic acids, such as antibodies specifically reactive with the biomarker protein or a portion thereof. The invention further relates to kits for carrying out the methods of the invention. The invention further relates to a device for the rapid detection of one or more bladder cancer biomarkers in urine and methods for rapidly measuring bladder cancer biomarkers in urine.

This invention relates to a microbial flocculating agent. The invention isolates a high-yield bioflocculation microorganism-Paenibacilluspolymyxa GA1 CCTCC M 206017, and utilizes bean dregs as the substituted culture medium to synthesize the flocculating agent. The culture process comprises: processing the bean dregs at pH11.0 by boiling at high temperature and pressure, adjusting the pH to pH6.0-8.0, inoculating with 0.5-2% seed solution, applying two-stage fermentation process, wherein: at the early state of 24 hours, the culture temperature is 30deg C and the shaker speed is 150r/min; and at the late stage of 32 hours, the culture temperature is 25deg C and the shaker speed is 100r/min. By applying the two-stage fermentation process, the bacteria can make use of nutrients to synthesize the flocculating agent at a maximu rate, with the yield increaed to 7.86g/L and culture cycle decreased to 56h. By using the bean dregs and the two-stage fermentation process, it can lower the cost for producing the microbial flocculating agent, improve the yield, and realize the massive industrial production of microbial flocculating agent.

The invention relates to a turning plate type preliminary rainwater intercepting well. The structure of the turning plate type preliminary rainwater intercepting well comprises a vertical well and a turning plate, wherein the turning plate can rotate around a connecting shaft, the two ends of the shaft are connected to the well wall of the vertical well, a shaft sleeve is sheathed on the shaft, a panel is fixed on the shaft sleeve, the panel is divided into a left half part and a right half part, the left half part is watertight, a counterweight and a float are fixedly arranged below the left half part, the right half part comprises a water passing gap communicated with a water storage tank, a water leaking hole is formed at the bottom of the water storage tank, the turning plate is arranged below a water inlet pipe and a water outlet pipe and above an intercepting pipe, and front tenons and back tenons on two opposite sides on the well wall are arranged in the positions in the rotation direction of the turning plate. The turning plate type preliminary rainwater intercepting well disclosed by the invention can solve the respective defects of a leaping weir type intercepting well, an overflow weir type intercepting well and an intercepting groove type intercepting well. The turning plate type preliminary rainwater intercepting well disclosed by the invention has the advantages of automatically intercepting all high-concentration rainwater during the preliminary stage of rainfall, draining all clean rainwater during the medium-late stage of the rainfall and realizing diversion of the clean rainwater and the dirty rainwater; and furthermore, the structure is simple, no automatic control element and no energy power are required, automatic operation is realized, and the management is simple.

The invention relates to a circular awning with a cable dome and a spatial steel truss being combined and a construction method of the circular awning. The circular awning comprises an awning roof and a main body; the circular awning is an approximately spherical segment surface; the awning roof is of a cable dome structure; the main body is of a spatial steel truss structure; the bottom end of the cable dome is fixedly connected with the top end of the spatial steel truss structure. The spatial steel truss structure comprises at least one layer of weft curved beam which is a polygonal spatial steel truss. The spatial steel truss structure comprises at least two layers of weft curved beams and radial curved pillars; the radial curved pillars are connected with each layer of weft curved beams, and every two adjacent radial curved pillars are connected through weft pull rods which are arranged at intervals according to fixed latitudes. The circular awning disclosed by the invention combines tensile and rigid structures, integrates inward tension of the tensile structure and outward thrust of the spatial steel truss structure, and realizes self-balance of inside and outside stresses; the stress of an arched steel structure is reduced, the integral structural stability is better, and meanwhile, the horizontal thrust of the lower part of the steel truss structure and a support is reduced, the maintenance cost of late-stage anticorrosion is reduced, and the construction efficiency is high.

Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. The anti-HPV antibodies are used in performing immunological assays on clinical samples. Various immunological assays and kits for detecting HPV infection, cervical cancer, other HPV related cancers, early stage precancerous lesions as well as late stage cancer progression are also provided.