108results about How to "Positive therapeutic effect" patented technology

The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

The invention discloses a method for preparing a brown rice enzyme yogurt. The preparation method mainly comprises the steps of pretreatment of raw materials, homogenization, sterilization, cooling, addition of brown rice enzyme and a ferment, fermentation, cooling, filling and refrigeration. The addition of the brown rice enzyme and the ferment is as follows: 3-7 parts by weight of the brown rice enzyme and 4-6 parts by weight of the ferment are added in 100 parts by weight of mixed solution after the treatment for carrying out inoculation; and the ferment is mixed culture solution of streptococcus thermophilus and lactobacillus bulgaricus. The brown rice enzyme is formed by fermenting brown rice, dozens of types of new enzyme can be derived when having the nutrition of the brown rice, and the brown rice enzyme yogurt is further rich in gamma-aminobutyric acid, glutathione, gamma-oryzanol, ceramide, lipopolysaccharides from rice bran, minerals and other nutritional components. The brown rice enzyme yogurt mixes the dual functions of the brown rice enzyme and the yogurt, is easy to be absorbed by human body and can improve the immunity of the human body and activate cells, thereby being the beneficial complement to modern dietary nutrition.

Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β-cell function, aiding in preventing β-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.

The invention discloses a medicinal composition for treating or preventing the obesity and metabolic syndromes, and belongs to the medicine field. The medicinal composition treats orlistat and acarbose as medicinal active components, so the application amount of orlistat in the medicinal composition is substantially reduced, thereby the risk of the damage of orlistat to the liver of a body is reduced. The medicinal composition has a substantial synergistic effect when the medicinal composition is used for treating or preventing the obesity and the metabolic syndromes, can reduces the diabetes and angiocardiopathy suffering risks of obese patients, and has a wide medical application prospect.

A toilet bowl apparatus for positioning a user in a position that most closely approximates the physiologically natural position during bowel movement is disclosed. The toilet apparatus comprises a toilet bowl having a front end and a rear end, and a rim around the toilet bowl opening. The rim is curved and includes a raised portion proximate the front end of the toilet bowl. The apparatus further comprises a footstep positioned proximate to the toilet bowl. The footstep at least in part surrounds the toilet bowl and has a top surface including a foot placement area adapted to support the feet of a user while the user sits on the toilet bowl. In the preferred embodiment of the invention, one portion of the foot placement area is on one side of the toilet bowl while a second portion of the foot placement area is on the opposed side of the toilet bowl. The apparatus further comprises a water reservoir connected to the toilet bowl. The physiologically natural position created by the apparatus of the present invention facilitates the user's act of bowel movement and effectuates various therapeutic and prophylactic processes in the user's body.

The invention discloses a method of preparing purslane polyunsaturated fatty acids from purslane residues. The method comprises the following steps: selecting the purslane residues; raising the extraction pressure of subcritical fluid extraction by 0.8MPa and raising the extraction temperature by 40 DEG C, and extracting for 150 minutes; saponifying and hydrolyzing to prepare a fatty acid mixed before enrichment; heating and stirring urea and anhydrous ethanol for reflux at 60 DEG C in a ratio m/m of urea and fatty acid mixed before enrichment of 1 to 1 and in a ratio m/v of fatty acid mixed before enrichment and ethanol of 1 to 16; after dissolving urea and uniformly mixing with the fatty acid mixed before enrichment, heating and stirring for reflux for 20 minutes; cooling to room temperature; crystallizing for 24 hours at 4 DEG C; filtering to obtain the fatty acid mixed after enrichment. Verified by diabetic rat test, the prepared purslane polyunsaturated fatty acid microcapsule and soft capsule can effectively reduce the levels of blood glucose and insulin and have wide application value and prospect in preparing foods or medicines for preventing and treating diabetes.

The invention relates to unpolished rice ferment nutritional steamed bread and a making method thereof. The unpolished rice ferment nutritional steamed bread is made of flour, unpolished rice ferment, Saccharomyces cerevisiae activating nutrient solution and water. A prescription comprises the following components based on 100 parts by mass of flour: 10-15 parts of unpolished rice ferment, 0.4-0.7 part of Saccharomyces cerevisiae activating nutrient solution and 40-50 parts of water. The invention creatively discovers the condition that the unpolished rice ferment added in the making process of the steamed bread can improve the quality of the flour, dough and the steamed bread and endows the steamed bread with more abundant nutritional value; and the steamed bread not only has multifunctionality of nutrition and health care but also has the advantages of simple prescription, simple making, low production cost and easy popularization.

A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents.

The invention relates to a traditional Chinese medicine sweetmeat sausage for dispelling wind damp, and belongs to the technical field of processing of a ham sausage and a sweetmeat sausage. The traditional Chinese medicine sweetmeat sausage integrates the advantages of the traditional Chinese medicine and the sweetmeat sausage; the traditional Chinese medicine does not need decoction and is not bitter; the traditional Chinese medicine is wrapped inside a film casing, and comprises the following components in parts by weight: 3 parts of radices sileris, 3 parts of notopterygium root, 3 parts of radix angelicae pubescentis, 3 parts of large-leaved gentian, 3 parts of radix clematidis, 3 parts of pawpaw, 3 parts of ligusticum wallichii, 40-50% of traditional Chinese medicine, 15-20% of sugar, 30-40 parts of water, and 5-8 parts of starch. The advantages of medicine properties and sweet taste of the traditional Chinese medicine are utilized to the maximal extent; the sweetmeat sausage has a health-care treatment effect, is based on a principle that a patient eats more if being seriously ill, and eats less if being lightly ill, and has positive significance.

The invention discloses a receipt of gypenoside lipidosome consisting of sterol. The receipt comprises gypenoside, a phosphatide material and the sterol. The invention further discloses a preparation method of the gypenoside lipidosome consisting of the sterol. A preparation form of the lipidosome can be a freeze-drying injection, an injection, a transdermal preparation, aerosol, oral liquid, a solution, an eye-drops preparation, a tablet or a capsule. The gypenoside lipidosome has important treatment effects for hyperlipidemia and cardiovascular and cerebrovascular diseases, and furthermore, has positive treatment and prevention effects for tumor, hepatitis, gastritis, gastric and duodenal ulcer, gastroptosis, stomatitis, diabetes mellitus, astriction, haemorrhoids, asthma, cephalagra, acne, stain, gall-stone, numbness of limbs, pachulosis, male infertility, recession of sexual functions, fatness, white hair and baldness. Furthermore, the physical strength of a human body can be enhanced, the immunity of the organism is improved, the state of fatigue can be relieved, the sleep quality can be obviously improved, the appetite can be whetted, and the senescence can be delayed.

The invention relates to novel medical application of anhydroicaritin, particularly to application of anhydroicaritin in preparing a drug for treating or preventing thrombopenia, and belongs to the field of medicines. In order to overcome the technical defects that, in the prior art, the thrombopenia therapeutic drug is unabiding in therapeutic effect, high in possibility of recidivation during drug discontinuance and high in side effect, the invention provides a therapeutic drug containing anhydroicaritin. The therapeutic drug can greatly improve the platelet level of a parent when being used for treating thrombopenia, particularly immune thrombopenia, and has an obvious therapeutic effect; the therapeutic drug further has the obvious therapeutic effect on treating thrombopenia caused by myelosuppression; when being used for treating thrombopenia, anhydroicaritin has the advantages of being obvious in curative effect, low in treatment cost and little in toxic and side effects, and the therapeutic drug is quite suitable for clinical popularization and application.

Disclosed herein are genetic markers related to the efficacy and/or safety of thiazolidinedione therapy identified by a physiogenomic methodology that correlates the genetic markers with a physiological response. The genetic markers described herein were not previously associated with the efficacy and/or safety of thiazolidinedione therapy. The markers related to safety are those associated with the important side effects of BMI increase and development of edema. In one embodiment, markers related to efficacy of thiazolidinedione therapy are associated with glycosylated hemoglobin. Method of assessing an individual for markers associated with the safety and/or efficacy of thiazolidinedione therapy are described.

An emulsion injection of fluoroplex for treating colon cancer, rectum cancer, stomach cancer, breast cancer and primary liver cancer is proportionally prepared from fluoroplex, plant oil for injection, polyose, emulsifier, isotonic regulator, and the water for injection through dissolving, heating, mixing, emulsifying, cooling and sterilizing.

The invention discloses bag tea with effects of improving immunity and preventing viruses. The bag tea is made of the following raw material medicines: 1.5-6 parts of herb of winkled gianthyssop, 2.5-10 parts of honeysuckle flowers, 1.5-6 parts of dried tangerine peel, 1-4 parts of common reed rhizome , 1-4 parts of mulberry leaves and 1.5-6 parts of ginseng. According to the bag tea, traditionalChinese medicine materials are screened according to the idea of syndrome differentiation and treatment, the traditional Chinese medicine bag tea disclosed by the invention is scientific and reasonable in proportioning, and experiment results show that the traditional Chinese medicine bag tea disclosed by the invention has functions of clearing heat and removing toxins, diaphoresis relieving superficies and drying dampness, preventing viruses and improving immunity, and is capable of improving the capability of preventing influenza viruses and novel coronaviruses (SARS-CoV-2 for short). In addition, the bag tea has effects of clearing heat and moisturizing the lung, and the like, has a good assistant treatment function on viral pneumonia and the like, is natural in medicine taste, is safe,is free of adverse reaction in long-term taking, and is applicable to both the old and the young.

The present invention relates to visco-elastic inserts, in particular to shoe inserts, and in particular to heel supports having a main body with regions of dissimilar hardness.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to application of a lung-tonifying and blood-activating capsule to the preparation of a drug for treating chronic bronchitis. The lung-tonifying and blood-activating capsule is prepared from a traditional Chinese medicine extract and an auxiliary material according to the ratio of 1:(0.05-0.2); and the traditional Chinese medicine extract is prepared from the following raw materials in part by weight: 50-100 parts of radix astragali, 50-100 parts of radix paeoniae rubra and 25-50 parts of fructus psoraleae. The lung-tonifying and blood-activating capsule provided by the invention can significantly reduce the contents of TNF and ET in chronic bronchitis model rat lung tissues and has a positive therapeutic effect on the chronic bronchitis. In addition, through electric field pretreatment on traditional Chinese medicine fine powder, the load difference of the hard capsule is significantly improved, so that the quality of the hard capsule is greatly improved.

The invention discloses feed capable of remarkably improving disease resistance of a pangolin and a preparation method of the feed. The feed is prepared by proportionally mixing termite powder, shrimp shell powder, rice, black locust leaf powder, cooked egg yolks, milk powder, pomegranate barks, Indian kalimeris herbs, merremia boisiana, Chinese mosla herbs, oxalis corymbosa, compound vitamin, compound microelements, glucose, hydrolyzed protein and miramycin, wherein the compound vitamin comprises vitamin B, vitamin A, vitamin E and vitamin D, and the compound microelements comprise iron, copper, zinc, manganese, selenium, iodine and tin. The feed is excellent in taste, low in preparation cost and rich and reasonable in nutrition, the autoimmunity of the pangolin can be enhanced while growth and development of the pangolin are promoted, the disease resistance of the pangolin is enhanced, the scale and shell quality and the meat quality of the pangolin are ensured, common diseases of the pangolin in the artificial breeding process can be actively treated, the breeding risk of the pangolin is remarkably reduced, and economic benefits are improved.

The invention discloses a medical candy food having the health-care function of protecting liver. The medical candy food having the health-care function of protecting liver comprises ointment internalfillings and external coating candy coats, wherein the weight ratio of the ointment internal fillings to the external coating candy coats is 1 to (5-8), the ointment internal fillings consist of thefollowing traditional Chinese medicine materials of fructus phyllanthi, hoveniae semoveniae semen, hippophae rhamnoides fruits, fingered citron, dandelions, cardamun, turmeric and licorice roots; andthe external coating candy coats are prepared by using maltitol liquid as a base candy solution. The medical candy food having the health-care function of protecting liver disclosed by the invention has the following beneficial effects that all used raw materials are medicinal and edible raw materials, the raw materials are easy to obtain, safe and effective, the formula is comprehensive, reasonable and scientific, comprehensive effects are better than those of a single product, and the medical candy food having the health-care function of protecting liver has positive prevention and treatmenteffects on liver injury caused by drunkenness and excessive drinking; and effective components are injected into candies, so that the mouth feel is improved, the medical candy food having the health-care function of protecting liver is convenient to carry, the effects can also be guaranteed, and the medical candy food having the health-care function of protecting liver is greatly convenient for crowds having requirements.

The invention belongs to the field of medical and pharmaceutical technologies, relates to a novel preparation of tumor chemotherapy medicine, and particularly relates to nanometer particle colloid, amethod for preparing the same and application of the nanometer particle colloid. Gemcitabine hydrochloride and compound glycyrrhizin injection are mixed with each other to obtain the colloid, and theaverage diameters of particles of the colloid are 100nm. The nanometer particle colloid, the method and the application have the advantages that the novel method is provided for tumor interventional therapy and preparation of interventional materials for the tumor interventional therapy, and active therapy effects can be realized by the nanometer particle colloid for tumor patients; two types of medicine which is already applied clinically and has positive therapeutic effects are mixed with each other to obtain the novel nanometer particle colloid, operation is easy and convenient, the qualityis easy to control, and the nanometer particle colloid is high in nanometer particle rate.

The invention relates to application of great burdock root polysaccharide in preparation of a drug for treating non-alcoholic fatty liver disease (NAFLD). The great burdock root polysaccharide provided by the invention is prepared from great burdock roots, and is prepared by carrying out enzyme inactivation, extraction, filtration, suction filtration, centrifugation, ethanol precipitation, macroporous resin decolorization, trichloroacetic acid deproteinization and the like; and the great burdock root polysaccharide has an average molecular weight of 3000-5000 Da. According to the application of the great burdock root polysaccharide in the preparation of the drug for treating the NAFLD, NAFLD mouse models are established through induction by high fat diet (HFD), and are used for study on activity of the burdock root polysaccharide in NAFLD treatment; and it is found that the great burdock root polysaccharide is capable of significantly reducing liver weight and liver index so as to reduce accumulation of liver lipid, alleviate liver damage and regulate inflammatory factors so as to achieve positive therapeutic effects on the NAFLD.

The invention provides a traditional Chinese medicine combination for external application for treating arthritis. The traditional Chinese medicine combination comprises, by weight, 13-17 parts of tetradium ruticarpum, 13-17 parts of semen brassicae, 13-17 parts of perillaseed, 13-17 parts of semen raphani, 13-17 parts of pseudo-ginseng and 26-34 parts of coarse salt. The invention further provides a traditional Chinese medicine pack comprising the traditional Chinese medicine combination. The traditional Chinese medicine combination and the traditional Chinese medicine pack have the advantage that the traditional Chinese medicine combination is simple in composition, low in cost, convenient to use, good in efficacy and low in toxic or side effect.

The invention relates to the technical field of microorganisms, and particularly relates to lactobacillus casei L.Cassi21 with a treatment effect on diarrhea and application thereof. The lactobacillus casei L.Cassi21 is classified and named as lactobacillus casei, has a preservation number of CGMCC NO.21373, and is preserved on December 14, 2020, is preserved in the China General Microbiological Culture Collection Center located at No.3, Yard 1, West Beichen Road, Chaoyang District, Beijing. The lactobacillus casei L.Cassi21 can be used for preparing a product for treating diarrhea. After the product prepared from the lactobacillus casei L.Cassi21 is taken, the thallus can enter intestinal tracts through digestive tracts to inhibit pathogenic bacteria and colonize the intestinal tracts, so that environmental flora balance can be kept, diarrhea symptoms can be improved, and the diarrhea recurrence risk can be reduced.

The invention discloses an application of butyric acid and salts thereof in the preparation of medicines for treating or preventing gastric ulcer, and belongs to the field of medicine. According to the above application, the butyric acid and salts thereof, through anti-inflammation and antioxidation, promote the secretion of gastric mucus, upregulate the apoptin BCL2, downregulate the pro-apoptotic protein Bax, have positive curative and preventive effects on gastric ulcer injury, effectively reduce falling, defect, atrophy and bleeding of the gastric mucous membrane, and have important significance to the prevention or treatment of gastric ulcer.

The invention discloses a tumor stem cell vaccine as well as a preparation method and application thereof. A breast cancer stem cell vaccine provided by the invention comprises inactivated breast cancer stem cells, mannatide and fat emulsion which are mixed according to the volume ratio of 3:1:1. The preparation method of the breast cancer stem cell vaccine comprises the following steps: obtaining breast cancer stem cells; inactivating the breast cancer stem cells; freeze-thawing the inactivated breast cancer stem cells into normal saline, and mixing the inactivated breast cancer stem cells with adjuvant mannatide and the fat emulsion, so as to obtain the breast cancer stem cell vaccine. The invention further provides the application of the breast cancer stem cell vaccine, prepared according to the preparation method provided by the invention, in preparing medicines for treating breast cancer. The invention provides a novel way for the treatment of breast cancer and the preparation of the vaccine, an active curative effect on a breast cancer patient is achieved, the immune function of the patient is enhanced, the lifetime of the patient is prolonged, and the active effect is achieved.