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Gypenoside lipidosome consisting of sterol and preparation method thereof

A technology of gypenoside and blue saponin, which is applied in the field of pharmaceutical preparations, can solve problems such as no gypenoside liposome reports, and achieve the effects of improving the body's immunity, making it simple, and improving sleep quality

Inactive Publication Date: 2013-03-27
YANCHENG TEACHERS UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no related report about gypenoside liposome

Method used

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  • Gypenoside lipidosome consisting of sterol and preparation method thereof
  • Gypenoside lipidosome consisting of sterol and preparation method thereof
  • Gypenoside lipidosome consisting of sterol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] craft

[0043] (1) selection of raw materials: get phosphate buffer saline and gypenoside by above-mentioned prescription, gypenoside is dissolved in phosphate buffer saline, for subsequent use;

[0044] (2) Preparation of gypenoside liposomes: get sphingomyelin, β-sitosterol and ether according to the above prescription, mix well, and then rotary evaporate to make it into a uniform lipid film covering the bottom of the pear-shaped bottle, add Add glass beads to the phosphate buffer solution containing gypenoside, rotate and shake at 60°C for 30 minutes, then place it for 2 hours to fully hydrate.

Embodiment 2

[0047] craft

[0048] (1) Preparation of oil phase: get gypenoside, lecithin, stigmasterol, ethanol according to the above prescription, mix well, as oil phase;

[0049] (2) Preparation of the water phase: take phosphate buffer as the water phase according to the above prescription;

[0050] (3) Preparation of liposomes: under constant temperature stirring, inject the oil phase into the water phase at a temperature of 45°C at a constant speed with a needle, stir at constant temperature for 2 hours to remove ethanol, and obtain the liposome.

Embodiment 3

[0053] craft

[0054] (1) Get phosphatidylserine according to the above prescription: campesterol: dichloromethane=200mg: 50mg: 50mL to prepare the oil phase, place the oil phase in a round-bottomed flask, and spin off the dichloromethane;

[0055] (2) 200mg gypenoside was dissolved in 20mL phosphate buffer (pH=8.0) as the water phase;

[0056] (3) Add 20 mL of phosphate buffer (pH=8.0) containing 200 mg of gypenoside to the oil phase, and in an ice bath, sonicate the probe for 10 minutes to form a uniform emulsion;

[0057] (4) Rotary evaporation to remove the organic phase, after forming a colloidal state, continue to add 20 mL of phosphate buffer, continue to evaporate under reduced pressure for 0.5 h, and ultrasonically probe for 10 min to obtain the product.

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Abstract

The invention discloses a receipt of gypenoside lipidosome consisting of sterol. The receipt comprises gypenoside, a phosphatide material and the sterol. The invention further discloses a preparation method of the gypenoside lipidosome consisting of the sterol. A preparation form of the lipidosome can be a freeze-drying injection, an injection, a transdermal preparation, aerosol, oral liquid, a solution, an eye-drops preparation, a tablet or a capsule. The gypenoside lipidosome has important treatment effects for hyperlipidemia and cardiovascular and cerebrovascular diseases, and furthermore, has positive treatment and prevention effects for tumor, hepatitis, gastritis, gastric and duodenal ulcer, gastroptosis, stomatitis, diabetes mellitus, astriction, haemorrhoids, asthma, cephalagra, acne, stain, gall-stone, numbness of limbs, pachulosis, male infertility, recession of sexual functions, fatness, white hair and baldness. Furthermore, the physical strength of a human body can be enhanced, the immunity of the organism is improved, the state of fatigue can be relieved, the sleep quality can be obviously improved, the appetite can be whetted, and the senescence can be delayed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a method for producing gypenoside liposomes, more specifically, the invention relates to gypenoside liposomes and pharmaceutical preparations containing gypenoside liposomes. Background technique [0002] Gynostemma pentaphyllum, also known as Aescin gallbladder and five-leaf ginseng, its main active ingredients are polysaccharides, flavonoids, saponins and trace elements. Its effects are mainly to promote the metabolism of human fat substances, nourish human cells, and have good detoxification and anti-inflammatory properties. It is widely used in the treatment and health care of hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, and chronic respiratory inflammation (pharyngitis, gastroenteritis, etc.). Saponin is one of the active ingredients. The reason why Gypenoside is "miraculous" is that its saponins (84 species) are several times more th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/08A61K9/19A61K9/12A61K9/20A61K9/48A61K31/704A61K45/00A61K47/28A61P3/06A61P9/00A61P35/00A61P1/16A61P1/04A61P1/00A61P1/02A61P3/10A61P1/10A61P9/14A61P11/06A61P25/06A61P17/10A61P17/00A61P15/08A61P3/04A61P17/14A61P25/00
Inventor 喻樊
Owner YANCHENG TEACHERS UNIV
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