69 results about "Aescin" patented technology

The present invention relates to aescin medicine composition and its preparation process and use. The aescin product of purity over 90 % may be compounded with medicine carrier to form composition with obvious synergistic effect, reduced stimulation of aescin on blood vessels and muscles, and obviously raised effects of diminishing inflammation, antagonizing effusion, improving blood circulation, etc. The composition features its less stimulation, high safety, high treating index, etc.

The invention discloses a nanometer aescin injection and preparing method, which is characterized by the following: extracting from effective position from aescin to prepare nanometer aescin with medical carrier; blending with drug auxiliary material to prepare water injection, transfusion agent and powder injection; controlling the content of beta-aescin at 50-85%.

A lysine escin, its compound, production and use are disclosed. The compound consists of beta-escin lysine salt, isoescin lysine salt or their mixture and/or the other accepted carriers. It has better anti-inflammatory and anti-exudative performances, better suppressant for brain edema and medicinal safety. It can also improve blood circulation increase venous tension.

The invention relates to oleanane saponin compounds aescin A and aescin B extracted and separated from aesculus carnea, and a purpose thereof. The oleanane saponin compounds have a chemical general formula as the following. The R group represents =O or -OH. As a result of experiments, the compounds has activities such as malignant tumor inhibiting, body immunity improving, liver disease preventing and curing, cardio-cerebrovascular disease preventing and curing, and diabetes mellitus preventing and curing. The invention provides novel medicine resources for treating malignant tumors, improving body immunities, and preventing and curing liver diseases, cardio-cerebrovascular diseases or diabetes mellitus.

The invention provides an automatic detection and control method of elusion start points and end points during macroporous resin purification of buckeye extract. An aescin macroporous resin purification near-infrared calibration model is built by using total content of aescin as evaluation index, the calibration model is used in online detection of buckeye extract macroporous resin elusion, and accordingly automatic judgment of elusion start points and end points during macroporous resin purification of buckeye extract is achieved, and automatic control of eluant receiving and receiving stopping is achieved. The method is fast, accurate, high in automation level and the like, manual errors are reduced, the problem that products of different batches are poor in quality uniformity is solved, effective component loss and waste can be avoided effectively, and a new technique is provided for automatic control and process quality control during macroporous resin purification of buckeye extract.

The present invention discloses a kind of medicine composition for preventing and treating orthopaedics diseases, and the medicine composition consists of deer bone extract and saponin extract with the functions of promoting blood circulation to disperse blood clots. Experiments show that the deer bone extract has obvious synergistic effect on notoginseng saponin, achyranthes root saponin and beta-aescin sodium, and the medicine composition can remit various symptoms of osteoarthritis and speed the healing of fracture. The medicine composition may be prepared into different preparation forms and has wide application foreground.

The invention relates to an environment-friendly type low temperature resistant crude oil demulsifier and its preparation method and belongs to the technical field of a demulsifier. The environment-friendly type low temperature resistant crude oil demulsifier comprises the following ingredients, by weight, 28-49 parts of polyoxyethylene-polyoxypropylene block polyether, 4-10 parts of imperata rhizome, 2-5 parts of sophora bud, 0.2-0.6 part of sodium bicarbonate, 0.5-1 part of magnesium sulfate, 1-3 parts of oligosaccharide, 0.7-1.5 parts of seaweed gel, 0.1-0.2 part of aescine, 1-3 parts of decyl glucoside, 0.5-2.8 parts of cocamidopropyl betaine and 80-99 parts of water. The demulsifier prepared in the invention has an excellent demulsification effect and can be used to effectively remove water with soluble salt in crude oil and remove residual water after desalination so as to settle residual water through aggregation. Water removal efficiency can reach up to 90-98%, and desalinization rate reaches up to 90-95%.

The invention discloses a method for purifying aescin from a semen aesculi extract. The method can comprise the steps that (1) sedimentation is conducted through acetone, specifically, the semen aesculi extract is dissolved through 3-5 times amount of low mass molecule alcohol, the acetone of the equal volume is added in a suspended status, stewing and sedimentation are conducted at 15-20 DEG C, and yellowish-brown sediment on the lower layer is obtained, decompressed and concentrated to obtain an aescin extract; (2) purification is conducted through macroporous adsorption resin, specifically, the extract is completely dissolved through 1-2 times amount of pure water, adsorption is conducted through the macroporous adsorption resin AB-8 with the sample loading quantity being 5g of the extract per 100 ml of the resin and the flow rate being 0.1-0.3 BV/h, elution is conducted through ethyl alcohol with the elution speed controlled to be 0.5-1 BV/h, and aescin flow is collected; and (3) washing and decoloration are conducted through acetone, specifically, the aescin flow is decompressed and concentrated, and obtained power is washed and decolored through the acetone, and subjected to vacuum drying to obtain an off-white aescin product. By adoption of the method, the aescin can be purified from the semen aesculi extract, and the method has the advantages that technological operation is easy and convenient, and the method is efficient and low in energy consumption, and meets production requirements of large-scale industrial extraction and purification of the aescin.

The present invention relates to development of a simplified process for purification of β-aescin from Indian horse chestnut (Aesculus indica) by aqueous alcohol extraction, solvent—solvent partition, treatment with base followed by passing the organic layer through acidic alumina in 2.0-3.0% yield of purity. minimum 90%.

The present invention relates to amino butanetriol aescin and its isomer for relieving swelling, diminishing inflammation and improving blood circulation. The amino butanetriol aescin is prepared with amino butanetriol and aescin, and has the structural formula as shown. The amino butanetriol aescin has high water solubility, lowered possibility of resulting in vasospasm and raised administrating safety.

The invention relates to a manufacture method for a non-heady liquor and a nutrient fluid neutralizing the effect of alcoholic drinks, which comprises that extracted aescin, alcohol dehydrogenase, acetaldehyde dehydrogenase, daidzein, pueraria flavonoid, taurine, citric acid and the like are combined according to a definite proportion, well stirred, treated for 28 min in an ultrasonic instrument with 120 Hz so as to reinforce the association among molecules, and then stands for hours, is added with soapy clay for defog and stability treatment, and then filtered; finally the nutrient fluid neutralizing the effect of alcoholic drinks is obtained. The nutrient fluid neutralizing the effect of alcoholic drinks is directly added into various liquors according to one in a thousand to ten in a thousand proportion and reserved for 15 days, and then can be drank, can play a good role in anti-intoxication, neutralizing the effect of alcoholic drinks and enlarging capacity for liquor. Or 25m of nutrient liquid is drunk directly before drinking liquor and after intoxication, which also can achieve the purpose of neutralizing the effect alcoholic drinks.

The invention discloses a method for preparing aescin of Chinese buckeye seeds and a method for preparing sodium aescinate. The method for preparing aescin of Chinese buckeye seeds comprises the following steps: (1) extracting the Chinese buckeye seeds by adopting a 10-70vol% ethanol solution as a solvent, so as to obtain an extract; (2) preparing the extract into a fed sample, feeding the sample onto a reverse-phase chromatographic column, performing gradient elution by using a 8-25vol% ethanol solution and a 35-80vol% ethanol solution in sequence, and collecting the 35-80vol% ethanol solution, thereby obtaining an eluant. By adopting the method disclosed by the invention, impurities can be effectively removed, meanwhile the loss amount of aescin components is small, and in addition, decoloring can be achieved without additional activated carbon decoloring operation.

The invention discloses an oil-control and acne-removal composition and application thereof. The oil-control and acne-removal composition disclosed by the invention is prepared from the following components in parts by weight: 0.1-8 parts of mongolian thyme herb extracts, 0.01-5 parts of aescin, 0.01-8 parts of cortex magnoliae officinalis extracts, 0.1- 5 parts of Rhodomyrtus tomentosa fruit extracts and 0.001-2 parts of totarol. The oil-control and acne-removal composition disclosed by the invention is mild, does not have irritation to the skin, has a good antibacterial effect, and has an obvious oil-control and acne-removal composition effect.

The invention discloses an aescin injectable hydrogel, and a preparation method and application thereof. The aescin injectable hydrogel is a hydrogels formed by self-assembly of aescin in an alkalineaqueous solution, and the preparation method is to dissolve aescin in the alkaline aqueous solution and then perform standing. The aescin injectable hydrogel has performance of shear thinning and self-repairing, does not need chemical modification and auxiliary additives, does not need additional drug carrier materials, and can be injected for administration directly. The aescin injectable hydrogel is good in sustained release, high in drug utilization, high in safety and good in therapeutic effect, and the preparation method is simple.

The invention discloses horse chestnut extract gel and a preparation method thereof. The effective ingredients of the horse chestnut extract preparation comprise aescine and L-arginine. According to the horse chestnut extract gel, the mucosal irritation of the horse chestnut extract is reduced by adopting aescine, and the horse chestnut extract gel directly acts on the local part with cervical erosion through locally external administration; and the horse chestnut extract is rich in hydroxyl, has strong moisture absorption, can be used for relieving local swelling of a patient to improve localedema to improve the compliance, and provides a new administration way to patients.

An ocular medicine for treating fundus macular degeneration is prepared from foxglover leaf, aescin, sodium hyaluronate, and pharmacologically acceptable carrier. Its preparing process is also disclosed.

The invention discloses application of aescin and salt thereof in preparing medicine for treating cataracts, and belongs to the field of pharmacy. Through a rat cataract model built by injecting galactose, the treatment effect of aescin and salt thereof on rat cataracts is evaluated by adopting a phacoscotasmus grading method; the result shows that aescin and salt thereof can significantly lower the phacoscotasmus grade, and thus it is verified that aescin and salt thereof have the effect of delaying the formation and development of rat cataracts.

The invention provides application of aescin in treatment of non-alcoholic fatty liver diseases. Pharmacological experiments in the invention show for the first time that aescin has a good treatment effect on a tyloxapol-induced non-alcoholic fatty liver disease mouse model and an oleic acid-induced and palmitic acid-induced hepatocyte lipid accumulation model. Experimental results prove that aescin can inhibit the accumulation of lipid in HepG2 and AML12 cells, and can reduce the content of TG in the liver of an NAFLD mouse, reduce ALT and AST in serum and increase SOD. Therefore, the aescin is exact in curative effect, remarkable in effect and low in side effect when used for treating the NAFLD, and has wide medical application prospects.

The invention discloses preparation and application methods of a ganoderma extract. A plant extract cosmetic comprises the following components in percentage by weight: 10-30 percent of ganoderma, 10-50 percent of tremella fuciformis, 5-20 percent of fructus lycii, 5-10 percent of aescin and 1-40 percent of liquorice. The preparation and application methods of the ganoderma extract, disclosed by the invention, have the benefits that a plant extract derives from a conventional folk plant or a medicinal and edible plant, is safe and reliable, and has no toxic or side effect; through preferable selection, a formula is reasonable in proportion and good in repair effect.

The present invention discloses a kind of aescin oral disintegrant tablet and its preparation process. The aescine oral disintegrant tablet is prepared with aescin extracted from seed of Chinese buckeye as a kind of Chinese medicinal material and medicinal supplementary material, including disintegrating agent, filler and lubricant in proper contents. The extracted aescin has beta-aescin content controlled in 50-85 wt%. Pharmacological experiment shows that the aescin oral disintegrant tablet has fast disintegrating, quick acting and high pharmacological effect.

The invention discloses aescin A and B liposome gel which comprises aescin A, aescin B, soybean phospholipids, cholesterol, Carbomer, triethanolamine, EDTA (ethylene diamine tetraacetic acid)-2Na, menthol and the like. The invention further discloses a preparation method which includes the steps of liposome preparation and liposome gel preparation. Compared with common gel, the liposome gel has better transdermal absorption effects, has sustained and controlled release functions and can be slowly released at a certain rate, constant plasma concentration is formed in skins, drug therapy time can be prolonged, and the occurrence rate of skin irritation reaction can be decreased.