Joint health-care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium and preparation method of joint health-care tablet
Through scientific proportioning and extraction technology, the prepared joint health tablets combine multiple active ingredients, which solves the problem of poor effect of traditional products and achieves comprehensive protection of joints and relief of pain and inflammation.
Patent Information
- Application Number
- CN202510817233.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-18
- Publication Date
- 2025-09-12
AI Technical Summary
Traditional joint health products lack ingredient selection and extraction technology, making it difficult to achieve comprehensive and efficient joint health effects, especially in relieving joint pain and inflammation.
Joint health tablets are prepared using multiple active ingredients such as glucosamine hydrochloride, sodium chondroitin sulfate, frankincense extract and horse chestnut extract, combined with supercritical carbon dioxide extraction and ultrasound-assisted extraction methods. The scientific proportioning and mixing process are used to improve joint health effects.
It achieves comprehensive protection for joint health, promotes the repair and regeneration of joint cartilage, effectively relieves joint pain and inflammation, and improves joint health care effects.
Smart Images
Figure CN120617336A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of medicine and health care, in particular to a joint health care tablet based on glucosamine hydrochloride and sodium chondroitin sulfate and a preparation method thereof. Background Art
[0002] With the aging of the population and changes in people's lifestyles, the incidence of joint diseases such as osteoarthritis and rheumatoid arthritis has increased year by year, becoming an important health issue affecting the quality of life of middle-aged and elderly people. As a key component of the human movement system, the health of joints is directly related to an individual's mobility and quality of life.
[0003] Traditional joint health products are mostly based on a single ingredient or simple formula, which makes it difficult to fully utilize the synergistic effects between the various ingredients, resulting in limited health effects. For example, products containing only glucosamine hydrochloride or sodium chondroitin sulfate, although they can promote the repair of articular cartilage to a certain extent, are not effective in relieving joint pain and inflammation. In addition, some traditional products may ignore the potential value of natural plant extracts in joint health, such as boswellic acid compounds in frankincense extract and aescin in horse chestnut extract. These ingredients have significant anti-inflammatory and analgesic effects and make important contributions to joint health. Therefore, traditional technology has limitations in the formula design of joint health products, making it difficult to achieve comprehensive and efficient joint health effects.
[0004] In summary, traditional joint health products have obvious deficiencies in ingredient selection and extraction technology, and are difficult to meet the high requirements of modern people for joint health. Therefore, it is particularly important to develop a joint health tablet based on glucosamine hydrochloride and sodium chondroitin sulfate and a preparation method. Summary of the Invention
[0005] The purpose of the present invention is to make up for the shortcomings of the existing technology and provide a joint health care tablet based on glucosamine hydrochloride and sodium chondroitin sulfate and a preparation method. It can combine multiple active ingredients such as glucosamine hydrochloride, sodium chondroitin sulfate, frankincense extract and horse chestnut extract to achieve comprehensive protection of joint health. This comprehensive formula not only promotes the repair and regeneration of articular cartilage, but also effectively relieves joint pain and inflammation through anti-inflammatory and analgesic effects, thereby improving the overall effect of joint health care.
[0006] In order to solve the above technical problems, the present invention provides the following technical solution: a joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium, which is prepared from the following raw materials in parts by weight: Glucosamine hydrochloride, chondroitin sulfate sodium, boswellia serrata extract, horse chestnut extract, microcrystalline cellulose, povidone, croscarmellose sodium, and silicon dioxide; The frankincense extract is derived from the resin exuded from the bark of the frankincense tree of the olive family and plants of the same genus, and its main active ingredient is frankincense acid compounds; The horse chestnut extract is derived from the dried mature seeds of the horse chestnut tree of the Aesculus family, and its main active ingredient is aescin; The frankincense extract is extracted by supercritical carbon dioxide extraction, and the extraction conditions are: extraction pressure 20-30MPa, extraction temperature 35-45°C, and extraction time 2-3 hours; The horse chestnut extract is extracted by ultrasound-assisted extraction, and the extraction conditions are: using 70%-80% volume fraction of ethanol as the extraction solvent, a solid-liquid ratio of 1:10-1:15 g / mL, an ultrasound power of 200-300 W, and an ultrasound time of 30-45 minutes.
[0007] Furthermore, the raw materials include, by weight: 30-50 parts of glucosamine hydrochloride, 20-40 parts of sodium chondroitin sulfate, 5-15 parts of frankincense extract, 3-10 parts of horse chestnut extract, 10-20 parts of microcrystalline cellulose, 3-8 parts of povidone, 3-8 parts of cross-linked sodium carboxymethyl cellulose, and 1-3 parts of silicon dioxide.
[0008] On the other hand, a method for preparing a joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium is provided, characterized in that the preparation method comprises the following steps: Weighing the formulated amounts of glucosamine hydrochloride, sodium chondroitin sulfate, microcrystalline cellulose, povidone, croscarmellose sodium, and silicon dioxide respectively, placing the mixture in a mixing container, and mixing the mixture at a speed of 80-100 r / min for 15-20 minutes to obtain a first mixed material; Adding the frankincense extract and the horse chestnut extract to the first mixed material, and continuing mixing at a speed of 60-80 r / min for 10-15 minutes to obtain a second mixed material; Add an appropriate amount of purified water to the second mixed material to make a soft material. The criterion for judging a soft material is: it can be formed into a ball when lightly grasped by hand and falls apart when lightly pressed; The soft material is granulated through a 16-20 mesh screen and dried at 50-60°C until the moisture content is less than 5% to obtain dry granules; After the dry granules are granulated, they are compressed into tablets using a rotary tablet press, and the tablet weight difference is controlled within ±5% to obtain plain tablets of joint health tablets; The joint health care tablets are coated with hydroxypropyl methylcellulose as the coating material, and the coating weight gain is 2%-3%, thereby obtaining the finished joint health care tablets.
[0009] Furthermore, the weight portion of the glucosamine hydrochloride is 35-45 parts, and the weight portion of chondroitin sulfate sodium is 25-35 parts.
[0010] Furthermore, the weight portion of the frankincense extract is 8-12 parts, and the weight portion of the horse chestnut extract is 5-8 parts.
[0011] Furthermore, the frankincense extract is extracted by supercritical carbon dioxide extraction with an extraction pressure of 22-28 MPa, an extraction temperature of 38-42° C., and an extraction time of 2.2-2.8 hours.
[0012] Furthermore, the horse chestnut extract is extracted by ultrasound-assisted extraction, with 72%-78% volume fraction of ethanol as the extraction solvent, a solid-liquid ratio of 1:11-1:14 g / mL, an ultrasound power of 220-280 W, and an ultrasound time of 32-42 minutes.
[0013] Furthermore, the weight portion of the microcrystalline cellulose is 12-18 parts, and its particle size is 50-100 μm; the povidone is povidone K30, and its weight portion is 4-7 parts; the degree of substitution of the cross-linked sodium carboxymethyl cellulose is 0.6-0.8, and its weight portion is 4-7 parts; the silicon dioxide is micropowder silica gel, and its specific surface area is 150-300 m² / g, and its weight portion is 1.5-2.5 parts.
[0014] Compared with the existing technology, the joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium and the preparation method have the following beneficial effects: 1. The present invention achieves comprehensive protection for joint health by scientifically proportioning multiple active ingredients including glucosamine hydrochloride, sodium chondroitin sulfate, frankincense extract, and horse chestnut extract. Glucosamine hydrochloride and sodium chondroitin sulfate serve as basic ingredients, helping to promote the repair and regeneration of articular cartilage. Boswellic acid compounds in frankincense extract and aescin in horse chestnut extract have anti-inflammatory and analgesic effects, effectively relieving joint pain and inflammation. The multiple effects synergistically enhance joint health.
[0015] 2. The present invention adopts supercritical carbon dioxide extraction to extract frankincense extract and ultrasound-assisted extraction to extract horse chestnut extract. Both extraction methods can effectively retain the active ingredients in the raw materials and improve the extraction efficiency. The supercritical carbon dioxide extraction method has the advantages of being non-toxic, harmless, and not destroying the active ingredients, while the ultrasound-assisted extraction method can accelerate the penetration and dissolution of the solvent into the target ingredients, thereby ensuring the content and biological activity of the active ingredients in the final product, providing strong support for joint health.
[0016] Other advantages, objects and features of the present invention will be described in part in the following description and, in part, will be apparent to those skilled in the art based on an examination of the following or may be learned from the practice of the invention. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. Those skilled in the art can also derive other drawings based on these drawings without inventive effort.
[0018] Figure 1 The present invention is a flow chart of a method for preparing joint health care tablets based on glucosamine hydrochloride and sodium chondroitin sulfate. DETAILED DESCRIPTION
[0019] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined purpose of the invention, the specific implementation methods, structures, features and effects of the present invention are described in detail below in conjunction with the accompanying drawings and preferred embodiments.
[0020] Examples 1 to 3 only change the content of frankincense extract Example 1 Raw material formula: weigh 40 parts of glucosamine hydrochloride, 30 parts of sodium chondroitin sulfate, 5 parts of frankincense extract, 6 parts of horse chestnut extract, 15 parts of microcrystalline cellulose, 5 parts of povidone K30, 5 parts of cross-linked sodium carboxymethyl cellulose, and 2 parts of micropowder silica gel, wherein the particle size of microcrystalline cellulose is 80 μm, the specific surface area of micropowder silica gel is 200 m² / g, and the degree of substitution of cross-linked sodium carboxymethyl cellulose is 0.7 Frankincense extract: extracted by supercritical carbon dioxide extraction method, extraction pressure 25MPa, extraction temperature 40℃, extraction time 2.5 hours, extracted from the resin exuded from the bark of the Oleaceae plant Frankincense tree and plants of the same genus. Its main active ingredient is boswellic acid compounds. Aesculus hippocastanum extract: Using 75% ethanol by volume as the extraction solvent, the dried mature seeds of Aesculus hippocastanum (Herculia sibiricum) of the Aesculaceae family were taken and extracted by ultrasound-assisted extraction at a solid-liquid ratio of 1:12 g / mL under the conditions of ultrasonic power of 250 W and ultrasonic time of 35 minutes. The main active ingredient is aescin. Preparation steps: Weighed glucosamine hydrochloride, sodium chondroitin sulfate, microcrystalline cellulose, povidone K30, cross-linked sodium carboxymethyl cellulose, and silica gel were placed in a mixing container and mixed at a speed of 90 r / min for 18 minutes to obtain a first mixed material. The extracted frankincense extract and horse chestnut extract were added to the first mixed material, and the mixture was mixed at a rotation speed of 70 r / min for 12 minutes to obtain a second mixed material. An appropriate amount of purified water is added to the second mixed material to prepare a soft material. The soft material meets the standard of being able to be formed into a ball when lightly grasped by hand and to fall apart when lightly pressed. The soft material was granulated through an 18-mesh screen and dried at 55°C until the moisture content was less than 5% to obtain dry granules. The dry granules are sized and then tableted using a rotary tablet press, with the tablet weight difference controlled within ±5%, to obtain plain joint health tablets. The joint health care tablets were coated with hydroxypropyl methylcellulose as the coating material, and the coating weight gain was 2.5% to obtain the finished joint health care tablets. Effect parameters: After taking it continuously for 8 weeks, the pain intensity of about 68% of patients with joint pain was reduced by 1 visual analogue scale (VAS) level, and the frequency of pain attacks was reduced by about 25%; after taking it for 12 weeks, the proteoglycan content in articular cartilage increased by about 22%, and the average cartilage thickness increased by 0.1mm; after taking it for 6 weeks, the average joint flexion and extension angle increased by 8°, joint stiffness was relieved by about 30%, and the daily activity impairment score was reduced by about 25%.
[0021] Example 2 Raw material formula: Weigh 40 parts of glucosamine hydrochloride, 30 parts of sodium chondroitin sulfate, 10 parts of frankincense extract, 6 parts of horse chestnut extract, 15 parts of microcrystalline cellulose, 5 parts of povidone K30, 5 parts of cross-linked sodium carboxymethyl cellulose, and 2 parts of micropowder silica gel, wherein the particle size of the microcrystalline cellulose is 80 μm, the specific surface area of the micropowder silica gel is 200 m² / g, and the degree of substitution of the cross-linked sodium carboxymethyl cellulose is 0.7.
[0022] Frankincense extract: extracted by supercritical carbon dioxide extraction method, extraction pressure 25MPa, extraction temperature 40℃, extraction time 2.5 hours, extracted from the resin exuded from the bark of the Oleaceae plant Frankincense tree and plants of the same genus. Its main active ingredient is boswellic acid compounds. Aesculus hippocastanum extract: Using 75% ethanol by volume as the extraction solvent, the dried mature seeds of Aesculus hippocastanum (Herculia sibiricum) of the Aesculaceae family were taken and extracted by ultrasound-assisted extraction at a solid-liquid ratio of 1:12 g / mL under the conditions of ultrasonic power of 250 W and ultrasonic time of 35 minutes. The main active ingredient is aescin. Preparation steps: Weighed glucosamine hydrochloride, sodium chondroitin sulfate, microcrystalline cellulose, povidone K30, cross-linked sodium carboxymethyl cellulose, and silica gel were placed in a mixing container and mixed at a speed of 90 r / min for 18 minutes to obtain a first mixed material. The extracted frankincense extract and horse chestnut extract were added to the first mixed material, and the mixture was mixed at a rotation speed of 70 r / min for 12 minutes to obtain a second mixed material. An appropriate amount of purified water is added to the second mixed material to prepare a soft material. The soft material meets the standard of being able to be formed into a ball when lightly grasped by hand and to fall apart when lightly pressed. The soft material was granulated through an 18-mesh screen and dried at 55°C until the moisture content was less than 5% to obtain dry granules. The dry granules are sized and then tableted using a rotary tablet press, with the tablet weight difference controlled within ±5%, to obtain plain joint health tablets. The joint health care tablets were coated with hydroxypropyl methylcellulose as the coating material, and the coating weight gain was 2.5% to obtain the finished joint health care tablets. Effect parameters: After taking it continuously for 8 weeks, the pain intensity of about 82% of patients with joint pain was reduced by 1-2 visual analogue scale (VAS) levels, and the frequency of pain attacks was reduced by about 35%; after taking it for 12 weeks, the proteoglycan content in articular cartilage increased by about 28%, and the average cartilage thickness increased by 0.15mm; after taking it for 6 weeks, the average joint flexion and extension angle increased by 12°, joint stiffness was relieved by about 40%, and the daily activity impairment score was reduced by about 32%.
[0023] Example 3 Raw material formula: Weigh 40 parts of glucosamine hydrochloride, 30 parts of sodium chondroitin sulfate, 15 parts of frankincense extract, 6 parts of horse chestnut extract, 15 parts of microcrystalline cellulose, 5 parts of povidone K30, 5 parts of cross-linked sodium carboxymethyl cellulose, and 2 parts of micropowder silica gel, wherein the particle size of the microcrystalline cellulose is 80 μm, the specific surface area of the micropowder silica gel is 200 m² / g, and the degree of substitution of the cross-linked sodium carboxymethyl cellulose is 0.7.
[0024] Frankincense extract: extracted by supercritical carbon dioxide extraction method, extraction pressure 25MPa, extraction temperature 40℃, extraction time 2.5 hours, extracted from the resin exuded from the bark of the Oleaceae plant Frankincense tree and plants of the same genus. Its main active ingredient is boswellic acid compounds. Aesculus hippocastanum extract: Using 75% ethanol by volume as the extraction solvent, the dried mature seeds of Aesculus hippocastanum (Herculia sibiricum) of the Aesculaceae family were taken and extracted by ultrasound-assisted extraction at a solid-liquid ratio of 1:12 g / mL under the conditions of ultrasonic power of 250 W and ultrasonic time of 35 minutes. The main active ingredient is aescin. Preparation steps: Weighed glucosamine hydrochloride, sodium chondroitin sulfate, microcrystalline cellulose, povidone K30, cross-linked sodium carboxymethyl cellulose, and silica gel were placed in a mixing container and mixed at a speed of 90 r / min for 18 minutes to obtain a first mixed material. The extracted frankincense extract and horse chestnut extract were added to the first mixed material, and the mixture was mixed at a rotation speed of 70 r / min for 12 minutes to obtain a second mixed material. An appropriate amount of purified water is added to the second mixed material to prepare a soft material. The soft material meets the standard of being able to be formed into a ball when lightly grasped by hand and to fall apart when lightly pressed. The soft material was granulated through an 18-mesh screen and dried at 55°C until the moisture content was less than 5% to obtain dry granules. The dry granules are sized and then tableted using a rotary tablet press, with the tablet weight difference controlled within ±5%, to obtain plain joint health tablets. The joint health care tablets were coated with hydroxypropyl methylcellulose as the coating material, and the coating weight gain was 2.5% to obtain the finished joint health care tablets. Effect parameters: After taking it continuously for 8 weeks, the pain intensity of about 90% of patients with joint pain was reduced by 2 visual analogue scale (VAS) levels, and the frequency of pain attacks was reduced by about 45%; after taking it for 12 weeks, the proteoglycan content in articular cartilage increased by about 35%, and the average cartilage thickness increased by 0.2mm; after taking it for 6 weeks, the average joint flexion and extension angle increased by 15°, joint stiffness was relieved by about 50%, and the daily activity impairment score was reduced by about 40%.
[0025] Examples 4 to 6 only changed the content of the horse chestnut extract Example 4 Raw material formula: Weigh 40 parts of glucosamine hydrochloride, 30 parts of sodium chondroitin sulfate, 10 parts of frankincense extract, 3 parts of horse chestnut extract, 15 parts of microcrystalline cellulose, 5 parts of povidone K30, 5 parts of cross-linked sodium carboxymethyl cellulose, and 2 parts of micropowder silica gel, wherein the particle size of the microcrystalline cellulose is 80 μm, the specific surface area of the micropowder silica gel is 200 m² / g, and the degree of substitution of the cross-linked sodium carboxymethyl cellulose is 0.7.
[0026] Frankincense extract: extracted by supercritical carbon dioxide extraction method, extraction pressure 25MPa, extraction temperature 40℃, extraction time 2.5 hours, extracted from the resin exuded from the bark of the Oleaceae plant Frankincense tree and plants of the same genus. Its main active ingredient is boswellic acid compounds. Aesculus hippocastanum extract: Using 75% ethanol by volume as the extraction solvent, the dried mature seeds of Aesculus hippocastanum (Herculia sibiricum) of the Aesculaceae family were taken and extracted by ultrasound-assisted extraction at a solid-liquid ratio of 1:12 g / mL under the conditions of ultrasonic power of 250 W and ultrasonic time of 35 minutes. The main active ingredient is aescin. Preparation steps: Weighed glucosamine hydrochloride, sodium chondroitin sulfate, microcrystalline cellulose, povidone K30, cross-linked sodium carboxymethyl cellulose, and silica gel were placed in a mixing container and mixed at a speed of 90 r / min for 18 minutes to obtain a first mixed material. The extracted frankincense extract and horse chestnut extract were added to the first mixed material, and the mixture was mixed at a rotation speed of 70 r / min for 12 minutes to obtain a second mixed material. An appropriate amount of purified water is added to the second mixed material to prepare a soft material. The soft material meets the standard of being able to be formed into a ball when lightly grasped by hand and to fall apart when lightly pressed. The soft material was granulated through an 18-mesh screen and dried at 55°C until the moisture content was less than 5% to obtain dry granules. The dry granules are sized and then tableted using a rotary tablet press, with the tablet weight difference controlled within ±5%, to obtain plain joint health tablets. The joint health care tablets were coated with hydroxypropyl methylcellulose as the coating material, and the coating weight gain was 2.5% to obtain the finished joint health care tablets. Effect parameters: After taking it for 6 weeks, the average joint flexion and extension angle of patients increased by 8°, joint stiffness was relieved by about 28%, and the daily activity impairment score decreased by about 22%; after taking it for 8 consecutive weeks, the pain level of about 65% of patients with joint pain decreased by 1 visual analog scale (VAS) level, and the frequency of pain attacks decreased by about 23%; after taking it for 12 weeks, the proteoglycan content in articular cartilage increased by about 20%, and the average cartilage thickness increased by 0.08mm.
[0027] Example 5 Raw material formula: Weigh 40 parts of glucosamine hydrochloride, 30 parts of sodium chondroitin sulfate, 10 parts of frankincense extract, 8 parts of horse chestnut extract, 15 parts of microcrystalline cellulose, 5 parts of povidone K30, 5 parts of cross-linked sodium carboxymethyl cellulose, and 2 parts of micropowder silica gel, wherein the particle size of the microcrystalline cellulose is 80 μm, the specific surface area of the micropowder silica gel is 200 m² / g, and the degree of substitution of the cross-linked sodium carboxymethyl cellulose is 0.7.
[0028] Frankincense extract: extracted by supercritical carbon dioxide extraction method, extraction pressure 25MPa, extraction temperature 40℃, extraction time 2.5 hours, extracted from the resin exuded from the bark of the Oleaceae plant Frankincense tree and plants of the same genus. Its main active ingredient is boswellic acid compounds. Aesculus hippocastanum extract: Using 75% ethanol by volume as the extraction solvent, the dried mature seeds of Aesculus hippocastanum (Herculia sibiricum) of the Aesculaceae family were taken and extracted by ultrasound-assisted extraction at a solid-liquid ratio of 1:12 g / mL under the conditions of ultrasonic power of 250 W and ultrasonic time of 35 minutes. The main active ingredient is aescin. Preparation steps: Weighed glucosamine hydrochloride, sodium chondroitin sulfate, microcrystalline cellulose, povidone K30, cross-linked sodium carboxymethyl cellulose, and silica gel were placed in a mixing container and mixed at a speed of 90 r / min for 18 minutes to obtain a first mixed material. The extracted frankincense extract and horse chestnut extract were added to the first mixed material, and the mixture was mixed at a rotation speed of 70 r / min for 12 minutes to obtain a second mixed material. An appropriate amount of purified water is added to the second mixed material to prepare a soft material. The soft material meets the standard of being able to be formed into a ball when lightly grasped by hand and to fall apart when lightly pressed. The soft material was granulated through an 18-mesh screen and dried at 55°C until the moisture content was less than 5% to obtain dry granules. The dry granules are sized and then tableted using a rotary tablet press, with the tablet weight difference controlled within ±5%, to obtain plain joint health tablets. The joint health care tablets were coated with hydroxypropyl methylcellulose as the coating material, and the coating weight gain was 2.5% to obtain the finished joint health care tablets. Effect parameters: After taking it for 6 weeks, the average joint flexion and extension angle of patients increased by 14°, joint stiffness was relieved by about 45%, and the daily activity impairment score decreased by about 38%; after taking it for 8 consecutive weeks, the pain level of about 88% of patients with joint pain decreased by 1-2 visual analog scale (VAS) levels, and the frequency of pain attacks decreased by about 40%; after taking it for 12 weeks, the proteoglycan content in articular cartilage increased by about 32%, and the average cartilage thickness increased by 0.18mm.
[0029] Example 6 Raw material formula: Weigh 40 parts of glucosamine hydrochloride, 30 parts of sodium chondroitin sulfate, 10 parts of frankincense extract, 10 parts of horse chestnut extract, 15 parts of microcrystalline cellulose, 5 parts of povidone K30, 5 parts of cross-linked sodium carboxymethyl cellulose, and 2 parts of micropowder silica gel, wherein the particle size of the microcrystalline cellulose is 80 μm, the specific surface area of the micropowder silica gel is 200 m² / g, and the degree of substitution of the cross-linked sodium carboxymethyl cellulose is 0.7.
[0030] Frankincense extract: extracted by supercritical carbon dioxide extraction method, extraction pressure 25MPa, extraction temperature 40℃, extraction time 2.5 hours, extracted from the resin exuded from the bark of the Oleaceae plant Frankincense tree and plants of the same genus. Its main active ingredient is boswellic acid compounds. Aesculus hippocastanum extract: Using 75% ethanol by volume as the extraction solvent, the dried mature seeds of Aesculus hippocastanum (Herculia sibiricum) of the Aesculaceae family were taken and extracted by ultrasound-assisted extraction at a solid-liquid ratio of 1:12 g / mL under the conditions of ultrasonic power of 250 W and ultrasonic time of 35 minutes. The main active ingredient is aescin. Preparation steps: Weighed glucosamine hydrochloride, sodium chondroitin sulfate, microcrystalline cellulose, povidone K30, cross-linked sodium carboxymethyl cellulose, and silica gel were placed in a mixing container and mixed at a speed of 90 r / min for 18 minutes to obtain a first mixed material. The extracted frankincense extract and horse chestnut extract were added to the first mixed material, and the mixture was mixed at a rotation speed of 70 r / min for 12 minutes to obtain a second mixed material. An appropriate amount of purified water is added to the second mixed material to prepare a soft material. The soft material meets the standard of being able to be formed into a ball when lightly grasped by hand and to fall apart when lightly pressed. The soft material was granulated through an 18-mesh screen and dried at 55°C until the moisture content was less than 5% to obtain dry granules. The dry granules are sized and then tableted using a rotary tablet press, with the tablet weight difference controlled within ±5%, to obtain plain joint health tablets. The joint health care tablets were coated with hydroxypropyl methylcellulose as the coating material, and the coating weight gain was 2.5% to obtain the finished joint health care tablets. Effect parameters: After taking it for 6 weeks, the average joint flexion and extension angle of patients increased by 16°, joint stiffness was relieved by about 52%, and the daily activity impairment score decreased by about 42%; after taking it for 8 consecutive weeks, the pain level of about 92% of patients with joint pain decreased by 2 visual analog scale (VAS) levels, and the frequency of pain attacks decreased by about 48%; after taking it for 12 weeks, the proteoglycan content in articular cartilage increased by about 38%, and the average cartilage thickness increased by 0.22mm.
[0031] The specific contents are shown in the following table: Frankincense extract content (parts) Horse chestnut extract content (parts) Example 1 5 6 Example 2 10 6 Example 3 15 6 Example 4 10 3 Example 5 10 8 Example 6 10 10 As shown in the table above, through the three examples with different frankincense extract contents, it can be seen that, with other raw materials and preparation parameters remaining unchanged, as the frankincense extract content increases, the effectiveness of the joint health tablet in relieving joint pain, promoting articular cartilage repair, and enhancing joint flexibility gradually improves. A low frankincense extract content (5 parts) can provide some relief to most patients' joint pain, but the effect is relatively weak. At a medium frankincense extract content (10 parts), all effects are good and can significantly improve the patient's joint condition. A high frankincense extract content (15 parts) further enhances the efficacy of the health tablet, with more prominent effects in relieving pain, promoting cartilage repair, and improving joint flexibility, providing stronger support for joint health.
[0032] By comparing three examples in which only the content of horse chestnut extract was changed, it can be seen that, when other raw materials and preparation conditions remain unchanged, the change in the content of horse chestnut extract has a significant impact on the efficacy of the joint health tablets. A low content (3 parts) of horse chestnut extract can improve joint flexibility, relieve pain and promote cartilage repair to a certain extent, but the effect is relatively limited; at a medium content (8 parts), various indicators perform well, and can effectively improve joint mobility, relieve pain and promote cartilage health; a high content (10 parts) of horse chestnut extract further enhances the comprehensive effect of the health tablets, showing better performance in improving synovial fluid circulation, enhancing joint flexibility, relieving pain and promoting cartilage repair, providing more comprehensive support for joint health.
[0033] The above description is merely a preferred embodiment of the present invention and does not constitute any form of limitation to the present invention. Although the present invention has been disclosed as above in terms of a preferred embodiment, it is not intended to limit the present invention. Any person skilled in the art can, without departing from the scope of the technical solution of the present invention, make some changes or modifications to equivalent embodiments using the technical contents disclosed above. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.
Claims
1. A joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium, characterized in that: Made from the following raw materials by weight: Glucosamine hydrochloride, chondroitin sulfate sodium, boswellia serrata extract, horse chestnut extract, microcrystalline cellulose, povidone, croscarmellose sodium, and silicon dioxide; The frankincense extract is extracted by supercritical carbon dioxide extraction, and the extraction conditions are: extraction pressure 20-30MPa, extraction temperature 35-45°C, and extraction time 2-3 hours; The horse chestnut extract is extracted by ultrasound-assisted extraction, and the extraction conditions are: using 70%-80% volume fraction of ethanol as the extraction solvent, a solid-liquid ratio of 1:10-1:15 g / mL, an ultrasound power of 200-300 W, and an ultrasound time of 30-45 minutes.
2. A joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium according to claim 1, characterized in that: The raw materials include, by weight, 30-50 parts of glucosamine hydrochloride, 20-40 parts of sodium chondroitin sulfate, 5-15 parts of frankincense extract, 3-10 parts of horse chestnut extract, 10-20 parts of microcrystalline cellulose, 3-8 parts of povidone, 3-8 parts of cross-linked sodium carboxymethyl cellulose, and 1-3 parts of silicon dioxide.
3. A method for preparing a joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium according to any one of claims 1 to 2, characterized in that: The following steps are involved: Weighing the formulated amounts of glucosamine hydrochloride, sodium chondroitin sulfate, microcrystalline cellulose, povidone, croscarmellose sodium, and silicon dioxide respectively, placing the mixture in a mixing container, and mixing the mixture at a speed of 80-100 r / min for 15-20 minutes to obtain a first mixed material; Adding the frankincense extract and the horse chestnut extract to the first mixed material, and continuing mixing at a speed of 60-80 r / min for 10-15 minutes to obtain a second mixed material; Adding an appropriate amount of purified water to the second mixed material to prepare a soft material; The soft material is granulated through a 16-20 mesh screen and dried at 50-60°C until the moisture content is less than 5% to obtain dry granules; After the dry granules are granulated, they are compressed into tablets using a rotary tablet press, and the tablet weight difference is controlled within ±5% to obtain plain tablets of joint health tablets; The joint health care tablets are coated with hydroxypropyl methylcellulose as the coating material, and the coating weight gain is 2%-3%, thereby obtaining the finished joint health care tablets.
4. The method for preparing a joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium according to claim 3, characterized in that: The weight portion of the glucosamine hydrochloride is 35-45 parts, and the weight portion of sodium chondroitin sulfate is 25-35 parts.
5. The method for preparing a joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium according to claim 3, characterized in that: The weight portion of the frankincense extract is 8-12 parts, and the weight portion of the horse chestnut extract is 5-8 parts.
6. The method for preparing a joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium according to claim 3, characterized in that: The frankincense extract is extracted by supercritical carbon dioxide extraction method, with an extraction pressure of 22-28 MPa, an extraction temperature of 38-42° C., and an extraction time of 2.2-2.8 hours.
7. The method for preparing a joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium according to claim 3, characterized in that: The horse chestnut extract is extracted by ultrasound-assisted extraction, with 72%-78% ethanol as the extraction solvent, a solid-liquid ratio of 1:11-1:14 g / mL, an ultrasound power of 220-280 W, and an ultrasound time of 32-42 minutes.
8. The method for preparing a joint health care tablet based on glucosamine hydrochloride and chondroitin sulfate sodium according to claim 3, characterized in that: The weight portion of the microcrystalline cellulose is 12-18 parts, and its particle size is 50-100 μm. The povidone is povidone K30, and its weight portion is 4-7 parts. The degree of substitution of the cross-linked sodium carboxymethyl cellulose is 0.6-0.8, and its weight portion is 4-7 parts. The silicon dioxide is micropowder silica gel, and its specific surface area is 150-300 m² / g, and its weight portion is 1.5-2.5 parts.