306 results about "Proteinuria" patented technology

Systemic suppression of the complement system has been shown to be effective to treat inflammatory disease, yet at the potential cost of compromising host defense and immune homeostasis. Herein disclosed are methods for antigen-specific targeting of complement inhibitors that show that complement inhibitors targeted to the proximal tubular epithelium protect against tubulointerstitial injury and renal dysfunction in a rat model of nephrosis. It is shown that appropriate targeting of a systemically administered complement inhibitor to a site of disease markedy enhances efficacy and obviates the need to systemically inhibit complement. Additionally, it is shown by specifically inhibiting the terminal pathway of complement, that the membrane attack complex (MAC) plays a key role in proteinuria-induced tubulointerstitial injury, thus establishing the MAC as a valid target for pharmacological intervention in proteinuric disorders. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.

The present invention is directed to a method of inhibiting at least one of vascular leakage, inflammation and fibrosis in an animal by administering to the animal a vascular leakage inhibiting amount of a composition, wherein at a substantially higher amount the composition is effective in inhibiting angiogenesis, and wherein the anti-angiogenic activity of the composition is separate from the vascular leakage inhibiting activity of the composition. The animal experiencing at least one of vascular leakage, inflammation and fibrosis has a disease selected from the group consisting of diabetes, chronic inflammation, brain edema, arthritis, uvietis, macular edema, cancer, hyperglycemia, a kidney inflammatory disease, a disorder resulting in kidney fibrosis, a disorder of the kidney resulting in proteinuria, and combinations thereof. The composition capable of inhibiting at least one of vascular leakage, inflammation and fibrosis is selected from the group consisting of angiostatin, fragments of angiostatin, analogs or derivatives of angiostatin, kringle 5 of plasminogen, fragments of kringle 5 of plasminogen, analogs or derivatives of kringle 5 of plasminogen, pigment epithelium-derived factor, fragments of pigment epithelium-derived factor, analogs or derivatives of pigment epithelium-derived factor and combinations thereof.

Methods are provided for preventing or treating risk factors for cardiovascular disease in an individual, comprising administering a therapeutically effective amount of a composition comprising an estradiol metabolite to said individual. Such risk factors include obesity, the metabolic syndrome, diabetes mellitus, vascular disorders, and renal disorders. Preferred estradiol metabolites include 2-methoxyestradiol, 4-methoxyestradiol, 2-hydroxyestradiol, and 4-hydroxyestradiol or prodrugs thereof. The compositions may also be in the form of a controlled release formulation. Methods are also provided for use of estradiol metabolites to treat or prevent insulin resistance, vascular endothelial dysfunction, hyperlipidemia, hypertension, diabetic nephropathy, proteinuria and reducing leptin levels. In addition, the methods provide a method of stabilizing glucose levels. These treatments may be used in either gender because of their lack of a feminizing estrogenic effect.

The invention discloses a new traditional Chinese medicine composition for treating nephrotic syndrome and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following Chinese medicinal herbs such as American ginseng, ginseng, codonopsis pilosula, unprocessed astragalus mongholicus, Chinese yam, turtle shell, tortoise plastron, cornu cervi degelatinatum, fruit of Chinese wolfberry, root of Chinese trichosanthes, fruit of Chinese magnoliavine, seed of Chinese dodder, herba cistanche, Chinese caterpillar fungus, prepared rehmannia root, polygonum multiflorum, fructus ligustri lucidi, dried orange peel, myristica fragrans, fructus amomi, semen euryales, mangnolia officinalis, fructus chebulae, fructus rosae laevigatae, fructus alpiniae oxyphyllae, oyster, drynaria rhizome, dogwood, root-bark of Chinese wolfberry, phellodendron, fructus gardenia, white atractylodes rhizome, lucid asparagus, ophiopogon japonicus, herba epimedii, rhizoma anemarrhenae, root of kudzu vine and the like. The traditional Chinese medicine composition can be prepared into any one common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can remarkably improve symptoms of proteinuria, hypoalbuminemia, hematuresis, generaldropsy, listlessness, poor physical strength, inappetence, insomnia and amnesia, hypomnesis and the like of the patients suffering from the nephrotic syndrome and has accurate clinical treatment effect, remarkable treatment effect and rapid effect taking. Because of being combined by basically adopting medicinal and edible medicines specified in National Formulary, the invention has the advantages of low cost, basically no toxic and side effects and the like.

In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and / or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.

Methods of treating lupus, including systemic lupus erythematosus, cutaneous lupus erythmetosus, and lupus nephritis, are provided. The methods involve administration of a combination of a non-depleting CD4 antibody and another compound used clinically or experimentally to treat lupus. Methods of treating lupus nephritis by administration of a non-depleting CD4 antibody that results in an improvement in renal function and / or a reduction in proteinuria or active urinary sediment are also provided. Methods of treating multiple sclerosis by administration of a non-depleting CD4 antibody, optionally in combination with another compound used clinically or experimentally to treat MS, are described. Methods of treating transplant recipients and subjects with rheumatoid arthritis, asthma, psoriasis, Crohn's disease, ulcerative colitis, and Sjogren's syndrome are also provided.

The invention discloses a single-chain antibody of human source anti-alexin C3d molecules. A light chain and a heavy chain of the antibody have a unique CDR region; excellent antigen binding activityis realized; the affinity constant reaches 1.22*10<-7> mol / L. Biological distribution experiments prove that the anti-C3d single-chain antibody provided by the invention can be highly gathered in thearthritis positions after entering a mouse model with rheumatoid arthritis; the arthritis serious degree of the three ScFv treatment groups is obviously lower than that of a PBS group; the healing degree has the obvious dose dependency relationship; the result shows that the excellent anti-adhesion / anti-inflammatory targeted inhibition effects are achieved. In the treatment process on MRL / lpr mice with lupus erythematosus, the anti-C3d single-chain antibody provided by the invention can obviously improve the survival rate of the mice; the symptoms of proteinuria, glomerular score, interstitial inflammation, vasculitis and crescent / necrosis and the like in the treatment group are obviously relieved. The result shows that the anti C3d single-chain antibody provided by the invention has excellent application prospects in the preparation of medicine for treating autoimmune diseases.

The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.

A support vector machine (110) is used to predict who, among a population of patients with diabetes mellitus, will develop proteinuria which is in indicator of diabetic nephropathy. The support vector machine (110) is trained using test results of the patients from blood biochemistry and haemotology tests. The training and testing of the support vector machine (110) used data in which the entire patient population did not exhibit signs of proteinuria at a predetermined time period and three months later, and some of the patient population had proteinuria six months from the predetermined time period. The support vector machine (110) is used to predict who, among patients with diabetes mellitus using lest results from a predetermined time period and three months later, will develop proteinuria at six months from the predetermined time period. The input data to the support vector machine (110) included different parameters of test results at a predetermined time and three months later.

Systemic suppression of the complement system has been shown to be effective to treat inflammatory disease, yet at the potential cost of compromising host defense and immune homeostasis. Herein disclosed are methods for antigen-specific targeting of complement inhibitors that show that complement inhibitors targeted to the proximal tubular epithelium protect against tubulointerstitial injury and renal dysfunction in a rat model of nephrosis. It is shown that appropriate targeting of a systemically administered complement inhibitor to a site of disease markedy enhances efficacy and obviates the need to systemically inhibit complement. Additionally, it is shown by specifically inhibiting the terminal pathway of complement, that the membrane attack complex (MAC) plays a key role in proteinuria-induced tubulointerstitial injury, thus establishing the MAC as a valid target for pharmacological intervention in proteinuric disorders. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.

The invention relates to novel methods of using 2-methylene-19-nor-20(S)-1,25-dihydroxyvitamin D3 to prevent renal disease, particularly Lupus nephritis, in a subject at risk of developing renal disease. Methods of preventing symptoms of renal disease, such as proteinuria, splenomegaly or glomerular damage are also provided. Methods of treating symptoms of renal disease, including proteinuria and splenomegaly, are also provided.

The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.

Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to ameliorate renal failure (e.g., improved diuretic effect and / or lowering blood urea nitrogen, proteinuria, and / or serum creatinine levels) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using such compositions.

A composition including an aliquot of the herb Herba Epimedii; and an aliquot of at least three supplemental herbs selected from the group consisting of Fructus Rosae Laevigatae; Fructus Rubi; Fructus Psoralea; Radix Morindae Officinalis; Fructus Schisandrac Chinensis; Fructus Ligustri Lucidi; Semen Cuscutae; and Radix Astragali. A composition including icariin; ursolic acid; ellagic acid; psoralen; deoxyschizandrin; oleanolic acid; quercetin; aslvagaloside; and an extract of the herb Radix Morindae Officinalis. Methods including administering a composition directed at treatment of various kidney disorders or the promotion of kidney health and to the overall health of the kidney, including the use of a composition in the treatment of prostate cancer, prophylatic prostate health, reduction of polyuria, incontinence, proteinuria, as well as for sexual satisfaction.

The invention discloses a composite kidney-benefiting medicine and belongs to Chinese herbal composite medicine. The composite kidney-benefiting medicine comprises astragalus, angelica sinensis, red peony root, rhizoma chuanxiong, glossy privet fruit, eclipta, lalang grass rhizome, moutan bark, fructus kochiae and glycyrrhiza. The composite kidney-benefiting medicine can effectively cure pure simple hematuresis and hematuresis proteinuria, comprises immune globulin A (IgA) nephropathy, anaphylatic purpura nephritis, nephrotic syndrome, comprises nephritis type with hematuresis, can confront side effect of nephrotic syndrome which is cured by hormone, can play roles in promoting blood circulation to remove blood stasis and preventing and curing hypercoagulable state and has the advantages of being prominent in curative effect, convenient to take and good in taste.

A composition including an aliquot of the herb Herba Epimedii; and an aliquot of at least three supplemental herbs selected from the group consisting of Fructus Rosae Laevigatae; Fructus Rubi; Fructus Psoralea; Radix Morindae Officinalis; Fructus Schisandrac Chinensis; Fructus Ligustri Lucidi; Semen Cuscutae; and Radix Astragali. A composition including icariin; ursolic acid; ellagic acid; psoralen; deoxyschizandrin; oleanolic acid; quercetin; aslvagaloside; and an extract of the herb Radix Morindae Officinalis. Methods including administering a composition directed at treatment of various kidney disorders or the promotion of kidney health and to the overall health of the kidney, including the use of a composition in the treatment of prostate cancer, prophylatic prostate health, reduction of polyuria, incontinence, proteinuria, as well as for sexual satisfaction.

The invention discloses a traditional Chinese medicine composition for treating chronic nephritis proteinuria, and the traditional Chinese medicine composition is mainly prepared by the following active pharmaceutical ingredients in parts by weight: 20-50 parts of raw membranous milkvetch root, 15-30 parts of pilose Asiabell root, 15-30 parts of Chinese peashrub root, 15-30 parts of raw coix seedroot, 18-30 parts of fructus forsythiae, 12-30 parts of honeysuckle flower, 18-30 parts of heartleaf houttuynia herb, 15-30 parts of spreading hedyotis herb, 9-20 parts of Szechuan lovage rhizome, 9-20 parts of tree peony bark, 15-30 parts of motherwort herb, 15-30 parts of Indian buead, 15-30 parts of corn silk and 15-30 parts of winged euonymus twig. In addition, the invention further disclosesa preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition can combine tonification with purgation, perform warming and cooling simultaneously,effectively eliminate the proteinuria and other pathological indicators of kidneys, delay and even block the progress of chronic nephritis and realize the significant protection effect for the kidneys.

The invention provides a use of a bisbenzylisoquinoline alkaloid derivative or analogue to prepare medicine medicines for treating diabetic nephropathy. The bisbenzylisoquinoline alkaloid derivative of general formula I provided by the invention by relieving glomerular basement membrane thickening, reduces foot process fusion of glomerular epithelial cells and restores mechanical barrier and charge barrier of glomerulus, thus reducing protein leakage, having a good therapeutic effect on diabetic nephropathy (stage III or stage IV) patients, reducing 24h micro-albumin (UAE) and 24h urine protein (UPQ), having a good inhibitory effect on the albuminuria symptom of the diabetic nephropathy, and providing a new choice for the clinical treatment of the diabetic nephropathy.

In one aspect, the invention provides methods for reducing proteinuria in a human subject suffering, or at risk of developing Immunoglobulin A Nephropathy (IgAN). The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory antibody effective to inhibit MASP-2-dependent complement activation.

The invention relates to a rosuvastatin calcium sustained-release preparation and a preparation method thereof. The rosuvastatin calcium sustained-release preparation basically contains 5 to 10mg of rosuvastatin calcium, and the balance of sustained-release framework material and other pharmaceutical excipients. The preparation method is simple; and all the materials are proportioned and the preparation is prepared by the preparation method for common tablets, granules or capsules. The rosuvastatin calcium sustained-release preparation prepared by the method avoids adverse reactions such as rhabdomyolysis, proteinuria, nephrosis, kidney failure, hepatotoxicity and the like caused by overdosage of medicaments; meanwhile, due blood concentration and time for treating diseases after the medicaments are taken can be maintained, and the peak valley phenomenon of the blood concentration is effectively avoided.

The invention relates to methods, compositions, and kits for the treatment of proteinuria and / or hypertension (e.g., proteinuria and / or hypertension arising from primary renal disease (e.g., focal segmental glomerulosclerosis, glomerular disease) or secondary to other conditions (e.g., diabetes, diabetic nephropathy, liver disease). Specifically, the invention relates to methods involving combination therapy wherein an indoline (e.g., indapamide) is administered in combination with an anti-aldosterone agent (e.g., spironolactone and / or epleronone).

Methods of treating lupus, including systemic lupus erythematosus, cutaneous lupus erythmetosus, and lupus nephritis, are provided. The methods involve administration of a combination of a non-depleting CD4 antibody and another compound used clinically or experimentally to treat lupus. Methods of treating lupus nephritis by administration of a non-depleting CD4 antibody that results in an improvement in renal function and / or a reduction in proteinuria or active urinary sediment are also provided. Methods of treating multiple sclerosis by administration of a non-depleting CD4 antibody, optionally in combination with another compound used clinically or experimentally to treat MS, are described. Methods of treating transplant recipients and subjects with rheumatoid arthritis, asthma, psoriasis, Crohn's disease, ulcerative colitis, and Sjogren's syndrome are also provided.

The invention relates to a compound Chinese medicinal preparation for treating IgA (Immunoglobulin A) nephropathy. The compound Chinese medicinal preparation comprises the following Chinese medicinal raw materials by weight: 13-17 grams of astragalus, 8-12 grams of rehmannia root, 8-12 grams of red-rooted salvia root, 8-12 grams of common bletilla pseudobulb, 2-4 grams of cicada shell, 8-12 grams of garden burnet root, 16-24 grams of cogongrass rhizome and 2-4 grams of Chinese caterpillar fungus (brewed). A preparation method of the compound Chinese medicinal preparation comprises the following steps of: cleaning the eight types of medicinal materials; mixing proportionally; adding water in an amount which is 6-8 times the total weight of the medicinal materials or 70 percent by volume of ethanol for decocting for three times, every time for 40 minutes; combining decoction solutions obtained in the three times; filtering; and concentrating to obtain a liquid extract of which the specific weight is 1.21 at 60 DEG C. The compound Chinese medicinal preparation can be prepared into any pharmaceutical dosage form, such as tablets, capsules, granules, oral liquid, pills and syrup with the conventional preparation process. The compound Chinese medicinal preparation prepared with the method has the advantages of great reduction in the concentrations of albuminuria and hematuria of patient suffering from IgA nephropathy, great improvement on the kidney function, remarkable curative effect and great reduction in side effects and untoward reactions.

The invention discloses application of umbilical cord mesenchymal stem cell-derived exosome in preparing drug or preparation for treating preeclampsia, in particular relates to application of treating preeclampsia by extracting exosome through umbilical cord mesenchymal stem cells of humans. The exosome can effectively alleviate hypertension and proteinuria of preeclampsia and glomerulonephritis, reduce inflammatory response in placenta, and promote fetal development. This kind of exosome has the advantages of convenience in storage and transport and provides a new strategy for treating related diseases of refractory inflammations of preeclampsia.

The invention discloses a novel low-toxicity tripterygium polyglycoside. The novel low-toxicity tripterygium polyglycoside is obtained via chemical processing and adding of triptolide. The invention also discloses applications of the novel low-toxicity tripterygium polyglycoside in the field of medicine. The novel low-toxicity tripterygium polyglycoside is capable of relieving nephrotic syndromes such as kidney pathological injury and proteinuria, improving body inflammation level, possesses obvious curative effect on nephrotic syndromes, is low in toxicity, and effect lasts long.

The invention discloses a traditional Chinese medicine preparation for treating chronic kidney disease proteinuria, which comprises the following raw materials in parts by weight: 15-30 parts of codonopsis pilosula, 6-15 parts of radix asparagi, 10-15 parts of prepared rehmannia root, 5-10 parts of bark of Chinese corktree, 10-15 parts of rehmannia root, 3-5 parts of villous amomum fruit and 3-10parts of licorice root. The preparation method comprises the steps of decocting the raw materials in water according to required proportions first, carrying out reduced-pressure concentration after filtering, then adding adjuvants, and carrying out granulating and drying. The traditional Chinese medicine preparation not only has an obvious curative effect on kidney yin deficiency syndrome, but also can effectively relieve the symptom of hyperactivity of fire due to yin deficiency.

The present disclosure provides a biochemical basis of nephrotic syndrome and provides and explanation for the observed proteinuria and other effects. As a result, the present disclosure provides method for treating and / or preventing nephrotic syndrome as well as methods of alleviating symptoms associated with nephrotic syndrome. The present disclosure further provides methods for reducing proteinuria in nephrotic syndrome and other disease states as discussed herein.

The invention relates to an ampelopsis grossedentata leaf and herba cichorii composition and a preparation method thereof and application of the composition. The ampelopsis grossedentata leaf and herba cichorii composition consists of ampelopsis grossedentata leaves, herba cichorii, fructus gardeniae, folium mori, radix puerariae and bulbus lilii. The composition of the invention takes medicinal and edible medicinal materials as raw materials; according to the theory of traditional Chinese medicine, medicine properties and dosage, the composition is reasonably proportioned, keeps pathogenesis,and performs treatment based on syndrome differentiation, and has a significant treatment effect on damp-heat blockage type uricemia (symptoms including proteinuria, hematuresis, edema, uric acid calculus, glucose and lipid metabolism disorder and the like). In addition, the prescription of the invention has no toxic and side effects, is safe and reliable, and is convenient to take.

The invention relates to the technical field of medicine, in particular to a new application of scutellarin, and provides the application of the scutellarin in preparing medicine for reducing pathological changes of kidney tissue and the application of the scutellarin in preparing medicine for treating nephritis. The new application of the scutellarin is proved by experiments to show that the intragastric administration is continuously performed on nephritis model rats with the scutellarin in the dose of 20 mg / kg and 40 mg / kg for eight weeks, the proteinuria of the model animals can be obviously reduced, hypoproteinemia, hyperlipidemia and the hypercoagulable state of blood can be corrected, the serum lipid peroxidation product content of the model rats can be lowered, the expression of TNF-alpha in the kidney tissue can be inhibited, and a protection effect on the kidney tissue and a good improvement effect on the kidney function are achieved; in addition, the maximum dose of intragastric administration on the rats is equal to and more than 18 g / kg, and obvious acute toxicity reaction and death do not occur on the animals.