22 results about "Arteriole" patented technology

The invention relates to an application of a histone H3K18 lactic acid modification related target in preparation of a medicine for preventing or treating atherosclerosis. The invention belongs to the field of biological medicine, and discloses histone acetyltransferase P300 and application of histone H3K18 lactylation (H3K18la) modification mediated by the histone acetyltransferase P300 as a new target spot for treating atherosclerosis (AS). Researches find that in the AS process, lactic acid accumulation in vascular smooth muscle cells (VSMCs) up-regulates H3K18la through P300 catalysis, and then the pathological phenotype of the VSMCs is induced, and plaque development is promoted. H3K18la can be reduced and the phenotype can be improved by inhibiting LDHA and MCT1 in vitro or knocking out a P300 gene; the P300 for in-vivo targeted inhibition of the VSMCs can significantly reduce the artery plaque. Therefore, the P300 and H3K18la inhibitors can be used for preparing the anti-atherosclerosis medicine.

The invention discloses a bionic wrist pulse generator, and relates to the technical field of medical instruments, the bionic wrist pulse generator comprises a wrist bionic structure and a blood vessel bionic structure, the wrist bionic structure comprises a bionic skin layer, a mounting layer and a supporting layer, and the mounting layer is arranged between the bionic skin layer and the supporting layer; when the device is used, the peristaltic pump draws liquid from the liquid groove and outputs the liquid into the elastic tube, the purpose of simulating pulse vibration signals of the wrist of the human body is achieved by adjusting parameters of the peristaltic pump, adjusting the flow of the liquid in the elastic tube and reproducing periodic signals, the three-stage branch network structure is designed, the first-stage branch simulates the arteriole, and the second-stage branch simulates the arteriole; the second-stage branch and the third-stage branch simulate a micro artery and a blood capillary respectively, and then a periodic signal is sensed on the bionic skin layer, so that the practice effect is achieved.

The invention belongs to the technical field of medicines, and discloses application of WZ3146 in preparation of products for preventing and / or treating pulmonary arterial hypertension and complications thereof. The WZ3146 and the pharmaceutically acceptable salt thereof have a remarkable treatment effect on pulmonary arterial hypertension and complications thereof, such as mean pulmonary arterial pressure, high right ventricular systolic pressure, right heart enlargement, right heart dysfunction, pulmonary vascular remodeling, pulmonary arterial intima thickness, increase of vascular myelization, pulmonary artery smooth muscle cell proliferation and migration and the like; the effects of preventing and / or treating pulmonary arterial hypertension comprise expanding the right heart, improving the pulmonary arterial intima thickness and the vascular myelization level, reversing pulmonary vascular remodeling and inhibiting pulmonary artery smooth muscle cell proliferation and migration.

A phosphodiesterase type 5 inhibitor is used in the preparation of a medicament for resisting fibrotic diseases. Experiments in animal models of ischemia-reperfusion (UIRI)-induced renal fibrosis, unilateral ureteral obstruction (UUO)-caused kidney fibrosis and idiopathic pulmonary fibrosis show that a PDE5 inhibitor such as tadalafil, sildenafil and vardenafil can significantly inhibit the expression of multiple fibrosis iconic proteins such as fibronectin, collagen I, renal injury molecule-1, and α-skeletal muscle actin in UIRI and UUO renal fibrosis lesions, improves glomerulopathy, degree of renal tubular distension, renal interstitial collagen fiber deposition and inflammatory cell infiltration, reduces the fibrotic area within the lesion, and significantly inhibits the progression of renal fibrosis; and the PDE5 inhibitor can significantly improve smooth muscle proliferation and inflammatory cell infiltration in bronchioles and pulmonary arterioles of idiopathic pulmonary fibrosis lesion, improve damage condition of alveolar tissue, and significantly inhibit the progression of pulmonary fibrosis.

The present invention relates to a method and an apparatus for detecting a sleep disturbing event from a signal indicative of peripheral arterial tension of an individual, the signal being affected by a small venous artery reflex wherein the sleep disturbing event is detected by: determining a vasoconstriction event from a change in the signal; deriving a reference amplitude and a baseline amplitude for the vasoconstriction event, the reference amplitude being different from the baseline amplitude; correlating the reference amplitude of the vasoconstriction event with the baseline amplitude of the vasoconstriction event, thereby obtaining a magnitude measurement of the vasoconstriction event; and thereby detecting a sleep disturbing event.

The invention relates to application of taurochenodeoxycholic acid in preparation of a medicine for preventing and treating hypertension. The key effect of the taurochenodeoxycholic acid in prevention and treatment of hypertension is found for the first time, that is, the taurochenodeoxycholic acid can significantly enhance the diastolic function of arteriole of a hypertensive patient, so that the effect of reducing blood pressure is achieved. Therefore, the invention provides a new application of taurochenodeoxycholic acid in preparation of the medicine for preventing and treating hypertension, a new medicine for preventing and treating hypertension is provided clinically, and the taurochenodeoxycholic acid has a good clinical application value and a wide application prospect. The taurochenodeoxycholic acid can be prepared into a medicine, a pharmaceutical composition, food, a health care product or a food additive by utilizing the key effect of the taurochenodeoxycholic acid in hypertension diseases, can be used for treating hypertension diseases including primary hypertension and salt-sensitive hypertension, and has important application value.

The invention discloses application of scopalactone in treatment of pulmonary arterial hypertension, and relates to the technical field of medicinal chemistry. The scoparone is applied to preparation of the medicine for treating pulmonary arterial hypertension. The medicine comprises scopalactone, a pharmaceutically acceptable carrier, a diluent and an excipient, the medicine further comprises other medicines for treating the pulmonary arterial hypertension, and the other medicines for treating the pulmonary arterial hypertension are selected from a prostacyclin medicine, an endothelin receptor antagonist and a phosphodiesterase-5 inhibitor. The scopalactone is applied to preparation of the medicine for treating pulmonary arterial hypertension, right heart insufficiency caused by hypoxia can be remarkably reversed, and the right heart function is effectively improved by reducing the transverse diameter of the right ventricle and the transverse diameter of the right atrium and improving the indexes such as tricuspid valve ring plane contraction displacement; the average pulmonary arterial pressure and right ventricular systolic pressure can be obviously reduced, and hemodynamic parameters are improved; the area and thickness of a blood vessel wall can be remarkably reduced, the blood vessel structure is improved, and pulmonary arteriole reconstruction is relieved.

The utility model discloses a dynamic teaching aid for simulating urine and hematuria forming processes. The dynamic teaching aid comprises a teaching aid bracket, a renal artery model, a globular arteriole model, a glomerulus model, a globular arteriole model, a capillary network model, a renal vein model, a renal capsule model and a bladder model, the renal artery model, the renal vein model, the renal capsule model and the bladder model are sequentially arranged on the teaching aid support; the glomerulus model is mounted in the kidney capsule model; a kidney tubule model is arranged at the bottom of the kidney capsule model, the tail end of the kidney tubule model is communicated with the bladder model, and decoloration cotton is distributed in the kidney capsule model; the capillary network is wound on the renal tubule model of the renal capsule model; one end of the ball-entering arteriole model is communicated with the renal artery model, and the other end is communicated with the glomerular model; one end of the bulbous arteriole model is communicated with the glomerulus model, and the other end is communicated with the capillary network model; and the tail end of the capillary network model is communicated with the renal vein model. The teaching aid has the advantages of being simple in structure, convenient to operate and capable of improving teaching quality.

A blood pressure (BP) detection apparatus and method based on an arteriolar photoplethysmogram (APPG) is disclosed. The BP detection apparatus includes a ring structure, a photoplethysmogram (PPG) detection unit, a temperature sensing unit, a pressure sensing unit and a microcontroller unit (MCU) provided at a bottom of the ring structure, and spring control units respectively provided at two inner sides of the ring structure. Under an adjustment amount of the spring control unit determined according to a pressure, the MCU calculates an APPG according to a PPG detected by the PPG detection unit, and a temperature detected by the temperature sensing unit, and detects a BP according to the APPG. The BP detection apparatus has a simple structure and a simple operation, and makes an obtained signal achieve a high signal-to-noise ratio (SNR) and a high accuracy.

This invention relates to a method and apparatus for detecting sleep disturbance events from signals indicative of peripheral arterial tension in an individual, the signals being influenced by venous arteriole reflections, wherein sleep disturbance events are detected by: determining vasoconstriction events based on changes in the signal; deriving a reference amplitude and a baseline amplitude for the vasoconstriction event, the reference amplitude being different from the baseline amplitude; correlating the reference amplitude of the vasoconstriction event with the baseline amplitude of the vasoconstriction event to obtain a magnitude measurement of the vasoconstriction event; and thereby detecting the sleep disturbance event.

The utility model discloses a urine formation dynamic demonstration instrument capable of segmentally demonstrating, which comprises a nephrology main body structure model, a display board bracket, a solution collector, a circulating water pump, an appendage part and a liquid simulation part, the renal unit main body structure model comprises a glomerulus model, a renal capsule model, a renal tubule model, a filter screen, a globular arteriole model, a globular arteriole model, a renal vein model and a capillary model; the filter screen is embedded at the bottom of a sphere of the glomerular model; the glomerulus model, the kidney capsule model, the bulblet arteriole model and the capillary model penetrate through the display board bracket and extend to the corresponding solution collectors; wherein one end of one renal tubule model passes through the display board bracket and extends to the corresponding solution collector, and the other end extends to the corresponding solution collector on the front side of the display board bracket. According to the utility model, not only can the urine formation process be visually demonstrated, but also students can understand the occurrence mechanism of diseases such as proteinuria and hematuria caused by urinary organ abnormity.

A processor of a fundus image processing device acquires a fundus image 50 photographed by a fundus image photographing device. The processor acquires blood vessel images 60A and 60B that indicate at least one of an arteriole and a venule in the fundus image 50 by inputting the fundus image 50 into a mathematical model trained by a machine learning algorithm. The processor acquires a blood vessel area that is an area of at least one of the arteriole and the venule in the whole of the blood vessel images 60A and 60B.

A system and method for determining blood flow using multi-wavelength photoplethysmography is provided. The method including: receiving the photoplethysmography signals from an optical input sensor positioned to capture the photoplethysmography signals from the skin of a user, the photoplethysmography signals including at least two different optical wavelengths; determining arteriolar pulse transit time using time delays determined between the photoplethysmography signals of different wavelengths; determining skin blood flow as a function of the determined arteriolar pulse transit time; and outputting the skin blood flow.

The invention provides application of a Phb2 inhibitor YL-939 in preparation of a medicine for treating pulmonary arterial hypertension, and relates to the technical field of medicine development. In the pulmonary arterial hypertension disease process, the histone lactylation level is remarkably increased, and the Phb2 can be used as a histone lactylation modifying enzyme for up-regulating expression in pulmonary arterial hypertension and playing an important role, and can lead to abnormal proliferation of vascular smooth muscle cells and pathological change of vascular walls by promoting histone lactylation modification. Through targeted inhibition of Phb2, pulmonary artery blood vessel middle layer thickening can be significantly relieved, the small artery myelization degree can be reduced, extravascular collagen deposition can be inhibited, and thus pulmonary circulation dynamics can be improved. As a Phb2 inhibitor, YL-939 can effectively relieve ventricular hypertrophy caused by pulmonary arterial hypertension, has no obvious toxic or side effect, and shows unique advantages and good application prospects in the aspect of treating pulmonary arterial hypertension.

The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates. The AVR is an important predictor of increases in the risk for stroke, cerebral atrophy, cognitive decline. and myocardial infarct.

The application provides a traditional Chinese medicine composition for treating pulmonary arterial hypertension and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is composed of ginseng, astragalus, cassia bark, prepared licorice, prepared rehmannia, angelica, white peony root, chuanxiong, persicae semen and safflower. The preparation method is as follows: water is added to decoct and extract to obtain a traditional Chinese medicine extract; the traditional Chinese medicine extract can be further concentrated into a clear paste, and excipients are added to prepare other dosage forms. Animal experiments show that the traditional Chinese medicine composition can significantly reduce the pulmonary arterial pressure of a hypoxic pulmonary arterial hypertension model rat, reduce the right ventricular hypertrophy index, reduce the wall thickness percentage and area percentage of pulmonary arterioles, increase the lumen area percentage of pulmonary arterioles, and effectively improve pulmonary vascular remodeling; clinical cases show that the traditional Chinese medicine composition can significantly improve the symptoms of pulmonary arterial hypertension and heart failure. The traditional Chinese medicine composition has the effects of tonifying qi, activating blood, removing blood stasis and dredging collaterals, can be used for preventing and / or treating pulmonary arterial hypertension, and has good safety.

A computer-implemented method for assessing peripheral arterial tone (100), PAT, of an individual (1) monitored by optical plethysmography and for detecting therefrom occurrence of a sleep-related event, comprising: − obtaining: o an optical plethysmography signal (101) measured at an investigated volume (11); and o light intensities (102;103) acquired at two or more points in time (12;13) along said optical plethysmography signal (101); − determining changes in arterial blood volume (16) in said investigated volume (11) between said two or more points in time (12;13) by determining a logarithm (17) or a function approximation thereof (17) of a function of said light intensities (102;103), thereby assessing PAT (100) of said individual (1); and − determining a drop in said PAT (100) indicative for a vasoconstriction of arteries and arterioles in said investigated volume (11), thereby detecting occurrence of a sleep-related event.

The present application relates to the technical field of medical devices, and particularly relates to a radial artery arteriole blood gas puncture fixing device. The radial artery arteriole blood gas puncture fixing device comprises a mounting frame, a notch is formed in the mounting frame, a bandage is symmetrically mounted on two sides of the mounting frame, a rotating cover plate is rotatably connected to the mounting frame, a control panel is mounted on the rotating cover plate, a universal coupling is symmetrically rotatably mounted on the inner wall of the mounting frame, a mounting plate is rotatably mounted on the end of the universal coupling, and a guide tube is connected to the mounting plate. The universal coupling and the mounting plate are arranged, so that the guide tube can be freely adjusted in angle and position in three-dimensional space, can be fitted to the actual bending trend of the radial artery in three-dimensional space, and can solve the problem that the prior art can only adjust the angle in a single plane. When operating, the angle of the mounting plate and the guide tube is flexibly adjusted through the universal coupling, the universal joint is locked by an electromagnet after the position is determined, so as to fix the guide tube. The structure enables the puncture needle to be inserted along the real track of the blood vessel.

The invention discloses an application of a mesenchymal stem cell exosome in preparation of an atomized preparation for treating pulmonary arterial hypertension, and relates to the field of biological medicines, the diameter peak value of the exosome is 125.4 nm, and the exosome expresses positive marker proteins CD9, TSG101 and CD63 and does not express Calnexin and GAPDH. The composition is delivered in an aerosol inhalation way, the administration dosage is 1 * 10 < 11 > particles per kilogram of body weight, and the composition is administered once every three days for at least one month. Compared with the prior art, the exosome is directly delivered to the lung tissue through aerosol inhalation, whole-body circulation loss is avoided, the concentration of focus medicine is remarkably improved, and the whole-body side effect risk is reduced; the pathological process can be reversed, and pulmonary arterial hypertension is effectively reduced; the thickness of the wall of the pulmonary arteriole can be obviously narrowed, collagen deposition is reduced, and pulmonary fibrosis is relieved.

The invention relates to a plateau ambulance group comprehensive training anthropomorphic dummy which comprises a trunk, a blood circulation simulation assembly and a lung simulation assembly are arranged in the trunk, the lung simulation assembly and the blood circulation simulation assembly are in through connection, and the blood circulation simulation assembly is used for simulating blood circulation in a plateau environment. The lung simulation assembly is used for controlling the pressure change at the joint of the blood circulation simulation assembly and the lung simulation assembly to simulate the formation process of plateau pulmonary edema; the lung simulation assembly simulates pulmonary arteriole hypoxic contraction in the plateau environment by controlling the pressure change of the joint of the blood circulation simulation assembly and the lung simulation assembly, and the permeation direction and process of blood in the blood circulation simulation assembly in the lung simulation assembly are observed. The formation process and typical signs of plateau pulmonary edema can be accurately simulated, and confusion with plain diseases such as common pneumonia and heart failure is avoided.

The embodiment of the invention provides a neural network processing and wide-angle retina artery and vein segmentation method, and relates to the technical field of image processing and target segmentation. The method comprises the steps that a multi-task learning network is constructed, the multi-task learning network comprises a blood vessel segmentation branch, an arteriovenous classification branch and an uncertainty prediction branch, and the uncertainty prediction branch is connected with the blood vessel segmentation branch and / or the arteriovenous classification branch and used for generating segmentation and / or classification uncertainty quantification information; and determining a loss function of a multi-task learning network according to the loss function of the blood vessel segmentation branch, the loss function of the arteriovenous classification branch and the loss function of the uncertainty prediction branch, so as to train the multi-task learning network based on the loss function of the multi-task learning network to realize accurate segmentation of the retinal arteriovenous blood vessel.

The application discloses an animal model construction method simulating human ischemic heart failure, and relates to the field of biomedical experimental animal models, and comprises the following steps: S1, model construction: embolism suspension liquid containing microspheres with a specific diameter is injected into the left ventricular cavity of a target animal through percutaneous puncture, so that the microspheres are embolized in myocardial microvessels through coronary artery circulation, thereby establishing a coronary artery microembolism model; S2, early screening: within 24 hours after model construction, cardiac ultrasound detection and serum biomarker detection are performed on the target animal; the animal model construction method simulating human ischemic heart failure simulates embolism of human myocardial arterioles and capillary arterioles by controlling the particle size (15-45 mu m) of the microspheres, induces diffuse myocardial ischemia closer to the clinic, thereby stably leading to progressive ventricular remodeling and chronic heart failure, rather than acute transmural infarction.