13 results about "Biomedical tissue" patented technology

The invention belongs to the technical field of biomedical tissue engineering materials, and particularly relates to injectable composite plastic gel and a preparation method thereof. The injectable plastic gel provided by the invention is formed by suspending and compounding the cross-linked sodium hyaluronate gel particles and the biological tissue extracellular matrix particles, the two material particles in the injectable composite plastic gel are uniform in size and controllable in size, other toxic catalysts do not need to be added in the preparation process, and the injectable plastic gel is easy to prepare. The collagen / elastin composite material is rich in collagen and elastin, and shows good biomechanical properties. Meanwhile, the composite plastic gel contains a plurality of bioactive factors, and after the composite plastic gel is injected and filled into a body, the composite plastic gel is slowly degraded and can promote the generation and ingrowth of autologous fat cells and microvessels, so that the balance of degradation and remodeling is achieved. The preparation method of the injectable plastic gel provided by the invention can be widely applied to the fields of plastic surgery, medical beauty and the like.

The invention discloses a preparation method and application of organic-inorganic composite hydrogel with high mechanical adaptability and wet adhesion stability, and belongs to the technical field of biomedical tissue engineering. The hydrogel is prepared from the following components in percentage by mass: 8.125 percent to 65 percent of calcium phosphate and 35 percent to 91.875 percent of lipoic acid. The bionic wound dressing is beneficial to proliferation and migration of fibroblasts, and more ideal soft tissue regeneration is realized. Experimental results prove that the suture has good cytocompatibility, can quickly promote rat skin defect repair (20 + / -1mm limit skin injury repair time is shortened to 2 weeks), and has a more remarkable healing effect compared with a contrast traditional suture and gauze with an optimal clinical repair effect. The organic-inorganic composite hydrogel with high mechanical adaptability and wet adhesion stability prepared by the invention shows good mechanical properties, also has excellent adhesion, and is beneficial to soft tissue repair.

The invention relates to the technical field of biomedical tissue engineering, and particularly discloses a multi-modal response bone tissue engineering material as well as a preparation method and application thereof. The multi-mode response bone tissue engineering material is prepared by mixing methylacryloylated gelatin, sodium hyaluronate subjected to methacrylic acid esterification, 2, 4, 6-trimethylbenzoyl lithium phosphate, Michaene and nano-hydroxyapatite and then carrying out ultraviolet light cross-linking curing on the mixture. In the multi-mode response bone tissue engineering material provided by the invention, MXene has near-infrared light thermal response capability, nHAP provides release of multiple ions such as calcium, phosphorus, magnesium, strontium and the like, vascularization and osteogenic differentiation are synergistically promoted, and GelMA, HAMA and LAP provide mechanical support. Diabetes fracture animal model verification shows that the bone tissue engineering material with multi-mode response provided by the invention can significantly accelerate bone regeneration.

The invention discloses a three-layer artificial soft tissue repair membrane with progressively-changed porosity in the field of biomedical tissue engineering, and the repair membrane sequentially comprises an ordered fiber layer, a spiral disordered fiber layer and an ordered fiber layer from inside to outside to form a structure with progressively-increased porosity. Each layer is made of biodegradable materials which can be selected from various natural or synthetic polymers. The diameter of the fiber is in a range from nanoscale to micron scale, and the distance between the fibers of the ordered fiber layer is adjustable and is gradually increased from inside to outside. The membrane can load various bioactive substances and drugs, and the surface of the membrane can also be modified by growth factors or nano materials and the like. The preparation method mainly adopts a near-field direct-writing 3D printing process and is realized by regulating and controlling printing parameters. The obtained repair membrane is unique in pore structure, can simulate natural tissues and promote cell ordered growth and tissue repair, and is suitable for the field of tissue engineering scaffolds.

The invention discloses a three-layer artificial soft tissue composite repair membrane with progressive variable porosity and a preparation method and application of the three-layer artificial soft tissue composite repair membrane in the field of biomedical tissue engineering.The repair membrane is composed of three composite layers, and the first composite layer comprises a spiral disordered fiber layer and a first ordered fiber layer; the second composite layer comprises a spiral disordered fiber layer and a second ordered fiber layer, and the third composite layer is a middle disordered fiber layer. The middle disordered fiber layer is formed by stacking fibers which are spirally and disorderly arranged, and the ordered fiber layers on the two sides are formed by stacking fibers which are linearly arranged. And each layer of material is a biodegradable natural or synthetic polymer. The membrane can be loaded with active substances or subjected to surface modification. The preparation method adopts a thermal method and a near-field direct-writing printing process, and is realized by respectively printing each composite layer and then carrying out thermal bonding. The membrane is unique in structure, can effectively guide cell growth and promote tissue integration and regeneration, and is suitable for the field of tissue engineering scaffolds.

The application belongs to the technical field of biomedical tissue adhesive materials, and relates to a rapid asymmetric tissue sealing patch as well as a preparation method and application thereof. The rapid asymmetric tissue sealing patch is composed of a strong water-absorbing biological adhesion layer and a hydrophobic biological anti-adhesion layer which is spin-coated on the strong water-absorbing biological adhesion layer. The rapid asymmetric tissue sealing patch provided by the application can realize strong adhesion between a wet dynamic tissue and an engineering solid within 5 seconds, can seal the tissue, and can improve the prevention effect of anastomotic leakage. Meanwhile, the rapid asymmetric tissue sealing patch has excellent anti-adhesion performance, can achieve the effect of preventing tissue adhesion after operation, and can be used in the repair of gastrointestinal defects.

The invention belongs to the technical field of biomedical tissue bonding materials, and relates to a rapid asymmetric tissue sealing patch and a preparation method and application thereof, and the rapid asymmetric tissue sealing patch is composed of a strong water absorption biological adhesion layer and a hydrophobic biological anti-adhesion layer spin-coated on the strong water absorption biological adhesion layer. The rapid asymmetric tissue sealing patch provided by the invention can rapidly realize strong adhesion between wet dynamic tissues and engineering solids within 5 seconds, the tissues are sealed, and the prevention effect of anastomotic leakage is improved; meanwhile, the anti-adhesion performance is excellent, the postoperative tissue anti-adhesion effect is achieved, and the anti-adhesion hydrogel is used for repairing gastrointestinal tract defects.

The invention provides a preparation method of bionic high-adhesion tissue repair hydrogel based on silk fibroin, and relates to the technical field of biomedical tissue engineering materials. The preparation method of the PDA-silk-PAM hydrogel provided by the invention comprises the following steps: firstly, carrying out a Schiff base reaction on silk fibroin and dopamine, and then further carrying out in-situ free radical polymerization on the obtained product and acrylamide hydrogel, thereby obtaining the PDA-silk-PAM hydrogel. The maximum tensile strain of the PDA-silk-PAM hydrogel prepared by the method disclosed by the invention can reach 1000%, the tensile strength can reach 220kPa, and the PDA-silk-PAM hydrogel has excellent mechanical properties; the composition has strong adhesion to natural surfaces such as glass, leaves, paper, plastics, aluminum and fresh organ tissues containing tissue fluid, and shows excellent tissue healing capability and capability of promoting wound healing faster and more efficiently.

This invention relates to the field of medical materials technology, specifically to a biomedical tissue adhesive and its preparation method. This application provides a biomedical tissue adhesive whose raw materials include a prepolymer and a polyphenolic compound. The prepolymer includes one or more combinations of polyvinyl alcohol, acrylic acid, and N-hydroxysuccinimide acrylate. The biomedical tissue adhesive provided by this invention can quickly and persistently adhere to moist tissue surfaces, exhibits good biocompatibility, and allows for simple and controllable clinical application conditions.

The application discloses a preparation method and application of an organic-inorganic composite hydrogel with high mechanical adaptability and wet-state adhesion stability, and belongs to the technical field of biomedical tissue engineering. The hydrogel comprises calcium phosphate with a mass fraction of 8.125% to 65% and thioctic acid with a mass fraction of 35% to 91.875%. The biomimetic wound dressing is favorable for fibroblast proliferation and migration, and realizes more ideal soft tissue regeneration. Experimental results prove that the hydrogel has good cell compatibility and can quickly promote rat skin defect repair (20±1 mm limit skin damage repair time is shortened to 2 weeks), and the healing effect is more significant compared with traditional suture and gauze which are clinically optimal in repair effect. The prepared organic-inorganic composite hydrogel with high mechanical adaptability and wet-state adhesion stability has good mechanical properties, and at the same time, has excellent adhesion, and is favorable for soft tissue repair.

This invention relates to the field of biotechnology, and in particular to human type III recombinant collagen-related peptides and their applications. This invention obtains human type III recombinant collagen-related peptides suitable for recombinant expression by selecting specific functional fragments from human type III collagen and repetitively constructing them. These peptides can be prepared using nucleic acids, recombinant vectors, and host cell systems, and are characterized by clear origin, controllable sequence, well-defined preparation pathways, and a wide range of applications. The obtained peptides exhibit good expression and purification properties and can promote fibroblast adhesion, proliferation, migration, or differentiation, thus making them suitable as functional components in materials used in the biomedical, tissue engineering, or cosmetic fields.

The present invention belongs to the field of biomedical tissue engineering technology. In order to solve the technical problem that the existing stents for repairing oral and maxillofacial bone defects do not have corresponding fixing components, the stability of the stent is insufficient in the early stage of bone recovery, and the stent may be offset and dislocated due to the patient's movement during the recovery process, thereby affecting the subsequent recovery quality, the present invention provides a stent for repairing oral and maxillofacial bone defects, including a stent body, which is arranged at the defect site of the oral and maxillofacial bone, and the stent body and the defect site cooperate with each other; the stent body and the defect site of the oral and maxillofacial bone are fixed by a fixing mechanism. The present invention can achieve fixation of a filling unit to the oral and maxillofacial bone through the design of the fixing mechanism, thereby improving the stability of the filling unit.