537results about How to "With hemostasis" patented technology

The invention discloses a cryoablation probe shell covered by expandable hydrogel and a preparation method thereof. The cryoablation probe shell is characterized by comprising a cryoablation probe shell made of metal and a hydrogel coating covering the probe shell, wherein the cryoablation probe shell comprises integrated working section and non-working section; the hydrogel coating is uniformly coated on the non-working section of the cryoablation probe shell, and the thickness of the hydrogel coating is 50 mu m to 500 mu m. The hydrogel coating comprises degradable porous hydrophilic hydrogel and absorbs water to rapidly expand to form a hydrogel isolating membrane to isolate the cryoablation probe from normal tissue, and plays the function of protecting the normal tissue of a non-target area.

The invention discloses a method for preparing porous compound type high permeability absorption hemostasis coating with modified nano-crystalline cellulose, and belongs to the field of biological medical materials. The method comprises the following steps of: pre-processing bacterial cellulose by alkali water at high temperature to remove endotoxin; scattering the obtained bacterial cellulose under a high-speed bacterial pulverizer to be fine fibers; performing alkalization treatment on the fine fibers by alkali liquid with the proper concentration to activate the cellulose; adding an etherifying agent grafted modified bacterial cellulose to ensure that the fiber has a certain hemostasis function; uniformly compounding the modified bacterial cellulose with sodium alga acid to form gel network by ion crosslinking; and freezing and drying the gel network to obtain the hemostasis compound material with good performance. The porous compound material prepared by the method is a good medicine carrier, which can carry the medicines capable of resisting bacteria, stopping the pain and coagulating blood, so that the material has good medicine sustained release effect under different PH values. The porous compound material is high in biocompatibility and cell affinity, can promote proliferation and differentiation of stem cells, and facilitates rapid recovery of damaged tissues.

The present invention relates to a method for preparing a drug-loaded biodegradable nanofiber medical dressing. The dressing is a nanofiber membrane that mainly co-spun hyaluronic acid (chitosan) and pore-forming agent to obtain composite nanofibers. The hyaluronic acid (chitosan) is cross-linked using a cross-linking agent, and then selectively The pore-forming agent and cross-linking agent are removed to obtain hyaluronic acid (chitosan) porous nanofibers. Finally, the free binding characteristics of polycations and anions are used to encapsulate therapeutic drugs in hyaluronic acid (chitosan) nanofibers. The obtained drug-loaded biodegradable nanofiber medical dressing can well absorb permeate, maintain moisture around the wound, and can continuously release therapeutic drugs for a long time. It is biodegradable, antibacterial, and hemostatic, and is beneficial to wound tissue. The growth and regeneration can accelerate wound healing and other functions.

The invention relates to a traditional Chinese medicine white wine medicament for effectively curing dermatopathy, which has the advantages of reasonable and scientific composing prescriptions, evident effect, convenient and hygienic employment, and is natural without hormones and chemical auxiliary agent, and is safe and reliable, and does not have side effect. The invention is made from raw material with the following part by weight, anoelica sinensis 8-10 parts by weight ( the following unit is the same), red peony root 6-10, chuanxiong rhizome 3-5, schizonepeta tenuifolia 3-5, coralbean bark 6, astragalus root 6-8, Chinese dittany bark 10-15, phillyrin 12-15, flavescent sophora root 15, honeysuckle flower 8-12, borneo camphor 3-5, radix salvia miltiorrhiza 9, frank incense 5, myrrh 5, and white wine 1.5-2, and the following operating procedures are concluded, the raw material except the borneo camphor, the frank incense, and the myrrh are positioned in a vessel and are filled with the white wine with the amount of 3-5cm higher than the medicine surface, and are sealed, and are opened and churned once a weak, and are immersed for three months in spring and two months in summer, and are filled with the frank incense and the myrrh one week before the employment, and can be employed when the medicine is filtered and is added with the borneo camphor.

The present invention discloses a self-adhesive type chitosan hemostatic film, which is composed of components by weight percentage: 85-93% chitosan, 5-10% glycerin, 2-5% citric acid. The preparing steps includes: weighing chitosan, glycerin and citric acid, then adding chitosan into acetum with 1.5%-2% mass concentration, mixing to chitosan dissolved, adding glycerin and citric acid again, mixing to mixed solution; pouring said solution into glass mould and self-levelling, drying to form film, and cooling to room temperature; supporting the mould with film in closed container filling with absolute ethyl alcohol, and suffocating 2-3 hours, exposing film from mould. The film has no bacterium, and the self-adhesive surface absorbs moisture and forms gel instantly when contacts with blood or body fluid after is planted into body, the gel has adhesive and has effects of hemostasia and healing. Other side of the film has no adhesive and acts on isolation function with periphery.

The invention relates to a method for preparing a medicament-loaded biodegradable nano-fiber medical dressing. The method comprises the following steps: dissolving hyaluronic acid in a mixed solvent comprising water, methanoic acid and N,N-dimethylformamide (DMF) for preparing solution, standing the solution under ultrasonic waves for 1 hour for completely releasing bubbles and further obtaining transparent hyaluronic acid solution; adding the prepared hyaluronic acid electrospinning solution into an injection pump, adjusting the appropriate spinning voltage, the distance from a spinneret to a collecting plate and the flow rate of the spinning solution of the spinneret, electrospinning onto a folding fan-shaped aluminum foil within the temperature range of 5-60 DEG C, and getting hyaluronic acid nano-fiber non-woven fabric with the fiber average diameter of 200-600nm. The preparation process and the post-treatment process step are simple, the hyaluronic acid nano-fiber non-woven fabric can be obtained within the larger temperature range, and the diameter distribution of the obtained hyaluronic acid nano-fiber is uniform.

A tissue-engineered epidermis is prepared from skin fibroblasts through obtaining the skin fibroblasts, preparing culture medium, amplifying culture, preparing extocytic matrix compound, preparing biologic scaffold, compounding the skin fibroblasts on the surface of biologic scaffold, and 3D culture. Its advantages are a certain elasticity and toughness, short culture time, and no obvious immunorejection reaction.

The invention discloses a facial wound restoration dressing including the following components by the weight percentage: 0.05%-1% of chitosan, 0.1-0.3% of macromolecular sodium hyaluronate, 0.1-0.3% of low-molecular sodium hyaluronate, 0.1-0.3% of oligomeric sodium hyaluronate, 1-5% of a sodium hyaluronate elastomer, 2-3% of a purslane extract liquid, 2-3% of a notoginseng extract liquid, 2-5% of a chamomile extract liquid, 2-5% of an aloe extract liquid, 2-5% of an argy worwood extract liquid, 2-5% of a hamamelis mollis extract liquid, 1-5% of 1,2-pentanediol, 0.5-2.0% of SC-10 with the registered trademark of sensival, and the balance sterile water. The preparation method of the dressing comprises that the components are added in turn and mixed evenly and the pH value is adjusted to 5.5-7.5. The plaster containing the dressing is obtained by combining the dressing with a non-woven facial mask. The plaster is capable of inhibiting bacteria, diminishing inflammation, stopping bleeding, and promoting tissue healing and restoration.

The invention provides a novel anti-tissue-adhesion material and a preparation method thereof. Used raw materials are from natural polysaccharides and modified natural polysaccharides; the use of micromolecular cross linking agents is avoided; and the excellent biosecurity is realized. A compound prepared from the natural polysaccharides and the modified natural polysaccharides through chemical reaction can be used for the anti-adhesion purpose in positions such as the pelvic cavity, the abdominal cavity, the achilles tendon and nerves. Meanwhile, the hemostatic, antibacterial and healing promotion functions are realized. The anti-adhesion material provided by the invention can be prepared into anti-adhesion sponge, anti-adhesion films and anti-adhesion gel through different process conditions; the surgical operation convenience is high; good clinic application prospects are realized.

The invention provides a compound guanidine disinfectant, which comprises the following ingredients in percentage by weight: 0.5 to 4.0 percent of guanidine disinfectants, 0.05 to 0.2 percent of low-molecular-weight chitosan, 0.5 to 2.5 percent of high-molecular-weight chitosan, 0.1 to 0.5 percent of Chinese herbal medicine extracts, 0.1 to 1.0 percent of surfactants, 0.1 to 1.0 percent of penetrants, 0.1 to 0.5 percent of skin protectants, 0.1 to 0.5 percent of macromolecule film forming agents and the balance water; and the pH value of the compound guanidine disinfectant is regulated to 7.0 to 7.5 by pH regulating agents. Through the proportional combination of all the ingredients of the compound guanidine disinfectant, a good synergistic effect is achieved; and good sterilization and antibiosis capability is realized on bacterial reproductive bodies, fungi and partial viruses. The invention also provides a preparation method of the compound guanidine disinfectant. The compound disinfectant has the advantages that the preparation process is simple; the operation is convenient; the production cost is low; the scale production is convenient; meanwhile, the property of the disinfectant is stable; and the compound disinfectant is safe and nontoxic and can be easily stored.

The invention relates to a traditional Chinese medicine parasite-expelling reagent, which comprises the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of santolina chamaecyparissus, 10-20 parts of herba pogostemonis, 10-20 parts of herbaagrimoniae, 10-20 parts of herba schizonepetae, 10-20 parts of sweet basil, 10-20 parts of fructusarctii, 10-20 parts of rhizoma atractylodis, 10-20 parts of herbamenthae, 10-20 parts of radix notoginseng, 10-20 parts of rhizoma acori tatarinowii, 10-20 parts of folium artemisiae argyi, 10-20 parts of herbaasari, 10-20 parts of floscaryophylli, 10-20 parts of radix saposhnikoviae, 10-20 parts of ramulus cinnamomi, 10-20 parts of rhizoma cyperi, 10-20 parts of radix angelicae dahuricae, 10-20 parts of radix sophorae flavescentis, 10-20 parts of radix angelicae pubescentis and 10-20 parts of fructus evodiae. The traditional Chinese medicine parasite-expelling reagent adopts multiple natural phytoextraction constituents, thus being natural and mild; the traditional Chinese medicine parasite-expelling reagent can prevent biting of mosquitos and insects, also can fast relieve the discomfortableness due to biting of mosquitos, the traditional Chinese medicine parasite-expelling reagent is pure and mild, irritation-free, and gives skin safer care. People can keep away from invasion of mosquitos in summer. The traditional Chinese medicine parasite-expelling reagent is natural and mild, safe, non-greasy and close fitted and comfortable.

The invention relates to a bacterial cellulose / chitosan composite medical dressing and a preparation method thereof. The bacterial cellulose / chitosan composite medical dressing comprises the following components in percentage by mass: 1-20% of bacterial cellulose and 80-99% of chitosan. The preparation method comprises the following steps: (1) boiling a bacterial cellulose membrane by using a NaOH aqueous solution, washing the bacterial cellulose membrane to a neutral state, drying the bacterial cellulose membrane in a vacuum state and grinding the bacterial cellulose membrane into a fibrid; and (2) adding the bacterial cellulose fibrid to a chitosan solution, standing and defoaming the bacterial cellulose fibrid, pouring and covering the bacterial cellulose fibrid on the surface of a chitosan medical dressing, curing the medical dressing by using a coagulating bath, and washing and drying the medical dressing so as to obtain the bacterial cellulose / chitosan composite medical dressing. According to the invention, the excellent characteristics of the chitosan medical dressing can be kept and the strength, ventilating property and hydrophilcity of the chitosan medical dressing can be improved; and the bacterial cellulose / chitosan composite medical dressing provided by the invention has the advantages of simple process and easiness for controlling the process.

The invention provides chitosan petrolatum gauze. The chitosan petrolatum gauze is prepared according to the following steps: dissolving a chitosan mixture in a weak acid solution to prepare a chitosan mixed solution; subsequently soaking medical gauze in the chitosan mixed solution to prepare chitosan gauze; soaking the chitosan gauze in a melt petrolatum and paraffin oil mixed solution to prepare the chitosan petrolatum gauze of which the concentration is 1% to 5%. The chitosan petrolatum gauze is a novel medical dressing which is prepared in combination with the advantages of the chitosan and the traditional petrolatum gauze, anti-bacterial, capable of retaining moisture, stopping bleeding and prompting healing of wounds, and low in price. The chitosan petrolatum gauze provided by the invention has the effect of enhancing the original moisture retention properties and also has anti-bacterial properties and unique properties of stopping bleeding, relieving pain, prompting the healing of wounds, reducing formation of scars and the like. The chitosan petrolatum gauze is free of irritation to the human body, free of obvious toxicity, rich in raw materials and low in preparation cost and can be widely applied to wound surface treatment.

The invention provides a pelvic floor repairing sheet. The repairing sheet comprises a fiber membrane, wherein the fiber membrane at least comprises a first fiber layer with directed orientation and a second fiber layer without orientation. The pelvic floor repairing sheet has excellent biocompatibility, excellent softness and excellent tissue compliance, is beneficial to tissue penetration to form firm repairing, and further has the properties of anti-infection and hemostasis. The pelvic floor repairing sheet can be used for manufacturing a tension-free vaginal tape for treating stress incontinence.

The invention discloses a chitosan-based hydrogel, and a preparation method and application thereof. The chitosan-based hydrogel is prepared with chitosan or a derivative thereof as a raw material bygrafting an ortho-phenyl dihydroxyl group compound onto the main chain of the raw material and then performing cross-linking via a cross-linking agent. The preparation method for the hydrogel comprises the following steps: firstly grafting an ortho-phenyl dihydroxy group onto chitosan or the derivative thereof to allow a product to have wet adhesion; and then, performing a cross-linking reaction to form the hydrogel material with sufficient mechanical strength and viscoelasticity. The hydrogel material has wet adhesion, hemostasis and wound healing promotion functions, and has good applicationprospects in tissue engineering and skin repairing.

The invention discloses a Chinese medicament for treating gynecological inflammation and a preparation method. The Chinese medicament mainly comprises the following components in parts by weight: 90 to 200 parts of phellodendron, 90 to 200 parts of coptis, and 100 to 6,000 parts of kuh-seng. The method comprises the following steps of: putting the components of the Chinese medicaments into a container for decocting, adding water with weight which is 5 to 10 times of that of the components, soaking for 1 to 5 hours at normal temperature, boiling over big fire, concentrating over slow fire to 70 to 80 percent of the liquor, cooling, removing residue, and thus obtaining the prepared Chinese medicament liquor. The Chinese medicament is convenient to use, does not have side effect, and can effectively solve the gynecological inflammation.

The invention belongs to the technical field of medical dressing, and discloses a carbon quantum dot / nano-silver alginate dressing and a preparation method and application thereof. A carbon quantum dot / nano-silver composite material is prepared from silver nitrate, polyethylene glycol 400, sodium citrate, ascorbic acid and carbon quantum dots; and the carbon quantum dot / nano-silver composite material is added to a sodium alginate solution to prepare the carbon quantum dot / nano-silver alginate dressing through an electrostatic spinning technology and a non-woven technology. According to the dressing prepared by the technology, the mechanical property of the alginate dressing can be significantly improved; meanwhile, the dressing has an excellent fluorescent display tracking function; the migration change and the accumulation condition of silver ions in a body can be effectively inspected; and a fast and effective detection method is provided for clinical supervision of the silver ions.

The invention discloses a method for preparing a composite porous scaffold. According to the method, silk fibroin, collagen and chitosan are compounded together to form the white spongy composite porous scaffold. The porous scaffold prepared by the method can be applied in the technical fields of filling and repair of tissues and wounds, tissue engineering, medicament release and the like. The porosity of the prepared composite porous scaffold reaches more than 98 percent, the size distribution is 50 to 400 microns, and micro pores are intercommunicated. The obtained composite porous scaffold can keep the original form after being soaked into water, has the function of sponge, and can recover the original form after extrusion.

The invention discloses amorphous hydrocolloid dressing formed by high-energy ray irradiation proper crosslinking. The amorphous hydrocolloid dressing disclosed by the invention has good deformability, film forming property, moisture retention, biocompatibility and wound healing facilitation, and can protect various surgical incisions, cover various acute and chronic wounds and wound surfaces, prevent infection, accelerate healing and relive cicatrization. The amorphous hydrocolloid dressing is suitable for the filling covering protection on various wounds with tissue defects and for the protection and treatment of the surgical incisions and burns and scales including the wound surfaces formed by chemical burns as well as various acute and chronic wounds and wound surfaces. Moreover, through radiation sterilization, the amorphous hydrocolloid dressing can be stored for a long time. The formula of the amorphous hydrocolloid dressing disclosed by the invention comprises the following components in percentage by weight: 2-8% of sodium carboxymethylcellulose, 1-6% of chitosan and the balance of water. The amorphous hydrocolloid dressing also can comprise 0.1-0.3% of silver nitrate or silver chloride, 3-8% of polyvinyl alcohol, 15-25% of propylene glycol and the like all by weight. The amorphous hydrocolloid dressing is subjected to high-energy ray irradiation proper crosslinking and sterilization, thus the irradiation dose is 5-15KGy.

The invention relates to a bacterial cellulose / chitosan composite gel and preparation thereof, and application of the composite gel in body surface wound surface healing. The composite gel is composed of a chitosan solution, bacterial cellulose, an antimicrobial agent, a thickener solution and a neutralization agent. The invention also relates to application of the bacterial cellulose / chitosan composite gel in preparing body surface wound surface healing medicines. The preparation method comprises the following steps: uniformly mixing the chitosan solution, thickener solution, bacterial cellulose and antimicrobial agent, adding the neutralization agent to regulate the pH value to 6.0-9.0, and standing for deforming. The composite gel provided by the invention has favorable film-forming action, and performs the functions of isolating the wound surface and protecting the wound; and the bacterial cellulose / chitosan has the advantages of simple preparation process and easy technical control, and is convenient for industrial production.

The invention discloses an OLED phototherapy adhesive bandage. The OLED phototherapy adhesive bandage comprises at least one phototherapy assembly and at least one medical therapy part, wherein the phototherapy assembly comprises at least one OLED light-emitting panel, a power supply device and a shell; the medical therapy part comprises a medical proof fabric and a water absorption layer; the phototherapy assembly is detachably fixed on the medical therapy part; and the light-emitting surface of the phototherapy assembly faces the water absorption layer. The phototherapy assembly is a modularized assembly and can be detached at any time and replaced with a new water absorption layer to be continuously used; carrying is convenient, and resources are saved; and the modularized phototherapy assembly can be detached, added or reduced at will and can adapt to wounds of different shapes and sizes.

The invention discloses a liquid wound dressing and a preparation method thereof. The raw materials include polyvinyl alcohol, dioctyl phthalate, glycerin, laurocaprazine, chitosan, and nude flower purple pearl; the preparation method is as follows: After polyvinyl alcohol and ethanol are stirred and dissolved at 50°C, laurocaprazine, glycerin, and dioctyl phthalate are added to prepare a sputum solution; add nudibranchs to the scorpion solution, and mix well. The liquid wound plaster of the invention is easy to use, has the effects of hemostasis, antibacterial, anti-inflammatory, etc., and has the advantages of good water-proof, air-permeable, no allergic reaction and drug resistance, and not limited by the size and shape of the wound.

The invention provides a biological repair membrane and a preparation method thereof. In the prior art, the existing biological repair membrane has the following disadvantages that the mechanical strength is poor, the suture point has the cerebrospinal fluid leakage risk, the tissue regeneration and repair promoting performance is weakened, the residual toxicity exists after the degradation, the biocompatibility is poor, and the adhesion between the repair material and the brain tissue is easily caused, and other complications are easily induced. According to the present invention, the animal-derived membrane tissue is subjected to cell removing and antigen removing, and a natural polymer material coating capable of being adsorbed and providing bleeding stopping effect is coated on the treated animal-derived membrane tissue so as to solve the problems in the prior art; the method specifically comprises: pretreatment, degreasing with an organic reagent, cell removing and antigen removing with an alkali liquid, coating preparation, vacuum compression and freeze-drying, packaging, and sterilization so as to complete the preparation of the biological repair membrane; and the biological repair membrane has advantages of bleeding stopping, antibacterial property, adhesion, natural three-dimensional space structure retaining, good mechanical property, good biocompatibility, good tissue growth induction, degradation non-toxicity, wide raw material source, low price, and easy mass-production.

The present invention discloses a pure natural medical dressing. The pure natural medical dressing is composed of a covering layer, a moisture-absorbing layer and a stanching layer which are orderly combined together. The covering layer is made from a non-woven fabric with certain air permeability, one side of which is provided with adhesive. The moisture-absorbing layer is made from a vegetable sponge; the natural vegetable sponge is processed into honeycomb thin fibers, which are then compacted into the shape of a sponge; and after sterilization, natural honey is sprayed into the vegetable sponge by high pressure. The stanching layer is made from algal protein fibers with a hemostatic function. The pure natural medical dressing, which adopts the pure natural materials with pharmaceutical functions, has the functions of antibiosis, pain relief, antiphlogosis, stanching and accelerating the healing of wound, and moreover, the pure natural medical dressing also has good natural degradability and is environment-friendly.

The invention discloses a preparation method of a fish collagen combined chitosan biological dressing. The preparation method comprises the following steps: cutting clean fish wastes, from which surface impurities are removed, into fish meal of 50-200 meshes; putting the fish meal in an airtight container and then adding distilled water and a reaction enzyme into the airtight container, and stirring to form slurry; reacting the slurry under high pressure and ultrasonic treatment; after the reaction is finished, subjecting the slurry to purification treatment; adding chitosan to the purified slurry, heating until the temperature is in a range from 80 DEG C to 90 DEG C and stirring for 20-30 minutes; and finally, carrying out dialysis, concentration and drying, thereby obtaining the fish collagen combined chitosan biological dressing. The preparation method disclosed by the invention is simple in process, easy to implement, convenient to operate, and low in cost; the quickly extracted fish collagen is even in molecular weight distribution and few in impurities; the prepared biological dressing is good in mechanical strength, and has the effects of stopping bleeding and promoting wound healing, and also has the effect of antibiosis.

The invention discloses a wet tissue for relieving hemorrhoid symptoms and a production method thereof, wherein the wet tissue is composed of a non-woven fabric as a carrier and a solution attached to the non-woven fabric. The invention is characterized in that the solution is prepared from the following raw materials in proportions: 2-3 percent of witch-hazel extracting solution, 1-1.5 percent of glycerol, 1-1.5 percent of propylene glycol, 0.5 percent of triclosan-II, 0.2 percent of IPBC-II and the balance of pure water. The invention has the effects of effectively relieving the hemorrhoid symptoms, protecting an affected part from being continuously damaged any more and effectively inhabiting the bacterial breeding so as to protect the skin.

The invention belongs to the field of medical dressings, and particularly relates to a bamboo alginate functional dressing and a preparation method thereof. The dressing comprises the following components in parts by weight: 1-4.2 parts of sodium alginate, 0.05-0.4 part of sodium hyaluronate, 0.25-2 parts of collagen, 4.5-31 parts of bioactive glass powder and 62-95 parts of bamboo fiber. The dressing can quickly promote healing of a wound surface, and healed wound surface is smooth and resilient and is less prone to scar proliferation; and the dressing has the functional characteristics of antisepsis, imbibition, hemostasis, adhesion prevention, no cytotoxicity and the like, and can satisfy various requirements for wound surface healing. According to the preparation method of the bamboo alginate functional dressing, the problem that the alginate medical dressing is cracked after exudate imbibition is solved, thereby facilitating dressing change by medical personnel.