Self-adhering type chitosan haemostatic membrane and preparation thereof

A technology of chitosan and hemostatic film, which is applied in the fields of pharmaceutical formulation, medical science, bandages, etc., and can solve the problems of hard and brittle films, inability to fix them, etc.

Inactive Publication Date: 2008-08-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because chitosan has a unique molecular structure and the intermolecular force is very large, chitosan cannot be formed into a film by traditional polymer material film forming technology. At present, chitosan acetate solution casting method is mostly used to dry, Membrane production by over-alkali neutralization process
This kind of membrane has two defects when used as a hem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Invented self-adhesive chitosan hemostatic film contains (by weight)

[0022] Chitosan 90%

[0023] Glycerin 10%

[0024] Citric acid 2%

[0025] Preparation method, the steps are as follows:

[0026] 1) Weigh chitosan, glycerin and citric acid according to the amount of the ingredients, first add chitosan to 2% acetic acid solution with a mass concentration, stir until chitosan dissolves, then add glycerin and citric acid, stir evenly , to prepare a mixed solution;

[0027] 2) Pour the above mixed solution into a glass mold for self-leveling, then put it in an oven and dry at 40°C for 6 hours to form a film, take out the mold, and cool to room temperature;

[0028] 3) The mold frame with the film of step 2) is placed in an airtight container filled with absolute ethanol, without contact with liquid, fumigated for 3 hours, takes out the mold, and peels off the film, which is a self-adhesive chitosan hemostatic film.

[0029] The water content of the hemostatic film...

Embodiment 2

[0032] Invented self-adhesive chitosan hemostatic film contains (by weight)

[0033] Chitosan 85%

[0034] Glycerin 8%

[0035] Citric Acid 5%

[0036] 1) Weigh chitosan, glycerin and citric acid according to the amount of the ingredients, first add the chitosan to the acetic acid solution with a mass concentration of 1.5%, stir until the chitosan dissolves, then add glycerin and citric acid, and stir evenly , to prepare a mixed solution;

[0037] 2) Pour the above mixed solution into a glass mold for self-leveling, then put it in an oven and dry at 75°C for 4 hours to form a film, take out the mold, and cool to room temperature;

[0038] 3) The mold frame with the film of step 2) is placed in an airtight container filled with absolute ethanol, without contact with liquid, fumigated for 2 hours, the mold is taken out, and the film is peeled off, which is a self-adhesive chitosan hemostatic film.

[0039] The water content of the hemostatic film is 15%, the pH value of the ...

Embodiment 3

[0042] Invented self-adhesive chitosan hemostatic film contains (by weight)

[0043] Chitosan 93%

[0044] Glycerin 5%

[0045] Citric Acid 3%

[0046] 1) Weigh chitosan, glycerin and citric acid according to the amount of the ingredients, first add the chitosan to the acetic acid solution with a mass concentration of 1.5%, stir until the chitosan dissolves, then add glycerin and citric acid, and stir evenly , to prepare a mixed solution;

[0047] 2) Pour the above mixed solution into a glass mold for self-leveling, then put it in an oven and dry at 55°C for 5 hours to form a film, take out the mold, and cool to room temperature;

[0048] 3) The mold frame with the film of step 2) is placed in an airtight container filled with absolute ethanol, without contact with liquid, fumigated for 2.5 hours, takes out the mold, and peels off the film, which is a self-adhesive chitosan hemostatic film.

[0049] The water content of the hemostatic film is 15%, the pH value of the film ...

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PUM

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Abstract

The present invention discloses a self-adhesive type chitosan hemostatic film, which is composed of components by weight percentage: 85-93% chitosan, 5-10% glycerin, 2-5% citric acid. The preparing steps includes: weighing chitosan, glycerin and citric acid, then adding chitosan into acetum with 1.5%-2% mass concentration, mixing to chitosan dissolved, adding glycerin and citric acid again, mixing to mixed solution; pouring said solution into glass mould and self-levelling, drying to form film, and cooling to room temperature; supporting the mould with film in closed container filling with absolute ethyl alcohol, and suffocating 2-3 hours, exposing film from mould. The film has no bacterium, and the self-adhesive surface absorbs moisture and forms gel instantly when contacts with blood or body fluid after is planted into body, the gel has adhesive and has effects of hemostasia and healing. Other side of the film has no adhesive and acts on isolation function with periphery.

Description

technical field [0001] The invention relates to a hemostatic film and a preparation method thereof, in particular to a self-adhesive chitosan hemostatic film and a preparation method thereof. Background technique [0002] Chitosan has good film-forming properties and good biocompatibility, so it is widely used in the manufacture of artificial skin, postoperative adhesion isolation film, etc. More recent studies have shown that chitosan also has a good hemostatic effect, and its hemostatic mechanism is completely different from the conventional waterfall coagulation mechanism. Chitosan mainly realizes its hemostatic effect through the adsorption and aggregation of red blood cells. In addition, It also has certain effects on platelets and fibrinogen. Moreover, chitosan is a biodegradable natural polymer material, which can be absorbed and degraded by the human body when implanted in the body. Material. However, because chitosan has a unique molecular structure and the inter...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42
CPCA61L2400/04
Inventor 胡巧玲戴晓光
Owner ZHEJIANG UNIV
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