22 results about "Postoperative adhesion" patented technology

The invention discloses a preparation method and application of collagen derivative and polysaccharide substance compounded self-gel hemostatic powder, and relates to the field of biomedical materials. Aminated collagen derivatives and aldehyde polysaccharide substances are subjected to a Schiff base reaction through amino groups and aldehyde groups; further obtaining the Schiff base cross-linked aminated collagen derivative-aldehyde polysaccharide hydrogel, freeze-drying, and grinding into powder, so as to obtain the self-gel hemostatic powder. The self-gel hemostatic powder disclosed by the invention forms hydrogel in a wound tissue for adhesion and sealing, so that rapid hemostasis is realized, postoperative adhesion at the wound tissue is avoided, and healing of a wound is facilitated; after hemostasis is completed, the self-gel powder can be dissociated and removed from the tissue surface, and the risk that thrombus is formed and immunological rejection is caused is reduced; after hemostasis is completed, the hemostasis powder can be metabolized and absorbed by a human body along with thrombus, so that the residue of the hemostasis powder in the body is reduced, and the safety is improved.

This invention belongs to the field of biomaterials technology and discloses a two-component in-situ crosslinking agent, a biodegradable two-component hydrogel, and their applications. The two-component in-situ crosslinking agent disclosed in this invention has injectability and rapid gelation properties. The hydrogel formed after crosslinking has a low self-swelling rate, good elasticity, and is not easily crushed. It also has a suitable metal ion slow-release cycle and degradation cycle for preventing tissue adhesion or tissue repair. It is especially suitable for high-risk areas of postoperative adhesion such as the uterine cavity, abdominal cavity, and joints, and can also promote tissue regeneration.

The invention relates to the field of biological materials, and particularly discloses a hydrogel material for retroperitoneal tumor operation wound repair and recurrence prevention. A matrix phase, a functional phase, an auxiliary phase and a solvent are arranged to form a hydrogel material, sulfhydrylated gelatin and oxidized sodium alginate can rapidly complete gelation under the action of calcium chloride in a body temperature environment to form a first gel body, and then the hydrogel material is formed in the first gel body. Polyvinyl alcohol and carboxymethyl chitosan form a second gel under the action of glutaraldehyde and graphene oxide, the existence time of the gel is prolonged, continuous protection on postoperative wounds is formed, rapid hemostasis of tumor wounds is achieved, meanwhile, rapid repair of the postoperative large wounds is promoted, hydrogel can effectively isolate organs behind peritoneum, postoperative adhesion is reduced, and the wound healing effect is improved. The gel can be connected to the surface of a wound tissue to promote fibroblast migration, and meanwhile, along with decomposition of the gel, the drug-loaded nanoparticles in the gel are continuously released and act on a postoperative wound surface to continuously inhibit tumor cells.

The application discloses a kind of full biological Janus hydrogel based on density driving in the field of biological medicine and its preparation method and application, the present application utilizes the gravity stability brought by the density difference of N-acryloyl aspartic acid precursor solution and methacrylated gelatin precursor solution, by sequential pouring, combined with one-step photopolymerization process, successfully prepared a kind of adherent-adhesion type full biological Janus hydrogel with excellent mechanical properties, the Janus hydrogel can withstand large size strain stretching without delamination, also has other physical and chemical asymmetric characteristics, such as gradient degradation, asymmetric hydrophilicity and asymmetric swelling, can adapt to complex gastric environment and gastric perforation repair cycle, realize strong adhesion while preventing postoperative adhesion, provide an effective way for the design of advanced surgical sealant.

The invention relates to the technical field of biological medicines, and particularly discloses a tissue repair patch with a double-layer functional structure as well as a preparation method and application of the tissue repair patch. The tissue repair patch with the double-layer functional structure comprises a collagen layer which is used for being attached to tissue and is subjected to crosslinking treatment, a plurality of grooves are distributed in the front face of the collagen layer, and a hyaluronic acid layer is arranged on the back face of the collagen layer. According to the tissue repair patch, through mutual cooperation of the collagen layer and the hyaluronic acid layer, the synergistic effect of tissue regeneration promotion of collagen and lubrication and anti-inflammation of hyaluronic acid is achieved, and due to the grooves of the collagen layer, adhesion is improved, postoperative displacement is reduced, and postoperative adhesion is effectively prevented.

The utility model relates to a medical anti-adhesion film wrapped silicon rubber stent for preventing adhesion and draining after a uterine cavity operation. The medical anti-adhesion film wrapped silicon rubber stent consists of a triangular silicon rubber stent frame (2) with a mould pressing flash film (1), a wrapped medical anti-adhesion film (3), an anti-adhesion composite stent (4), an assembling pull wire (7) and a connecting silicon rubber drainage tube (8), the device is used for preventing endometrial adhesion and draining after the uterine cavity operation. The configuration and the flexible mechanical property of the anti-adhesion composite stent (4) are matched with the anatomical form of the uterine cavity, and a perfect physical barrier isolation effect is achieved. The surface of the medical anti-adhesion membrane (3) has good affinity with the inner membrane of an operative wound, so that the repair and regeneration of the inner membrane of the wound can be promoted. A surgeon can longitudinally lengthen the anti-adhesion composite stent (4) and transversely fold the anti-adhesion composite stent (4) into a slender strip shape by means of the soft plastic push rod (6) and the pull line (7), the anti-adhesion composite stent (4) is gently pushed into a uterine cavity, and the anti-adhesion composite stent (4) automatically retracts to restore a triangular structure after being released and is smoothly spread in the uterine cavity. And after treatment, the uterine cavity is gently pulled out.

The invention provides a modified starch for medical uses and a method for preparing said 5 modified starch by steam-sterilization. The invention further provides said steam-sterilized modified starch for use in the inhibition of the formation of postoperative adhesions. Said steam-sterilized modified starch is preferably a gel comprising or consisting of carboxymethylated starch or etherified starch, which may optionally contain sodium citrate or citric acid. The invention also relates to a pharmaceutical composition comprising or consisting of a steam-sterilized gel comprising carboxymethylated starch or etherified starch and optionally sodium citrate and / or citric acid.

The invention discloses a hysteromyoma postoperative anti-adhesion absorbable film and a preparation method thereof, and belongs to the technical field of biomedical materials. The membrane is prepared from hydroformylated hyaluronic acid, catechol functionalized gelatin, a siTGF-beta1 / LMWC nano-composite and a siSmad3 / PEI nano-composite through a dynamic covalent cross-linking and gene sequential controlled release technology. A-HA and C-Gel are subjected to a Schiff base reaction to form a dynamic crosslinking matrix with self-healing, wet adhesion and controllable degradability; the siTGF-beta1 and the siSmad3 respectively target an upstream switch and a central hub of a TGF-beta1 / Smad pathway, and time sequence release is realized by means of the characteristic difference between the LMWC and the PEI. An in-vitro experiment proves that the inhibition rate gt of the membrane on a fibroblast fibrosis marker is gt; the effect can be maintained for 28 days, the biocompatibility is excellent, the clinical operation is convenient, the postoperative adhesion is prevented from the molecular source, the defects of single target spot and short effect in the prior art are overcome, and the clinical application value is great.

The invention relates to a bionic sucker type double-layer composite fiber membrane patch, preparation and application of the bionic sucker type double-layer composite fiber membrane patch in preparation of an intestinal anastomosis device, and belongs to the field of biomedical engineering. The patch comprises a double-layer composite fiber membrane, a flexible suction cup, a suction cup structure and a round hole structure. The double-layer composite fiber membrane comprises an outer hydrophobic layer and an inner hydrophilic layer; the inner side hydrophilic layer is bonded and fixed with the flexible sucking disc; the suction cup structures are arranged on the periphery of the flexible suction cup, and the round hole structures are arranged on the flexible suction cup in an array mode. The suction cup structure comprises a hemispherical base and a cylindrical top. The patch designed by the invention can be used in an intestinal anastomosis operation, the physical adsorption effect of the flexible sucker and the chemical adhesion effect of the hydrophilic layer of the composite fiber membrane are in synergistic interaction, and the strong tissue adhesion characteristic is exerted; the hydrophobic layer of the composite fiber membrane has a physical barrier effect, and postoperative adhesion of surrounding tissues is avoided. The biological patch designed by the invention has the characteristics of simple operation, firm adhesion, adhesion prevention and biological safety.

The invention discloses a multifunctional gelatin microsphere and a preparation method and application thereof, the multifunctional gelatin microsphere is prepared from gelatin, tea hair and an oxidation initiator as raw materials, and the multifunctional gelatin microsphere has multiple biological functions of water absorption, oxidation resistance, hemostasis, photo-thermal and the like. The preparation method comprises the following steps: filling an injector with a water-phase prefabricated liquid containing gelatin and tea hair, delivering the prefabricated liquid into an oil phase by a syringe needle through vertical reciprocating motion, cutting the prefabricated liquid into micro-droplets with uniform sizes through shearing force of a liquid-liquid interface and tension of an oil / water interface when the syringe needle leaves the oil phase, and solidifying the micro-droplets in the oil phase, so as to obtain the gelatin / tea hair-containing micro-droplets. And initiating crosslinking of the micro-droplets through an oxidation initiator to form the gelatin microspheres. The diameter of the microsphere is controlled by adjusting the injection rate of the prefabricated liquid, the reciprocating motion frequency of the needle and the size of the needle, the preparation process is simple, the diameter is controllable, and the cost is low. The multifunctional gelatin microspheres can be used in the biomedical fields of hemostasis, prevention of postoperative adhesion, promotion of tissue repair and the like.

The invention belongs to the technical field of nasal cavity dressings, and particularly relates to a nasal cavity hemostasis anti-adhesion dressing and a preparation method and application thereof. Comprising a gel matrix, a channel structure is arranged in the gel matrix, and each channel is axially parallel to a nasal cavity; the super-hydrophobic functional layer is coated on the surface of the gel matrix; the super-hydrophobic functional layer is used for being in contact with the wound surface of the nasal cavity, blocking blood permeation and preventing tissue adhesion. High air permeability is maintained through the channel structure, blood scab formation is blocked through the low adhesion characteristic of the super-hydrophobic coating, the postoperative wound surface gas exchange requirement is met, postoperative adhesion caused by adhesion of a fibrous protein compound can be effectively prevented, stripping injury is remarkably reduced, meanwhile, the breathing comfort of a patient is improved, and the postoperative wound healing effect is improved. The nasal cavity operation recovery effect is comprehensively optimized, and the problem that an existing nasal cavity dressing cannot give consideration to postoperative hemostasis, adhesion reduction and ventilation is solved.

A zwitterionic-based material used to inhibit and / or prevent post-surgical adhesions is described. In particular, a method of synthesizing zwitterionic polymers for use in the zwitterionic material is disclosed. Zwitterionic components have both positive and negative charges yet remain electrically neutral. Cross-linking zwitterionic polymers with polysaccharides may result in a material that exhibits ultralow fouling properties. The zwitterionic-based material can be synthesized and self-assemble in the form of a liquid or gel, enabling uniform deposition during surgery. A zwitterionic-based material described herein may be applied during a surgical procedure. The degradation rate of the adhesion barrier is highly tunable to accommodate various healing times and is naturally excreted by the body, eliminating the need for post-operative surgery to remove the material.

The invention belongs to the technical field of biomedical materials, and provides a spraying type anti-adhesion Janus heterogeneous hydrogel film used after cholecystectomy and a preparation method of the spraying type anti-adhesion Janus heterogeneous hydrogel film. The system is prepared from a tube A cationic sulfobetaine-quaternized chitosan (QCS-SB) solution and a tube B cationic sulfobetaine-quaternized chitosan (QCS-SB) solution, wherein the QCS-SB solution contains temperature-sensitive lipidosome for packaging diphenhydramine and blood coagulation peptide; and a cartridge B anionic polycarboxy betaine (PCB-AA) solution, wherein the cartridge B anionic polycarboxy betaine (PCB-AA) solution contains calcium alginate microspheres loaded with a cholic acid adsorbent. In the operation, after the gel is synchronously sprayed to an irregular wound surface through a double-barrel spray gun, a double-layer hydrogel film is rapidly formed through electrostatic self-assembly, wet-state strong adhesion and body temperature triggered drug release are achieved on the cation function side, and a super-lubricating surface is constructed on the anion function side and actively captures bile acid. The material has the functions of physical barrier, chemical adsorption and pharmacological intervention, the postoperative adhesion rate and the allergy occurrence rate can be remarkably reduced, and an intelligent, accurate and degradable barrier solution is provided for general surgery operations.

The utility model belongs to the technical field of electrocoagulation hooks, and particularly discloses an attractable and bendable open operation coarse electric hook with a low-temperature coating, which comprises an electric hook body, the electric hook body comprises a connecting part and a right-angle electric hook part which are integrally connected, irregular barbs are arranged on the periphery of the right-angle electric hook part, and the low-temperature coating is coated on the periphery of the right-angle electric hook part. The right-angle electric hook part is fixedly arranged on the end wall of one end of the connecting part, the other end of the connecting part is fixedly connected with one end of the copper hose, and the other end of the copper hose is fixedly connected with the steel pipe. By arranging the electric hook with the low-temperature coating, the temperature of the electric hook can be reduced, so that the heat pair injury of the electric hook is reduced, the formation of incrustation is reduced, and the formation of postoperative adhesion can also be reduced; and the copper hose is designed, so that the device can be bent in any direction, and the bending operation requirement of an open operation is met.

The invention relates to the technical field of biomedical materials, in particular to a chitosan-hyaluronic acid hydrogel composition based on astragaloside and salvianolic acid B as well as a preparation method and application of the chitosan-hyaluronic acid hydrogel composition. According to the hydrogel, a three-dimensional network formed by synergistic crosslinking of chitosan and hyaluronic acid is constructed, various natural active ingredients including astragaloside, salvianolic acid B, ferulic acid and notoginsenoside R1 are loaded, and the composite hydrogel with good biocompatibility, controllable degradability and anti-inflammatory and anti-adhesion functions is formed. C-S covalent crosslinking is realized by adopting a maleimide-cysteine system, so that the structural stability and the component release efficiency are improved. Animal experiment results show that the hydrogel can significantly reduce postoperative adhesion score and inflammatory factor level, and has wide postoperative anti-adhesion application potential.

The application provides a preparation method and application of a double-sided tissue adhesive, which is based on dopamine chemistry and hydrogel coating technology, uses a xenogeneic acellular dermal matrix dressing as a substrate, and polydopamine as a coating. First, a xenogeneic acellular dermal matrix dressing with polydopamine nanoparticles deposited thereon is obtained, anisotropic xenogeneic acellular dermal matrix dressing is prepared through hydrophobic modification, and then a hydrogel coating is assembled to the hydrophilic side of the modified xenogeneic acellular dermal matrix dressing to obtain a double-layer tissue adhesive with asymmetric adhesive properties. The method for preparing the double-layer tissue adhesive has the advantages of reusability, low cost, simple operation and convenience for large-scale production, and the double-sided tissue adhesive prepared has the properties of anti-bursting, asymmetric wettability, asymmetric adhesion and anti-oxidation, can promote tissue repair and resist postoperative adhesion, and can be applied in the preparation of a dressing for promoting tissue repair.

This invention discloses a method for preparing a nanocomposite hydrogel and its application in preventing postoperative tissue adhesions. The hydrogel consists of a basic framework of adipate dihydrazide-functionalized polysaccharide-drug-loaded nanomicelles cross-linked via dynamic acylhydrazone bonds. Further, benzodiazepine is formed through a click reaction between a dihydrolipoic acid prodrug molecule containing 2-formylphenylboronic acid and the functionalized polysaccharide, reinforcing the cross-linking density of the gel network and endowing it with reactive oxygen species-responsive sequential drug release functionality. This hydrogel possesses strong mechanical strength and can adhere to the wound surface, effectively isolating damaged peritoneum. In the highly reactive oxygen species environment of the postoperative wound, the benzodiazepine bonds break, releasing dihydrolipoic acid, achieving a dual cascade scavenging of reactive oxygen species, thereby alleviating inflammatory responses and oxidative stress. Subsequently, the pore size of the gel network increases, accelerating the release of antifibrotic drugs loaded in the micelles, thus effectively inhibiting the TGF-β1-mediated fibrosis process. Ultimately, this achieves effective prevention and treatment of postoperative adhesions.

The present disclosure relates to an extracellular matrix-based biomaterial that allows for the prevention of post-operative adhesions. The disclosed extracellular matrix-based biomaterial is produced from decellularized porcine small intestinal serosa. Methods of producing the extracellular matrix-based biomaterial from decellularized porcine small intestinal serosa are also disclosed.

The present application relates to a kind of preparation method of amino acid-based polyester amide / polyglycolide fiber membrane.The fiber membrane is that protein-based hypoglycemic drug is added to 0.2~0.5g / ml amino acid-based polyester amide solution to obtain drug-loaded nanocomposite, then is added to 0.2~0.5g / ml polyglycolide solution, is prepared by electrospinning technology, wherein the volume ratio of amino acid-based polyester amide drug-loaded nanocomposite polyglycolide solution is 0.5~2:5.The fiber membrane of the present application has very high porosity, has good adhesion when implanted into patient's body, prevents the risk of postoperative adhesion, can effectively promote the rapid healing of postoperative wound of diabetic patients;In addition, the preparation method of the fiber membrane is simple, has good application in the preparation of diabetic wound repair material.

The invention relates to the technical field of medical materials, in particular to a material for stopping bleeding of surgical wounds and preventing postoperative adhesion as well as a preparation method and application of the material. The patch material provided by the invention comprises the hydrogel adhesion layer and the anti-adhesion layer which are stacked and respectively have different biological functions, the hydrogel adhesion layer has good wet adhesion and hemostasis performance, and the anti-adhesion layer has hydrophobicity and cell adhesion resistance. The patch material provided by the invention integrates good wet adhesion, hemostasis and anti-adhesion functions, and meets the requirements of simplicity and convenience in operation, firmness in adhesion and stability in use in an operation.

The application belongs to the technical field of biomedical materials, and particularly relates to an injectable temperature-sensitive hydrogel material containing zwitterions and a preparation method and application thereof. The application provides an injectable temperature-sensitive hydrogel material containing zwitterions, and preparation raw materials include: temperature-sensitive biological polymer derivatives and zwitterionic monomers; the temperature-sensitive biological polymer derivatives include temperature-sensitive chitin derivatives and / or temperature-sensitive cellulose derivatives; and the mass ratio of the temperature-sensitive biological polymer derivatives to the zwitterionic monomers is 5 / 1-1 / 20. The injectable temperature-sensitive hydrogel material containing zwitterions provided by the application forms a completely physically cross-linked double network structure, is applied to temperature-sensitive anti-adhesion materials, can effectively resist non-specific adhesion of various proteins and bacteria, is very suitable for resisting postoperative adhesion, and simultaneously has the characteristics of not being easy to flow away at a wound and being biodegradable.