7 results about "Postoperative adhesion" patented technology

This invention belongs to the field of biomaterials technology and discloses a two-component in-situ crosslinking agent, a biodegradable two-component hydrogel, and their applications. The two-component in-situ crosslinking agent disclosed in this invention has injectability and rapid gelation properties. The hydrogel formed after crosslinking has a low self-swelling rate, good elasticity, and is not easily crushed. It also has a suitable metal ion slow-release cycle and degradation cycle for preventing tissue adhesion or tissue repair. It is especially suitable for high-risk areas of postoperative adhesion such as the uterine cavity, abdominal cavity, and joints, and can also promote tissue regeneration.

The application discloses a kind of full biological Janus hydrogel based on density driving in the field of biological medicine and its preparation method and application, the present application utilizes the gravity stability brought by the density difference of N-acryloyl aspartic acid precursor solution and methacrylated gelatin precursor solution, by sequential pouring, combined with one-step photopolymerization process, successfully prepared a kind of adherent-adhesion type full biological Janus hydrogel with excellent mechanical properties, the Janus hydrogel can withstand large size strain stretching without delamination, also has other physical and chemical asymmetric characteristics, such as gradient degradation, asymmetric hydrophilicity and asymmetric swelling, can adapt to complex gastric environment and gastric perforation repair cycle, realize strong adhesion while preventing postoperative adhesion, provide an effective way for the design of advanced surgical sealant.

The invention relates to the technical field of biological medicines, and particularly discloses a tissue repair patch with a double-layer functional structure as well as a preparation method and application of the tissue repair patch. The tissue repair patch with the double-layer functional structure comprises a collagen layer which is used for being attached to tissue and is subjected to crosslinking treatment, a plurality of grooves are distributed in the front face of the collagen layer, and a hyaluronic acid layer is arranged on the back face of the collagen layer. According to the tissue repair patch, through mutual cooperation of the collagen layer and the hyaluronic acid layer, the synergistic effect of tissue regeneration promotion of collagen and lubrication and anti-inflammation of hyaluronic acid is achieved, and due to the grooves of the collagen layer, adhesion is improved, postoperative displacement is reduced, and postoperative adhesion is effectively prevented.

The invention provides a modified starch for medical uses and a method for preparing said 5 modified starch by steam-sterilization. The invention further provides said steam-sterilized modified starch for use in the inhibition of the formation of postoperative adhesions. Said steam-sterilized modified starch is preferably a gel comprising or consisting of carboxymethylated starch or etherified starch, which may optionally contain sodium citrate or citric acid. The invention also relates to a pharmaceutical composition comprising or consisting of a steam-sterilized gel comprising carboxymethylated starch or etherified starch and optionally sodium citrate and / or citric acid.

The utility model belongs to the technical field of electrocoagulation hooks, and particularly discloses an attractable and bendable open operation coarse electric hook with a low-temperature coating, which comprises an electric hook body, the electric hook body comprises a connecting part and a right-angle electric hook part which are integrally connected, irregular barbs are arranged on the periphery of the right-angle electric hook part, and the low-temperature coating is coated on the periphery of the right-angle electric hook part. The right-angle electric hook part is fixedly arranged on the end wall of one end of the connecting part, the other end of the connecting part is fixedly connected with one end of the copper hose, and the other end of the copper hose is fixedly connected with the steel pipe. By arranging the electric hook with the low-temperature coating, the temperature of the electric hook can be reduced, so that the heat pair injury of the electric hook is reduced, the formation of incrustation is reduced, and the formation of postoperative adhesion can also be reduced; and the copper hose is designed, so that the device can be bent in any direction, and the bending operation requirement of an open operation is met.

This invention discloses a method for preparing a nanocomposite hydrogel and its application in preventing postoperative tissue adhesions. The hydrogel consists of a basic framework of adipate dihydrazide-functionalized polysaccharide-drug-loaded nanomicelles cross-linked via dynamic acylhydrazone bonds. Further, benzodiazepine is formed through a click reaction between a dihydrolipoic acid prodrug molecule containing 2-formylphenylboronic acid and the functionalized polysaccharide, reinforcing the cross-linking density of the gel network and endowing it with reactive oxygen species-responsive sequential drug release functionality. This hydrogel possesses strong mechanical strength and can adhere to the wound surface, effectively isolating damaged peritoneum. In the highly reactive oxygen species environment of the postoperative wound, the benzodiazepine bonds break, releasing dihydrolipoic acid, achieving a dual cascade scavenging of reactive oxygen species, thereby alleviating inflammatory responses and oxidative stress. Subsequently, the pore size of the gel network increases, accelerating the release of antifibrotic drugs loaded in the micelles, thus effectively inhibiting the TGF-β1-mediated fibrosis process. Ultimately, this achieves effective prevention and treatment of postoperative adhesions.

The present application relates to a kind of preparation method of amino acid-based polyester amide / polyglycolide fiber membrane.The fiber membrane is that protein-based hypoglycemic drug is added to 0.2~0.5g / ml amino acid-based polyester amide solution to obtain drug-loaded nanocomposite, then is added to 0.2~0.5g / ml polyglycolide solution, is prepared by electrospinning technology, wherein the volume ratio of amino acid-based polyester amide drug-loaded nanocomposite polyglycolide solution is 0.5~2:5.The fiber membrane of the present application has very high porosity, has good adhesion when implanted into patient's body, prevents the risk of postoperative adhesion, can effectively promote the rapid healing of postoperative wound of diabetic patients;In addition, the preparation method of the fiber membrane is simple, has good application in the preparation of diabetic wound repair material.