3 results about "Postoperative adhesion" patented technology

This invention belongs to the field of biomaterials technology and discloses a two-component in-situ crosslinking agent, a biodegradable two-component hydrogel, and their applications. The two-component in-situ crosslinking agent disclosed in this invention has injectability and rapid gelation properties. The hydrogel formed after crosslinking has a low self-swelling rate, good elasticity, and is not easily crushed. It also has a suitable metal ion slow-release cycle and degradation cycle for preventing tissue adhesion or tissue repair. It is especially suitable for high-risk areas of postoperative adhesion such as the uterine cavity, abdominal cavity, and joints, and can also promote tissue regeneration.

The application discloses a kind of full biological Janus hydrogel based on density driving in the field of biological medicine and its preparation method and application, the present application utilizes the gravity stability brought by the density difference of N-acryloyl aspartic acid precursor solution and methacrylated gelatin precursor solution, by sequential pouring, combined with one-step photopolymerization process, successfully prepared a kind of adherent-adhesion type full biological Janus hydrogel with excellent mechanical properties, the Janus hydrogel can withstand large size strain stretching without delamination, also has other physical and chemical asymmetric characteristics, such as gradient degradation, asymmetric hydrophilicity and asymmetric swelling, can adapt to complex gastric environment and gastric perforation repair cycle, realize strong adhesion while preventing postoperative adhesion, provide an effective way for the design of advanced surgical sealant.

The present application relates to a kind of preparation method of amino acid-based polyester amide / polyglycolide fiber membrane.The fiber membrane is that protein-based hypoglycemic drug is added to 0.2~0.5g / ml amino acid-based polyester amide solution to obtain drug-loaded nanocomposite, then is added to 0.2~0.5g / ml polyglycolide solution, is prepared by electrospinning technology, wherein the volume ratio of amino acid-based polyester amide drug-loaded nanocomposite polyglycolide solution is 0.5~2:5.The fiber membrane of the present application has very high porosity, has good adhesion when implanted into patient's body, prevents the risk of postoperative adhesion, can effectively promote the rapid healing of postoperative wound of diabetic patients;In addition, the preparation method of the fiber membrane is simple, has good application in the preparation of diabetic wound repair material.