Hydrogel material for retroperitoneal tumor operation wound repair and recurrence prevention

The hydrogel formed by combining materials such as thiolated gelatin and oxidized sodium alginate has solved the problems of difficult wound healing and recurrence after retroperitoneal tumor resection, and has achieved rapid hemostasis, repair and continuous anti-tumor treatment.

CN120884528APending Publication Date: 2025-11-04PEOPLES HOSPITAL PEKING UNIV
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Patent Information

Application Number
CN202511086058.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-05
Publication Date
2025-11-04

AI Technical Summary

Technical Problem

Existing materials cannot effectively solve the problems of difficult wound healing and tumor recurrence after retroperitoneal tumor resection. Traditional hemostatic materials lack anti-tumor activity, local chemotherapy drug delivery systems have insufficient adhesion, and commercially available anti-adhesion membranes are difficult to adhere to irregular wounds.

Method used

A hydrogel material is formed by combining a matrix phase composed of thiolated gelatin, sodium alginate oxide, polyvinyl alcohol and carboxymethyl chitosan, a functional phase composed of drug-loaded nanoparticles and recombinant human collagen, and an auxiliary phase composed of calcium chloride, glutaraldehyde, graphene oxide and vitamin E succinate, to achieve rapid gelation and sustained drug release.

Benefits of technology

It achieves rapid hemostasis of tumor wounds and rapid repair of large wounds, reduces postoperative adhesions, and continuously inhibits tumor cells through the sustained release of drug-loaded nanoparticles, thereby reducing the risk of recurrence.

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Abstract

The invention relates to the field of biological materials, and particularly discloses a hydrogel material for retroperitoneal tumor operation wound repair and recurrence prevention. A matrix phase, a functional phase, an auxiliary phase and a solvent are arranged to form a hydrogel material, sulfhydrylated gelatin and oxidized sodium alginate can rapidly complete gelation under the action of calcium chloride in a body temperature environment to form a first gel body, and then the hydrogel material is formed in the first gel body. Polyvinyl alcohol and carboxymethyl chitosan form a second gel under the action of glutaraldehyde and graphene oxide, the existence time of the gel is prolonged, continuous protection on postoperative wounds is formed, rapid hemostasis of tumor wounds is achieved, meanwhile, rapid repair of the postoperative large wounds is promoted, hydrogel can effectively isolate organs behind peritoneum, postoperative adhesion is reduced, and the wound healing effect is improved. The gel can be connected to the surface of a wound tissue to promote fibroblast migration, and meanwhile, along with decomposition of the gel, the drug-loaded nanoparticles in the gel are continuously released and act on a postoperative wound surface to continuously inhibit tumor cells.
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