36 results about "Polyglycolide" patented technology

The invention discloses an absorbable suture line containing fibroin and a preparation method of the absorbable suture line, and relates to the technical field of absorbable suture lines. The absorbable suture line containing the silk protein is prepared from the following raw materials in parts by weight: 35 to 50 parts of silk protein, 10 to 20 parts of polylactic acid, 15 to 25 parts of polyglycolide-lactide, 1 to 3 parts of antibacterial agent, 2 to 5 parts of modified toughening agent, 1 to 4 parts of nano mineral filler, 0.5 to 2 parts of cross-linking agent and 2 to 5 parts of plasticizer, the preparation method comprises the following steps: reacting protocatechuic acid with ethanolamine to generate an intermediate 1; and reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate the antibacterial agent. The prepared absorbable suture line containing the silk protein has good mechanical performance, self-repairing performance and antibacterial performance.

This invention discloses a method for preparing poly(glycolic acid-caprolactone) copolymers, belonging to the field of polymer synthesis technology. The method includes: prepolymerizing ε-caprolactone with a catalyst and initiator at 40–60°C below the melting point of glycolide under an inert atmosphere; adding glycolide and heating to 160–220°C for the main polymerization reaction; after the reaction, dissolving, precipitating, washing, and drying to obtain the poly(glycolic acid-caprolactone) copolymer. This invention utilizes the physical difference in melting points between glycolide and ε-caprolactone, preferentially prepolymerizing ε-caprolactone at a temperature below the melting point of glycolide, resulting in a higher conversion rate of ε-caprolactone than glycolide in the initial stage of the main polymerization, effectively controlling the copolymerization reaction pathway. Using this method, copolymers with a weight-average molecular weight of not less than 100,000 Da and an intrinsic viscosity of 1.8–3.5 dL / g can be obtained within a wide range of glycolide molar content from 15% to 85%, and the degradation behavior is stable and controllable. This method is simple and requires no special equipment or chain extender, making it suitable for the large-scale preparation of medical materials such as absorbable sutures and tissue repair scaffolds.

This disclosure relates to crystalline forms of 3-acyl-buprenorphine derivatives and sustained release injectable pharmaceutical compositions for treatment of opioid dependence, pain or depression, including an aqueous suspension of crystalline 3-acyl-buprenoprhine, or a pharmaceutically acceptable salt thereof, wherein the composition does not include an organic solvent, a polylactide polymer, a polyglycolide polymer, or a copolymer of polylactide and polyglycolide. This disclosure also includes 3-acyl-buprenoprhine or a pharmaceutically acceptable salt thereof prepared in a controlled release matrix, including poly(lactide-co-glycolide), sucrose acetoisobutyrate, lecithin, diolein and a combination of two or more thereof.

Symmetric Star Poly(Substituted Glycolide) Homopolymers and Their Surface Properties The invention include the synthesis, thin film formation, surface properties, and comprehensive analysis of star-shaped well-defined symmetric poly(substituted glycolide) (s-PSG) homopolymers, which are alternatives to polylactides and polyglycolides. Four-armed symmetric poly(L-diisopropyl glycolide) (4s-PLDIPG) and poly(L-diisobutyl glycolide) (4s-PLDIBG) prepared by ring opening polymerization (ROP) under melt conditions with tin (II) 2- ethylhexanoate catalyst and pentaerythritol initiator exhibited high conversions (92-98%) and desirable PDI values (1.23-1.49). The NMR data of all s-PSGs showed that the methylene peaks of pentaerythritol were shifted, proving that polymerization took place in all arms. The molecular weights (Mn NMR, Mw GPC, Mn GPC) of s-PSGs determined by NMR and GPC data were consistent with the theoretical values. By increasing the side chain length of s-PSG homopolymers, there was a consistent increase in the water contact angles and surface roughness values of the thin films, whereas the surface free energy diminished.

The application discloses a kind of high uniformity medical grade absorbable polyester, preparation method and production system, production system includes kettle type closed stirrer, auxiliary tank, three-way valve and closed kettle type reactor;Three-way valve is communicated with kettle type closed stirrer by melt metering pump;It is communicated with auxiliary tank by micro-injection pump;It is communicated with closed kettle type reactor by static mixer;The side inside of three-way valve and micro-injection pump communication side is designed funnel shape, including funnel neck and funnel mouth, the side surface and bottom surface of funnel neck are equipped with uniform small hole.The application discloses a kind of system specially used for preparing high uniformity medical grade absorbable polyester and the preparation method matched therewith, by using special production system again cooperation specific process parameter can successfully prepare with medical grade absorbable polyester, especially suitable for the preparation of poly-l-lactide and polyglycolide with higher viscosity, more difficult to produce, the product obtained has high uniformity, high molecular weight and low monomer residue.

The application discloses a degradable fiber electrode fabric for three-dimensional electrogastrography monitoring and a preparation method thereof. The preparation method comprises the following steps: subjecting degradable polyglycolide fibers to plasma treatment, and evaporating a gold layer on the polyglycolide fibers; in-situ polymerizing a polypyrrole conversion layer on the surface of the gold layer; in-situ reducing gold nanoparticles on the surface of the polypyrrole conversion layer; coating a poly(1,8-octyleneglycol citrate) solution on the surface of the gold nanoparticle layer to form an insulation layer, and obtaining a degradable flexible fiber electrode; using a knitting technology to synchronously knit the flexible fiber electrode and the polyglycolide fibers to form a three-dimensional flexible fabric structure, removing the insulation layer on a target area of the flexible fabric structure to expose a conductive layer, and obtaining the degradable fiber electrode fabric. The fiber electrode fabric prepared by the application can realize full-curve fitting of a gastric serosal surface, does not need external fixation, and can be used for long-term, stable and real-time multi-dimensional gastric electrophysiological signal acquisition.

The invention belongs to the technical field of high polymer materials, and provides a method for preparing polyglycolide through catalysis of metal-based ionic liquid. The method comprises the following steps: mixing a metal-based ionic liquid solution and an initiator solution in a nitrogen atmosphere, and removing a solvent to obtain a mixed solution; adding glycolide into the mixed solution to obtain a homogeneous-phase mixed solution; and carrying out ring-opening polymerization reaction on the homogeneous-phase mixed solution. The adopted metal-based ionic liquid catalyst belongs to homogeneous catalysis in the ring-opening polymerization reaction of the glycolide, on one hand, the contact area between metal active sites and the glycolide can be increased, the ring-opening polymerization activity can be improved, on the other hand, hydrogen bonds or an ionic microenvironment in the ionic liquid can promote ring opening of the glycolide, and therefore the dosage of the catalyst is reduced, and the cost is reduced. Meanwhile, metal residues in the polyglycolide are reduced, and the biological safety of the polyglycolide is improved; the metal-based ionic liquid catalyst is simple in preparation process, easy for industrial production and high in catalytic efficiency.

The application relates to an electrostatic spinning anti-adhesion membrane and a preparation method and application thereof. The electrostatic spinning anti-adhesion membrane comprises an inner layer, an intermediate layer and an outer layer which are sequentially stacked; the inner layer comprises polyglycolide-lactide-polyethylene glycol, the intermediate layer comprises polyglycolide-lactide, and the outer layer comprises polylactic acid-caprolactone. The electrostatic spinning anti-adhesion membrane has a three-dimensional nanofiber network structure of a biomimetic extracellular matrix, excellent mechanical properties, body temperature response softening and gradient degradation characteristics, can balance the degradation speed and the mechanical properties, reduce the mechanical damage of the material to the surrounding tissues, and can effectively prevent postoperative tissue adhesion.

This invention discloses a method for preparing a sustained-release levofloxacin and fluorometholone lacrimal canaliculus plug, comprising: (1) dispersing levofloxacin, polyglycolic acid, chitosan, and polylysine in a first solvent to form a first dispersion, dispersing fluorometholone and alginate in a second solvent to form a second dispersion, and then mixing the first and second dispersions evenly; (2) performing a crosslinking reaction at 45-55℃ for 3-10 hours, cooling, and drying to obtain a mixture; (3) subjecting the mixture obtained in step (2) to plasma treatment at less than 6 Pa for 30 seconds to 5 minutes, and then solidifying it. The lacrimal canaliculus plug of this invention can reduce the frequency of antibiotic use or eliminate the need for antibiotic use, has good patient compliance, good comfort, good biocompatibility, short-term degradation, few side effects, good water-swelling properties, and is not easy to fall off, and has a triple effect of anti-inflammatory, anti-infective, and dry eye treatment after corneal refractive surgery.

The application discloses a system and method for continuously and industrially producing high-molecular-weight crude PGA. In a 100,000-3,000,000 tons / year polyglycolide PGA device, three different types of polymerization reactors are connected in series, and polymerization reactions are carried out step by step to obtain high-molecular-weight crude PGA. By using the system and method, the conversion rate of the polymerization reaction is 75%-95%, the molecular weight of the polyglycolide PGA is greater than 150,000, and large-scale industrial continuous production of the polyglycolide PGA product is realized. Moreover, the equipment type is simple, the operation is convenient and easy, and the system and method can be applied to the preparation of polyglycolide products in a polyglycolide PGA industrial production device.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

This invention provides a three-center Schiff base catalyst and its preparation method, as well as a method for preparing poly(ethylene glycol) lactide. The three-center Schiff base catalyst has a structure shown in Formula I or Formula II, both of which contain three active sites. The catalytic activity is enhanced through synergistic coordination among the three metal centers. Furthermore, in the preparation method of the catalyst provided by this invention, the synthesis process of the Schiff base compound and the catalyst involves multiple continuous reactions in a one-pot process, saving the purification process of intermediates, reducing the use of organic solvents, simplifying the production process, increasing the catalyst yield, and reducing production costs. This invention uses the catalyst to catalyze the ring-opening polymerization of glycolide and lactide to produce poly(ethylene glycol) lactide. Gel permeation chromatography analysis shows that the prepared poly(ethylene glycol) lactide has a high number-average molecular weight, exceeding 70,000 g / mol, and a high yield, exceeding 94%.

The application discloses a kind of biodegradable synthetic resin and preparation method thereof, the biodegradable synthetic resin includes the following weight parts raw materials: hydroxyl-terminated biodegradable polyester elastomer 10-30 parts, modified polybutylene succinate 60-80 parts, polyglycolide resin 15-30 parts, compatibility agent 5-10 parts, antioxidant 0.1-1 part and lubricant 0.1-1 part.The raw materials of biodegradable synthetic resin used in the application are all full biodegradable materials, not only widely available, but also can complete biodegradation, it is an environment-friendly synthetic resin;The biodegradable synthetic resin of the application has good mechanical comprehensive performance and high thermal decomposition temperature.

The invention discloses a preparation method of an absorbable antibacterial coating material capable of slowly releasing antibiotics. The preparation method comprises the following steps: step 1, blending antibiotics, an absorbable polymer and a mixed solvent to obtain a coating solution; the antibiotics are selected from rifampicin and minocycline hydrochloride; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the mixed solvent is selected from hexafluoroisopropanol and acetonitrile, and the volume ratio of the hexafluoroisopropanol in the mixed solvent is not less than 25%; and 2, uniformly spraying the coating solution on the surface of the degradable base material through ultrasonic spraying, and then carrying out drying treatment. According to the preparation method disclosed by the invention, the antibiotic, the absorbable polymer and the organic solvent are blended and dissolved and then are attached to the surface of the absorbable material through ultrasonic spraying, and the release of the antibiotic is regulated and controlled while the stability of the coating is ensured by regulating and controlling the ratio of the antibiotic to the polymer and the swelling characteristic of the solvent to the base material.

The invention discloses a polyglycolide-polyether-polycarbonate copolymer and a preparation method thereof, the number-average molecular weight of the polyglycolide-polyether-polycarbonate copolymer is 3-185 kg / mol, the molecular weight distribution is 1.4-6.8, and the content of glycolide chain links in the copolymer is 0.1-90%. The copolymer disclosed by the invention has the characteristics of higher relative molecular mass, higher melting point, adjustable component composition and excellent mechanical property. The preparation method is low in raw material cost, simple to operate and mild in condition, does not need a complicated post-treatment purification process, and is more beneficial to industrialization.

The invention discloses a poly (p-dioxanone) drug-loaded microsphere, which comprises a microsphere main material, a bioactive substance and a drug, the microsphere main material is prepared by using a poly (p-dioxanone) monomer as a raw material through an emulsion polymerization method, and the bioactive substance is a synthetic degradable high polymer material and a natural biodegradable high polymer material. Comprising but not limited to polylactide and polyglycolide. According to the poly (p-dioxanone) drug-loaded microsphere as well as the preparation method and the application thereof, the monomer (p-dioxanone) and the required drug are taken as raw materials, the raw materials are continuously polymerized and wrap the drug in the emulsification process to form poly (p-dioxanone) with a certain molecular weight, and a certain bioactive substance can be added, so that the poly (p-dioxanone) drug-loaded microsphere is relatively wide in application range and relatively low in cost. According to the microsphere stability and biocompatibility, the degradation time can be controlled by controlling the catalyst and the polymerization time, a certain slow release property is achieved, the toxic and side effects are reduced, the preparation method is simple, and industrial production is facilitated.

A block copolymer includes a block A and a block B. The A block provides mechanical strength and the B block provides elasticity to the polymeric material. The block copolymer may be an ABA triblock copolymer. The A block may include one or more of polyglycolide (PGA), polylactic acid (PLA), or a copolymer thereof. The B block may include a random copolymer of (i) glycolide (GA) and / or lactide (LA), (ii) trimethylene carbonate (TMC), and (iii) epsilon-caprolactone (CL). The block copolymer can cover an implantable device, and the implantable device can be used for achieving immediate hemostasis at a punctured part of a blood vessel wall.

The application discloses a silk protein-containing absorbable suture and a preparation method thereof, and relates to the technical field of absorbable sutures.The silk protein-containing absorbable suture comprises the following raw materials in parts by weight: 35-50 parts of silk protein, 10-20 parts of polylactic acid, 15-25 parts of polyglycolide, 1-3 parts of an antibacterial agent, 2-5 parts of a modified toughening agent, 1-4 parts of a nano-mineral filler, 0.5-2 parts of a crosslinking agent and 2-5 parts of a plasticizer.The application generates an intermediate 1 by reacting protocatechuic acid with ethanolamine; the intermediate 1 is reacted with 5,10,15,20-tetra(4-carboxyphenyl)porphyrin to generate the antibacterial agent.The silk protein-containing absorbable suture prepared by the application has good mechanical properties, self-repairing properties and antibacterial properties.

The application relates to a preparation method of a degradable toughened polyester elastomer and a blended polymer alloy, which comprises the following steps: preparing the degradable toughened polyester elastomer by melt esterification and polycondensation of a hydroxyl-terminated PGA oligomer and a dibasic acid; the molecular weight of the hydroxyl-terminated PGA oligomer is 400-7000 g / mol; the dibasic acid is an aliphatic linear dibasic acid or a flexible alicyclic diacid with 2-12 carbon atoms; drying and uniformly mixing PGA and the degradable toughened polyester elastomer, and then blending and extruding in a double-screw extruder to obtain a PGA / PGA-based elastomer blended polymer alloy. The degradable toughened polyester elastomer prepared by the application balances the tensile strength and the elongation at break, and solves the problem that the degradation performance and the mechanical performance of a conventional polyglycolide copolyester cannot be compatible; the PGA-based elastomer is used to modify PGA to prepare the blended polymer alloy, the two phases have good compatibility, the process is simple, and the blended polymer alloy has high tensile strength and toughness.

The application discloses a modified polyether ether ketone material and a manufacturing method and application. The method comprises the following steps: (1) performing surface etching on a polyether ether ketone base material, so that a plurality of micro columns are formed on the surface of the polyether ether ketone base material, and a first polyether ether ketone is obtained; (2) placing the first polyether ether ketone in an organic amine and reacting at 100-150 DEG C for 2-8 hours to obtain a second polyether ether ketone; (3) repeatedly dip-coating the second polyether ether ketone in a modification liquid to obtain a modified polyether ether ketone material; wherein the modification liquid is an organic solution containing bioactive inorganic substances and biodegradable polyesters, and the biodegradable polyesters in the modification liquid are selected from one or more of polylactic acid, polyglycolide, polyglycolide-co-lactide and polycaprolactone. The method can obviously improve the hydrophilicity of the polyether ether ketone and improve the surface bioactivity of the polyether ether ketone.

The present application relates to a kind of deep antioxidant EGCG nano composition and its preparation method and purposes, belong to nanocarrier technical field.Deep antioxidant EGCG nano composition of the present application preparation raw material includes carrier, stabilizer, active substance, water, polyhydric alcohol;Active substance is EGCG;The mass percentage of EGCG in preparation raw material is 0.5-5%;Stabilizer is selected from plant sphingosine and its derivatives;Carrier is amphiphilic polymer, general formula is X m -Y n , wherein X m It is polyglycolide, Y n It is poly 2-methacryloyloxy ethyl phosphorylcholine.The nano composition is prepared by removing polyhydric alcohol in raw material after self-assembly by specific preparation method.The nano composition provided by the present application has high encapsulation efficiency, good stability, and good transdermal absorption, and is used in cosmetics, which can provide excellent deep antioxidant effect on skin.

This invention discloses a method for preparing and weaving a highly repairing composite biological anti-leakage patch, belonging to the field of composite biological patches. It aims to solve the problems of insufficient adhesion in humid environments, easy postoperative leakage, significant inflammatory response, and limited tissue regeneration capacity of existing biological patches. The invention comprises 30-50 parts of polyglycolic acid fiber; 20-40 parts of polyglycolic acid-lactide fiber; 10-30 parts of poly(p-dioxanone) fiber; 5-15 parts of sodium carboxymethyl cellulose; 3-10 parts of chitosan; 2-8 parts of collagen; 0.1-2 parts of 1,3-dimethylaminopropyl-3-ethylcarbodiimide hydrochloride; and 1-5 parts of polyether ester catechol. Polyether ester catechol, as a key innovative component, effectively prevents body fluid leakage, reduces oxidative stress and inflammatory response, and accelerates tissue repair and regeneration, making it suitable for various tissue repair applications.

The present application relates to a kind of preparation method of amino acid-based polyester amide / polyglycolide fiber membrane.The fiber membrane is that protein-based hypoglycemic drug is added to 0.2~0.5g / ml amino acid-based polyester amide solution to obtain drug-loaded nanocomposite, then is added to 0.2~0.5g / ml polyglycolide solution, is prepared by electrospinning technology, wherein the volume ratio of amino acid-based polyester amide drug-loaded nanocomposite polyglycolide solution is 0.5~2:5.The fiber membrane of the present application has very high porosity, has good adhesion when implanted into patient's body, prevents the risk of postoperative adhesion, can effectively promote the rapid healing of postoperative wound of diabetic patients;In addition, the preparation method of the fiber membrane is simple, has good application in the preparation of diabetic wound repair material.

The invention relates to the field of oral medical materials, and particularly discloses a degradable oral restoration support membrane. The degradable dental restoration support membrane comprises a support matrix and a degradable outer protection layer, the support matrix is made of a pure magnesium or magnesium alloy material, and the degradable outer protection layer is one of a poly (lactide-caprolactone) coating, a poly (glycolide-caprolactone) coating and a poly (lactide-caprolactone) blended poly (glycolide-caprolactone) coating; in addition, the preparation method disclosed by the invention has the advantage of balancing the mechanical strength and biodegradability of the dental restoration support membrane.

The invention provides an in-situ gel composition containing xenomeline. The in-situ gel composition containing xenomeline is prepared from 1 to 30 percent of xenomeline, 25 to 50 percent of a slow-release carrier material and 30 to 70 percent of a solvent. The slow-release carrier material is selected from one or more of sucrose acetate isobutyrate (SAIB), polyorthoester (POE) and poly (lactic-co-glycolic acid) (PLGA). The composition can be applied by injection, forms a gelatinized medicine storage cavern at an administration part, continuously delivers medicines, and has a remarkable long-acting slow-release effect and good stability and safety.

The invention relates to a novel degradable acupuncture needle. According to the technical scheme, the needle comprises a needle body, a needle head and a needle handle, one side of the needle body is fixedly connected with the needle head, the other side of the needle body is fixedly provided with the needle handle, the outer side of the needle body is fixedly connected with a pigment layer, and the needle body, the needle head and the needle handle are made of poly (lactic-co-glycolic acid). According to the invention, by arranging the poly (lactic-co-glycolic acid), the product is made of a poly (lactic-co-glycolic acid) material, and the poly (lactic-co-glycolic acid) material is non-toxic, is a degradable functional high-molecular organic compound, and has multiple recovery modes such as hydrolysis, biodegradation and polymer-to-polymer, so that the recovery modes are more, and the recovery safety and environmental protection property are greatly improved; the pollution to the environment is small, and metal pollution is avoided.

The present invention relates to electrospun multilayer tubes or wraps for the protection or bridging of damaged nerves, said tubes or wraps comprising an electrospun isolating outer layer and an active inner layer, said electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers or mixtures thereof, said active inner layer comprising at least one electrically conductive compound and / or at least one ionically conductive compound and / or at least one peptide or protein to stimulate nerve growth. Furthermore, the present invention relates to a method for the manufacture of such tubes or wraps and their use for the protection or bridging of nerves or for the stimulation of nerve growth and cell proliferation.

The present invention aims to provide a tissue reinforcement material having water absorbency and high stretchability. Provided is a tissue reinforcement material including a non-woven fabric containing polyglycolide, wherein the tissue reinforcement material has an average fiber diameter of 0.5 μm or more and 7.0 μm or less, an areal density of 1.0 g / m2 or more and 50 g / m2 or less, and a flexural rigidity (B value) measured with a pure bending tester of 0.001 gf·cm2 / cm or more and 0.01 gf·cm2 / cm or less.

This invention belongs to the field of suture technology, specifically relating to a drug-loaded suture and its preparation method. The drug-loaded suture provided by this invention includes a matrix and a drug loaded on the surface of the matrix; the matrix has a core-skin structure, the core layer of the matrix being polylactic acid filaments; the skin layer of the matrix is ​​a nanofiber membrane, the nanofiber membrane being composed of polycaprolactone and polyglycolic acid; the polyglycolic acid accounts for 10-90% of the mass percentage of the nanofiber membrane. The skin layer of the drug-loaded suture provided by this invention is prepared from two biodegradable materials with different degradation rates, polycaprolactone and polyglycolic acid. By limiting the ratio of polycaprolactone and polyglycolic acid in the skin layer, this invention can control the degradation cycle and drug release cycle of the drug-loaded suture, thereby adapting to different types of wounds with different healing times. Simultaneously, the core-skin structure of the drug-loaded suture provided by this invention provides excellent mechanical properties.

The application provides a polyether ester-based thermoplastic elastomer and a preparation method thereof, and belongs to the field of high polymer materials. Specifically, a random copolymer of an alkylene oxide and a lactone is used as a soft segment, and a levorotatory polylactic acid, a dextrorotatory polylactic acid, a racemic polylactic acid, a polyglycolide, a polycaprolactone or a polypentolactone is used as a hard segment; a homogeneous or heterogeneous bimetallic catalyst and a cheap and easily available cocatalyst are used to prepare a triblock elastomer through a one-pot two-step method; the performance of the elastomer can be directly controlled by adjusting the raw material addition ratio; and a series of polyether ester-based thermoplastic elastomers with controllable performance are prepared. The polyether ester-based thermoplastic elastomer has a use window temperature of -65-170 DEG C, a maximum tensile strength of 5-50 MPa and an elongation at break of 300-1500%.