13 results about "Polyglycolide" patented technology

This invention discloses a method for preparing poly(glycolic acid-caprolactone) copolymers, belonging to the field of polymer synthesis technology. The method includes: prepolymerizing ε-caprolactone with a catalyst and initiator at 40–60°C below the melting point of glycolide under an inert atmosphere; adding glycolide and heating to 160–220°C for the main polymerization reaction; after the reaction, dissolving, precipitating, washing, and drying to obtain the poly(glycolic acid-caprolactone) copolymer. This invention utilizes the physical difference in melting points between glycolide and ε-caprolactone, preferentially prepolymerizing ε-caprolactone at a temperature below the melting point of glycolide, resulting in a higher conversion rate of ε-caprolactone than glycolide in the initial stage of the main polymerization, effectively controlling the copolymerization reaction pathway. Using this method, copolymers with a weight-average molecular weight of not less than 100,000 Da and an intrinsic viscosity of 1.8–3.5 dL / g can be obtained within a wide range of glycolide molar content from 15% to 85%, and the degradation behavior is stable and controllable. This method is simple and requires no special equipment or chain extender, making it suitable for the large-scale preparation of medical materials such as absorbable sutures and tissue repair scaffolds.

Symmetric Star Poly(Substituted Glycolide) Homopolymers and Their Surface Properties The invention include the synthesis, thin film formation, surface properties, and comprehensive analysis of star-shaped well-defined symmetric poly(substituted glycolide) (s-PSG) homopolymers, which are alternatives to polylactides and polyglycolides. Four-armed symmetric poly(L-diisopropyl glycolide) (4s-PLDIPG) and poly(L-diisobutyl glycolide) (4s-PLDIBG) prepared by ring opening polymerization (ROP) under melt conditions with tin (II) 2- ethylhexanoate catalyst and pentaerythritol initiator exhibited high conversions (92-98%) and desirable PDI values (1.23-1.49). The NMR data of all s-PSGs showed that the methylene peaks of pentaerythritol were shifted, proving that polymerization took place in all arms. The molecular weights (Mn NMR, Mw GPC, Mn GPC) of s-PSGs determined by NMR and GPC data were consistent with the theoretical values. By increasing the side chain length of s-PSG homopolymers, there was a consistent increase in the water contact angles and surface roughness values of the thin films, whereas the surface free energy diminished.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

This invention provides a three-center Schiff base catalyst and its preparation method, as well as a method for preparing poly(ethylene glycol) lactide. The three-center Schiff base catalyst has a structure shown in Formula I or Formula II, both of which contain three active sites. The catalytic activity is enhanced through synergistic coordination among the three metal centers. Furthermore, in the preparation method of the catalyst provided by this invention, the synthesis process of the Schiff base compound and the catalyst involves multiple continuous reactions in a one-pot process, saving the purification process of intermediates, reducing the use of organic solvents, simplifying the production process, increasing the catalyst yield, and reducing production costs. This invention uses the catalyst to catalyze the ring-opening polymerization of glycolide and lactide to produce poly(ethylene glycol) lactide. Gel permeation chromatography analysis shows that the prepared poly(ethylene glycol) lactide has a high number-average molecular weight, exceeding 70,000 g / mol, and a high yield, exceeding 94%.

The application discloses a kind of biodegradable synthetic resin and preparation method thereof, the biodegradable synthetic resin includes the following weight parts raw materials: hydroxyl-terminated biodegradable polyester elastomer 10-30 parts, modified polybutylene succinate 60-80 parts, polyglycolide resin 15-30 parts, compatibility agent 5-10 parts, antioxidant 0.1-1 part and lubricant 0.1-1 part.The raw materials of biodegradable synthetic resin used in the application are all full biodegradable materials, not only widely available, but also can complete biodegradation, it is an environment-friendly synthetic resin;The biodegradable synthetic resin of the application has good mechanical comprehensive performance and high thermal decomposition temperature.

The application discloses a modified polyether ether ketone material and a manufacturing method and application. The method comprises the following steps: (1) performing surface etching on a polyether ether ketone base material, so that a plurality of micro columns are formed on the surface of the polyether ether ketone base material, and a first polyether ether ketone is obtained; (2) placing the first polyether ether ketone in an organic amine and reacting at 100-150 DEG C for 2-8 hours to obtain a second polyether ether ketone; (3) repeatedly dip-coating the second polyether ether ketone in a modification liquid to obtain a modified polyether ether ketone material; wherein the modification liquid is an organic solution containing bioactive inorganic substances and biodegradable polyesters, and the biodegradable polyesters in the modification liquid are selected from one or more of polylactic acid, polyglycolide, polyglycolide-co-lactide and polycaprolactone. The method can obviously improve the hydrophilicity of the polyether ether ketone and improve the surface bioactivity of the polyether ether ketone.

This invention discloses a method for preparing and weaving a highly repairing composite biological anti-leakage patch, belonging to the field of composite biological patches. It aims to solve the problems of insufficient adhesion in humid environments, easy postoperative leakage, significant inflammatory response, and limited tissue regeneration capacity of existing biological patches. The invention comprises 30-50 parts of polyglycolic acid fiber; 20-40 parts of polyglycolic acid-lactide fiber; 10-30 parts of poly(p-dioxanone) fiber; 5-15 parts of sodium carboxymethyl cellulose; 3-10 parts of chitosan; 2-8 parts of collagen; 0.1-2 parts of 1,3-dimethylaminopropyl-3-ethylcarbodiimide hydrochloride; and 1-5 parts of polyether ester catechol. Polyether ester catechol, as a key innovative component, effectively prevents body fluid leakage, reduces oxidative stress and inflammatory response, and accelerates tissue repair and regeneration, making it suitable for various tissue repair applications.

The present application relates to a kind of preparation method of amino acid-based polyester amide / polyglycolide fiber membrane.The fiber membrane is that protein-based hypoglycemic drug is added to 0.2~0.5g / ml amino acid-based polyester amide solution to obtain drug-loaded nanocomposite, then is added to 0.2~0.5g / ml polyglycolide solution, is prepared by electrospinning technology, wherein the volume ratio of amino acid-based polyester amide drug-loaded nanocomposite polyglycolide solution is 0.5~2:5.The fiber membrane of the present application has very high porosity, has good adhesion when implanted into patient's body, prevents the risk of postoperative adhesion, can effectively promote the rapid healing of postoperative wound of diabetic patients;In addition, the preparation method of the fiber membrane is simple, has good application in the preparation of diabetic wound repair material.

The invention provides an in-situ gel composition containing xenomeline. The in-situ gel composition containing xenomeline is prepared from 1 to 30 percent of xenomeline, 25 to 50 percent of a slow-release carrier material and 30 to 70 percent of a solvent. The slow-release carrier material is selected from one or more of sucrose acetate isobutyrate (SAIB), polyorthoester (POE) and poly (lactic-co-glycolic acid) (PLGA). The composition can be applied by injection, forms a gelatinized medicine storage cavern at an administration part, continuously delivers medicines, and has a remarkable long-acting slow-release effect and good stability and safety.

The present invention relates to electrospun multilayer tubes or wraps for the protection or bridging of damaged nerves, said tubes or wraps comprising an electrospun isolating outer layer and an active inner layer, said electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers or mixtures thereof, said active inner layer comprising at least one electrically conductive compound and / or at least one ionically conductive compound and / or at least one peptide or protein to stimulate nerve growth. Furthermore, the present invention relates to a method for the manufacture of such tubes or wraps and their use for the protection or bridging of nerves or for the stimulation of nerve growth and cell proliferation.

This invention belongs to the field of suture technology, specifically relating to a drug-loaded suture and its preparation method. The drug-loaded suture provided by this invention includes a matrix and a drug loaded on the surface of the matrix; the matrix has a core-skin structure, the core layer of the matrix being polylactic acid filaments; the skin layer of the matrix is ​​a nanofiber membrane, the nanofiber membrane being composed of polycaprolactone and polyglycolic acid; the polyglycolic acid accounts for 10-90% of the mass percentage of the nanofiber membrane. The skin layer of the drug-loaded suture provided by this invention is prepared from two biodegradable materials with different degradation rates, polycaprolactone and polyglycolic acid. By limiting the ratio of polycaprolactone and polyglycolic acid in the skin layer, this invention can control the degradation cycle and drug release cycle of the drug-loaded suture, thereby adapting to different types of wounds with different healing times. Simultaneously, the core-skin structure of the drug-loaded suture provided by this invention provides excellent mechanical properties.

This invention provides a poly(glycolic acid) graft copolymer having the structure shown in the following general formula, wherein R1, R2, R3, R4, ..., R n‑3 R n‑2 R n‑1 and R n The substituents are independently selected from H or two substituents attached to the same carbon atom, and are not simultaneously R1, R2, R3, R4, ..., R n‑3 R n‑2 R n‑1 and R n In this invention, the substituents constitute at least 5% of the molar percentage. The invention first grafts maleic anhydride onto polyethylene glycol (PEG) to obtain MA-GA, then prepolymerizes MA-GA at low temperature followed by high temperature polymerization to obtain a high molecular weight copolymer. This invention significantly improves grafting efficiency, increases polymer molecular weight, and successfully introduces more maleic anhydride polar groups onto the side chains of PEG through the grafting reaction, thereby improving the toughness and elongation at break of the PEG material.

The application discloses a system and method for large-scale industrial continuous production of PGA. In a 100,000-3,000,000 tons / year polyglycolide PGA device, glycolide raw materials and catalyst are firstly sent into a first polymerization reactor to perform adiabatic polymerization, then are sent into a second polymerization reactor to perform further polymerization, part of polymerization heat is removed through heat conduction oil in a jacket of the second polymerization reactor and a winding pipe, then the glycolide raw materials and the catalyst are sent into a third polymerization reactor to perform adiabatic polymerization, after the polymerization reaction is completed, antioxidants and deactivation agents are added to terminate the reaction, then unreacted glycolide raw materials in the polymerization product are removed through a devolatilizer, finally, the polymerization product is subjected to crystallization, granulation and packaging and stacking to obtain a polyglycolide product with a molecular weight of 156,000-212,000, a melt viscosity of 460-540 Pa·S and a tensile strength of 65-73 MPa, which can be applied to large-scale commercial continuous industrial production of polyglycolide PGA.