62 results about "Polyglycolide" patented technology

The invention discloses a composite medical suture and a preparation method thereof, and belongs to the field of biomedicine. In order to solve the problems that an existing medical suture is poor in antibacterial effect and biological safety, the composite medical suture comprises a core layer, a degradation regulation and control layer, a slow release layer and an antibacterial layer which are sequentially arranged from inside to outside; the core layer is prepared from a blend fiber of poly (hydroxybutyrate-hydroxyvalerate) and polycaprolactone-co-polyglycolide; the degradation regulation and control layer comprises a mixture of at least two kinds of polyethylene glycol with different molecular weights; the slow release layer comprises quaternary ammonium salt loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. Through the synergistic effect of the four layers, the comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function is realized; the purposes of improving the slow-release antibacterial performance, reducing damage to the human body, reducing inflammation and the like are achieved, and the antibacterial and degradation effects meet the recovery requirements.

The invention discloses an anti-fibrosis drug coating degradable woven stent for treating urethrostenosis, the stent is a hollow cylinder formed by spirally weaving wires, the wires are made of biodegradable polymer materials, the surface of the stent is coated with a drug coating, anti-fibrosis drugs are selected as the drugs, and the anti-fibrosis drug coating is made of biodegradable polymer materials. The drug coating is prepared by using an ultrasonic atomization spraying method; the biodegradable polymer material comprises one or a compound of more than one of poly L-lactic acid, poly D, L-lactic acid, poly (L-lactic acid / D, L-lactic acid), poly (glycolide / lactide), poly (glycolide-lactide), poly (L-lactic acid / caprolactone), poly (glycolide / caprolactone), poly (D, L-lactic acid / caprolactone), polydioxanone and the like. The stent body is made into a self-expanding stent by adopting a weaving method; the biodegradable ureteral stent with the drug coating has good biocompatibility, degradability and mechanical property, and has a wide market application prospect.

The present invention relates to methods of manufacturing beverage capsules, the method comprising: (a) providing a biopolymer film, wherein the biopolymer film comprises a layered structure comprising biopolymer layer - polyglycolide (PGA) layer - biopolymer layer; and (b) thermoforming the biopolymer film to form at least one layer of a capsule body comprising or consisting of the biopolymer film.

The invention discloses an absorbable suture line containing fibroin and a preparation method of the absorbable suture line, and relates to the technical field of absorbable suture lines. The absorbable suture line containing the silk protein is prepared from the following raw materials in parts by weight: 35 to 50 parts of silk protein, 10 to 20 parts of polylactic acid, 15 to 25 parts of polyglycolide-lactide, 1 to 3 parts of antibacterial agent, 2 to 5 parts of modified toughening agent, 1 to 4 parts of nano mineral filler, 0.5 to 2 parts of cross-linking agent and 2 to 5 parts of plasticizer, the preparation method comprises the following steps: reacting protocatechuic acid with ethanolamine to generate an intermediate 1; and reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate the antibacterial agent. The prepared absorbable suture line containing the silk protein has good mechanical performance, self-repairing performance and antibacterial performance.

The present invention relates to a process for the ring-opening polymerization of glycolide using a novel initiator. A polymerization system is composed of glycolide, a catalyst, and an initiator. The initiator contains hydrophilic and hydrophobic groups and heteroatoms such as sulfur and nitrogen. While metal ions in traditional catalysts catalyze polymerization, they will complex with the oxygen atoms of ester bonds to catalyze the cleavage of the ester bonds of polyglycolide (PGA), resulting in a decrease in the molecular weight of PGA and an increase in the chromaticity of the product. The heteroatoms contained in the novel initiator of the present invention have a strong complexing ability with metals, can form a relatively stable coordination complex with the catalyst, prevent the cleavage of PGA, and reduce the chromaticity of the product. In addition, the addition of this novel initiator introduces some flexible chain segments, lowers the freezing point of PGA, and enables the polymerization temperature to be reduced. Compared with the prior art, the present invention has the advantages of high product molecular weight, relatively uniform molecular weight distribution, large operation flexibility in the polymerization reaction time, and wide temperature control window, and is suitable for industrial production.

This invention discloses a method for preparing poly(glycolic acid-caprolactone) copolymers, belonging to the field of polymer synthesis technology. The method includes: prepolymerizing ε-caprolactone with a catalyst and initiator at 40–60°C below the melting point of glycolide under an inert atmosphere; adding glycolide and heating to 160–220°C for the main polymerization reaction; after the reaction, dissolving, precipitating, washing, and drying to obtain the poly(glycolic acid-caprolactone) copolymer. This invention utilizes the physical difference in melting points between glycolide and ε-caprolactone, preferentially prepolymerizing ε-caprolactone at a temperature below the melting point of glycolide, resulting in a higher conversion rate of ε-caprolactone than glycolide in the initial stage of the main polymerization, effectively controlling the copolymerization reaction pathway. Using this method, copolymers with a weight-average molecular weight of not less than 100,000 Da and an intrinsic viscosity of 1.8–3.5 dL / g can be obtained within a wide range of glycolide molar content from 15% to 85%, and the degradation behavior is stable and controllable. This method is simple and requires no special equipment or chain extender, making it suitable for the large-scale preparation of medical materials such as absorbable sutures and tissue repair scaffolds.

This disclosure relates to crystalline forms of 3-acyl-buprenorphine derivatives and sustained release injectable pharmaceutical compositions for treatment of opioid dependence, pain or depression, including an aqueous suspension of crystalline 3-acyl-buprenoprhine, or a pharmaceutically acceptable salt thereof, wherein the composition does not include an organic solvent, a polylactide polymer, a polyglycolide polymer, or a copolymer of polylactide and polyglycolide. This disclosure also includes 3-acyl-buprenoprhine or a pharmaceutically acceptable salt thereof prepared in a controlled release matrix, including poly(lactide-co-glycolide), sucrose acetoisobutyrate, lecithin, diolein and a combination of two or more thereof.

The present invention relates to capsules for preparation of a beverage upon injection of liquid under pressure into the capsule, wherein the capsule body comprises or consists of a biopolymer film comprising polyglycolide (PGA), wherein the biopolymer film comprises a layered structure comprising biopolymer layer - PGA layer - biopolymer layer, and wherein the PGA is blended with poly(butylene adipate-co-terephthalate) (PBAT), polycaprolactone (PCL), polylactic acid (PLA), and / or nanocellulose.

Symmetric Star Poly(Substituted Glycolide) Homopolymers and Their Surface Properties The invention include the synthesis, thin film formation, surface properties, and comprehensive analysis of star-shaped well-defined symmetric poly(substituted glycolide) (s-PSG) homopolymers, which are alternatives to polylactides and polyglycolides. Four-armed symmetric poly(L-diisopropyl glycolide) (4s-PLDIPG) and poly(L-diisobutyl glycolide) (4s-PLDIBG) prepared by ring opening polymerization (ROP) under melt conditions with tin (II) 2- ethylhexanoate catalyst and pentaerythritol initiator exhibited high conversions (92-98%) and desirable PDI values (1.23-1.49). The NMR data of all s-PSGs showed that the methylene peaks of pentaerythritol were shifted, proving that polymerization took place in all arms. The molecular weights (Mn NMR, Mw GPC, Mn GPC) of s-PSGs determined by NMR and GPC data were consistent with the theoretical values. By increasing the side chain length of s-PSG homopolymers, there was a consistent increase in the water contact angles and surface roughness values of the thin films, whereas the surface free energy diminished.

The invention relates to a preparation method of a degradable toughened polyester elastomer and a blend polymer alloy. The preparation method comprises the following steps: carrying out melt esterification and polycondensation on a hydroxyl-terminated PGA oligomer and binary acid to prepare the degradable toughened polyester elastomer; the molecular weight of the hydroxyl-terminated PGA oligomer is 400 to 7000 g / mol; the binary acid is aliphatic linear binary acid or flexible alicyclic diacid with the carbon atom number of 2-12; and drying PGA and the degradable toughened polyester elastomer, uniformly mixing, and carrying out blending extrusion in a twin-screw extruder to obtain the PGA / PGA-based elastomer blended polymer alloy. The degradable toughening polyester elastomer prepared by the method disclosed by the invention takes balance between tensile strength and elongation at break into account, and solves the problem that the degradation property and mechanical property of the conventional polyglycolide copolyester cannot be achieved at the same time; the blended polymer alloy is prepared by using the PGA-based elastomer to modify the PGA, the two-phase compatibility is good, the process is simple, and meanwhile, the high tensile strength and toughness are achieved.

The application discloses a kind of high uniformity medical grade absorbable polyester, preparation method and production system, production system includes kettle type closed stirrer, auxiliary tank, three-way valve and closed kettle type reactor;Three-way valve is communicated with kettle type closed stirrer by melt metering pump;It is communicated with auxiliary tank by micro-injection pump;It is communicated with closed kettle type reactor by static mixer;The side inside of three-way valve and micro-injection pump communication side is designed funnel shape, including funnel neck and funnel mouth, the side surface and bottom surface of funnel neck are equipped with uniform small hole.The application discloses a kind of system specially used for preparing high uniformity medical grade absorbable polyester and the preparation method matched therewith, by using special production system again cooperation specific process parameter can successfully prepare with medical grade absorbable polyester, especially suitable for the preparation of poly-l-lactide and polyglycolide with higher viscosity, more difficult to produce, the product obtained has high uniformity, high molecular weight and low monomer residue.

The application discloses a degradable fiber electrode fabric for three-dimensional electrogastrography monitoring and a preparation method thereof. The preparation method comprises the following steps: subjecting degradable polyglycolide fibers to plasma treatment, and evaporating a gold layer on the polyglycolide fibers; in-situ polymerizing a polypyrrole conversion layer on the surface of the gold layer; in-situ reducing gold nanoparticles on the surface of the polypyrrole conversion layer; coating a poly(1,8-octyleneglycol citrate) solution on the surface of the gold nanoparticle layer to form an insulation layer, and obtaining a degradable flexible fiber electrode; using a knitting technology to synchronously knit the flexible fiber electrode and the polyglycolide fibers to form a three-dimensional flexible fabric structure, removing the insulation layer on a target area of the flexible fabric structure to expose a conductive layer, and obtaining the degradable fiber electrode fabric. The fiber electrode fabric prepared by the application can realize full-curve fitting of a gastric serosal surface, does not need external fixation, and can be used for long-term, stable and real-time multi-dimensional gastric electrophysiological signal acquisition.

Provided are an absorbable biomedical polymer material, a ligation clip, and a method for preparing same. The ingredients selected for the absorbable biomedical polymer material consist of a first polymer and a second polymer. The first polymer consists of 50 wt%-100 wt% of poly(L-lactide) and 0 wt%-50 wt% of polyglycolide, and the second polymer is poly(p-dioxanone). The absorbable biomedical polymer material has suitable rigidity and flexibility, and can be used in preparing a medical device, such as a ligation clip. In particular, when containing 2.5 wt%-40 wt% of the first polymer, the ligation clip can readily pierce the fascia, and is less likely to undergo plastic deformation at a bend. Also disclosed are some structural forms of ligation clips and a method for preparing same.

The present invention relates to the field of nerve repair technology, and discloses a hydrogen and magnesium ion pump catheter with a Janus structure for peripheral nerve defect repair and a preparation method thereof. The pump catheter is composed of a hydrophilic inner layer, a hydrophobic outer layer, and a reservoir middle layer. The hydrophilic inner layer and the hydrophobic outer layer are made of degradable polymer materials, and the reservoir middle layer is made of a mixture of one or more of polylactic acid, polyglycolide, or polylactic-glycolic acid and a magnesium-based material. The pump catheter has a Janus structure, the hydrophilic inner layer provides biophysical clues, improves the cell compatibility of the catheter, and promotes the adhesion and migration of nerve cells. The hydrophobic outer layer blocks the adhesion and invasion of unfavorable cells such as fibroblasts to the damaged area. The magnesium ion and hydrogen reservoir middle layer can continuously release hydrogen and magnesium ions, exerting biological effects, improving the nerve regeneration microenvironment, and improving the effect of the stent in repairing nerve damage.

The invention relates to a deep antioxidant EGCG (epigallocatechin gallate) nano composition as well as a preparation method and application thereof, and belongs to the technical field of nano carriers. The deep antioxidant EGCG nano composition is prepared from the following raw materials: a carrier, a stabilizer, an active substance, water and polyhydric alcohols, the active substance is EGCG; the mass percent of the EGCG in the preparation raw materials is 0.5-5%; the stabilizer is selected from phytosphingosine and derivatives thereof; the carrier is an amphiphilic polymer, the general formula is Xm-Yn, Xm is polyglycolide, and Yn is poly (2-methacryloyloxyethyl phosphorylcholine). The nano composition is prepared by self-assembling and entrapment through a specific preparation method and then removing polyhydric alcohols in the raw materials. The nano composition provided by the invention is high in encapsulation efficiency, good in stability and good in transdermal absorption, and can play an excellent deep antioxidant effect on skin when being used in cosmetics.

The present invention discloses a composite medical suture and a preparation method thereof, which belong to the field of biomedicine. In view of the problems of poor antibacterial effect and biosafety of existing medical sutures, the present invention provides a composite medical suture, comprising a core layer, a degradation regulating layer, a sustained-release layer and an antibacterial layer arranged in sequence from the inside to the outside; the core layer comprises a blended fiber of polyhydroxybutyrate-valerate copolyester and polycaprolactone-co-glycolide; the degradation regulating layer comprises a mixture of at least two polyethylene glycols of different molecular weights; the sustained-release layer comprises quaternary ammonium salt-loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. The present invention achieves comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function through the synergistic effect between the four layers; achieves the purpose of improving sustained-release antibacterial performance, reducing damage to the human body and reducing the occurrence of inflammation, etc., so that its antibacterial and degradation effects meet recovery requirements.

The invention discloses a high melt strength polyglycolide material and a preparation method thereof, and belongs to the technical field of polymer material processing and modification. The raw materials of the high melt strength polyglycolide material include: 100 parts of polyglycolide, 0.1-10 parts of auxiliary agent, and 0.01-3 parts of initiator; the auxiliary agent is cardanol glycidyl ether; the preparation method includes the following steps: polyglycolide, auxiliary agent and initiator are uniformly mixed to obtain a mixed material, and the mixed material is melt-extruded to obtain the high melt strength polyglycolide material. During the melt extrusion process, under the action of a peroxide initiator, the double bond of the auxiliary agent reacts with the secondary carbon of the polyglycolide molecule by free radical reaction, and then the epoxy group and the terminal hydroxyl group or terminal carboxyl group of the polyglycolide molecule undergo a ring-opening reaction to obtain a high melt strength grafted polyglycolide material. The preparation method of the invention is simple, and the obtained high melt strength polyglycolide material can be used in agricultural production, food packaging, biomedicine and other fields.

The present invention refers to an electro-spun multilayer tube or wrap to protect or bridge damaged nerve comprising an electro-spun isolating outer layer comprising at least one polymer selected from poly(caprolactone), polylactide, polyglycolide, poly(trimethylene carbonate), poly(dioxanone), polyethylene glycol, polyurethane, their copolymers or mixtures thereof and at least one electro-spun inner layer comprising a reagent which is able to undergo covalent bonds with proteins and peptides, which comprises at least one group selected from N-hydroxy succinimide, maleimide, sulfur-NHS and biotin-NHS, carboxylic acid or aldehydes. Furthermore, the present invention refers to methods of manufacturing such tubes or wraps as well as their use in protecting or bridging nerves or to stimulate nerve growth and cell proliferation.

The present invention relates to capsules for preparation of a beverage upon injection of liquid under pressure into the capsule, wherein the capsule body comprises or consists of a biopolymer film comprising polyhydroxyalkanoate (PHA) and polyglycolide (PGA), wherein the biopolymer film comprises a layered structure comprising PHA layer - PGA layer - PHA layer, and wherein the PHA has been chemically modified with one or more chain extenders and / or one or more compatibilizers.

The invention belongs to the technical field of high polymer materials, and provides a method for preparing polyglycolide through catalysis of metal-based ionic liquid. The method comprises the following steps: mixing a metal-based ionic liquid solution and an initiator solution in a nitrogen atmosphere, and removing a solvent to obtain a mixed solution; adding glycolide into the mixed solution to obtain a homogeneous-phase mixed solution; and carrying out ring-opening polymerization reaction on the homogeneous-phase mixed solution. The adopted metal-based ionic liquid catalyst belongs to homogeneous catalysis in the ring-opening polymerization reaction of the glycolide, on one hand, the contact area between metal active sites and the glycolide can be increased, the ring-opening polymerization activity can be improved, on the other hand, hydrogen bonds or an ionic microenvironment in the ionic liquid can promote ring opening of the glycolide, and therefore the dosage of the catalyst is reduced, and the cost is reduced. Meanwhile, metal residues in the polyglycolide are reduced, and the biological safety of the polyglycolide is improved; the metal-based ionic liquid catalyst is simple in preparation process, easy for industrial production and high in catalytic efficiency.

The application relates to an electrostatic spinning anti-adhesion membrane and a preparation method and application thereof. The electrostatic spinning anti-adhesion membrane comprises an inner layer, an intermediate layer and an outer layer which are sequentially stacked; the inner layer comprises polyglycolide-lactide-polyethylene glycol, the intermediate layer comprises polyglycolide-lactide, and the outer layer comprises polylactic acid-caprolactone. The electrostatic spinning anti-adhesion membrane has a three-dimensional nanofiber network structure of a biomimetic extracellular matrix, excellent mechanical properties, body temperature response softening and gradient degradation characteristics, can balance the degradation speed and the mechanical properties, reduce the mechanical damage of the material to the surrounding tissues, and can effectively prevent postoperative tissue adhesion.

The present invention discloses a sustained-release levofloxacin punctal plug and a preparation method thereof. The sustained-release levofloxacin punctal plug prepared by cross-linking levofloxacin, polyglycolide, chitosan, and polylysine and then plasma-treating the plug can reduce the frequency of antibiotic use or eliminate the need for antibiotics. The plug has good patient compliance, comfort, biocompatibility, short-term degradation, minimal side effects, good water swelling properties, and is not easily dislodged.

The invention relates to the technical field of VOCs treatment, and discloses hydrophobic activated carbon and a preparation method and application thereof.The method comprises the steps that formed activated carbon is dried and then mixed with a short-chain polymer and an organic solvent, then rotary evaporation drying and vacuum drying are conducted, and the hydrophobic activated carbon is obtained; the short-chain polymer is selected from poly (butyl acrylate), polyvinyl acetate, polylactic acid, polysiloxane, polyethylene, polypropylene, polyisobutene, polystyrene, poly (4-tert-butylstyrene), polybutadiene, polyvinyl ether, polyvinyl formal, polyvinyl carbonate, polyepichlorohydrin, polyethyleneimine and polyetherimide; the component A is at least one of polymethyl isopropyl ether and polyglycolide. The formed activated carbon is used as a modification starting point, the short-chain polymer is used as a modifier, and through specific selection of the short-chain polymer and rotary evaporation drying and vacuum drying, the prepared hydrophobic activated carbon is excellent in hydrophobic performance and excellent in adsorption effect on VOCs in high-humidity crude oil volatile gas.

This invention discloses a method for preparing a sustained-release levofloxacin and fluorometholone lacrimal canaliculus plug, comprising: (1) dispersing levofloxacin, polyglycolic acid, chitosan, and polylysine in a first solvent to form a first dispersion, dispersing fluorometholone and alginate in a second solvent to form a second dispersion, and then mixing the first and second dispersions evenly; (2) performing a crosslinking reaction at 45-55℃ for 3-10 hours, cooling, and drying to obtain a mixture; (3) subjecting the mixture obtained in step (2) to plasma treatment at less than 6 Pa for 30 seconds to 5 minutes, and then solidifying it. The lacrimal canaliculus plug of this invention can reduce the frequency of antibiotic use or eliminate the need for antibiotic use, has good patient compliance, good comfort, good biocompatibility, short-term degradation, few side effects, good water-swelling properties, and is not easy to fall off, and has a triple effect of anti-inflammatory, anti-infective, and dry eye treatment after corneal refractive surgery.

The present application relates to the field of medical devices and discloses a ureteral stent and a preparation method thereof. The ureteral stent comprises a stent body and a nanofiber membrane. The stent body is woven into a 90-140ppi tube by spinning component A and component B in a mass ratio of 4:(1-2). The spun yarn obtained by component B is melted by heating and then combined with the spun yarn obtained by component A. The stent body is obtained after cooling. The nanofiber membrane components include polyethylene glycol and polyglycolide, as well as fucoidan-modified chitosan. A lubricant is sprayed on one side of the nanofiber membrane away from the stent body, and the membrane is wound around the outer surface of the stent body by electrostatic adsorption. The ureteral stent increases the stability and stiffness of the tube wall, improves the mechanical strength and durability, and the material is biocompatible and biodegradable, and can reduce irritation and damage to the urothelium, and prevent urothelial tissue ingrowth and adhesion.

The application discloses a system and method for continuously and industrially producing high-molecular-weight crude PGA. In a 100,000-3,000,000 tons / year polyglycolide PGA device, three different types of polymerization reactors are connected in series, and polymerization reactions are carried out step by step to obtain high-molecular-weight crude PGA. By using the system and method, the conversion rate of the polymerization reaction is 75%-95%, the molecular weight of the polyglycolide PGA is greater than 150,000, and large-scale industrial continuous production of the polyglycolide PGA product is realized. Moreover, the equipment type is simple, the operation is convenient and easy, and the system and method can be applied to the preparation of polyglycolide products in a polyglycolide PGA industrial production device.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

This invention provides a three-center Schiff base catalyst and its preparation method, as well as a method for preparing poly(ethylene glycol) lactide. The three-center Schiff base catalyst has a structure shown in Formula I or Formula II, both of which contain three active sites. The catalytic activity is enhanced through synergistic coordination among the three metal centers. Furthermore, in the preparation method of the catalyst provided by this invention, the synthesis process of the Schiff base compound and the catalyst involves multiple continuous reactions in a one-pot process, saving the purification process of intermediates, reducing the use of organic solvents, simplifying the production process, increasing the catalyst yield, and reducing production costs. This invention uses the catalyst to catalyze the ring-opening polymerization of glycolide and lactide to produce poly(ethylene glycol) lactide. Gel permeation chromatography analysis shows that the prepared poly(ethylene glycol) lactide has a high number-average molecular weight, exceeding 70,000 g / mol, and a high yield, exceeding 94%.

The application discloses a kind of biodegradable synthetic resin and preparation method thereof, the biodegradable synthetic resin includes the following weight parts raw materials: hydroxyl-terminated biodegradable polyester elastomer 10-30 parts, modified polybutylene succinate 60-80 parts, polyglycolide resin 15-30 parts, compatibility agent 5-10 parts, antioxidant 0.1-1 part and lubricant 0.1-1 part.The raw materials of biodegradable synthetic resin used in the application are all full biodegradable materials, not only widely available, but also can complete biodegradation, it is an environment-friendly synthetic resin;The biodegradable synthetic resin of the application has good mechanical comprehensive performance and high thermal decomposition temperature.

The invention discloses a preparation method of an absorbable antibacterial coating material capable of slowly releasing antibiotics. The preparation method comprises the following steps: step 1, blending antibiotics, an absorbable polymer and a mixed solvent to obtain a coating solution; the antibiotics are selected from rifampicin and minocycline hydrochloride; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the mixed solvent is selected from hexafluoroisopropanol and acetonitrile, and the volume ratio of the hexafluoroisopropanol in the mixed solvent is not less than 25%; and 2, uniformly spraying the coating solution on the surface of the degradable base material through ultrasonic spraying, and then carrying out drying treatment. According to the preparation method disclosed by the invention, the antibiotic, the absorbable polymer and the organic solvent are blended and dissolved and then are attached to the surface of the absorbable material through ultrasonic spraying, and the release of the antibiotic is regulated and controlled while the stability of the coating is ensured by regulating and controlling the ratio of the antibiotic to the polymer and the swelling characteristic of the solvent to the base material.