51 results about "Polyglycolide" patented technology

The invention discloses a composite medical suture and a preparation method thereof, and belongs to the field of biomedicine. In order to solve the problems that an existing medical suture is poor in antibacterial effect and biological safety, the composite medical suture comprises a core layer, a degradation regulation and control layer, a slow release layer and an antibacterial layer which are sequentially arranged from inside to outside; the core layer is prepared from a blend fiber of poly (hydroxybutyrate-hydroxyvalerate) and polycaprolactone-co-polyglycolide; the degradation regulation and control layer comprises a mixture of at least two kinds of polyethylene glycol with different molecular weights; the slow release layer comprises quaternary ammonium salt loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. Through the synergistic effect of the four layers, the comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function is realized; the purposes of improving the slow-release antibacterial performance, reducing damage to the human body, reducing inflammation and the like are achieved, and the antibacterial and degradation effects meet the recovery requirements.

The invention discloses an absorbable suture line containing fibroin and a preparation method of the absorbable suture line, and relates to the technical field of absorbable suture lines. The absorbable suture line containing the silk protein is prepared from the following raw materials in parts by weight: 35 to 50 parts of silk protein, 10 to 20 parts of polylactic acid, 15 to 25 parts of polyglycolide-lactide, 1 to 3 parts of antibacterial agent, 2 to 5 parts of modified toughening agent, 1 to 4 parts of nano mineral filler, 0.5 to 2 parts of cross-linking agent and 2 to 5 parts of plasticizer, the preparation method comprises the following steps: reacting protocatechuic acid with ethanolamine to generate an intermediate 1; and reacting the intermediate 1 with 5, 10, 15, 20-tetra (4-carboxyl phenyl) porphyrin to generate the antibacterial agent. The prepared absorbable suture line containing the silk protein has good mechanical performance, self-repairing performance and antibacterial performance.

This invention discloses a method for preparing poly(glycolic acid-caprolactone) copolymers, belonging to the field of polymer synthesis technology. The method includes: prepolymerizing ε-caprolactone with a catalyst and initiator at 40–60°C below the melting point of glycolide under an inert atmosphere; adding glycolide and heating to 160–220°C for the main polymerization reaction; after the reaction, dissolving, precipitating, washing, and drying to obtain the poly(glycolic acid-caprolactone) copolymer. This invention utilizes the physical difference in melting points between glycolide and ε-caprolactone, preferentially prepolymerizing ε-caprolactone at a temperature below the melting point of glycolide, resulting in a higher conversion rate of ε-caprolactone than glycolide in the initial stage of the main polymerization, effectively controlling the copolymerization reaction pathway. Using this method, copolymers with a weight-average molecular weight of not less than 100,000 Da and an intrinsic viscosity of 1.8–3.5 dL / g can be obtained within a wide range of glycolide molar content from 15% to 85%, and the degradation behavior is stable and controllable. This method is simple and requires no special equipment or chain extender, making it suitable for the large-scale preparation of medical materials such as absorbable sutures and tissue repair scaffolds.

This disclosure relates to crystalline forms of 3-acyl-buprenorphine derivatives and sustained release injectable pharmaceutical compositions for treatment of opioid dependence, pain or depression, including an aqueous suspension of crystalline 3-acyl-buprenoprhine, or a pharmaceutically acceptable salt thereof, wherein the composition does not include an organic solvent, a polylactide polymer, a polyglycolide polymer, or a copolymer of polylactide and polyglycolide. This disclosure also includes 3-acyl-buprenoprhine or a pharmaceutically acceptable salt thereof prepared in a controlled release matrix, including poly(lactide-co-glycolide), sucrose acetoisobutyrate, lecithin, diolein and a combination of two or more thereof.

Symmetric Star Poly(Substituted Glycolide) Homopolymers and Their Surface Properties The invention include the synthesis, thin film formation, surface properties, and comprehensive analysis of star-shaped well-defined symmetric poly(substituted glycolide) (s-PSG) homopolymers, which are alternatives to polylactides and polyglycolides. Four-armed symmetric poly(L-diisopropyl glycolide) (4s-PLDIPG) and poly(L-diisobutyl glycolide) (4s-PLDIBG) prepared by ring opening polymerization (ROP) under melt conditions with tin (II) 2- ethylhexanoate catalyst and pentaerythritol initiator exhibited high conversions (92-98%) and desirable PDI values (1.23-1.49). The NMR data of all s-PSGs showed that the methylene peaks of pentaerythritol were shifted, proving that polymerization took place in all arms. The molecular weights (Mn NMR, Mw GPC, Mn GPC) of s-PSGs determined by NMR and GPC data were consistent with the theoretical values. By increasing the side chain length of s-PSG homopolymers, there was a consistent increase in the water contact angles and surface roughness values of the thin films, whereas the surface free energy diminished.

The application discloses a kind of high uniformity medical grade absorbable polyester, preparation method and production system, production system includes kettle type closed stirrer, auxiliary tank, three-way valve and closed kettle type reactor;Three-way valve is communicated with kettle type closed stirrer by melt metering pump;It is communicated with auxiliary tank by micro-injection pump;It is communicated with closed kettle type reactor by static mixer;The side inside of three-way valve and micro-injection pump communication side is designed funnel shape, including funnel neck and funnel mouth, the side surface and bottom surface of funnel neck are equipped with uniform small hole.The application discloses a kind of system specially used for preparing high uniformity medical grade absorbable polyester and the preparation method matched therewith, by using special production system again cooperation specific process parameter can successfully prepare with medical grade absorbable polyester, especially suitable for the preparation of poly-l-lactide and polyglycolide with higher viscosity, more difficult to produce, the product obtained has high uniformity, high molecular weight and low monomer residue.

The application discloses a degradable fiber electrode fabric for three-dimensional electrogastrography monitoring and a preparation method thereof. The preparation method comprises the following steps: subjecting degradable polyglycolide fibers to plasma treatment, and evaporating a gold layer on the polyglycolide fibers; in-situ polymerizing a polypyrrole conversion layer on the surface of the gold layer; in-situ reducing gold nanoparticles on the surface of the polypyrrole conversion layer; coating a poly(1,8-octyleneglycol citrate) solution on the surface of the gold nanoparticle layer to form an insulation layer, and obtaining a degradable flexible fiber electrode; using a knitting technology to synchronously knit the flexible fiber electrode and the polyglycolide fibers to form a three-dimensional flexible fabric structure, removing the insulation layer on a target area of the flexible fabric structure to expose a conductive layer, and obtaining the degradable fiber electrode fabric. The fiber electrode fabric prepared by the application can realize full-curve fitting of a gastric serosal surface, does not need external fixation, and can be used for long-term, stable and real-time multi-dimensional gastric electrophysiological signal acquisition.

Provided are an absorbable biomedical polymer material, a ligation clip, and a method for preparing same. The ingredients selected for the absorbable biomedical polymer material consist of a first polymer and a second polymer. The first polymer consists of 50 wt%-100 wt% of poly(L-lactide) and 0 wt%-50 wt% of polyglycolide, and the second polymer is poly(p-dioxanone). The absorbable biomedical polymer material has suitable rigidity and flexibility, and can be used in preparing a medical device, such as a ligation clip. In particular, when containing 2.5 wt%-40 wt% of the first polymer, the ligation clip can readily pierce the fascia, and is less likely to undergo plastic deformation at a bend. Also disclosed are some structural forms of ligation clips and a method for preparing same.

The present invention relates to the field of nerve repair technology, and discloses a hydrogen and magnesium ion pump catheter with a Janus structure for peripheral nerve defect repair and a preparation method thereof. The pump catheter is composed of a hydrophilic inner layer, a hydrophobic outer layer, and a reservoir middle layer. The hydrophilic inner layer and the hydrophobic outer layer are made of degradable polymer materials, and the reservoir middle layer is made of a mixture of one or more of polylactic acid, polyglycolide, or polylactic-glycolic acid and a magnesium-based material. The pump catheter has a Janus structure, the hydrophilic inner layer provides biophysical clues, improves the cell compatibility of the catheter, and promotes the adhesion and migration of nerve cells. The hydrophobic outer layer blocks the adhesion and invasion of unfavorable cells such as fibroblasts to the damaged area. The magnesium ion and hydrogen reservoir middle layer can continuously release hydrogen and magnesium ions, exerting biological effects, improving the nerve regeneration microenvironment, and improving the effect of the stent in repairing nerve damage.

The invention relates to a deep antioxidant EGCG (epigallocatechin gallate) nano composition as well as a preparation method and application thereof, and belongs to the technical field of nano carriers. The deep antioxidant EGCG nano composition is prepared from the following raw materials: a carrier, a stabilizer, an active substance, water and polyhydric alcohols, the active substance is EGCG; the mass percent of the EGCG in the preparation raw materials is 0.5-5%; the stabilizer is selected from phytosphingosine and derivatives thereof; the carrier is an amphiphilic polymer, the general formula is Xm-Yn, Xm is polyglycolide, and Yn is poly (2-methacryloyloxyethyl phosphorylcholine). The nano composition is prepared by self-assembling and entrapment through a specific preparation method and then removing polyhydric alcohols in the raw materials. The nano composition provided by the invention is high in encapsulation efficiency, good in stability and good in transdermal absorption, and can play an excellent deep antioxidant effect on skin when being used in cosmetics.

The present invention discloses a composite medical suture and a preparation method thereof, which belong to the field of biomedicine. In view of the problems of poor antibacterial effect and biosafety of existing medical sutures, the present invention provides a composite medical suture, comprising a core layer, a degradation regulating layer, a sustained-release layer and an antibacterial layer arranged in sequence from the inside to the outside; the core layer comprises a blended fiber of polyhydroxybutyrate-valerate copolyester and polycaprolactone-co-glycolide; the degradation regulating layer comprises a mixture of at least two polyethylene glycols of different molecular weights; the sustained-release layer comprises quaternary ammonium salt-loaded graphene oxide nanofibers; the antibacterial layer comprises titanium dioxide loaded with silver nanoparticles. The present invention achieves comprehensive optimization of mechanical properties, degradation rate, drug sustained release and antibacterial function through the synergistic effect between the four layers; achieves the purpose of improving sustained-release antibacterial performance, reducing damage to the human body and reducing the occurrence of inflammation, etc., so that its antibacterial and degradation effects meet recovery requirements.

The invention belongs to the technical field of high polymer materials, and provides a method for preparing polyglycolide through catalysis of metal-based ionic liquid. The method comprises the following steps: mixing a metal-based ionic liquid solution and an initiator solution in a nitrogen atmosphere, and removing a solvent to obtain a mixed solution; adding glycolide into the mixed solution to obtain a homogeneous-phase mixed solution; and carrying out ring-opening polymerization reaction on the homogeneous-phase mixed solution. The adopted metal-based ionic liquid catalyst belongs to homogeneous catalysis in the ring-opening polymerization reaction of the glycolide, on one hand, the contact area between metal active sites and the glycolide can be increased, the ring-opening polymerization activity can be improved, on the other hand, hydrogen bonds or an ionic microenvironment in the ionic liquid can promote ring opening of the glycolide, and therefore the dosage of the catalyst is reduced, and the cost is reduced. Meanwhile, metal residues in the polyglycolide are reduced, and the biological safety of the polyglycolide is improved; the metal-based ionic liquid catalyst is simple in preparation process, easy for industrial production and high in catalytic efficiency.

The application relates to an electrostatic spinning anti-adhesion membrane and a preparation method and application thereof. The electrostatic spinning anti-adhesion membrane comprises an inner layer, an intermediate layer and an outer layer which are sequentially stacked; the inner layer comprises polyglycolide-lactide-polyethylene glycol, the intermediate layer comprises polyglycolide-lactide, and the outer layer comprises polylactic acid-caprolactone. The electrostatic spinning anti-adhesion membrane has a three-dimensional nanofiber network structure of a biomimetic extracellular matrix, excellent mechanical properties, body temperature response softening and gradient degradation characteristics, can balance the degradation speed and the mechanical properties, reduce the mechanical damage of the material to the surrounding tissues, and can effectively prevent postoperative tissue adhesion.

The present invention discloses a sustained-release levofloxacin punctal plug and a preparation method thereof. The sustained-release levofloxacin punctal plug prepared by cross-linking levofloxacin, polyglycolide, chitosan, and polylysine and then plasma-treating the plug can reduce the frequency of antibiotic use or eliminate the need for antibiotics. The plug has good patient compliance, comfort, biocompatibility, short-term degradation, minimal side effects, good water swelling properties, and is not easily dislodged.

The invention relates to the technical field of VOCs treatment, and discloses hydrophobic activated carbon and a preparation method and application thereof.The method comprises the steps that formed activated carbon is dried and then mixed with a short-chain polymer and an organic solvent, then rotary evaporation drying and vacuum drying are conducted, and the hydrophobic activated carbon is obtained; the short-chain polymer is selected from poly (butyl acrylate), polyvinyl acetate, polylactic acid, polysiloxane, polyethylene, polypropylene, polyisobutene, polystyrene, poly (4-tert-butylstyrene), polybutadiene, polyvinyl ether, polyvinyl formal, polyvinyl carbonate, polyepichlorohydrin, polyethyleneimine and polyetherimide; the component A is at least one of polymethyl isopropyl ether and polyglycolide. The formed activated carbon is used as a modification starting point, the short-chain polymer is used as a modifier, and through specific selection of the short-chain polymer and rotary evaporation drying and vacuum drying, the prepared hydrophobic activated carbon is excellent in hydrophobic performance and excellent in adsorption effect on VOCs in high-humidity crude oil volatile gas.

This invention discloses a method for preparing a sustained-release levofloxacin and fluorometholone lacrimal canaliculus plug, comprising: (1) dispersing levofloxacin, polyglycolic acid, chitosan, and polylysine in a first solvent to form a first dispersion, dispersing fluorometholone and alginate in a second solvent to form a second dispersion, and then mixing the first and second dispersions evenly; (2) performing a crosslinking reaction at 45-55℃ for 3-10 hours, cooling, and drying to obtain a mixture; (3) subjecting the mixture obtained in step (2) to plasma treatment at less than 6 Pa for 30 seconds to 5 minutes, and then solidifying it. The lacrimal canaliculus plug of this invention can reduce the frequency of antibiotic use or eliminate the need for antibiotic use, has good patient compliance, good comfort, good biocompatibility, short-term degradation, few side effects, good water-swelling properties, and is not easy to fall off, and has a triple effect of anti-inflammatory, anti-infective, and dry eye treatment after corneal refractive surgery.

The present application relates to the field of medical devices and discloses a ureteral stent and a preparation method thereof. The ureteral stent comprises a stent body and a nanofiber membrane. The stent body is woven into a 90-140ppi tube by spinning component A and component B in a mass ratio of 4:(1-2). The spun yarn obtained by component B is melted by heating and then combined with the spun yarn obtained by component A. The stent body is obtained after cooling. The nanofiber membrane components include polyethylene glycol and polyglycolide, as well as fucoidan-modified chitosan. A lubricant is sprayed on one side of the nanofiber membrane away from the stent body, and the membrane is wound around the outer surface of the stent body by electrostatic adsorption. The ureteral stent increases the stability and stiffness of the tube wall, improves the mechanical strength and durability, and the material is biocompatible and biodegradable, and can reduce irritation and damage to the urothelium, and prevent urothelial tissue ingrowth and adhesion.

The application discloses a system and method for continuously and industrially producing high-molecular-weight crude PGA. In a 100,000-3,000,000 tons / year polyglycolide PGA device, three different types of polymerization reactors are connected in series, and polymerization reactions are carried out step by step to obtain high-molecular-weight crude PGA. By using the system and method, the conversion rate of the polymerization reaction is 75%-95%, the molecular weight of the polyglycolide PGA is greater than 150,000, and large-scale industrial continuous production of the polyglycolide PGA product is realized. Moreover, the equipment type is simple, the operation is convenient and easy, and the system and method can be applied to the preparation of polyglycolide products in a polyglycolide PGA industrial production device.

The present invention relates to an electrospun multilayer tube or wrap for the protection or bridging of damaged nerves, comprising an electrospun isolating outer layer and at least one electrospun inner layer, the electrospun isolating outer layer comprising at least one polymer selected from the group consisting of polycaprolactone, polylactide, polyglycolide, polytrimethylene carbonate, polydioxanone, polyethylene glycol, polyurethane, copolymers thereof or mixtures thereof, the at least one electrospun inner layer comprising an agent capable of forming a covalent bond with proteins and peptides, the agent comprising at least one group selected from the group consisting of N-hydroxysuccinimide, maleimide, thio-NHS, biotin-NHS, carboxylic acid or aldehyde. Furthermore, the present invention relates to a method of manufacturing such a tube or wrap and to their use for the protection or bridging of nerves or for stimulating nerve growth and cell proliferation.

This invention provides a three-center Schiff base catalyst and its preparation method, as well as a method for preparing poly(ethylene glycol) lactide. The three-center Schiff base catalyst has a structure shown in Formula I or Formula II, both of which contain three active sites. The catalytic activity is enhanced through synergistic coordination among the three metal centers. Furthermore, in the preparation method of the catalyst provided by this invention, the synthesis process of the Schiff base compound and the catalyst involves multiple continuous reactions in a one-pot process, saving the purification process of intermediates, reducing the use of organic solvents, simplifying the production process, increasing the catalyst yield, and reducing production costs. This invention uses the catalyst to catalyze the ring-opening polymerization of glycolide and lactide to produce poly(ethylene glycol) lactide. Gel permeation chromatography analysis shows that the prepared poly(ethylene glycol) lactide has a high number-average molecular weight, exceeding 70,000 g / mol, and a high yield, exceeding 94%.

The application discloses a kind of biodegradable synthetic resin and preparation method thereof, the biodegradable synthetic resin includes the following weight parts raw materials: hydroxyl-terminated biodegradable polyester elastomer 10-30 parts, modified polybutylene succinate 60-80 parts, polyglycolide resin 15-30 parts, compatibility agent 5-10 parts, antioxidant 0.1-1 part and lubricant 0.1-1 part.The raw materials of biodegradable synthetic resin used in the application are all full biodegradable materials, not only widely available, but also can complete biodegradation, it is an environment-friendly synthetic resin;The biodegradable synthetic resin of the application has good mechanical comprehensive performance and high thermal decomposition temperature.

The invention discloses a preparation method of an absorbable antibacterial coating material capable of slowly releasing antibiotics. The preparation method comprises the following steps: step 1, blending antibiotics, an absorbable polymer and a mixed solvent to obtain a coating solution; the antibiotics are selected from rifampicin and minocycline hydrochloride; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the mixed solvent is selected from hexafluoroisopropanol and acetonitrile, and the volume ratio of the hexafluoroisopropanol in the mixed solvent is not less than 25%; and 2, uniformly spraying the coating solution on the surface of the degradable base material through ultrasonic spraying, and then carrying out drying treatment. According to the preparation method disclosed by the invention, the antibiotic, the absorbable polymer and the organic solvent are blended and dissolved and then are attached to the surface of the absorbable material through ultrasonic spraying, and the release of the antibiotic is regulated and controlled while the stability of the coating is ensured by regulating and controlling the ratio of the antibiotic to the polymer and the swelling characteristic of the solvent to the base material.

The invention discloses a polyglycolide-polyether-polycarbonate copolymer and a preparation method thereof, the number-average molecular weight of the polyglycolide-polyether-polycarbonate copolymer is 3-185 kg / mol, the molecular weight distribution is 1.4-6.8, and the content of glycolide chain links in the copolymer is 0.1-90%. The copolymer disclosed by the invention has the characteristics of higher relative molecular mass, higher melting point, adjustable component composition and excellent mechanical property. The preparation method is low in raw material cost, simple to operate and mild in condition, does not need a complicated post-treatment purification process, and is more beneficial to industrialization.

The invention discloses a poly (p-dioxanone) drug-loaded microsphere, which comprises a microsphere main material, a bioactive substance and a drug, the microsphere main material is prepared by using a poly (p-dioxanone) monomer as a raw material through an emulsion polymerization method, and the bioactive substance is a synthetic degradable high polymer material and a natural biodegradable high polymer material. Comprising but not limited to polylactide and polyglycolide. According to the poly (p-dioxanone) drug-loaded microsphere as well as the preparation method and the application thereof, the monomer (p-dioxanone) and the required drug are taken as raw materials, the raw materials are continuously polymerized and wrap the drug in the emulsification process to form poly (p-dioxanone) with a certain molecular weight, and a certain bioactive substance can be added, so that the poly (p-dioxanone) drug-loaded microsphere is relatively wide in application range and relatively low in cost. According to the microsphere stability and biocompatibility, the degradation time can be controlled by controlling the catalyst and the polymerization time, a certain slow release property is achieved, the toxic and side effects are reduced, the preparation method is simple, and industrial production is facilitated.

A block copolymer includes a block A and a block B. The A block provides mechanical strength and the B block provides elasticity to the polymeric material. The block copolymer may be an ABA triblock copolymer. The A block may include one or more of polyglycolide (PGA), polylactic acid (PLA), or a copolymer thereof. The B block may include a random copolymer of (i) glycolide (GA) and / or lactide (LA), (ii) trimethylene carbonate (TMC), and (iii) epsilon-caprolactone (CL). The block copolymer can cover an implantable device, and the implantable device can be used for achieving immediate hemostasis at a punctured part of a blood vessel wall.

The application discloses a silk protein-containing absorbable suture and a preparation method thereof, and relates to the technical field of absorbable sutures.The silk protein-containing absorbable suture comprises the following raw materials in parts by weight: 35-50 parts of silk protein, 10-20 parts of polylactic acid, 15-25 parts of polyglycolide, 1-3 parts of an antibacterial agent, 2-5 parts of a modified toughening agent, 1-4 parts of a nano-mineral filler, 0.5-2 parts of a crosslinking agent and 2-5 parts of a plasticizer.The application generates an intermediate 1 by reacting protocatechuic acid with ethanolamine; the intermediate 1 is reacted with 5,10,15,20-tetra(4-carboxyphenyl)porphyrin to generate the antibacterial agent.The silk protein-containing absorbable suture prepared by the application has good mechanical properties, self-repairing properties and antibacterial properties.

The application relates to a preparation method of a degradable toughened polyester elastomer and a blended polymer alloy, which comprises the following steps: preparing the degradable toughened polyester elastomer by melt esterification and polycondensation of a hydroxyl-terminated PGA oligomer and a dibasic acid; the molecular weight of the hydroxyl-terminated PGA oligomer is 400-7000 g / mol; the dibasic acid is an aliphatic linear dibasic acid or a flexible alicyclic diacid with 2-12 carbon atoms; drying and uniformly mixing PGA and the degradable toughened polyester elastomer, and then blending and extruding in a double-screw extruder to obtain a PGA / PGA-based elastomer blended polymer alloy. The degradable toughened polyester elastomer prepared by the application balances the tensile strength and the elongation at break, and solves the problem that the degradation performance and the mechanical performance of a conventional polyglycolide copolyester cannot be compatible; the PGA-based elastomer is used to modify PGA to prepare the blended polymer alloy, the two phases have good compatibility, the process is simple, and the blended polymer alloy has high tensile strength and toughness.

The invention discloses a degradable fiber electrode fabric for three-dimensional electrogastrogram monitoring and a preparation method of the degradable fiber electrode fabric. The preparation method comprises the following steps: carrying out plasma treatment on degradable polyglycollide fibers, and evaporating a gold layer on the polyglycollide fibers; polymerizing a polypyrrole transduction layer on the surface of the gold layer in situ; performing in-situ reduction on gold nanoparticles on the surface of the polypyrrole transduction layer; the surface of the gold nanoparticle layer is coated with a poly (1, 8-octylene glycol citrate) solution to form an insulating layer, and the degradable flexible fiber electrode is prepared; and synchronously weaving the flexible fiber electrode and the polyglycollide fiber by using a knitting technology to form a three-dimensional flexible fabric structure, and removing the insulating layer in a target area on the flexible fabric structure to expose the conductive layer, thereby obtaining the degradable fiber electrode fabric. The fiber electrode fabric prepared by the invention can realize full-curved-surface fitting of a gastric serosa surface, does not need additional fixation, and can be used for long-term, stable and real-time multi-dimensional gastric electrophysiological signal acquisition.

The application discloses a modified polyether ether ketone material and a manufacturing method and application. The method comprises the following steps: (1) performing surface etching on a polyether ether ketone base material, so that a plurality of micro columns are formed on the surface of the polyether ether ketone base material, and a first polyether ether ketone is obtained; (2) placing the first polyether ether ketone in an organic amine and reacting at 100-150 DEG C for 2-8 hours to obtain a second polyether ether ketone; (3) repeatedly dip-coating the second polyether ether ketone in a modification liquid to obtain a modified polyether ether ketone material; wherein the modification liquid is an organic solution containing bioactive inorganic substances and biodegradable polyesters, and the biodegradable polyesters in the modification liquid are selected from one or more of polylactic acid, polyglycolide, polyglycolide-co-lactide and polycaprolactone. The method can obviously improve the hydrophilicity of the polyether ether ketone and improve the surface bioactivity of the polyether ether ketone.

The present application relates to a kind of deep antioxidant EGCG nano composition and its preparation method and purposes, belong to nanocarrier technical field.Deep antioxidant EGCG nano composition of the present application preparation raw material includes carrier, stabilizer, active substance, water, polyhydric alcohol;Active substance is EGCG;The mass percentage of EGCG in preparation raw material is 0.5-5%;Stabilizer is selected from plant sphingosine and its derivatives;Carrier is amphiphilic polymer, general formula is X m -Y n , wherein X m It is polyglycolide, Y n It is poly 2-methacryloyloxy ethyl phosphorylcholine.The nano composition is prepared by removing polyhydric alcohol in raw material after self-assembly by specific preparation method.The nano composition provided by the present application has high encapsulation efficiency, good stability, and good transdermal absorption, and is used in cosmetics, which can provide excellent deep antioxidant effect on skin.