41 results about "Hemostatic Agent" patented technology

The present invention relates to a paste composition, a biodegradable injectable paste, and a method for producing the same. According to the present invention, the paste composition may offer the convenience of being applied to the application site using one syringe without the need to mix using two syringes immediately before use, by providing a crosslinked hydrogel as a paste phase, as well as biocompatibility, tackiness, and the balance between viscosity and elasticity, and thus is suitable for use in applications, including hemostatic agents, bone fillers, wound dressings, drug carriers, tissue repair materials, skin soothing agents, moisturizing agents, anti-inflammatory agents, and anti-atopic agents.

The present invention relates to nasal formulations for non-invasive delivery comprising a hemostatic agent and a super absorbent polymer in a powder form, and to uses of said formulations for preventing and / or treating epistaxis.

The invention discloses a hemostatic PW4-FIDD-SUP as well as a preparation method and application thereof, and belongs to the technical field of medicines. According to the preparation method, different phase-state preparations are prepared by performing different phase-state resolution on the wine-processed radix scutellariae and fructus gardeniae matched water decoction, and the difference condition among different preparations is determined through physical property detection, protein and total sugar content detection and component analysis. The invention also determines that the internal dialysis fluid-supernatant (PW4-FIDD-SUP) of the wine-processed radix scutellariae and fructus gardeniae matched water decoction has a remarkable effect in the aspects of regulating and controlling body functions and preventing and treating gastrorrhagia, and the PW4-FIDD-SUP has the effects of diminishing inflammation and relieving pain. The research result of the invention provides a new strategy for the development of a novel preparation of the fructus gardeniae stir-fried with wine radix scutellariae, and provides a theoretical basis for the research of pharmacodynamic substances of the fructus gardeniae stir-fried with wine radix scutellariae.

A medicinal composition and a hemostatic agent, exhibiting both excellent hemostatic properties and excellent retention properties over time, and a dispenser with which the medicinal composition or hemostatic agent can be satisfactorily sprayed are provided. The medicinal composition is applied to the surface of an inner lumen of the digestive tract of a living body; the dispenser sprays the medicinal composition and the hemostatic agent, which are powders containing polyacrylic acid and polyvinylpyrrolidone, onto the surface of the inner lumen of the digestive tract; the dispenser comprises a main body and a catheter, the main body having an intake section that draws in air from an exterior of the living body and is configured to expel the air by pressurizing the intake air, a reservoir that receives the medicinal composition, and at least two non-return valves; the catheter has a connecting section that is connected to the reservoir and through which the medicinal composition flows;and the dispenser is configured to spray the medical composition from an end part of the catheter onto the surface of the inner lumen of the digestive tract by expelling air from the receiving section.

The embodiments herein provide hemostatic compositions, methods, and kits comprising composite polymer particles. Upon contact with blood or other physiological fluids, the composite particles adsorb fluid and aggregate into a shape-retentive mass that halts bleeding. In certain embodiments, the particles comprise polymers of 2-hydroxyethyl methacrylate, 2-hydroxypropyl methacrylate, or combinations thereof. The particles may be used alone or blended with additional hemostatic agents. Methods of inducing hemostasis are provided for diffuse oozing, or surgical, mucosal, organ surface, fragile tissue or traumatic bleeding, including in patients receiving anticoagulant or antiplatelet therapy. Kits comprising sterile packages of composite particles, optionally with applicators, substrates, or sprays, are disclosed. The compositions exhibit intrinsic hemostatic activity and synergistically enhance the performance of conventional hemostats, achieving rapid clotting. After hemostasis is achieved, the compositions remain in situ as a conforming protective layer, reducing the need for additional covering materials and decreasing risk of re-bleeding.

A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.

The invention provides alimentary canal hemostatic particles and a preparation method thereof. The alimentary canal hemostatic particles are prepared from components as follows: a hemostatic and an excipient, the hemostatic is prepared from polyacrylic acid, polyethyleneimine and polyoxyethylene; the mass ratio of polyacrylic acid to polyethyleneimine to polyoxyethylene is 1: (1-2): (0.04-1). The hemostatic particles have excellent endoscope catheter conveying performance and can quickly absorb a large amount of water to form hydrogel in situ after being sprayed on a bleeding wound surface, the hydrogel adheres to the tissue surface to form a physical barrier, immediate hemostasis is achieved, meanwhile, the hydrogel formed in situ has excellent adhesion stability and corrosion resistance, and the hemostatic particles have good application prospects. It can be guaranteed that the wound surface is still protected within 72 h after the operation, and the risk of rebleeding is reduced.

The utility model provides a kind of hemostatic gauze ball with hemostatic medicament, it is related to gauze technical field, including sphere and medicament ball, the sphere includes absorbent cotton and gauze mesh belt, the absorbent cotton is spherical, the gauze mesh belt is wrapped in the outside of absorbent cotton, the inside center of absorbent cotton is equipped with inner cavity, the medicament ball is equipped inside inner cavity;The side of the sphere is equipped with hole, and hole is connected to the inside of inner cavity, the inside of hole is equipped with extrusion membrane;The utility model embeds medicament ball in sphere, without extra preparation medicine, when using, only need to lay under sphere to wound, extrude extrusion membrane, press the membrane of broken medicament ball, hemostatic medicament can flow out downwards, carry out quality to wound, it is convenient and fast to operate, it is convenient to use anytime, and when laying, by liquid guide wire core increase the speed of hemostatic medicament in inner cavity flowing downwards gauze mesh belt, with quick-dissolving effect, improve the efficiency of drug action.

A malleable sustained release formulation is created utilizing a local anesthetic wherein the composition is made sustained release by incorporating it into a bovine or porcine hemostatic agent. The composition is malleable enough to fit into a cavity such as a dental cavity and form the shape of the cavity. In addition to providing sustained release of the anesthetic, the composition also provides quicker reduction in bleeding.

The present invention relates to an absorbable internal hemostasis kit and an absorbable internal hemostatic agent, the kit comprising: a first syringe containing a powder mixture including gelatin, thrombin, and calcium chloride; a second syringe containing a mixed solution including a thermo-responsive gel, purified water, polyvinylpyrrolidone, polyethylene glycol, sodium chloride, and a protein extract obtained through a multi-stage decellularization process; and a connector for connecting the first syringe and the second syringe so that the powder mixture and the mixed solution can be combined, wherein the absorbable internal hemostatic agent according to the present invention promotes and activates primary physiological hemostasis through thrombin and provides a secondary physical hemostatic effect by gelling in a temperature range close to body temperature, while also offering additionally wound-healing effects, so as to achieve faster and more effective internal hemostasis.

A method for administering a medicament, the method comprising introducing a fluid into a container (100) containing the medicament, allowing the fluid to flow along a pressure relief channel (231) to an outlet of the container (100), and after the flow rate of the fluid has stabilized, closing the outlet and allowing the fluid to enter a pressure channel (232), flow along the pressure channel (232), exit the pressure channel (232) and push the medicament towards an outlet of the container (100). The method for administering the medicament can deliver the medicament in the container (100) in a more stable and sustained manner and in a more gentle form, effectively avoiding the sudden release of pressure which can cause the medicament to be pushed back by the target tissue and spread over the field of view of the endoscope, thereby allowing more accurate administration of the medicament (e.g. a hemostatic agent), improving the continuity of the endoscopic procedure, improving the hemostatic effect and reducing the time required for the procedure.

The invention belongs to the technical field of dressings, and particularly discloses an antibacterial slow-release dressing and a preparation method thereof.The antibacterial slow-release dressing comprises a carrier and a contact body composed of three contact layers, and raw materials of the first contact layer comprise a microporous contact material, a hemostatic and a first antibacterial agent; raw materials of the first contact layer comprise chitosan, polyurethane, a first antibacterial agent and a one-way isolating membrane, raw materials of the second contact layer comprise chitosan, polyurethane, a second antibacterial agent and a one-way isolating membrane, raw materials of the third contact layer comprise a liquid absorbent, a coagulator and a third antibacterial agent, liquid guiding fibers are further arranged in the three contact layers, and the antibacterial slow-release dressing with a specific function is obtained through preparation of specific components and a specific process. According to the antibacterial slow-release dressing provided by the invention, a multi-layer antibacterial structure with liquid guiding, storing and blocking functions is constructed on the bearing body, so that the antibacterial property of the dressing is obviously improved, and the antibacterial slow-release dressing is applicable to both a large amount of percolate and a small amount of percolate.

The present disclosure provides hydrophobically-modified biopolymers, including hydrophobically-modified chitosans, which comprise benzenediol groups, optionally where a portion are oxidized to the corresponding quinone. The biopolymers demonstrate a surprising ability to tune mucoadhesive properties, material cohesive properties, and hemostatic action of the material, to provide next generation hemostats, among other uses. Accordingly, in other aspects, the disclosure provides compositions comprising the modified biopolymers of the disclosure as well as methods for bleed and wound treatment.

The application relates to the technical field of medical materials, and discloses a hemostatic gel and a preparation method thereof. The hemostatic gel provided by the application comprises the following raw materials in parts by weight: modified chitosan 20-40 parts, hydrated gelatin particles 35-45 parts, fatty acid salt vesicles 5-20 parts, and a crosslinking agent 1-5 parts. The hemostatic gel takes modified chitosan as the main body, combines the hydrated gelatin particles and the fatty acid salt vesicles to form a ternary synergistic system, and is matched with the crosslinking agent, so that the uniformity and mechanical stability of the gel are ensured, the problem of insufficient hemostatic efficiency caused by single component of a traditional hemostatic agent is overcome, and the hemostatic gel has good biocompatibility and degradability, and is especially suitable for a hemostatic application scene of bleeding in a narrow anatomical space or a high-risk part.

The present invention relates to a phytological composition as a hemostatic agent, for example for use in the treatment of wounds and / or bleeding lesions of the skin and / or mucous membranes. The phytological composition consists of a polysaccharide of Tremella fuciformis, an extract of leaves of Vitis vinifera, an extract of leaves of Astragalus membranaceus, an extract of Medicago sativa, an extract of Fucus vesiculosus, a powder of Spirulia platensis, an extract of root of Beta vulgaris and an extract of Polygonum cuspidatum. The present invention also relates to pharmaceutical formulations comprising said phytological composition together with suitable pharmaceutically acceptable excipients.

The present invention relates to polysaccharide-based polymeric crosslinkers, polysaccharide-based biomaterials, preparation methods, and uses. In the present invention, the polysaccharide-based polymeric crosslinker is a polysaccharide-based polymeric crosslinker modified with ortho-phthalaldehyde groups, which does not rely on a synthetic hydrophilic polymer backbone or complex chemical synthesis processes. The polysaccharide-based polymeric crosslinker provided by the present invention, together with water-soluble small molecules or polymers containing one or more groups selected from the group consisting of primary amine, hydrazine, hydrazide, hydroxylamine, and mercapto groups, forms a two-component polysaccharide-based hydrogel material in an aqueous medium. This two-component polysaccharide-based hydrogel material has the advantages of being injectable, having low swelling, and having high tissue adhesion. Furthermore, the two-component polysaccharide-based hydrogel material provided by the present invention can be further fabricated into polysaccharide-based biomaterials in the form of membranes, powders, sponges, and other forms, and can be used as tissue adhesives, sealants, hemostats, tissue engineering materials, and other applications, demonstrating its potential for a wide range of biomedical applications.

A fluidic hemostat agent comprising a solid hemostatic additive suspended in a silanol carrier fluid to form a heterogeneous mixture that exhibits sufficient flowability to allow for injection and proliferation, while simultaneously having sufficient adhesive and viscoelastic characteristics to remain at the application site and enable the clotting cascade time to form a thrombus. The silanol carrier fluid preferably comprises liquid silanol-bearing POSS molecules, while the solid hemostatic additive preferably is selected from the group consisting of kaolin, chitin, chitosan, cellulose, keratin pectin, acetylated glucosamine, dry fibrin, gelatin, and calcium salts. A preferred silanol species is iso-octylPOSS trisilanol having the molecular representation [(i-ocylSiO1.5)4(i-octyl(OH)SiO1.0)3]Σ7.

A laparoscopic applicator for dispensing a substance, such as a substance containing a hemostatic agent, at a selected site through a surgical robotic arm, the laparoscopic applicator comprising: a delivery tube; an applicator tip connected to the distal end of the delivery tube, the applicator tip configured to be controllably operated by the robotic arm through an axially extending grip portion of the delivery tube, the grip portion having a perimeter transverse to the axis, the perimeter including a vertex-shaped portion, the gripping portion is configured to be gripped and spatially manipulated by a robot arm; a reservoir connected to the proximal end of the delivery tube, the reservoir having a fixed volume; and a one-way valve connected to the proximal end of the reservoir, wherein the one-way valve is configured to prevent a flow of substance from the reservoir through the one-way valve.

A novel active agent-eluting hemostatic agent and methods of use and manufacture thereof are presented. A polymer, such as gelatin or chitosan, is used as the base for a hemostatic agent. The polymer is crosslinked with a chemical crosslinker, such as a carbodiimide, in the presence of an active agent. The active agent may be an anesthetic, chemotherapeutic agent, or antimicrobial, such as an antibiotic. The novel process allows for the active agent to be both covalently bound to the polymer as well as be trapped within cages in the polymer that are formed from the crosslinking. This dual measure allows for controlled and sustained release of the active agent from the hemostatic agent to deliver the active agents to the wound sites.

The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and / or glycolide polymers; lactide / glycolide copolymers; silicate fibers; polyimide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.

Provided are a medical composition and a hemostatic agent which are excellent in both hemostatic properties and retention properties over time, and a dispenser with which the medical composition or the hemostatic agent can be satisfactorily sprayed.The medical composition is applied to a surface of an inner lumen of a digestive tract of a living body; the dispenser sprays the medical composition and the hemostatic agent, which are powder bodies containing polyacrylic acid and polyvinylpyrrolidone, and the medical composition onto the surface of the inner lumen of the digestive tract; the dispenser includes a main body and a catheter, in which the main body has an accommodation portion that accommodates air from an outside of the living body and that is configured to eject the air by pressurizing the accommodated air, a container that accommodates the medical composition, and at least two check valves; the catheter has a connecting portion that is connected to the container and through which the medical composition flows; and the dispenser is configured to spray the medical composition onto the surface of the inner lumen of the digestive tract from an end part of the catheter by ejecting the air from the accommodation portion.

The present invention relates to a powder composition comprising a specific biodegradable A and B block copolymer, at least one lubricant, and at least one hemostatic agent. The powder composition according to the present invention is particularly useful in methods for preventing and / or treating bleeding, preferably uterine bleeding. The present invention also relates to (i) the powder composition of the present invention, and (ii) a kit comprising means for inserting the powder composition into a body cavity, preferably the uterine cavity.

A hemostatic in the form of a paste is presented. The hemostatic comprises a) at least one particulate sugar alcohol; b) at least one saturated triglyceride having a melting point greater than or equal to 40 DEG C; and c) at least one saturated triglyceride having a melting point below 0 DEG C. Furthermore, the use of the hemostatic agent in the form of the paste and a method for the preparation thereof are described.

The present invention relates to an absorbent hemostatic patch using a biocompatible fibrous fabric substrate that is melt-blown, napped, or loosened on the surface, wherein the substrate has a low profile, high flexibility, strength, and porosity suitable for coating crosslinkable active molecules and is ultimately effective for use as a hemostatic agent in problematic bleeding situations.

A dressing comprises a delivery vehicle and platelet lysate. The dressing can also include an antimicrobial agent, a hemostatic agent, and a binder. It is contemplated that the dressing can be used for expediting hemostasis, improving antimicrobial activity, minimizing fluid loss, and accelerating wound healing when applied to a wound. The dressing would be useful in applications including military in-theater medical care and for conditions such as diabetic foot ulcers, as well as other applications.

Provided are: a medical composition and a hemostatic agent which have both excellent hemostatic properties and long-term retention properties; and a dispenser which is capable of satisfactorily dispensing the medical composition or hemostatic agent. A hemostatic agent and a medical composition suitable for use on the surface of the lumen of the alimentary canal of a living body and containing a powder of polyacrylic acid and polyvinylpyrrolidone, and a dispenser for dispensing the medical composition on the surface of the lumen of the alimentary canal, the dispenser being provided with: a main body having: an accommodating part capable of accommodating air from the outside of the body; air is injected by pressurizing the accommodated air; a container for accommodating the medical composition; and at least two check valves, the catheter has a connection part connected to the container and through which the medical composition flows, and the medical composition can be sprayed from the end of the catheter to the surface of the lumen of the digestive tract by spraying air from the accommodating part.

In some aspects, the present disclosure pertains to injectable polysaccharide-based hydrogels that comprises an anionic polysaccharide, a cationic crosslinking agent and a hemostatic agent. In some aspects, the present disclosure pertains to medical devices containing such injectable polysaccharide-based hydrogels, to kits that contain such injectable polysaccharide-based hydrogels, and to methods of using such injectable polysaccharide-based hydrogels.

The invention provides a powerful hemostatic adhesive prepared by taking American cockroach dregs as a main raw material. The preparation method comprises the following steps: firstly, extracting and preparing chitin whiskers from waste American cockroach dregs, taking the chitin whiskers as a polymer matrix of the adhesive, taking an aqueous solution of a deep eutectic solvent as a system medium, taking thrombin as a hemostatic functional substance, and improving the overall mechanical properties by gelatin, thereby finally obtaining the biological adhesive with good adhesion and hemostatic performance. According to the product, under the condition that a cross-linking agent does not need to be used, through heating-cooling operation, a polymer skeleton network is constructed through interaction between chitin whiskers and gelatin, a channel is provided for transmitting moisture and nutrient substances to damaged tissues, and the product has degradability while achieving an ideal adhesion effect; the whole system effectively fuses the components, is friendly and easy to prepare, and integrates respective advantages. In addition, the activity and the stability of the thrombin in the eutectic solvent are both in ideal states, so that the adhesive can play a powerful hemostatic role.

This invention discloses a post-implantation method for a radioactive source implantation device, comprising the following steps: Step 1: The radioactive source implantation device drives a push rod to push out the target number of radioactive sources from the puncture needle along the delivery conduit. Simultaneously, the device pulls the puncture needle backward a target distance, and then automatically pauses, or automatically pauses after the push rod has moved backward a certain distance; Step 2: The operator presses the continue button, the device continues the process, and the push rod is fully reset. This allows the blood at the tip of the puncture needle to coagulate before the push rod is fully retracted and reset. The coagulated blood acts as a hemostatic agent, preventing further bleeding.

The invention discloses a nano polymer hemostatic and a preparation method thereof, the hemostatic is a composite nanoparticle with a core-shell structure, and is formed by compounding a core layer, a shell layer and loaded active components through covalent crosslinking and electrostatic adsorption; the particle size (D50100nm-300nm), the porosity (60%-90%) and the active component loading capacity (0.5%-5%) of the composite nanoparticles are accurately controlled through the processes of intermittent ultrasonic treatment (working for 3s-5s, and the interval is 5s-10s), gradient freeze-drying and the like, the inter-batch variation coefficient of the product is less than 5%, and the problem of poor stability of the traditional nano preparation process is solved.